Immune evasive DNA donors and recombinases license kilobase-scale writing
Connor J. Tou, Keqiang Xie, Joana Ferreira da Silva, Pazhanichamy Kalailingam, Eliz Amar-Lewis, David Rufino-Ramos, William Sawyer, Madeline L. Eller, Jakob Starzyk, Ishita Majumdar, Jiao Wang, Danna Lee, Shaobo Yang, Ronald J. Meis, Gary A. Dahl, Jiahe Li, Richard Shan, Natalie Artzi, Patricia L. Musolino, Hao Wu, Benjamin P. Kleinstiver
Facile induction of immune tolerance by an interleukin-2âTGFÎČ surrogate agonist
Qinli Sun, Alison K. Barrett, Masato Ogishi, Huiyun Lyu, Hua Jiang, Honghui Liu, Yang Zhao, Grayson E. Rodriguez, Pingdong Tao, Matthias Obenaus, Karsten D. Householder, Qizhi Tang, Tobias V. Lanz, K. Christopher Garcia
B cell imprinting in children impairs antibodies to the haemagglutinin stalk
Jiayi Sun, Gyunghee Jo, Chloe A. Troxell, Yanbin Fu, Robert Hoezl, Huibin Lv, Hassanein H. Abozeid, Qi Wen Teo, Tossapol Pholcharee, Joshua J. C. McGrath, Siriruk Changrob, Sean A. Nelson, Atsuhiro Yasuhara, Min Huang, Nai-Ying Zheng, Jordan C. Chervin, Lei Li, Monica L. FernĂĄndez-Quintero, Johannes R. Loeffler, Alesandra J. Rodriguez, Jiachen Huang, Olivia M. Swanson, Angel Balmaseda, Guillermina Kuan, Lora Campredon, E. Kaitlynn Allen, Gabriele Neumann, Nicholas C. Wu, Yoshihiro Kawaoka, Florian Krammer, Asuncion Mejias, Octavio Ramilo, Paul G. Thomas, Aubree Gordon, Andrew B. Ward, Julianna Han, Patrick C. Wilson
Gene conversion empowers natural selection in a clonal fish species
Edward S. Ricemeyer, Nathan K. Schaefer, Kang Du, Irene da Cruz, Susanne Kneitz, Rafael D. Acemel, DarĂo G. Lupiåñez, Rachel A. Carroll, Rosie Drinkwater, Manfred Schartl, Wesley C. Warren
LenseâThirring precessing magnetar engine drives a superluminous supernova
Joseph R. Farah, Logan J. Prust, D. Andrew Howell, Yuan Qi Ni, Curtis McCully, Moira Andrews, Harsh Kumar, Daichi Hiramatsu, Sebastian Gomez, Kathryn Wynn, Alexei V. Filippenko, K. Azalee Bostroem, Edo Berger, Peter Blanchard
Matt Saha, Y. Henry Wen, Andrew S. Greenspon, Matthew Zimmermann, Kevin J. Palm, Alex Witte, Yin Min Goh, Chao Li, Jonathan Bumstead, Kevin SchÀdler, Ryan Fortin, Mark Dong, Andrew J. Leenheer, Genevieve Clark, Gerald Gilbert, Matt Eichenfield, Dirk Englund
Multidimensional profiling of heterogeneity in supratentorial ependymomas
Daeun Jeong, Sara G. Danielli, Kendra K. MaaĂ, David R. Ghasemi, Svenja K. Tetzlaff, Ekin Reyhan, Li Jiang, Shashank Katiyar, Julia K. Sundheimer, Costanza Lo Cascio, Sina Neyazi, Carlos Alberto Oliveira de Biagi-Junior, Elsa Couvillon, Sophia Castellani, Maria Pazyra-Murphy, Matthew Mullally, Marc Philipp Dehler, Bernhard Englinger, Andrezza Nascimento, Gustavo Alencastro Veiga Cruzeiro, Joana G. Marques, Rebecca D. Haase, Cuong M. Nguyen, Alicia-Christina Baumgartner, Jacob S. Rozowsky, Olivia A. Hack, McKenzie L. Shaw, Daniela Lotsch-Gojo, Katharina Bruckner, Andrey Korshunov, Stefan M. Pfister, Marcel Kool, Tomasz J. Nowakowski, Johannes Gojo, Lissa Baird, Sanda Alexandrescu, Kristian W. Pajtler, Varun Venkataramani, Mariella G. Filbin
Francesca Fabiana Settembrini, Arif Can Gungor, Andres Forrer, Steven A. Fortune, Alessandro DellâAquila, Preethi Padmanabhan, Ion E. Opris, Moise Sotto, Nikola Dordevic, Yevgeny Perelman, Thomas Christen, Mi Wang, Remus Nicolaescu
Alcohol group migration by proximity-enhanced H atom abstraction
Qian Xu, Yichen Nie, Jacob-Jan Haaksma, Ronghua Zhang, Natalie Holmberg-Douglas, Farid van der Mei, Paul M. Scola, Chloe Williams, Jeremiah A. Johnson, Alison E. Wendlandt
Ageing promotes metastasis via activation of the integrated stress response
Angana A. H. Patel, Jozefina J. Dzanan, Kevin X. Ali, Ella A. Eklund, Samantha W. Alvarez, Dorota Raj, Martin Dankis, Ilayda Altinönder, Maria Schwarz, Kristell Le Gal, Emre Bedel, Ahmed Ezat El Zowalaty, Emma Jonasson, Heba Albatrok, Nadia Gul, Jozef P. Bossowski, Ray Pillai, Patrick Micke, Johan Botling, Levent M. AkyĂŒrek, Davide Angeletti, Sama I. Sayin, Anetta HĂ€rtlova, Thales Papagiannakopoulos, Roger Olofsson Bagge, Anders StĂ„hlberg, Andreas Hallqvist, Clotilde Wiel, Volkan I. Sayin
Natural maternal immunity protects neonates from Escherichia coli sepsis
Raymond E. Diep, Ujjwal Adhikari, Kubra Gokce Tezel, Giang Pham, Allison R. Burrell, Mary A. Staat, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Kate M. Peters, Mark A. Schembri, Scott H. Saunders, David B. Haslam, John J. Erickson, Susana Chavez-Bueno, Sing Sing Way
Direct oxidative carbonylation of methane to acetic acid via high-valent iron-oxo mediated water activation
Haonan Zhang, Richard J. Lewis, A. Iulian Dugulan, Yang Li, Shuai Wang, Zhenxing Wang, Jianrong Zeng, Nicholas F. Dummer, Yanyan Xi, Yunyun Li, Thomas E. Davies, Mingbo Wu, Graham J. Hutchings, Wenting Wu
Pan-tumor activity of olomorasib, a next-generation KRAS G12C inhibitor in KRAS G12C-mutant advanced solid tumors: a first-in-human study
Yonina R. Murciano-Goroff, Antoine Hollebecque, Rebecca S. Heist, Philippe A. Cassier, Ji-Youn Han, So Yeon Kim, Joshua K. Sabari, Diego Tosi, Adrian Sacher, Timothy F. Burns, Toshio Shimizu, Natraj Reddy Ammakkanavar, Alexander Spira, Carlos Gomez-Roca, Amita Patnaik, Rasha Cosman, J. Nicholas Bodor, Misako Nagasaka, Arthur Xintian You, Samuel C. McNeely, Raimund Peter, Aaron Fink, Aaron Chen, Geoffrey R. Oxnard, Melinda D. Willard, Yasutoshi Kuboki, Takafumi Koyama
Cortical-limbic circuit dynamics of approach-avoidance conflict in humans
Brooke R. Staveland, Julia Oberschulte, Barbara Berger, Tamas Minarik, Olivia Kim-McManus, Jon T. Willie, Peter Brunner, Mohammad Dastjerdi, Jack J. Lin, Elizabeth L. Johnson, Michelle Paff, Ming Hsu, Robert T. Knight
Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice
Friederike A. Schulte, Francisco C. Marques, Julia K. Griesbach, Claudia Weigt, Marcella von Salis-Soglio, Floor M. Lambers, Clemens Kreutz, Michaela Kneissel, Peter J. Richards, Gisela A. Kuhn, Ralph MĂŒller
Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation
Joshua Kosnoff, Colton Gonsisko, Kai Yu, Joseph Zhang, Yidan Ding, Yisha Zhang, Bin He
Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues
S. Kourtis, A. Gañez Zapater, CR ElbĂŠk, A. Schmidt, R. Ghose, A. Coll Manzano, L. Espinar Calvo, M. Guirola, N. Pardo-Lorente, M. Garcia-Cao, M. Pfeiffer, S. Haynes, F. Fontaine, A. MĂŒller, S. Sdelci
Spatio-spectral light-by-light moulding in multimode fibre
Yago Arosa, Tigran Mansuryan, Arnaud Poisson, Wasyhun Asefa Gemechu, Katarzyna Krupa, Mario Ferraro, Fabio Mangini, Benjamin Wetzel, Stefan Wabnitz, Alessandro Tonello, Vincent Couderc
Molecular insights into the regulation of GNPTαÎČ by LYSET
Xi Yang, Balraj Doray, Danielle Henn, Varsha Venkatarangan, Benjamin C. Jennings, Zhongzheng Dong, Jiaxuan Liang, Weichao Zhang, Bokai Zhang, Linchen Yu, Liang Chen, Stuart Kornfeld, Ming Li
Polarity-tunable field-free room-temperature spin orbit torque switching via topological symmetry breaking in an all-vdW heterostructure for spin logic applications
Fan Gao, Zili Wang, Runyu Zhao, Jing Li, Xiaoyue Song, Peiyuan Yu, Yun Sun, Weiran Xie, Guodong Wei, Yuan Yao, Jin Zou, Jie Zhang, Shucheng Xing, Roberto Mantovan, Zongxia Guo, Nicolas Jaouen, Weisheng Zhao, Tianxiao Nie
Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum
Cecilia P. Sanchez, Maëlle Duffey, Romina V. Celada, Michal Kucharski, Marie Hoarau, Thanaya Saeyang, Sumalee Kamchonwongpaisan, Farzin Sohraby, Svenja de Buhr, Ariane Nunes Alves, Amuza Byaruhanga Lucky, Jun Miao, Clement Regnault, Jerzy M. Dziekan, Zbynek Bozdech, Michael P. Barrett, Michael Lanzer
The REDD1âNF-ÎșBâmiRNAsâeNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
Yoon Kyung Choi, Dong-Keon Lee, Minsik Park, Junyoung Byeon, Woo-Young Nam, Thuy Linh Lai, Kyu Nam Kim, Okhwa Kim, Sungwoo Ryoo, Jeong-Hyung Lee, Young-Guen Kwon, Ji-Yoon Kim, Young-Myeong Kim
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma
Daniel J. Renouf, James T. Topham, Jonathan M. Loree, David F. Schaeffer, Jennifer J. Knox, Petr Kavan, Derek Jonker, Stephen Welch, Felix Couture, Frederic Lemay, Mustapha Tehfe, Mohammed Harb, Nathalie Aucoin, Yoo-Joung Ko, Patricia A. Tang, Ravi Ramjeesingh, Brandon M. Meyers, Christina A. Kim, Pan Du, Shidong Jia, Joanna M. Karasinska, Sharlene Gill, Dongsheng Tu, Chris J. OâCallaghan
Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors
Callum Walker, Gabriel Kollarovic, Daniel Weekes, Jennifer Trendell, Ricarda M. Hoffmann, Alexia Martin, Riccardo Ferro, Blanca Navarro-Llinas, Luke Hitchen, Mercedes Pardo Calvo, Nicolae Balan, Harriet Kemp, Alexandra Carroll, Kathryn Davidson, Sarmi Nath, Nadja DâUonno, Ruifang Lu, Chris Starling, Marieke Otten, Nino Iakobachvili, Chiara Marcozzi, Ilhan Rahman, Jelmar Quist, Lu Yu, Dragomir B. Krastev, Valeria Amodeo, Ioannis Roxanis, Anita Grigoriadis, Richard Bayliss, Jyoti Choudhary, Syed Haider, Jonathon Pines, Stephen J. Pettitt, Christopher J. Lord, Andrew N. J. Tutt
Probing boron vacancy defects in hBN via single spin relaxometry
Alex L. Melendez, Ruotian Gong, Guanghui He, Yan Wang, Yueh-Chun Wu, Thomas Poirier, Steven Randolph, Sujoy Ghosh, Liangbo Liang, Stephen Jesse, An-Ping Li, Joshua T. Damron, Benjamin J. Lawrie, James H. Edgar, Ivan V. Vlassiouk, Chong Zu, Huan Zhao
NF-ÎșB activation in astrocytes impairs wound healing after traumatic brain injury in male mice
Tabea M. Hein, Ester Nespoli, Marsela Hakani, Heinrich Wendt, Stephanie Nadine May, Jasmin Jorzik, Duygu Yagdiran, Judith S. Schlett, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Vivien Prex, Melanie Mettang, Alireza Abaei, Volker Rasche, Michael Lattke, Franz Oswald, Markus Huber-Lang, Leda Dimou, Thomas Wirth, Bernd Baumann
Infection-acquired protection against SARS-CoV-2 infection and clinical severity by number of prior infections
Hannah E. Maier, Sergio Ojeda, Abigail Shotwell, Roger Lopez, Nery Sanchez, Saira Saborio, Miguel Plazaola, Carlos Barilla, Guillermina Kuan, Angel Balmaseda, Aubree Gordon
RejuAgro A as an antimicrobial for fire blight control of pome fruits and beyond
Jian Huang, Ton Nu Bao Vy Huyen, Xianyang Liu, Shreyashi Mitra, Manda Yu, Quan Zeng, George W. Sundin, Kerik D. Cox, Helga Förster, James E. Adaskaveg, Chih-Horng Kuo, Xiaochen Yuan, Russell L. Cuhel, Ching-Hong Yang
Wafer-scale manufacturing of ultra-broadband, high-power erbium-doped integrated lasers
Xinru Ji, Xuan Yang, Yang Liu, Zheru Qiu, Grigory Lihachev, Simone Bianconi, Jiale Sun, Andrey Voloshin, Taegon Kim, Joseph C. Olson, Tobias J. Kippenberg
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
Jennifer L. Duffen, Kimberly K. Crouse, Lin Ji, Amy L. Brault, Kristen Ford, Jonathan Brooks, Scott A. Jelinsky, Yizheng Li, Julia H. Shin, Yajuan Zhao, Tatyana Andreyeva, Katherine Hammerman, Christina Arnold, Richard T. Sheldon, Jeonifer Garren, Wes LaBarge, Anthony Resek, Jon Volmer, Scott W. Bagley, Agustin Casimiro-Garcia, Gary M. Chinigo, Jennifer E. Davoren, Rajiah Aldrin Denny, Susan Drozda, Timothy L. Foley, Robert W. Hicklin, Shenping Liu, Frank E. Lovering, Nicole L. Nedoma, Mihir D. Parikh, Joseph W. Strohbach, John I. Trujillo, Stefanus J. Steyn, Karl Nocka, Martin Hegen, Fabien Vincent, Katherine L. Lee, Brian S. Gerstenberger, Michael J. Primiano
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses
Balancing land use for conservation, agriculture, and renewable energy
Cameryn Brock, Patrick R. Roehrdanz, Tim Beringer, Rebecca Chaplin-Kramer, Brian J. Enquist, Amy E. Frazier, Justin A. Johnson, Christina M. Kennedy, Joseph Kiesecker, Ashley E. Larsen, Rafael Loyola, Pablo A. Marquet, Rachel A. Neugarten, James R. Oakleaf, Anand Roopsind, Richard Schuster, David R. Williams, Grace C. Wu, Alex Zvoleff, Lee Hannah
Moisture-tolerant Mg-metal electrodes for practical fabrication of rechargeable Mg batteries
Woo Joo No, Jonghyun Han, Jinyeon Hwang, Sibylle Riedel, Minji Jeong, Hyeong Kyu Park, Ju Young Kim, Kwan Young Lee, Minah Lee, Taeeun Yim, Hyun Deog Yoo, Hyung Chul Ham, Sang-Young Lee, Zhirong Zhao-Karger, Si Hyoung Oh
Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma
JongHoon Ha, Yifan Wang, Yifan Ma, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L. Edwards, Mengyu Chang, Yen-Tzu Chang, Xiaotian Wang, Maurice Dufilho, Michelle Najarro Torres, Shannon McCabe, Weiye Deng, Adam J. Grippin, Jeffrey S. Weinberg, Shaan M. Raza, Franco DeMonte, Ian E. McCutcheon, Sujit Prabhu, Sherise D. Ferguson, Chibawanye I. Ene, Kadir Akdemir, Sreyashi Basu, Sonali Jindal, Benjamin R. Schrank, Jian Hu, Sangeeta Goswami, Vinay K. Puduvalli, Frederick F. Lang, Kristin Huntoon, Padmanee Sharma, Betty Y. S. Kim, Wen Jiang
CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters
Fadi Shehadeh, Biswajit Mishra, Raquel Ferrer-Espada, Anindya Basu, LewisOscar Felix, Charilaos Dellis, Narchonai Ganesan, Liyang Zhang, Andrew T. Martens, Youlian Goulev, Michael B. Sherman, Johan Paulsson, Mandar T. Naik, Paul P. Sotiriadis, Eleftherios Mylonakis
VHL synthetic lethality screens uncover CBF-ÎČ as a negative regulator of STING
James A. C. Bertlin, Tekle Pauzaite, Qian Liang, Niek Wit, James C. Williamson, Jia Jhing Sia, Nicholas J. Matheson, Brian M. Ortmann, Thomas J. Mitchell, Anneliese O. Speak, Qing Zhang, James A. Nathan
Mode hopping via nonlinear magnon-magnon coupling in a synthetic antiferromagnet
Mujin You, Moojune Song, Jun Seok Seo, Donghyeon Lee, Seungha Yoon, Daiju Hayashi, Yoichi Shiota, Teruo Ono, Sanghoon Kim, Se Kwon Kim, Albert Min Gyu Park, Kab-Jin Kim
Millennial-to-orbital-scale subsurface ocean warming and Polynya formation off Dronning Maud Land during the last glacial
TainĂŁ M. L. Pinho, Dirk NĂŒrnberg, A. Nele Meckler, Gesine Mollenhauer, Juliane MĂŒller, Gerrit Lohmann, Lester Lembke-Jene, Salma Hidayat, Vincent Rigalleau, Frank Lamy, Ralf Tiedemann
NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary disease
Shi-Xia Liao, Yan-Wen Wang, Ling-Mei Shi, Lan-Ying Zhang, Jian Zhou, Peng-Peng Sun, Huai-Yu Hu, Yu-Ting Liu, Xuan An, Jing-Qing Xu, Li Chen, Yao Ouyang, Yang Xu, Ting-Hua Wang
A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma
G. J. M. Shanika R. Jayasinghe, Gu Zhu, Nirmala Pandeya, Catherine M. Olsen, Nicholas G. Martin, Penelope A. Lind, Sarah E. Medland, Scott D. Gordon, Santiago Diaz-Torres, Gareth Lingham, Samantha S. Y. Lee, Tamar Nijsten, Manfred Kayser, Luba M. Pardo, Grant W. Montgomery, Nicholas K. Hayward, Jane M. Palmer, David J. Hunter, Jiali Han, Alex W. Hewitt, Mario Falchi, D. Timothy Bishop, Kevin M. Brown, Veronique Bataille, David A. Mackey, Mark M. Iles, David C. Whiteman, David L. Duffy, Stuart MacGregor, Matthew H. Law
Gene expression dynamics of human and mouse craniofacial development at the single-cell level
Nagham Khouri-Farah, Alexandra Manchel, Emma Wentworth Winchester, Brian M. Schilder, Kelsey Robinson, Sarah W. Curtis, Nathan G. Skene, Elizabeth J. Leslie-Clarkson, Justin Cotney
Dynamic transcriptomic remodeling in grafted human neural progenitor cells uncovers mechanisms for vision preservation in a rat model of retinitis pigmentosa
Saba Shahin, Shaughn Bell, Bin Lu, Somanshu Banerjee, Vivek Swarup, Hui Xu, Jason Chetsawang, Stephany Ramirez, Jorge S. Alfaro, Alexander Laperle, Soshana Svendsen, Clive N. Svendsen, Shaomei Wang
Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage
Irina Poverennaya, Aliia Murtazina, Lei Li, Lorena Maili, Lukas Sourada, Luis Fernando Montano-Gutierrez, Rozalina Galimullina, Tobias Steinschaden, Marketa Kaiser, Tomas Zikmund, Adna Goralija, Teng Gao, Aurore Attina, Ornella Clara, Christoph Bartenhagen, Alek Erickson, Yaakov Gershtein, Shiyuan Chen, Kristyna Polaskova, Jaroslav Sterba, Bettina Semasch, Emma R. Anderson, Varsha Prakash, Theresa Vincent, Maria Arceo, Per Kogner, Susanne Schlisio, Peter V. Kharchenko, Alexandre David, Jozef Kaiser, Matthias Fischer, Jan Skoda, Paul A. Trainor, Andrei S. Chagin, Igor Adameyko
Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA
Michelle D. Noyes, Yang Sui, Youngjun Kwon, Nidhi Koundinya, Isaac Wong, Katherine M. Munson, Kendra Hoekzema, Jennifer Kordosky, Gage H. Garcia, Jordan Knuth, Alexandra P. Lewis, Evan E. Eichler
Diel and eddy driven changes in microbial gene expression and biogeochemistry in the oceanic chlorophyll maximum
Logan M. Peoples, John M. Eppley, Benedetto Barone, Brett W. Hobson, David M. Karl, Brian Kieft, Roman Marin, Christina M. Preston, Anna E. Romano, John P. Ryan, Christopher A. Scholin, Samuel T. Wilson, Yanwu Zhang, Matthew J. Church, Edward F. DeLong
Synthetic data-driven deep learning for label-free autonomous atomic force microscopy
Ruben Millan-Solsona, Marti Checa, Spenser R. Brown, Amber N. Bible, Bernadeta Srijanto, Laura Wiggins, Sita Sirisha Madugula, Alice L. B. Pyne, Jennifer L. Morrell-Falvey, Scott Retterer, Rama K. Vasudevan, Liam Collins
Accurate atomic resolution XFEL structures of a metalloenzyme reveal key insights into its catalytic mechanism*
Samuel L. Rose, Svetlana Antonyuk, Felix F. Ferroni, Hiroshi Sugimoto, Keitaro Yamashita, Kunio Hirata, Hideo Ago, Go Ueno, Hironori Murakami, Robert. R. Eady, Takehiko Tosha, Masaki Yamamoto, S. Samar Hasnain
Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning
Thomas D. Lewin, Tosuke Sakagami, Keisuke Shimizu, Li-Jung Kao, Yi-Ling Chiu, Isabel Jiah-Yih Liao, Mu-En Chen, Kanako Hisata, Kazuyoshi Endo, Noriyuki Satoh, Peter W. H. Holland, Yue Him Wong, Yi-Jyun Luo
Dominance and natural suppression of bacterial plant pathogens across global soils
Min Gao, Manuel Delgado-Baquerizo, Chao Xiong, Tadeo Såez-Sandino, Juntao Wang, Jinsong Liang, Emilio Guirado, Miriam Muñoz-Rojas, Raul Romån, Fernando T. Maestre, Brajesh K. Singh
Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis
Ji-Hee Min, Claudia Castillo-GonzĂĄlez, Borja Barbero Barcenilla, In-Cheol Yeo, Xiaoyuan Xie, Sreyashree Bose, Fausto Andres Ortiz-Morea, Di Liu, Eli Canal, David Curtis, Monisha Yerram, Joonyoung Shin, Pavel Ulianich, Chinmay Phadke, Ping He, Andrzej T. Wierzbicki, Junjie Zhang, Eugene V. Shakirov, Thomas E. Juenger, Dorothy E. Shippen
Thermal detection of single photons using Dirac fermions
Bevin Huang, Ethan G. Arnault, Woochan Jung, Caleb Fried, B. Jordan Russell, Kenji Watanabe, Takashi Taniguchi, Erik A. Henriksen, Dirk Englund, Gil-Ho Lee, Kin Chung Fong
Twisted atomic magnetic tunnel junctions with multiple nonvolatile states
Yuliang Chen, Kartik Samanta, Alexander J. Healey, Chi Fang, Haojie Zhang, Naafis A. Shahed, David A. Broadway, Arthur Ernst, Evgeny Y. Tsymbal, Stuart S. P. Parkin
Intraoperative fluorescence-guided fresh frozen sectioning for margin control in head and neck cancer: phase 2 clinical trial
Thomas S. Nijboer, Bas Keizers, Koos Boeve, Daan Roos, Sebastiaan A. H. J. de Visscher, Gyorgy B. Halmos, Boudewijn E. C. Plaat, Henrik K. Huizinga, Hendrikus H. Boersma, Jan J. Doff, Kees-Pieter Schepman, Bert van der Vegt, Max J. H. Witjes, Floris J. Voskuil
CXCR4-tropic HIV-1 infection in an immunocompetent monkey model
Nicholas R. Meyerson, Vanessa L. Bauer, Will T. Fattor, Cody J. Warren, Arturo Barbachano-Guerrero, Melisa J. Weiss, Obaiah Dirasantha, Bridget L. Burris, Adetunji S. Adesina, Joseph L. Timpona, Emily R. Feldman, Ryan T. Fahy, Paul Gendler, Ava Fainberg, Pramod N. Nehete, Kathryn A. Shelton, Analy Galvan, George W. Tustin, Paul J. Koehle, Maria D. Salinas, Omar Davila, Elizabeth I. Lindemann, Sean E. Clark, Mackenzie L. Garnett, C. Todd DeMarco, Salvatore R. Scianna, Thomas N. Denny, Jens H. Kuhn, Pyone P. Aye, Ron S. Veazey, Sarah M. Kezar, Gregory K. Wilkerson, Sara L. Sawyer
Gihyeon Bhin, Taeho Kang, Jeong Won Jin, Sangmin Ji, Seung Yong Lee, Chang Yong Park, Ji Hwan Lee, Saeroonter Oh, Ji-Sang Park, Young Jae Song, Sungjoo Lee
Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy
Winnie Fernando, Jarama Clucas, Alberto Rizzo, Ramsay Singer, Emily Goode, Crescens Tiu, Scott Layzell, Joshua Konecnik, Rebecca Wilson, Sidonie Wicky John, Samuel Jouny, Naomi Guppy, Victoire Boulat, Jonathan Mannion, Maria Goicoechea, Shaun Tan, Sam Lawson, Chris Starling, Gabrielle Elshtein, Nivedita Ravindran, Anna B. Montgomery, Rosa Andres-Ejarque, Mark Allen, Steven Lumbard, Fredrik Wallberg, Kai Betteridge, Ross Scrimgeour, David Robertson, George Ward, Martin Sims, Tomoko Smyth, Andre L. Samson, James M. Murphy, Daniela Kolarevic Ivankovic, Esther N. Arwert, Dinis P. Calado, Anita Grigoriadis, Matthew J. Smalley, Alan Melcher, Syed Haider, Toby Lawrence, Ioannis Roxanis, Andrew N. J. Tutt, Tencho Tenev, Pascal Meier
Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex
Wolfgang P. Ruf, Julia K. KĂŒhlwein, Laura Meier, Sarah J. Brockmann, Jaehyun LeeBae, Ghazaleh Sadri-Vakili, Deniz Yilmazer-Hanke, Susanne Petri, Dietmar R. Thal, Veselin Grozdanov, Karin M. Danzer
AMR-GNN: a multi-representation graph neural network framework to enable genomic antimicrobial resistance prediction
Hoai-An Nguyen, Anton Y. Peleg, Jessica A. Wisniewski, Xiaoyu Wang, Zhikang Wang, Luke V. Blakeway, Gnei Z. Badoordeen, Ravali Theegala, Nhu Quynh Doan, Matthew H. Parker, Anna G. Green, Jiangning Song, David L. Dowe, Nenad Macesic
MXene-driven nanoscale field-effect junction for advanced 4-terminal perovskite/silicon tandem solar panels
Antonio Agresti, Sara Pescetelli, George Viskadouros, Anna Pazniak, Enrico Leonardi, Alessia Di Vito, Peyman Amiri, Matthias Auf Der Maur, Francesca Menchini, Silvano Del Gobbo, Francesco Di Giacomo, Giuseppe Bengasi, Carmelo Connelli, Luca Sorbello, Marina Foti, Francesco Bonaccorso, Emmanuel Kymakis, Aldo Di Carlo
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells
Uma S. Kamaraj, Ying Chen, Junjie Lei, Pradeep Gautam, Pongsatorn Horcharoensuk, Czaryna K. M. Clemente, Katja G. Weinacht, Nicholas R. J. Gascoigne, Jinmiao Chen, Ching Kit Chen, Qingfeng Chen, Qi-Jing Li, Lai Guan Ng, Yuin-Han Loh
Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci
Dennis Hecker, Xiaoning Song, Nina Baumgarten, Anastasiia Diagel, Nikoletta Katsaouni, Ling Li, Shuangyue Li, Ranjan Kumar Maji, Fatemeh Behjati Ardakani, Lijiang Ma, Zhaolong Li, Aldo Moggio, Daniel Tews, Hendrik Sager, Lars Maegdefessel, Martin Wabitsch, Johan L. M. Björkegren, Heribert Schunkert, Zhifen Chen, Marcel H. Schulz
Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathology
Leire Melgosa-Ecenarro, Carola I. Radulescu, Nazanin Doostdar, Joe Airey, Francesca A. Chaloner, Nawal Zabouri, Giada Pedretti, Francesca Osso, Leire Garrido Perez, Kjara S. Pilch, Xingjian Wang, Anna Mallach, Sadra Sadeh, Johanna Jackson, Paul M. Matthews, Samuel J. Barnes
The association of natural environmental exposure and air pollution with depression incidence among cancer survivors, as well as the potential role of plasma metabolomics, remains unclear. Here, we analyze 21,507 cancer survivors from the UK Biobank over a median follow-up of 12.39 years and find that individuals exposed to higher levels of green space and natural environment (tertile 3 vs. tertile 1) within a 1000-m buffer have 15.8% (95% CI: 4.0%-26.1%) and 18.2% (95% CI: 7.0%-28.1%) lower risks of depression, respectively. The strongest protective association is observed among breast cancer survivors. In contrast, higher exposures to nitrogen dioxide and nitrogen oxides are associated with an increased risk of depression. Meanwhile, plasma metabolic signatures associated with green space and natural environment may partially mediate these associations. These findings highlight that residential green space, natural environment, and lower air pollution levels may reduce depression risk among cancer survivors, possibly via metabolic pathways.
How common depictions of wealth distributions can bias people to underestimate inequality
Economic inequality is a critical issue in elections and legislating, so having an informed electorate is vital to sensible policymaking. Unfortunately, misperceptions about the true extent of inequality abound. Here, we demonstrate that the most prevalent formats for representing economic distributions tend to dampen viewer impressions of inequality. We begin by showing that the most popular newspaper portrayals of inequality contain potentially biasing features. Next, in nine experiments ( N = 3599 U.S. adults), we explore how these common representations of inequality evoke biased impressions and we test methods to mitigate these biases. Specifically, we document two biases in how people evaluate economic distributions. First, people are under-sensitive to differences in the size of identified population groups (e.g., top 1% vs. top 10%) such that their judgments become distorted by arbitrary ways in which a population is divided ( partition dependence ). Second, peopleâs judgments under-weight information about intermediate groups relative to the most- and least-wealthy groups ( middle neglect ). We test ways to mitigate these biases and conclude by proposing presentation guidelines that promote more accurate impressions.
Meta-analyses on charitable giving clarify evidence for empathic and effective altruism
Matthew J. Hornsey, Jessica L. Spence, Cassandra M. Chapman
Erratum for the Research Article âMyeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in miceâ by B. Meng et al .
Spin excitation continuum from degenerate states in the mixed ferro-antiferromagnetic exchange system CeMgAl 11 O 19
Bin Gao, Tong Chen, Chunxiao Liu, Mason L. Klemm, Shu Zhang, Zhen Ma, Xianghan Xu, Choongjae Won, Gregory T. McCandless, Karthik Rao, Naoki Murai, Seiko Ohira-Kawamura, Stephen J. Moxim, Jason T. Ryan, Xiaozhou Huang, Xiaoping Wang, Manh Duc Le, Emilia Morosan, Julia Y. Chan, Sang-Wook Cheong, Oleg Tchernyshyov, Leon Balents, Pengcheng Dai
Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches
Julia Sbierski-Kind, Kelly M. Cautivo, Julia Nilsson, Johanna C. Wagner, Madelene W. Dahlgren, Nathan Ewing Crystal, Maria McClave, Nicholas M. Mroz, Marlene Ganslmeier, Carlos O. Lizama, Anna Lu Gan, Peri R. Matatia, Marcela T. Taruselli, Anthony A. Chang, Sofia Caryotakis, Claire E. OâLeary, Maya Kotas, Jun-Hoe Lee, Taeeun Gu, Hyeewon Seo, Hyun Je Kim, Aras N. Mattis, Tien Peng, Richard M. Locksley, Ari B. Molofsky
Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion
Manav Jain, Savannah E. Est-Witte, Sydney R. Shannon, Sarah Y. Neshat, Xinjie Yu, Sydney Dunham, Tina Tian, Leonardo Cheng, Jawaun Harris, Maximilian F. Konig, Stephany Y. Tzeng, Jonathan P. Schneck, Jordan J. Green
Chukun Gao, Pin-Hui Chen, Nicholas Alaniva, James H. J. Ellison, Mairon Frei, SnĂŠdĂs BjörgvinsdĂłttir, Edward P. Saliba, Yanhui Hu, Ioannis Pagonakis, Alexander DĂ€pp, Ronny Gunzenhauser, Michael Urban, Klaus Ensslin, Alexander B. Barnes
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
Martin C. Moncrieffe, Prasanna Suresh, Joe Boyle, Yuhao Cui, Bharti Nawalpuri, Brett Verstak, Yu P. Zhang, Ziwei Zhang, Marcus Taylor, Edward H. Egelman, Nicholas Gay, David Klenerman, Clare Bryant
Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Heather Karner, Tabea C. Mittmann, Vicky W. Chen, Ashir A. Borah, Andreas Langen, Hassan Yousefi, Lisa Fish, Balyn W. Zaro, Albertas Navickas, Hani Goodarzi
Claudin 24âA novel enhancer of AMPA receptor fidelity
Tobias Strasdeit, Ehsan Amin, Sebastian Obst, Barbara Biermann, Thomas P. Newton, Simon Chris Kösters, Marten Schouwink, Sergey Fedotov, Javeria Shaukat, Subhrajit Bhattacharya, Muhammad Aslam, Max Anstötz, Faik Nadi Okka, Oscar Gabriel Sevillano Quispe, Pascal Bouvain, Julia Vedyashkin, Alexander I. Sobolevsky, Stephen F. Traynelis, Jakob von Engelhardt, Nadine Erlenhardt, Michael Hollmann, Nikolaj Klöcker
A previously unrecognized class of fungal ice-nucleating proteins with bacterial ancestry
Rosemary J. Eufemio, Mariah Rojas, Kaden Shaw, Ingrid de Almeida Ribeiro, Hao-Bo Guo, Galit Renzer, Kassaye Belay, Haijie Liu, Parkesh Suseendran, Xiaofeng Wang, Janine Fröhlich-Nowoisky, Ulrich Pöschl, Mischa Bonn, Rajiv J. Berry, Valeria Molinero, Boris A. Vinatzer, Konrad Meister
Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord
Leslie Lafouasse, Konstantinos Koutsogiannis, Yu-Wen E. Dai, Lisa Del Vecchio, Andrea Pedroni, Dimitrios Tsagkogiannis, Judith Habicher, Konstantinos Ampatzis
Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines
Alice F. Versiani, Peter McCaffrey, Helder V. Ribeiro-Filho, Natalia I. O. Silva, Paulo S. Lopes-de-Oliveira, Jean-Paul Carrera, Mauricio L. Nogueira, Rafael E. Marques, Shannan L. Rossi, Nikos Vasilakis
Artificial intelligence (AI) writing assistants powered by large language models (LLMs) are increasingly used to make autocomplete suggestions to people as they write text. Can these AI writing assistants affect peopleâs attitudes in this process? In two large-scale preregistered experiments ( N = 2582), we exposed participants writing about important societal issues to an AI writing assistant that provided biased autocomplete suggestions. When using the AI assistant, the attitudes participants expressed in a posttask survey converged toward the AIâs position. However, a majority of participants were unaware of the AI suggestionsâ bias and their influence. Further, the influence of the AI writing assistant was stronger than the influence of similar suggestions presented as static text, showing that the influence is not fully explained by these suggestions, increasing accessibility of the biased information. Last, warning participants about assistantsâ bias before or after exposure does not mitigate the attitude-shift effect.
Trapped in declining occupations: Barriers to worker mobility in a changing economy
Xi Song, Jennie E. Brand, Sukie Xiuqi Yang, Michael Lachanski
The US has undergone substantial changes in jobs, occupations, and mobility over the past two decades. Using administrative data from the US Occupational Outlook Handbook (2000 to 2020), we examine how immediate and projected occupational restructuring affects workersâ mobility. In an update to prior research, we find that workers in both growing and declining occupations experience greater mobility than those in stable occupations. However, the direction of movement varies. Workers in declining occupations often move laterally into other declining occupations, with nearly 60% experiencing downward mobility. In contrast, growing occupations offer better prospects for upward mobility, particularly for workers transitioning from declining to growing occupations, where almost 50% enter higher-paying occupations. However, these moves to emerging jobs are relatively rare, accounting for only 5% of all occupational movements. These results highlight how recent shifts in the occupational structure exacerbate existing disadvantages for workers facing declining job opportunities.
Understanding the emergence of cooperation in social networks has advanced through pairwise interactions, but the corresponding theory for group-based public goods games (PGGs) remains less explored. Here, we provide theoretical conditions under which cooperation thrives in PGGs on arbitrary population structures, which are accurate under weak selection. We find that a class of networks that would otherwise fail to produce cooperation, such as star graphs, are particularly conducive to cooperation in PGGs. More generally, PGGs can support cooperation on almost all networks, which is robust across all kinds of model details. This fundamental advantage of PGGs derives from self-reciprocity realized by group separations and from clustering through second-order interactions. We also apply PGGs to empirical networks, which shows that PGGs could be a promising interaction mode for the emergence of cooperation in real-world systems.
Chimpanzees are not more aggressive than bonobos but target sexes differently
Emile Bryon, Tom S. Roth, Jonas R. R. Torfs, Marcel Eens, Edwin J. C. van Leeuwen, Nicky Staes
The long-standing view that bonobos ( Pan paniscus ) are peaceful while chimpanzees ( Pan troglodytes ) are aggressive has shaped our understanding of primate and human social evolution. However, recent observations from the wild challenge this dichotomy, warranting standardized comparative analyses of aggression in the Pan species. Here, we examined aggressive interactions across 22 zoo-housed groups of chimpanzees ( N = 9 groups, 101 individuals) and bonobos ( N = 13 groups, 88 individuals) using Bayesian social network analysis. We find no species differences in overall or contact aggression rates, accounting for group size and sex ratio. However, aggression patterns diverge by sex: Bonobos exhibit higher female-to-male aggression, while chimpanzees show the reverse. Notably, absolute aggression rates varied substantially between groups within each species, reinforcing recent evidence on group-specific social structures in Pan . These findings challenge the traditional aggression dichotomy between bonobos and chimpanzees and provide insights into the evolutionary dynamics of social conflict strategies in great apes, including humans.
PNAS
GPT-4o mini: Non-social science research article
Reassessing evidence for symmetric histone inheritance in Drosophila stem cells
Altermagnetic polar metallic phase in ultrathin epitaxially strained RuO 2 films
Seung Gyo Jeong, In Hyeok Choi, Sreejith Nair, Luca Buiarelli, Bita Pourbahari, Jin Young Oh, Bonnie Y.X. Lin, James M. LeBeau, Nabil Bassim, Daigorou Hirai, Ambrose Seo, Woo Seok Choi, Rafael M. Fernandes, Turan Birol, Liuyan Zhao, Jong Seok Lee, Bharat Jalan
The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion
Mohamed I. Khalil, Jie Wang, Lexi Vu, Canchai Yang, Congcong Yin, Smriti Chadha, Harrison Nabors, Daniel Vocelle, Danielle G. May, Rachel J. Chrisopulos, Craig C. Welbon, Li Zhou, Kyle J. Roux, William C. Spanos, Matthew P. Bernard, Qing-Sheng Mi, Dohun Pyeon
Ambient-pressure 151-K superconductivity in HgBa 2 Ca 2 Cu 3 O 8+ÎŽ via pressure quench
Liangzi Deng, Thacien Habamahoro, Artin Safezoddeh, Bishnu Karki, Sudaice Kazibwe, Daniel J. Schulze, Zheng Wu, Matthew Julian, Rohit P. Prasankumar, Hua Zhou, Jesse S. Smith, Pavan R. Hosur, Ching-Wu Chu
SypC, a symbiont outer membrane vesicle protein, impacts the development of the squidâvibrio partnership
Jill T. Kuwabara, Vera Beilinson, Alexis C. Hargadon, Grischa Y. Chen, Xiao-Meng Hu, Mark S. Ladinsky, Kathleen T. Hackett, Joseph P. Dillard, Karen L. Visick, Edward G. Ruby, Margaret McFall-Ngai
Early colonization before inundation consistent with northern glacial refugia in Southern Doggerland revealed by sedimentary ancient DNA
Robin G. Allaby, Rosie Ware, Rebecca Cribdon, Teri A. Hansford, Tim Kinnaird, Derek Hamilton, Logan Kistler, Phil Murgatroyd, Richard Bates, Simon Fitch, Vincent Gaffney
Mosaic phenotypic evolution underlies the adaptive success of water-surface colonization in Gerromorpha
Zezhong Jin, Mu Qiao, Siying Fu, Zihe Li, Boxiong Guo, Hongjiao Li, Zhaoqi Leng, Matthew R. Pintar, Jakob Damgaard, Benjamin L. Makepeace, Silvia A. Mazzucconi, Gavril Marius Berchi, Fabio Cianferoni, Dan A. Polhemus, Kohei Watanabe, Jun Nakajima, Seraphine Esemu, Chen Liu, Beichen Zhang, Huanhuan Yang, Shujing Wang, Huaijun Xue, Wenjun Bu, Zhen Ye
Opioid-specific brain connectivity dynamics distinguish analgesia from secondary effects: Studies in male mice
Jean-Charles Mariani, Samuel Le Meur-Diebolt, Laurianne Beynac, Renata Santos, Stefan Schulz, Thomas Deffieux, Mickael Tanter, Zsolt Lenkei, Andrea Kliewer
The Mycobacterium smegmatis bd -II terminal oxidase employs a carboxylate shift mechanism
Terezia Kovalova, Mateusz Janczak, Ana P. Gamiz-Hernandez, Daniel Lundin, Soni Sharma, Johanna VilhjĂĄlmsdĂłttir, Dan Sjöstrand, Ville R. I. Kaila, Martin Högbom, Pia Ădelroth
Bacterial reporterâpaired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense
Jessica B. von Pein, Stacey B. Andersen, Jon Xu, Minh-Duy Phan, Emma K. Dalton, Michael Koczerka, Claudia J. Stocks, James E. B. Curson, Zoe Vandeleur, Nicholas D. Condon, Steven J. Hancock, Christian M. Nefzger, Nathan J. Palpant, Divya Ramnath, Ronan Kapetanovic, Mark A. Schembri, Matthew J. Sweet
Gut microbiomeâproduced bile acid metabolite lengthens the circadian period in host intestinal cells
Chelsea E. Powell, Alana M. McSween, Lenka DohnalovĂĄ, Cecilia H. Kim, Robyn J. Eisert, Zhen-Yu J. Sun, Hyuk-Soo Seo, Vincent Marquardt, Sirano Dhe-Paganon, Christoph A. Thaiss, A. Sloan Devlin
BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
Oliver W. Chung, Shun Yao, Ling Wang, Fu Yang, Lauren Schier, Melissa Aldana, Christian Cerda-Smith, Haley M. Hutchinson, Kris C. Wood, Weijia Su, Mustafa Khasraw, Lee Zou, Dale A. Ramsden, ZZ Zhao Zhang
Immune cells employ intermittent integrin-mediated traction forces for 3D migration
Tina Czerwinski, Lars Bischof, David Böhringer, Sibel Kara, Pamela L. Strissel, Reiner Strick, Natalie Huhn, Alexander Winterl, Richard Gerum, Ernst Wittmann, Michael Schneider, Matthias W. Beckmann, Gina Nusser, Manuel Wiesinger, Silvia Budday, Anja Lux, Caroline Voskens, Ben Fabry, Christoph Mark
Locus coeruleusâamygdala circuit disrupts prefrontal control to impair fear extinction
Hugo Bayer, Annalise N. Binette, Samantha O. Sweck, Vitor A. L. Juliano, Samantha L. Plas, Lara M. Ferst, James E. Hassell, FlĂĄvio A. G. MourĂŁo, Stephen Maren
Macrophageâglia interactions regulate immune damage to enteric neurons during West Nile virus infection
Hana Janova, Fang R. Zhao, Ali Akgul, Meredith Schatz, Daniel M. Alligood, David M. Alvarado, Larissa B. Thackray, Thaddeus S. Stappenbeck, Michael S. Diamond
The path to room-temperature superconductivity: A programmatic approach
Rohit P. Prasankumar, Matthew Julian, Michael Hutcheon, Christoph Heil, Liangzi Deng, Dmitri Basov, Ching-Wu Chu, Riccardo Comin, Philip Kim, Bryce Meredig, Chris Pickard, Warren E. Pickett, Timothy Strobel, Stuart Wolf, Eva Zurek, Nathan Myhrvold
Expert evaluation of LLM world models: A high-T c superconductivity case study
Haoyu Guo, Maria Tikhanovskaya, Paul Raccuglia, Alexey Vlaskin, Chris Co, Daniel J. Liebling, Scott Ellsworth, Matthew Abraham, Elizabeth Dorfman, N. P. Armitage, Chunhan Feng, Antoine Georges, Olivier Gingras, Dominik Kiese, Steven A. Kivelson, Vadim Oganesyan, B. J. Ramshaw, Subir Sachdev, T. Senthil, J. M. Tranquada, Michael P. Brenner, Subhashini Venugopalan, Eun-Ah Kim
Crystal structure of Vibrio cholerae polysaccharide lyase RbmB bound to Vibrio polysaccharide (VPS) fragments provides insights into substrate recognition and cleavage
Ranjuna Weerasekera, Alexis Moreau, Xin Huang, Anna Potapova, Carmen Schwechheimer, Rajan Kandel, Yun Huynh, Owen Cannizzo, Ryan Gordon, Emma Gerace, Alexander J. Hinbest, Yiyan Yang, Xiaofang Jiang, Robert J. Woods, Jing Yan, Fitnat H. Yildiz, Rich Olson
Mixed-mobility supported lipid bilayers uncover the role of immobilized ICAM1 on T cell activation and immune synapse organization
Alexander Leithner, Audun Kvalvaag, Tanmay Mitra, Salvatore Valvo, Hannah Dada, Ewoud Compeer, Michael I. Barton, Sofia Bustamante Eguiguren, Edward Jenkins, Christoffer Lagerholm, Omer Dushek, Michael L. Dustin
Authorship remains the primary currency of academic credit and a cornerstone of research integrity, yet current practices often fail to reflect the collaborative and interdisciplinary nature of modern science and questionable authorship practices persist. We argue that addressing these shortcomings is a collective responsibility shared by researchers, journals, research funders, scholarly societies, and research institutions. We examined authorship guidelines issued by journals and research institutions and found that their recommendations to researchers are highly variable. We propose that fostering a responsible authorship culture requires a shared, principle-based framework grounded in transparency, credit, and accountability. These three interconnected principles highlight when authorship practices are questionable and offer a framework for constructive reflection on the meaning of authorship. We outline practical ways research leaders can embed these principles into everyday practice by initiating early, inclusive, and fair authorship discussions and ensuring transparent description of contributions. Research institutions have a unique opportunity to inculcate good practices and lead this culture change with harmonized guidance, education, fair conflict resolution, and reform of researcher assessment. Anchoring authorship in transparency, credit, and accountability will strengthen the credibility of individual research, the fairness of recognition systems, and, ultimately, the trustworthiness of science itself.
Cultural evolution accelerated human range expansion by more than two orders of magnitude
Humans occupy a geographic and ecological range wider than that of any other extant vertebrates, having rapidly expanded into nearly every habitat on the planet. This expansion was driven not only by biological adaptations but, crucially, by cultural evolutionâa process that enabled the rapid and cumulative acquisition of adaptive behaviors and technologies. Here, I quantify the unique contribution of cultural evolution by comparing the global human range to mammalian ranges aggregated at various taxonomic ranks. I show that achieving the human range would require about 88 My of lineage divergence, over 2,200 species, and a nearly four-order-of-magnitude range in body mass. Yet, cultural evolution also allows humans to adapt at finer spatial scales, as evidenced by ethnolinguistic groups occupying smaller, more ecologically specialized territories than species. These findings highlight the unique role of cultural evolution in accelerating human ecological adaptation.
Heightened risk of fatal police violence in and around reservations for American Indian/Alaska Native peoples in the United States
Gabriel L. Schwartz, Theresa Rocha Beardall, Jaquelyn L. Jahn
Fatal police violence is a public health problem in the United States, with large racial and spatial inequities that remain understudied. Indigenous people, for example, experience some of the highest rates of fatal police violence of any racial/ethnic group. Residents of American Indian/Alaska Native (AIAN) reservations may be at particular risk, given geographically specific police surveillance, jurisdictional mazes, and structural disinvestment. Yet little quantitative work has examined fatal police violence against Indigenous peoples in the United States, including by reservation geography. We examined whether AIAN people experience higher rates of fatal police violence in and around reservations at the population level. We analyzed data on all AIAN people killed by police (n = 203, 2013â2024) from the Mapping Police Violence database. We first summarized their geographic distribution and characteristics using descriptive statistics. We then estimated rate ratios using quasi-Poisson regression models with population offsets, comparing AIAN peoplesâ fatal police violence rates in and around reservations versus farther away. We find that fatal police violence against AIAN people is strongly concentrated in and around reservations: 73% of AIAN deaths occurred on or within 10 miles of reservations, despite only 39 to 51% of the AIAN population living there. Those areasâ residents were 1.60 to 5.84 times more likely to be killed by police than those living farther away, depending on location and choice of population offsets. Sensitivity analyses indicated these elevated risks could not plausibly be explained away by differential racial/ethnic misclassification. A coordinated public health response to police violence is urgently needed in Indian Country.
Insights into US life expectancy stagnation from birth cohort mortality dynamics
Leah Abrams, Octavio Bramajo, Alyson van Raalte, Mikko MyrskylÀ, Neil K. Mehta
US life expectancy remained essentially flat in the 2010s. This trend has occurred in the presence of advancing innovations in medical care, especially for chronic disease, and a growing economy. While research has identified selected contributing factors, including âdeaths of despairâ and cardiovascular disease mortality stagnation, a comprehensive understanding of the underlying mortality dynamics has not been provided. Notably missing is a systematic evaluation of birth cohort dynamics of mortality, which can reveal whether specific generations are driving adverse trends. Using Lexis diagrams, a powerful tool for visualizing the demographic landscape, we analyzed changes in mortality from 1979â2023 for all-cause mortality and three major cause groups (cardiovascular disease, cancer, external causes). Data included cohorts born between the 1890s and 1980s. Results reveal that both cohort- and period-based processes have produced stalling life expectancy improvement. The 1950â1959 birth cohort represents a transition cohort, wherein there were general improvements in mortality across cohorts born before and general deterioration in mortality across cohorts born after. Alarmingly, cohorts born after 1970 exhibited deteriorating patterns in all major cause groups at young and middle-adult ages. Layered on these cohort dynamics was a broad mortality deterioration that began around 2010 and was experienced by nearly all living adult cohorts at the time, driven primarily by cardiovascular disease mortality. These patterns reflect the complex, multifaceted nature of stalled life expectancy improvements that cannot be attributed to any single cause or temporal mechanism. It also portends an unprecedented longer-run stagnation, or even sustained decline, in US life expectancy.
Multifaceted ceramic analysis in the study of political expansion: Insights from the Zhou expansion in Shandong, China
This paper demonstrates the importance of applying multiple analytical methods in ceramic analysis for understanding colonial contact in the past. We examine the ShangâZhou transition (circa 1000 BCE) by investigating community-specific uses of li tripod cooking vessels at multiple sites in Shandong Province. Craft traditions and food practices serve as valuable proxies for understanding past social identities and offer new perspectives on culture contact, migration, and colonialism. Moving away from ethnicity and political control reflected in ceramic form and style, we focus on how these vessels were made and used. By combining petrography, use-alteration analysis, and residue analysis, we provide an integrated multimethod approach that enables us to reconstruct intersecting levels of social practice through a single ubiquitous artifact. Petrographic analysis reveals how and where vessels were made; use-alteration analysis shows how they were used to cook food; and residue analysis identifies what foods were prepared. By tracing production and consumption traditions before, during, and after Zhou expansion, we show that change in our multivariate dataset resist unidimensional ascription to the ShangâZhou transition, and hence to unequal outcomes from its impacts.
Scientific Data
GPT-4o mini: Non-social science research article
Chromosomal-level genome assembly of Ichthyurus bourgeoisi Gestro using PacBio HiFi and Hi-C sequencing
A map of high-altitude wetlands in the worldâs major mountain regions
Rike Becker, Jan KropĂĄÄek, Anthony C. Ross, Tom Gribbin, Fabian Drenkhan, Lilia Hernandez Sotelo, Marc Martinez Mendoza, Bethan Davies, Jeremy Ely, Wouter Buytaert
Human neuronal differentiation under AÎČ exposure: a single-cell transcriptomic and epigenomic dataset
Idoia Blanco-Luquin, Xabier MartĂnez-de-Morentin, Amaia Vilas-Zornoza, Daniel Mouzo, Alejandro Lumbreras Lopez, MĂłnica MacĂas, Diego Alignani, Alberto Maillo, Ana Cecilia Gonzalez Alvarez, Leena Ali Ibrahim, Vincenzo Lagani, Natalia RamĂrez, Jesper Tegner, Felipe PrĂłsper, Maite Mendioroz, David Gomez-Cabrero
CactEcoDB: Trait, spatial, environmental, phylogenetic and diversification data for the cactus family
Jamie B. Thompson, Catherine Martinez, Jorge Avaria-Llautureo, Santiago RamĂrez-Barahona, Gerardo Manzanarez-Villasana, Alastair Culham, Andrew Gdaniec, George Ryan, Chris Venditti, Georgia Keeling, Nicholas K. Priest
A Global-Scale Time Series Dataset for Groundwater Studies within the Earth System
Annemarie BÀthge, Claudia Ruz Vargas, Gunnar Lischeid, Raoul Collenteur, Mark Cuthbert, Jan Fleckenstein, Martina Flörke, Inge de Graaf, Sebastian Gnann, Andreas Hartmann, Xander Huggins, Nils Moosdorf, Yoshihide Wada, Thorsten Wagener, Robert Reinecke
A curated and integrated dataset for exploring global bee-plant interactions
Sajad Noori, Alice C. Hughes, Thais N. C. Vasconcelos, John S. Ascher, Jared T. Miller, Sarah M. Gaugel, Madeleine M. Ostwald, James B. Dorey, Victor H. Gonzalez, Aline C. Martins, Michael C. Orr, Katja C. Seltmann
Occurrence and environmental data for aquatic plants of Minnesota from 1999â2018
Michael R. Verhoeven, William L. Bartodziej, Matthew S. Berg, Simba Blood, Rachael Crabb, Eric Fieldseth, James A. Johnson, Jimmy Marty, Steve McComas, Raymond M. Newman, Meg Rattei, Jill B. Sweet, Justin Townsend, Brian Vlach, Justin Valenty, Jerry P. Spetzman, Susanna W. Witkowski, Andrea Prichard, Wesley J. Glisson, Daniel J. Larkin
SYN-OCT:A synthetic dataset of ocular optical coherence tomography images from healthy and glaucoma eyes
Damon Wong, Ashish Jith Sreejith Kumar, Rachel S. Chong, Monisha E. Nongpiur, Rahat Husain, Tina Wong, Shamira Perera, Tin Aung, Bingyao Tan, Ching-Yu Cheng, Eranga N. Vithana, Jacqueline Chua, Alina Popa Cherecheanu, Leopold Schmetterer
A hand biomechanics dataset of kinematics, kinetics, electromyography, and imaging in healthy adults
Maximillian T. Diaz, Alexis R. Benoit, Kalyn M. Kearney, Troy F. Kelly, Erica M. Lindbeck, Isaly Tappan, William S. Bowers, Lavanya Durai, Justin B. Nunag, Michael B. Officer, Joel B. Harley, Jennifer A. Nichols
Mental health impacts during the COVID-19 pandemic underscored the importance of real-time assessment methods to capture population-level changes (e.g., longitudinal changes in quality of life). This dataset contains questionnaire responses collected with the Corona Health app, a multilingual mHealth app available on Android and iOS platforms. The dataset includes baseline from 2,704 participants (i.e., adults aged 18 years and older, living in Germany) and 11,541 repeated ecological momentary assessment (EMA) responses, providing longitudinal mental health data throughout various phases during the pandemic period (i.e., data collected between July, 2020 and January, 2025). The questionnaires assessed domains such as quality of life, psychological well-being, coping mechanisms, and pandemic-related concerns. In addition to questionnaire responses, the dataset includes sensor data such as GPS location information and app usage statistics collected with participant consent. The described dataset enables researchers to examine mental health trajectories during and after COVID-19, analyze relationships between psychological factors and pandemic experiences, and investigate patterns in longitudinal mental health data.
Socio-Economic Review
Dependency or subsidization? An input-output analysis of the interconnectedness of regional growth models in Italy
This article demonstrates the applicability of the growth model framework at the regional level. Focusing on Italy as a paradigmatic case of persistent regional inequalities, we test two theories of center-periphery relations between Northern and Southern Italy: the dependency theory and the subsidization theory. Using EUREGIO regional input-output tables between 2000 and 2007, we decompose the GDP and GDP growth of Italian regions into final demand components and economic sectors. The results highlight the importance of distinguishing between static and dynamic analyses. The former reveal a greater reliance of the economy of the Southern regions on the public sector, corroborating the subsidization perspective. By contrast, the latter indicate that in 2000â2007 Southern Italyâs GDP growth was driven by low value-added exports to Northern regions, buttressing the Gramscian dependency argument. We link changes in regional growth models to the impact of EU fiscal policy rules.
The paradox of inequality that isnât: rising economic inequality depresses and polarizes citizensâ belief in meritocracy
This study examines how rising income inequality has been impacting individualsâ belief in merit-based success, using three decades of survey data from 39 advanced capitalist democracies. Challenging the seminal finding of a âparadox of inequality,â we find no evidence of a positive effect of inequality on meritocratic beliefs across countries. Instead, we identify a substantively moderate but robustly negative effect of inequality on perceptions of meritocracy from within-country changes over time: as inequality rises, citizensâ belief in meritocracy declines. We further uncover that inequality does not merely induce a mean shift, but affects the shape of the distribution of meritocracy beliefs insofar as we find the proportion of skeptical perceptions of meritocratic realities to be increasing with higher levels of inequality. Our findings thus suggest that growing inequality undermines citizensâ trust in procedural fairness and contributes to an increased polarization of attitudes and beliefs at the heart of open societies.