Nature DOI suffix â "/s..." : Not a
research article
Thrilling, frivolous, a waste: not everyoneâs happy about the Artemis II Moon mission
Maria Alejandra Camacho, Alexandre Soares Rosado, Elizabeth Ebert, Yarin Livneh, Steven Carter, Raul Paes de Barros, Urs Hofmann, Prajval Shastri, Arthur Maynard, Bruce Ott, Evelyn Leung
Mechanically driven Li dendrite penetration in garnet solid electrolyte
Yuwei Zhang, Soroush Motahari, Eric V. Woods, Stefan Zaefferer, Peter Schweizer, Zhiyuan Zhang, Yuqi Liu, Baptiste Gault, Franz Roters, Dierk Raabe, Christina Scheu, Yug Joshi, Siyuan Zhang, Chuanlai Liu, Gerhard Dehm
Astrocytes connect specific brain regions through plastic networks
Melissa L. Cooper, Maria Clara Selles, Michael Cammer, Chase Redd, Holly K. Gildea, Joseph Sall, Katelyn E. Chiurri, Philip Cheung, Damian G. Wheeler, Aiman S. Saab, Shane A. Liddelow, Moses V. Chao
Efficiency-optimized relativistic plasma harmonics for extreme fields
Robin J. L. Timmis, Colm R. J. Fitzpatrick, Jonathan P. Kennedy, Holly M. Huddleston, Elliott Denis, Abigail James, Chris Baird, Dan Symes, David McGonegle, Eduard Atonga, Heath Martin, Jeremy Rebenstock, John Neely, Jordan Lee, Joshua Redfern, Nicolas Bourgeois, Oliver Finlay, Rusko Ruskov, Sam Astbury, Steve Hawkes, Zixin Zhang, Matt Zepf, Karl Krushelnick, Edward Gumbrell, Paramel Pattathil Rajeev, Mark Yeung, Brendan Dromey, Peter Norreys
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells
Giulia Gallo, Antonello Di Nardo, Doreen Lugano, Adam J. Roberts, Bernadette Ataku Kutima, Moses Okombo, Aghnianditya Kresno Dewantari, Florence M. M. Buckley, Gavin J. Wright, James Nyagwange, Bernard Agwanda, Stephen C. Graham, Dalan Bailey
Transposable elements are driving rapid adaptation of Enterococcus faecium
Matthew P. Grieshop, Aaron A. Behr, Sierra Bowden, Jordan D. Lin, Marco Molari, Gabriella ZM Reynolds, Erin F. Brooks, Boryana Doyle, Ashley A. Moore, Guillermo Rodriguez-Nava, Jorge L. Salinas, Niaz Banaei, Ami S. Bhatt
Electronic origin of reorganization energy in interfacial electron transfer
Sonal Maroo, Leonardo Coello Escalante, Yizhe Wang, Matthew P. Erodici, Jonathon N. Nessralla, Ayana Tabo, Takashi Taniguchi, Kenji Watanabe, Ke Xu, David T. Limmer, D. Kwabena Bediako
H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses
Salma Akter, Monica Perri, Mikel Lavilla-Puerta, Sophie Lichtenauer, Yuming He, Vinay Shukla, Laura Dalle Carbonare, Yuri Telara, Daai Zhang, Beatrice Ferretti, Dona M. Gunawardana, William K. Myers, Pedro Barreto, Beatrice Giuntoli, Markus SchwarzlÀnder, Emily Flashman, Francesco Licausi
Myosin forces remodel F-actin for mechanosensitive protein recognition
Ayala G. Carl, Matthew J. Reynolds, Xiaoyu Sun, Pinar S. Gurel, Donovan Y. Z. Phua, Keith Hamilton, Lin Mei, John W. Watters, Yasuharu Takagi, Alex J. Noble, James R. Sellers, Gregory M. Alushin
Ubiquitination of glycogen and metabolites in cells and tissues
Marco Jochem, Simon A. Cobbold, Craig A. Goodman, Catharina Kueng, Anthony Cerra, Laura F. Fielden, Man Lyang Kim, Philipp Schenk, Ria Agarwal, Xiangyi S. Wang, Simon R. Scutts, Michael Pandos, Lin Tang, Thomas Hermanns, Shane M. Devine, Martin Brzozowski, Yuri Shibata, Niall D. Geoghegan, Catriona A. McLean, Bernhard C. Lechtenberg, Kay Hofmann, Paul Gregorevic, David Komander
Early fibrotic niches establish tumour-permissive microenvironments
Erik C. Cardoso, Hyeyoung Lee, Frances J. England, Hyunjin Cho, Robin Lu, Sagar S. Varankar, Moo Suk Park, Natasha Rekhtman, Bon-Kyoung Koo, Benjamin D. Simons, Jinwook Choi, Joo-Hyeon Lee
Dynamics of genetic and somatic trade-offs in ageing and mortality
Danny Arends, David G. Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur G. Centeno, Kurt H. Lamour, JoĂŁo Pedro de MagalhĂŁes, Pjotr Prins, Karl W. Broman, Saunak Sen, Sarah J. Mitchell, Michael R. MacArthur, Ăzlem Altintas Akin, Xiaoxu Li, Amandeep Bajwa, Vivian Diaz, David E. Harrison, Randy Strong, James F. Nelson, Khyobeni Mozhui, Johan Auwerx, Evan G. Williams, Richard A. Miller, Robert W. Williams
A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin
Maxwell T. White, Kang Wang, Hailong Zhang, Ulrich Eckhard, Karthik Hullahalli, Jason Chen, Shaoguang Wu, Abby L. Geis, Jie Zhang, Jessica Queen, F. Xavier Gomis-Ruth, Matthew K. Waldor, Min Dong, Cynthia L. Sears
Human cooperation is dynamic and often declines even under favourable conditions 1â4 . Many prevailing theories explain the decrease of cooperation in terms of strategic behaviour or learning, framed as evidence of rational behaviour or progression towards rationality 5â9 . Here we show that a key source of long-term decline derives from deviations from rational behaviour that systematically vary over time. We analyse a natural social dilemma in the fieldâthat is, group lending in Sierra Leoneâtracking cooperative dynamics over a five-year period. Borrowers enter a joint-liability contract, structured so that if the group loan is not repaid in full, all members lose access to future credit 10 . This produces a threshold social dilemma with incentives to free-ride 11,12 . The dataset includes 47,931 group payments made by 7,108 borrowers, augmented with a two-stage cluster sample of semi-structured interviews. We find a statistically robust pattern of punctuated decline driven by behavioural mechanisms 13 . Cooperation rates start out high but gradually decline due to decreases in group membersâ cooperative motivation and effort. Sharp rebounds occur when loans are restarted and clients resensitized to their cooperative responsibilities, even though the group membership and dilemma structure are largely unchanged. This pattern persists over the five-year observation window, but with each successive restart the subsequent decline is more rapid. The findings have direct implications for preventing behavioural decline in cooperative programmes and institutions.
Science
GPT-4o mini: Non-social science research article
A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
Celine K. Vuong, Alexis Weber, Patrick Seong, Nana Matoba, Yu-Jen Chen, Jordan Peyer, Shahab Younesi, Angelo Salinda, Daniel Gomez, Gabriella Rivas, Abril Morales, Beck Shafie, Pan Zhang, Susanne Nichterwitz, Le Qi, Nolan T. Fernandez, Emily Friedman, Michael I. Love, Michael J. Gandal, Daniel H. Geschwind, William E. Lowry, Jason L. Stein, Luis de la Torre-Ubieta
Severe obesity in human HFpEF alters contractile protein function and organization
Vivek P. Jani, Marcus Rhodehamel, Axel J. Fenwick, Weikang Ma, Eli Fisher, Maria T. Giannakopoulos, Sun Moon, Romi L. Castillo, Leslie M. Kennedy, Thomas C. Irving, Jil C. Tardiff, Elizabeth Murphy, Raghothama Chaerkady, Qing Wang, Meaghan E. Barry, Virginia S. Hahn, Kavita Sharma, Kenneth B. Margulies, Kenneth C. Bedi, Anthony Cammarato, David A. Kass
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, Sara A. Knaack, Masoumeh Hosseini, Rachel J. Chen, Pubudu Kumarage, Danielle K. Schmidt, Xiang Huang, Jie Sheng, Carlos J. Wang, Elisa Giusti, Shuang Liu, Su-Chun Zhang, Daifeng Wang, Anita Bhattacharyya, Andre M. M. Sousa
Mechanical load inhibits cancer growth in mouse and human hearts
Giulio Ciucci, Daniela Lorizio, Nicoletta Bartoloni, Mauricio Budini, Andrea Colliva, Simone Vodret, Anh-Vu Nguyen, Lorenzo Ciacci, Bernhard Texler, Benno Cardini, Rupert Oberhuber, Sofia Bindelli, Ilaria Luciana Carlotta Del Giudice, Roman Vuerich, Francesco Riccitelli, Elena Zago, Henrik Nicolay Finsberg, Mattia Chiesa, Gianluca Lorenzo Perrucci, Rossana Bussani, Furio Silvestri, Manuel Maglione, Gaetano Ivan Dellino, Gianfranco Sinagra, Mauro Giacca, Thomas Eschenhagen, Paolo Golino, Giulio Pompilio, Pier Giuseppe Pelicci, Laura Andolfi, Maurizio Pinamonti, Matteo Dal Ferro, Samuel Wall, Francesco S. Loffredo, Serena Zacchigna
Earliest octopuses were giant top predators in Cretaceous oceans
Shin Ikegami, Jörg Mutterlose, Kanta Sugiura, Yusuke Takeda, Mehmet Oguz Derin, Aya Kubota, Kazuki Tainaka, Takahiro Harada, Harufumi Nishida, Yasuhiro Iba
An unrecognized mode of small particles in the lower stratosphere
Ming Lyu, Adam T. Ahern, Gregory P. Schill, Michael J. Lawler, Daniel M. Murphy, Samuel J. Taylor, Anthony Fodel, Maya Abou-Ghanem, Colin Gurganus, Yunqian Zhu, Simone Tilmes, Eric Ray, Troy D. Thornberry, Ru-Shan Gao, Eric J. Hintsa, Fred Moore, Geoff Dutton, David Nance, Brad Hall, Andrew W. Rollins, Eleanor M. Waxman, Kristen Zuraski, Glenn S. Diskin, Yonghoon Choi, R. Bradley Pierce, Bernadett Weinzierl, Florian Kuderna, Maximilian Dollner, Eric Jensen, Charles A. Brock
Science abstract < 200 char.: Not a research
article
In Science Journals
Marc S. Lavine, L. Bryan Ray, Sacha Vignieri, Jake S. Yeston, Caroline Ash, Leoma Bere, Camilla F. Speller, Miguel Torres, Yevgeniya Nusinovich, Jesse Smith, Mattia Maroso, Courtney Malo, Wei Wong
Poor sleep impairs immune responses and influenza vaccine protection
Minhui Guan, Weihong Gu, Alex Gileles-Hillel, Abdelnaby Khalyfa, Pradeep Balamalaliyage, Wikanda Tunterak, Moran Li, Yi Huang, Yuhan Wen, John Driver, David Gozal, Xiu-Feng Wan
Fault-mediated magma propagation and triggered seismicity revealed by the 2022 SĂŁo Jorge Azores unrest
Stephen P. Hicks, Pablo J. Gonzalez, Anthony Lomax, Ana M. G. Ferreira, Ricardo S. Ramalho, Neil C. Mitchell, Graça Silveira, Nuno Afonso Dias, João Fontiela, Rui Fernandes, Susana Custódio, Maria Tsekhmistrenko, Virgilio Mendes, Adriano Pimentel, Rita Silva, Gonçalo Prates, William Sturgeon, Augustin Marignier, Fernando Carrilho, Rui Marques, Miguel Miranda, Arturo M. Garcia
Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting
Or Szekely, Yeongjoon Lee, Atul K. Rangadurai, Serafima Guseva, Joshua Cooksey, Edgar M. Faison, Nikita Zalenski, Qi Zhang, Zucai Suo, Hashim M. Al-Hashimi
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
Nour Aldin Kahlous, Maiju K. Rinne, Xin Zhang, Yanying Li, Yue Chen, Aikaterini Motso, Kaixuan Gao, Christina Bergqvist, Hongda Sheng, Yi Wang, Israel Cabeza de Vaca, Alejandro DĂaz-HolguĂn, Philip Ullmann, Tore Bengtsson, Volker M. Lauschke, Jyrki P. Kukkonen, Lucie Delemotte, Shane C. Wright, Xiangyu Liu, Dan Larhammar, Jens Carlsson
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
Kevin C. Robertson, Sascha J. Amann, Tongkun Liu, Adam V. Funk, Xianxi Wang, Irina Grishkovskaya, Aamir Mehmood, John R. Tabor, Jacqueline L. Norris-Drouin, Cheryl H. Arrowsmith, Jon L. Collins, Yinglong Miao, Michael J. Emanuele, David Haselbach, Lindsey I. James, Nicholas G. Brown
Neoadjuvant toripalimab plus CapeOX in locally advanced Epstein-Barr virus-associated gastric or gastroesophageal junction adenocarcinoma: a phase â Ą trial
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Edward P. Harvey, Jeffrey S. Smith, Joseph D. Hurley, Alyana J. Granados, Ernst W. Schmid, Jason G. Liang-Lin, Huyang Zhang, Emily M. Meara, Elizabeth K. Wren, Steffanie Paul, Matthew P. Ferguson, Victor G. Calvillo-Miranda, Miguel A. Alcantar, Debora S. Marks, Johannes C. Walter, Andrew C. Kruse, Katherine J. Susa
Multiomics immune profiling of a patient-relevant orthotopic lung cancer model using SEPARATE-Seq
Pauline M. R. Bardet, Lize Allonsius, Eva Hadadi, Daliya Kancheva, Morgane Paque, Sarka Vosahlikova, Aarushi A. Caro, Anouk Van Audenhove, Ayla Debraekeleer, Ria Roelandt, Kevin Verstaen, Michal Hensler, Delphine Hoton, GisÚle Mateu Cabrera, Louis Boon, Arnaud Blomme, Sofie Deschoemaeker, Geert Raes, Elly Marcq, Ahmed E. I. Hamouda, Jan P. Böttcher, Jitka Fucikova, Pierre Close, Frank Aboubakar Nana, Damya Laoui
Small RNA genomics of Aedes aegypti mosquitoes discovers infectious viruses that trigger an RNA interference response
Shruti Gupta, Rohit Sharma, Adeline E. Williams, Irma Sanchez-Vargas, Noah H. Rose, Chao Zhang, Alexander Crosbie-Villaseca, Margarita Kyza-Karavioti, Zheng Zhu, Gargi Dayama, Andrea Gloria-Soria, Doug E. Brackney, Jessica Manning, Sarah S. Wheeler, Angela Caranci, Trinidad Reyes, Massamba Sylla, Athanase Badolo, Jewelna Akorli, Ogechukwu B. Aribodor, Diego Ayala, Wei-Liang Liu, Chun-Hong Chen, Chalmers Vasquez, Cassandra Gonzalez Acosta, Alongkot Ponlawat, Tereza Magalhaes, Brendan H. Carter, Dawn M. Wesson, Darred Surin, Meg A. Younger, Andre Luis Costa-da-Silva, Matthew DeGennaro, Alexander Bergman, Louis Lambrechts, Carolyn S. McBride, Ken E. Olson, Eric Calvo, Nelson C. Lau
Mapping glioblastomaâs isoform diversity using long-read single-cell analysis
Wenshu Tang, Cario W. S. Lo, Annie T. W. Chu, Wing Lun Lee, Dingyuan Wang, Karrie Mei-Yee Kiang, Lai-Fung Li, Gilberto K. K. Leung, , Aya El Helali, Brian H. Y. Chung
Allogeneic hematopoietic cell transplantation in mature T- or NK-lymphomas: a phase II clinical trial
Kamil A. Rechache, Natalia S. Nunes, Jennifer Sponaugle, Elisabetta Xue, Amy Chai, Rebecca Combs, Jessenia Campos, Xingmin Feng, Francis A. Flomerfelt, Kalpana Upadhyaya, William Telford, Brian Dawson, Thomas E. Hughes, Syed Muhammad Salman Shah, Alicia Peluso, Christi McKeown, Anita Stokes, Scott Napier, Ruby Sabina, Jennifer Wilder, Kristen Cole, Judy Baruffaldi, Jennifer Cuellar-Rodriguez, Juan Gea-Banacloche, Mary M. Czech, Mustafa A. Hyder, Christopher G. Kanakry, Dimana Dimitrova, Jennifer A. Kanakry
Charting the transition from in vitro gliogenesis to the in vivo maturation of human glial progenitor cells transplanted into the hypomyelinated mouse brain
John N. Mariani, Steven J. Schanz, Benjamin Mansky, Xiaolu Wei, Carter C. Long, Devin Chandler-Militello, Hannah E. Aichelman, Nguyen P. T. Huynh, Steven A. Goldman
Author Correction: Electronic energy levels and optical spectra of trivalent lanthanide ions in water â Ce(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Tb(III), Dy(III), Ho(III), Er(III), Tm(III), and Yb(III)
Predicting individual differences of fear and cognitive learning and extinction
C. A. Gomes, D. R. Bach, A. Razi, G. Batsikadze, S. Elsenbruch, H. Engler, T. M. Ernst, M. C. Fellner, C. Fraenz, E. Genç, A. Klass, F. Labrenz, S. Lissek, C. J. Merz, D. Metzen, A. Nostadt, R. J. Pawlik, J. E. Schneider, M. Tegenthoff, A. Thieme, O. T. Wolf, O. GĂŒntĂŒrkĂŒn, H. H. Quick, R. Kumsta, D. Timmann, T. Spisak, N. Axmacher
Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2
Ling Yu, Mingquan Yan, Katherine Zimmel Scaturro, Osama Qureshi, Yu-Lieh Lin, Benjamin B. Bartelle, C. Addison Smith, Daniel Osorio Hurtado, James J. Cai, Lindsay A. Dawson, Regina Brunauer, Larry J. Suva, Manjong Han, Connor P. Dolan, Ken Muneoka
Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes
Yuanzhao Cao, Meredith A. Redd, Jennifer E. Outhwaite, Dalia Mizikovsky, Woo Jun Shim, Chen Fang, Courtney Vedelago, Clarissa Tan, Zhixuan Wu, Dara Daygon, Terra Stark, Robin Palfreyman, Han Sheng Chiu, Ulrich Thomas, Elena Dragicevic, Julian D. J. Sng, Natalie J. Saez, Helen L. Barrett, Emily S. Dorey, Glenn F. King, Alain Wuethrich, Matt Trau, Sonia Shah, Kirsty R. Short, Nathan J. Palpant
Insights into early continental crust formation from the most ancient heart of Scotland
Silvia Volante, Fernanda Torres-Mancinelli, Jonas Kaempf, Vitor Barrote, Tim Johnson, Christopher Kirkland, Maria Rosa Scicchitano, Lorenzo Tavazzani, Sampriti Basak, Anne-Sophie Bouvier, Annika Dziggel, Axel Gerdes
Indirect inhibition of the NLRP3-interleukin-1ÎČ axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis
Beibei Liu, Marianne R. Spalinger, Annalisa Invernizzi, Eike Gerdes, Babett Steglich, Marlene Schwarzfischer, Andres Machicote, Penelope Pelczar, Doris Pöhlmann, Mikolaj Nawrocki, Marius Böttcher, Ayob Aleko, Lis Noelia Velasquez, Sandra Wende, Franziska Stallbaum, Justus Neuendorff, Saskia Grosshauser, Franziska Muscate, Gemma Douilhet, Laura Garcia Perez, Morsal Sabihi, Katharina Möller, Florian Viehweger, Jan P. Sutter, Christoph Kilian, Yogesh Kumar, Thorben FrĂŒndt, Guido Sauter, Thomas Rösch, Nicola Gagliani, Amedeo Caflisch, Michael Scharl, Samuel Huber
Disruption of the SAGA CORE triggers collateral degradation of KAT2A
Paul Batty, Hannah Beneder, Caroline SchĂ€tz, Gabriel Onea, Maciej Zaczek, Ana P. Kutschat, Miriam Abele, Sophie MĂŒller, Giulio Superti-Furga, Georg E. Winter, Davide Seruggia
Human milk oligosaccharide mediates mutualism between Escherichia coli and Bifidobacterium bifidum
David Seki, Shaul Pollak, Magdalena Kujawska, Raymond Kiu, Antia Acuna-Gonzalez, Lucy I. Crouch, Cassie R. Bakshani, Peter T. Chivers, Monique Mommers, Nils van Best, John Penders, Lindsay J. Hall
TBL1X/TBL1XR1 govern ÎČ-cell identity through a PAX6-containing gene regulatory network
Alina A. Walth-Hummel, Celine Jouffe, Peter Weber, Karsten Motzler, Julia Geppert, Michael Sterr, Wei Gan, Iwona Szczerbinska, Ann-Christine König, Stefanie M. Hauck, Raul Terron-Exposito, Daniela Hass, Congcong Wang, Kenneth A. Dyar, James G. Lyon, Heiko Lickert, Carina ĂmmĂ€lĂ€, Stephan Herzig, Frances M. Ashcroft, Mostafa Bakhti, Patrick E. MacDonald, Maria Rohm
Syntheses of 2,2â-dihalo-1,1â-binaphthyl compounds via palladium-catalysed 1,2-halo shiftâcyclisation coupling reaction of α-hydroxyl haloalkynes
Katharina GeiĂler, Jan Philipp Kreysing, Yuning Wang, Desislava Glushkova, Agnieszka Obarska-Kosinska, Patrick C. Hoffmann, Stefanie Böhm, Alexander Schmidt, Jakob Meier-Credo, Julian D. Langer, Gerhard Hummer, Martin Beck
A pharmacokinetic and pharmacodynamic drug-drug interaction study of dorzagliatin and empagliflozin in patients with type 2 diabetes and obesity: an open-label phase I trial
Huan Liu, Yuanhui Zhang, Lingge Feng, Jiayi Zhang, Yu Sun, Yu Zhao, Muhan Jiang, Xiang Liu, Gregory J. Tracey, Li Chen, Dongyang Liu
Ketogenic diet exacerbates DSS-induced colitis through a ÎČ-hydroxybutyrate-Thomasclavelia spiroformis-γΎ17 T cell axis in mice
Yameng Liu, Xuan Wu, Li Chen, Shan Wang, Jingyi Xu, Weifeng Wang, Xueting Yao, Wei Xie, Xianchun Zhong, Shuai Li, Yueying Li, Lin Han, Cen Xie, Lei Chen, Frank J. Gonzalez, Weiwei Liu
Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations
Binh An Nguyen, Maria del Carmen Fernandez-Ramirez, Parker Bassett, Virender Singh, Preeti Singh, Maja PÄkaĆa, Layla Villalon, Yasmin Ahmed, Andrew Lemoff, Bret Evers, Christian Lopez, Barbara Kluve-Beckerman, Lorena Saelices
Challenges and prospects of 2D electronics for future monolithic complementary field-effect transistors
Md Mobaidul Islam, Yongin Cho, Anamika Sen, Prashant Bisht, Junoh Shim, Joo-On Oh, Geonyong Park, Antonio Rossi, Hyeongwu Lee, Lin Jiang, Camilla Coletti, Bo-In Park, Heeyeop Chae, SangHoon Shin, Heekyeong Park, Sunkook Kim
Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster
Julia Eberle, Ahmed Salem, Mara Hofmann, Anja Reisser, Yasser B. Ruiz-Blanco, Yasser Almeida-Hernandez, Boris Gole, Melanie Rall-Scharpf, Jessica Angulo-Capel, Thomas Monecke, Elsa Sanchez-Garcia, J. Christof M. Gebhardt, Lisa WiesmĂŒller
Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids
Carmen Menacho, Satoshi Okawa, Iris Ălvarez-Merz, Annika Wittich, Mikel Muñoz-Oreja, Pawel Lisowski, Mario LĂłpez MartĂn, Tancredi Massimo Pentimalli, Shiri Zakin, Mathuravani Thevandavakkam, Caleb Jerred, Selene Lickfett, Laura Petersilie, Agnieszka Rybak-Wolf, Annette Seibt, Diran Herebian, Gizem Inak, Susanne Brodesser, Andrea Zaliani, Barbara Mlody, Justin Donnelly, Kasey Woleben, Francesc Xavier Soriano, Jose C. Fernandez-Checa, Natascia Ventura, Sidney Cambridge, Ertan Mayatepek, Antonella Spinazzola, Markus Schuelke, Nikolaus Rajewsky, Andrea Rossi, Alex Peralvarez-Marin, Felix Distelmaier, Ethan Perlstein, Ian J. Holt, Emma Puighermanal, Ole Pless, Christine R. Rose, Antonio Del Sol, Alessandro Prigione
The membrane protein Amuc_1098 from Akkermansia muciniphila alleviates acute pancreatitis via TLR2 signaling and glycerophospholipid metabolism remodeling
Igh nuclear speckle association promotes V(D)J recombination
Saurabh Priyadarshi, Khalid H. Bhat, Ellen B. Drake, Sarah Naiyer, Hammad Farooq, Xinyan Qu, Jose F. Cantillo, Xue Lei, Ebru Ermis, Eden Kleiman, Sajad A. Bhat, Andrew Koh, Jie Liang, Ann J. Feeney, Jan H. Spille, Amy L. Kenter
Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion
Tae Young Kim, Kayoung Son, Chang-Hwan Moon, Keun-Young Yook, Soo A. Kim, Hyein Ham, Yurim Lee, Soo In Lee, Yejin Jo, Yunlong Yu, Dae-Hyun Kim, Jungmok Seo
Mll5 haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3ÎČ signaling and recapitulates ASD-like behaviors in mice
Shumin Gao, Qingxiu Lin, Xiaotong Liu, Meixiang Jia, An-Yi Zhang, Zhendong Feng, Lei Han, Nianzhuang Qiu, Xiao-Xing Liu, Huajie Zhai, Haizhen Zhang, Jing Zhang, Xiaodan Ding, Yan Zhang, Lin Lu, Jie Shi, Jia Jia Liu, Ya Bin Wei
Wastewater intelligence predicts the emergence of clinically-relevant and drug-resistant Candidozyma auris at healthcare facilities
Ching-Lan Chang, Michael A. Moshi, Quang-Huy Nguyen, Junghun Oh, Ha Nguyen, Pratik Paranjape, Mohammed Abushanab, Austin J. Tang, Jose Yani Itorralba, Lauryn Massic, Eakalak Khan, Cassius Lockett, Horng-Yuan Kan, Mark Pandori, Daniel Gerrity, Van Vo, Tin Nguyen, David Hess, Edwin C. Oh
Viral introductions and return to baseline sexual behaviors maintain low-level mpox incidence in Los Angeles
Miguel I. Paredes, Citina Liang, Sze-chuan Suen, Ian W. Holloway, Jacob M. Garrigues, Nicole M. Green, Trevor Bedford, Nicola F. MĂŒller, Joseph Osmundson
Author Correction: Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
Sathish Babu Vasamsetti, Samreen Sadaf, Mohammad A. Uddin, Jixing Shen, Ebin Johny, Awishi Mondal, Jonathan Florentin, Liqun Lei, Aleef Mannan, Krithika Sudhakar Rao, John Sembrat, Mauricio Rojas, Ian Sipula, Jake Kastroll, Michael J. Jurczak, Sruti Shiva, Robert M. OâDoherty, Vijay Yechoor, Partha Dutta
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging
Seung Hyuk T. Lee, Asha Kar, Kyla Z. Gelev, Zeyuan Johnson Chen, Sankha Subhra Das, Sini Heinonen, Tuure Saarinen, Maija Vaittinen, Dorota Kaminska, Hilkka Peltoniemi, Chongyuan Luo, Anne Juuti, Ville MÀnnistö, Jussi PihlajamÀki, Minna U. Kaikkonen, Kirsi H. PietilÀinen, Brunilda Balliu, PÀivi Pajukanta
The GFI1âFOXO1 axis regulates NK cell maturation and function
Qiutong Huang, M. Zeeshan Chaudhry, James Dight, Louisa Alim, Huiyang Yu, Renae Denman, Hiu On Man, Jaring Schreuder, Alexandra L. Garnham, Zewen K. Tuong, Fernando Souza-Fonseca-Guimaraes, Nicolas Jacquelot, Gabrielle T. Belz
CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration
Ioana I. N. Da Silva, Desiree Ramirez, Sarah L. Parylak, Leslie A. Wallace, James K. Tucker, Joel M. Erberich, Rutvi Katariya, Aidan H. McDonald, Iryna S. Gallina, Ariana L. Tucker, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua M. Pratt, Monique Pena, Vipula Racha, Christina K. Lim, Sarah Fernandes, Simone Benassi, Lynne Randolph-Moore, Krishna C. Vadodaria, Maria C. Marchetto, Nicola J. Allen, Fred H. Gage
Author Correction: Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa
Andrew Phillips, Jennifer Smith, Loveleen Bansi-Matharu, Kenly Sikwese, Cissy Kityo, Charles Flexner, Marco Vitoria, Nathan Ford, Meg Doherty, Zack Panos, David Ripin, Matthew Hickey, Diane Havlir, Monica Gandhi, Michael Reid, Paul Revill
Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation
Stephen QR Wong, Kazukuni Hayashi, Ethan J. Subel, Yung Hsing Huang, Hongbo Gao, Haley E. Garcia, Sophie J. Porter, Mustafa Karabicici, Xen Ping Hoi, Mark D. Alonzo, Armine Kasabyan, Efrosini Tsouko, Crystal S. Shin, Lisa Bouchier-Hayes, Dimitrios Korentzelos, Chen Chen, Michael Brooks, Zheng Yin, Renil S. Titus, Lan Zhou, Yinan Gong, Yulin LI, Stephen TC Wong, Ziad El-zaatari, Dharam Kaushik, Raj Satkunasivam, Fotis Nikolos, Keith S. Chan
γΎ T cell-stromal networks modulate matrix composition and vascularity in foreign body response
Anna Ruta, Kavita Krishnan, JiWon Woo, Joscelyn C. MejĂas, Elise F. Gray-Gaillard, David R. Maestas, Helen Hieu Nguyen, Alexandra N. Rindone, Christopher Cherry, Michael Patatanian, Frank Haoning Yu, Brenda Yang, Connor Amelung, Christina D. King, Birgit Schilling, Sharon Gerecht, Elana J. Fertig, Locke Davenport Huyer, Drew M. Pardoll, Jennifer H. Elisseeff
Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance
Minli Ruan, Sean M. Engels, Matthew R. Burroughs, Xiaoyan Li, Rosella Stower, Talia Tzadikario, Connor Powell, Dylan Bloch, Oleksandra Fanari, Stuart Akeson, Daniel E. Eyler, Chase A. Weidmann, Sara Rouhanifard, Miten Jain, Lydia M. Contreras, Kristin S. Koutmou
Salicylic acid modulates its catabolic enzymes via proteasomal degradation linked to SCF-associated proximity networks
Natalie Hamada, Malathy Palayam, Jacob Moe-Lange, Gabrielle Wyatt, Christian Montes, Sun Hyun Chang, Annie Hu, Savithramma P. Dinesh-Kumar, Philipp Zerbe, Justin W. Walley, Nitzan Shabek
Isoform-specific m6A deposition and coordinated splicing shape mammalian transcriptome evolution
Gabriela Santos-Rodriguez, Akanksha Srivastava, Agin Ravindran, Favour O. Oyelami, Chi Kin Ip, Pallavi Gupta, Jeanette Villanueva, Helen E. King, Abigail Grootveld, Alexandra Sneddon, James Blackburn, Ishaan Gupta, Helaine Graziele Santos Vieira, Nikolay E. Shirokikh, Eduardo Eyras, Robert J. Weatheritt
Hydro-geomorphological drivers across scales shape the trajectory of coastal wetland restoration
Junlin Ren, Sikai Wang, Tingting Zhang, Jun Ma, Ting Zhang, Chuyu Cheng, Kang Zhang, Changlin Xu, Johan van de Koppel, Daphne van der Wal, Tjeerd J. Bouma, Fangyan Cheng, Ping Zhuang, Feng Zhao
Metasurface analogues of molecular diastereomers from hierarchical multiscale chiral interactions with biomolecules
Dominic J. P. Koyroytsaltis-McQuire, Shailendra K. Chaubey, Rahul Kumar, Paula L. Lalaguna, Tamas Javorfi, Giuliano Siligardi, Affar Karimullah, Adrian J. Lapthorn, Yoshito Y. Tanaka, Shun Hashiyada, Nikolaj Gadegaard, Malcolm Kadodwala
Type I interferon drives T cell responses to amyloid beta in the central nervous system
Julius J. Michel, Khwab Sanghvi, Jakob Rosenbauer, Lea Humbs, Clara Tejido Dierssen, Saskia Grudzenski-Theis, Viktoria Sachs, Kristine JÀhne, Karoline Degenhardt, Lutz Frölich, Jochen Herms, Marc Fatar, Michael Platten, Lukas Bunse
Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth
Ting Miao, Ying Liu, Mujeeb Qadiri, Amaury Dasseux, John M. Asara, Yanhui Hu, Xiaomei Sun, Luz del Carmen Pliego-AlcĂĄntara, Christian C. Dibble, Norbert Perrimon
Leveraging remote sensing and crowd-sourced biodiversity data for enhanced plant functional trait mapping
Ălvaro Moreno-MartĂnez, Jordi Muñoz-MarĂ, Jose E. Adsuara, Benjamin Dechant, Jens Kattge, Teja Kattenborn, Francesco Maria Sabatini, Fabian D. Schneider, Gregory Duveiller, Peter M. van Bodegom, Ethan E. Butler, Miguel D. Mahecha, Emma Izquierdo-Verdiguier, Josep Peñuelas, Gerhard Boenisch, Ryan Pavlick, Philip A. Townsend, Nuno Carvalhais, Daniel Lusk, Gustau Camps-Valls
The dual role of azoles: lifesaving antifungals and drivers of resistance â a One Health perspective
Behrad Roohi, Joel D. A. Tyndall, Thomas Svoboda, Sybren de Hoog, Pedro W. Crous, Brian C. Monk, Birgit Strobl, Annemarie Weissenbacher, Joseph Strauss, Paul E. Verweij, Michaela Lackner
MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
James A. Watson, Beatrice K. Alexander-Howden, Theo S. Hall, Martin A. Wear, Finlay McGhie, Gillian Clifford, Hannah Wapenaar, Juan Zou, Adrian Bird, Marcus D. Wilson
Author Correction: First-line modified FOLFOX plus/minus nivolumab and Ipilimumab or FLOT plus nivolumab in advanced gastroesophageal adenocarcinoma: a phase II multi-cohort IKF-AIO-MOONLIGHT trial
Sylvie Lorenzen, Thorsten Oliver Goetze, Peter C. Thuss-Patience, Jorge Riera-Knorrenschild, Eray Goekkurt, Tobias Nicolaas Dechow, Thomas Jens Ettrich, Ralf Dieter Hofheinz, Kim Barbara Luley, Daniel Pink, Udo Lindig, Gunnar Folprecht, Gunter Schuch, Michael Bitzer, Volker Heinemann, Stefan Angermeier, Claus Bolling, Maria Loose, Sabine Junge, Claudia Pauligk, Salah-Eddin Al-Batran
Author Correction: Temporal structure of natural language processing in the human brain corresponds to layered hierarchy of large language models
Ariel Goldstein, Eric Ham, Mariano Schain, Samuel A. Nastase, Bobbi Aubrey, Zaid Zada, Avigail Grinstein-Dabush, Harshvardhan Gazula, Amir Feder, Werner Doyle, Sasha Devore, Patricia Dugan, Daniel Friedman, Michael Brenner, Avinatan Hassidim, Yossi Matias, Orrin Devinsky, Noam Siegelman, Adeen Flinker, Omer Levy, Roi Reichart, Uri Hasson
SPNS2 exports sphingosine-1-phosphate and imports glucose
Cynthia Weigel, Md Lokman Hossen, Ryan D. R. Brown, Can E. Senkal, Christopher D. Green, Jason Newton, Sumit Saha, Elisa N. D. Palladino, Bin Ni, Francesco S. Celi, Xianjun Fang, Frank D. Corwin, Huanyu Z. Li, David B. Sauer, Prem P. Chapagain, Sarah Spiegel
Photoactivatable CRISPR/Cas13d via upconversion nanoparticles for deep tissue RNA engineering and orthopedic therapy
Jie Zhao, Jingyu Zhang, Miaomiao Gao, Zukang Miao, Yang Zhang, Yue Guo, Zhengrui Fan, Jinglin Tian, Lu Yang, Ning Jiang, Jianxiong Ma, Jun Jiao, Jinbin Pan, Xinlong Ma
Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model
James Deng, Adrien Paumier, Lara Labarta-Bajo, Ashley N. Brandebura, Nick A. Andrews, Samuel B. Kahn, Reina Bassil, Tao Tao, Antonio F. M. Pinto, Jolene K. Diedrich, Nicola J. Allen
Author Correction: A Bayesian decision support system for automated insulin doses in adults with type 1 diabetes on multiple daily injections: a randomized controlled trial
Alessandra Kobayati, Anas El Fathi, Natasha Garfield, Laurent Legault, Adnan Jafar, Jean-François Yale, Michael A. Tsoukas, Ahmad Haidar
Binding items to contexts through conjunctive neural representations with the method of loci
Jiawen Huang, Akshay Manglik, Nick Dutra, Hannah Tarder-Stoll, Taylor Chamberlain, Robert Ajemian, Qiong Zhang, Kenneth A. Norman, Christopher Baldassano
Author Correction: Ocean heat forced West Antarctic Ice Sheet retreat after the Last Glacial Maximum
Elaine M. Mawbey, James A. Smith, Claus-Dieter Hillenbrand, Katharine R. Hendry, Erin L. McClymont, Mervyn J. Greaves, Johann P. Klages, Gerhard Kuhn, Svetlana Radionovskaya, Charlotte L. Spencer-Jones, Robert D. Larter, Julia S. Wellner, Pierre Dutrieux
Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD
Xiaofeng Zhou, Da Zhou, Yanni Pu, Hanseul Kim, Zhonghan Sun, Wenhao Qi, Jiadong Jin, Wanqin Zhang, Mingfeng Xia, Chengyan Wang, Shangyu Hong, Long H. Nguyen, Na Jiao, Yan Zheng, Taotao Liu
Prolonged ÎČ2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial
Pip M. G. Van Lier, Tineke van de Weijer, Froukje Vanweert, Kim Brouwers, Kevin M. R. Nijssen, Gert Schaart, Esther Moonen-Kornips, Sten M. M. van Beek, Sam Springer, Roel Wierts, Peter J. Joris, Vera B. Schrauwen-Hinderling, Esther Phielix, Tore Bengtsson, Patrick Schrauwen, Joris Hoeks
Recurrent DNA break clusters drive replication-stress-induced copy number variants and genome diversification
Lorenzo Corazzi, Alex Ing, Eva Benito, Marco Raffaele Cosenza, Patrick Hasenfeld, Thomas Weber, Anna J. M. Marx, Vivien S. Ionasz, Nathan Trausch, Sarah Benedetto, Giulia Di Muzio, Boyu Ding, Jana Berlanda, Marco Giaisi, Nina Claudino, Thomas Höfer, Jan O. Korbel, Pei-Chi Wei
Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion, Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, Nicholas X. Russell, Gerald Saunders, Amanda L. Zacharias, Samantha A. Brugmann, Jeffrey A. Whitsett, Debora Sinner, Xin Sun, Daniel T. Swarr, William J. Zacharias
NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma
Tereza Lanickova, Artemis Angelidou, Michal Hensler, Ann Vankerckhoven, Veronika Niederlova, Sarka Vosahlikova, Lenka Kasikova, Anna Bock, Ema Zacharova, Christos Stekas, Barbora Tunkova, Jana Tomankova, Daniela Glatzova, Irena Moserova, Jana Drozenova, Barbora Cveckova, Thrinethra Shankar, Jan Laco, Ales Ryska, Pavel Dundr, Munachiso Iheme Ndukwe, David Cibula, Jiri Vachtenheim, Robert Lischke, Linda Capkova, Marek Kovar, Michal J. Halaska, Lukas Rob, Lize Allonsius, Damya Laoui, Antoine Hanns, Isabelle Cremer, Sandra Orsulic, Ondrej Stepanek, Francis Jacob, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial
Abhinav Humar, Yannis Hadjiyannis, Camila Macedo, Lillian M. Tran, Beth D. Elinoff, Christopher B. Hughes, Swaytha R. Ganesh, Alan F. Zahorchak, Erin M. Ables, Mindi A. Styn, Douglas Landsittel, Adriana Zeevi, Fadi G. Lakkis, Diana M. Metes, Angus W. Thomson
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging
Tetiana Poliezhaieva, Yuting Li, Prerana Shrikant Chaudhari, Ulas Isildak, Pol Alonso-Pernas, Isabela Santos Valentim, Fengting Su, Lilia Espada, Melike Bayar, Li Fu, Andreas Koeberle, Handan Melike DönertaĆ, Maria A. Ermolaeva
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Amit Kumar Sahu, Alberto Minetti, Domenico Di Fraia, Antonio Marino, Patrick Rainer Winterhalter, Daniela Giustarini, Ranieri Rossi, Andreas Simm, Francesco Neri, Federico Galvagni, Christoph Gerhardt, Thorsten Pfirrmann, Alessandro Ori
Target Trial Emulation of Vaccine Effectiveness in 5- to 17-years-olds with Prior SARS-CoV-2 Infection
Yuqing Lei, Jiajie Chen, Qiong Wu, Ting Zhou, Bingyu Zhang, Michael J. Becich, Yuriy Bisyuk, Saul Blecker, Elizabeth A. Chrischilles, Dimitri A. Christakis, Lindsay G. Cowell, Mollie R. Cummins, Soledad A. Fernandez, Daniel Fort, Sandy L. Gonzalez, Sharon J. Herring, Benjamin D. Horne, Carol Horowitz, Mei Liu, Susan Kim, Parsa Mirhaji, Abu Saleh Mohammad Mosa, Jennifer A. Muszynski, Catharine I. Paules, Alice I. Sato, Hayden T. Schwenk, Soumitra Sengupta, Srinivasan Suresh, Bradley W. Taylor, David A. Williams, Yongqun He, Jeffrey S. Morris, Ravi Jhaveri, Christopher B. Forrest, Yong Chen,
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Justin A. Bosch, Pierre Michel Jean Beltran, Cooper Cavers, James Thai LaGraff, Randy Melanson, Ankita Singh, Weihang Chen, Yanhui Hu, Sudhir Gopal Tattikota, Ying Liu, Yousuf Hashmi, John M. Asara, Tess Branon, Alice Y. Ting, Steven A. Carr, Norbert Perrimon
Symbiotic phosphate transporter dynamics in rice expose functional plasticity of the arbuscules
Jennifer McGaley, Martina OrvoĆĄovĂĄ, Ben Schneider, Chai Hao Chiu, Ronelle Roth, Sarah Bowden, Matthew S. Hope, Jayne L. Davis, Warda Khalif, Emma J. Wallington, Uta Paszkowski
Erratum for the Research Article âα-Synuclein expression is required for somatodendritic dopamine release and immediate early gene inductionâ by S. J. Choi et al .
Erratum for the Research Article âB cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysisâ by Q.-H. Zeng et al .
Ancient regulatory evolution shapes individual language abilities in present-day humans
Lucas G. Casten, Tanner Koomar, Taylor R. Thomas, Jin-Young Koh, Dabney Hofammann, Savantha Thenuwara, Allison Momany, Marlea OâBrien, Jeffrey C. Murray, J. Bruce Tomblin, Jacob J. Michaelson
Patterns of mitochondrial ATP predict tissue folding
Bezia Lemma, Megan Rothstein, Pengfei Zhang, Bridget Waas, Marcus Kilwein, Safiya Topiwala, Sherry X. Zhang, Anvitha Sudhakar, Katharine Goodwin, Elizabeth R. Gavis, Ricardo Mallarino, Andrej Kosmrlj, Celeste M. Nelson
Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis
Soham Basu, Petrus Steenbergen, Florian Gabler, Alexandre Paix, Paolo Ronchi, Gleb Bourenkov, Thomas R. Schneider, Jonas Hellgoth, Anna Kreshuk, Suat Ăzbek, Aissam Ikmi
Malaria shaped human spatial organization for the past 74 thousand years
Margherita Colucci, Michela Leonardi, James Blinkhorn, Seth R. Irish, Cecilia Padilla-Iglesias, Stefanie Kaboth-Bar, William D. Gosling, Robert W. Snow, Andrea Manica, Eleanor M. L. Scerri
Selective elimination of circulating effector CD8 T cells via LTÎČR blockade separates anti-CD137 efficacy from toxicity
Sergey A. Shein, Anna A. Korchagina, Li-Ju Wang, Zhao Lai, Yidong Chen, Jacob S. Fisher, Burkhard Ludewig, Jessica N. Lancaster, Yang-Xin Fu, Ekaterina Koroleva, Alexei V. Tumanov
Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses
Yossi Paltiel, Daniel Goldberg, Nir Yuran, Shira Yochelis, Jia Hao Soh, Christopher Seibel, JĂŒrgen Gauss, Shmuel Zilberg, S. Furkan Ozturk, Jonas Fransson, Anna I. Krylov, Ron Naaman
PATCH: A deep learning method to assess heterogeneity of artistic practice in historical paintings
Andrew Van Horn, Lauryn Smith, Mahamad Salah Mahmoud, Michael McMaster, Clara G. Pinchbeck, Ina T. Martin, Andrew Lininger, Anthony Ingrisano, Adam Lowe, Carlos Bayod, Elizabeth S. Bolman, Kenneth Singer, Michael Hinczewski
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Christina Vagena-Pantoula, Konstantinos Kalyviotis, Shuyi Feng, Antoine Sanchez, Igor Kondrychyn, Moe Fukumoto, Xiangbin Pan, Thomas Juan, Didier Y. R. Stainier, Periklis Pantazis, Li-Kun Phng, Julien Vermot
Synthetic control of implanted engineered liver tissue growth
Amy E. Stoddard, Vardhman Kumar, Constantine N. Tzouanas, Veronica Hui, Jeffrey Li, Anisha Jain, Alanna Farrell, Sangeeta N. Bhatia, Christopher S. Chen
Seasonal bromate formation in the Arctic snowpack: Implications for the bromine biogeochemical cycle
Stefano Frassati, Elena Barbaro, Giulio Cozzi, Clara Turetta, Federico Scoto, Claudia Rossetti, Marco Roman, Matteo Feltracco, Kitae Kim, François Burgay, Alfonso Saiz-Lopez, Joseph S. Francisco, Ward Van Pelt, Feiyue Wang, David Cappelletti, Sofia Lerda, Giovanni Bistoni, Filippo De Angelis, Carlo Barbante, Andrea Gambaro, Andrea Spolaor
Extensive heterozygosity and genetic exchange among natural populations of Leishmania species
Eliza V. C. Alves-Ferreira, Mourad Barhoumi, Tiago R. Ferreira, Matthew W. Brown, Petr Volf, Yusr Saadi-BenAoun, Immen Khammari, Ihcen Kherachi, Akila Fathallah Mili, Zoubir Harrat, Ikram Guizani, David L. Sacks, Julius LukeĆĄ, Michael E. Grigg
Soil organic nitrogen rather than fertilizer drives dinitrogen losses in flooded rice systems
Yuanyuan Lei, Zhijun Wei, Kaiye Ye, Kees Jan van Groenigen, Yu Liu, Hongna Cui, Klaus Butterbach-Bahl, Pete Smith, Deli Chen, Shu Kee Lam, William R. Horwath, Wulf Amelung, Chaopu Ti, Wei Zhou, Jingrui Yang, Hongbo He, Xudong Zhang, Sheng Zhou, Xiaoyuan Yan, Longlong Xia
The intestinal microbiota impacts nutritional immunity and resistance to Acinetobacter baumannii pneumonia
Erin R. Green, Nicholas M. Negretti, Tess H. Brunner, Nicolas G. Shealy, Felipe A. Moser, Sydney L. Drury, Kacie A. Traina, Valeria M. Reyes Ruiz, Tzushan S. Yang, Christopher J. Lehmann, Mariana X. Byndloss, Raf van de Plas, Joseph P. Zackular, Samuel H. Light, Jennifer M. S. Sucre, Eric P. Skaar
Type I interferons induced upon respiratory viral infection impair lung metastatic initiation
Ana Farias, Victoria L. Bridgeman, Felipe S. Rodrigues, Franz Puttur, Amber Owen, Stefanie Ruhland, Rute M. M. Ferreira, Matthias Mack, Ilaria Malanchi, Cecilia Johansson
Hepatitis B virus covalently closed circular DNA formation in murine hepatic cells uncovers a late entry block
Xupeng Hong, Georgia Brousseau, Hsuan-An Chen, Catherine A. Freije, Leon L. Seifert, Mengyin Zhang, Yingpu Yu, William M. Schneider, Ype P. de Jong, Alan McLachlan, Charles M. Rice
Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy
Dimitri Robay, Ole Ackermann, Laurent Laborde, Xingyi Shi, Federico Oreglia, Ramona Stump, Sabina Ciaghi, Giorgio G. Galli, Laura Holzer, Lorraine Villemin, Joel Wagner, Jincheng Wu, Lang Ho Lee, Claudia Bossen, Thanos P. Mourikis, Millicent Gabriel, David Ruddy, Haiyan Yu, Cory Johannessen, Stephane Ferretti, Carlotta Costa
Emergence of genetic sex determination in an environmentally sex-determined animal
Wen Wei, Man Lin, Trent Bishop, Ryan Shahriari, Yue Hao, Logan Graham, Bret L. Coggins, Hannah Jee, Emma Fonseca, Swatantra Neupane, Li Wang, Sen Xu, Erin Kim, Michael Lynch, Zhiqiang Ye
Efficient replication of influenza D virus in the human airway underscores zoonotic potential
Christina G. Sanders, Min Liu, Jovanna A. Fusco, Elizabeth M. Ohl, Natalie N. Tarbuck, Emily M. King, Devra Huey, Thomas P. Fabrizio, Phylip Chen, Amanda R. Panfil, Richard J. Webby, Mark E. Peeples, Andrew S. Bowman, Cody J. Warren
B. A. Block, E. A. Aalto, C. M. L. S. Pagniello, R. E. Whitlock, M. J. W. Stokesbury, R. J. Schallert, M. R. Castleton, J. F. Walter, K. Ferter, L. NÞttestad, O. Bjelland, H. W. Maxwell, A. Drumm, C. Waters, P. Cermeño
Paramyxovirus infection driven by heteromultivalent sialoglycotope binding
Xuesheng Wu, Mengying Liu, Laura Blekkenhorst, Mare H. L. Verbruggen, Nancy N. M. P. Schuurman, Lemeng Chao, Jun Yang Ong, Tom Wennekes, Laura L. A. van Dijk, Rory D. de Vries, Frank J. M. van Kuppeveld, Henrik Clausen, Yoshiki Narimatsu, Erik de Vries, Cornelis A. M. de Haan
Failure of early B cell tolerance and possible BCR signaling dysregulation underlie NF155-mediated autoimmune nodopathies
Bhaskar Roy, Abeer H. Obaid, Zhenjian Wang, Kristof G. Kovacs, Sarah Ohashi, F. Naz Cemre Kalayci, Daniel Joo, Gianvito Masi, Carmina Coppola, Sameeran Das, Amanda L. Hernandez, Lorena Martin-Aguilar, Cinta LleixĂ , Richard J. Nowak, Luis Querol, Kevin C. OâConnor
Rotational 3D printing of activeâpassive filaments and lattices with programmable shape morphing
Mustafa K. Abdelrahman, Jackson K. Wilt, Yeonsu Jung, Rodrigo Telles, Gurminder K. Paink, Natalie M. Larson, Joanna Aizenberg, L. Mahadevan, Jennifer A. Lewis
CD28-driven ex vivo generation of stem-like memory CD8 + T cells bypassing CD3/TCR signaling
Fumie Ihara, Yota Ohashi, Evey Y. F. Zheng, Saori Fukao, Rowena Rodrigo, Babak Noamani, Giselle M. Boukhaled, Ben X. Wang, Dong-Hoon Han, Xinyu Wei, Brian D. Burt, Kayoko Saso, Yukiko Matsunaga, Dalam Ly, Yuki Kagoya, Marcus O. Butler, Tak W. Mak, Samuel D. Saibil, Naoto Hirano
Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3 1 topology
Maciej Sikora, Mariusz Mozajew, Julia A. Sikorska, Fernando Bruno da Silva, Agata P. Perlinska, Anna Kluza, Szymon Niewieczerzal, Maciej Lukaszewicz, Beata Wielgus-Kutrowska, Karolina Stachurska-Korzeniowska, Sophie E. Jackson, Joanna I. Sulkowska
A millennium of cold-water coral habitat loss in the East Pacific during low ENSO variability in the mid- to late Holocene
Joseph A. Stewart, Laura F. Robinson, Michelle L. Taylor, Daniel J. Fornari, Katleen Robert, Stuart Banks, Tianyu Chen, Tao Li, James Kershaw, Shannon Hoy, Qian Liu, Jessica D. Gordon, Maria Luiza de Carvalho Ferreira, Ana Samperiz, Yingchu Shen, Yun-Ju Sun, Maoyu Wang
Self-cleavage-dependent and -independent functions of Adgrg1/Gpr56 in mice
Frank E. Kwarcinski, Tyler F. Bernadyn, James P. Teuber, Mariane Nascimento, Ingrid Bergin, Tingzhen Shen, Riya Gandhi, Xinyi Lu, Matthew J. Brody, Michael Holinstat, Gregory G. Tall
For more than a century, studies have shown that children who grow up in homes with more books achieve higher levels of academic success, yet it remains unclear whether books themselves improve learning or simply reflect broader socioeconomic advantages. Skill-development theory holds that greater access to books directly improves literacy through increased print exposure and reading practice, whereas the cultural capital account suggests books are indicators of broader family resources, including parental education, academic norms, and enrichment opportunities, that promote achievement independently of the books themselves. To provide causal evidence, we conducted a school-level randomized controlled trial of a program that builds childrenâs home libraries. In 2018, we randomly assigned 60 high-poverty public elementary schools to treatment or control groups. Students in 30 treatment schools received four book distributions over 5 y, averaging about seven books per distribution, and prominently including high-interest and culturally relevant titles; students in 30 control schools received none. Tracking students from 2018â19 through 2022â23, we find a statistically significant intention-to-treat impact on reading achievement of d = 0.100 and a larger d = 0.207 advantage for those completing the full 5-y program. These impacts correspond to approximately 25 to 32% and 52 to 65% of a typical yearâs learning, respectively. The largest benefits are concentrated among students who received books across all distributions, indicating that cumulative exposure drives the strongest impacts. These findings provide evidence supporting skill-development theory and highlight a scalable strategy for improving literacy outcomes in high-poverty urban schools.
Bipartisan-cited science is rare, unevenly distributed, and disproportionately influential
This study offers a systematic analysis of scientific papers cited in both Republican and Democratic policy documents. Using data from Overton and Dimensions, we examine congressional reports, hearings, and think tank publications. We find that bipartisan citations, while rare, highlight papers of exceptional scientific influence. Policy documents citing these papers also receive more citations, amplifying their policy impact. Yet, bipartisan-cited science is unevenly distributedâconcentrated in monetary policy and healthcare, but notably absent in climate, inequality, and race and gender. These results show that bipartisan engagement, though limited, marks a uniquely influential core of science in both research and policy.
A simple threshold captures the social learning of conventions
A persistent puzzle throughout the cognitive and social sciences is how people manage to learn social conventions from the sparse and noisy behavioral data of diverse actors, without explicit instruction. Here, we show that the dominant theories of social learning perform poorly at capturing how individuals learn conventions in coordination experiments that task them with matching their behaviors while interacting in social networks. Across experiments, participantsâ choices systematically deviate from both imitation and optimization. Instead, they follow a categorical, two-stage learning process: they behave probabilistically until they acquire enough information about each other to trigger a mental threshold and then their choices stabilize. We effectively estimate this threshold using the tolerance principle (TP), a parameter-free equation developed to model how children learn rules in language. We show that threshold-based agents produce social learning that is more accurate than imitating and optimizing agents, while also providing a better model of how a critical mass of dissenters can overturn conventions. The superior performance of our model holds when comparing against a variety of optimization approaches, including Bayesian inference. Furthermore, in a preregistered dyadic experiment requiring people to infer nonlinguistic behavioral patterns amid controlled levels of noise in observed signals, TP outperforms all other models at reproducing learning rates among human participants. These findings offer compelling evidence that a simple, mathematical threshold underlies individual and social learning, from grammatical rules to behavioral conventions.
Masculinization of populations reverses sex differences in fertility
Henrik-Alexander Schubert, Thomas Spoorenberg, Christian Dudel, Vegard Fykse Skirbekk
Reproductive-age populations show a growing male surplus around the globe as a consequence of declining mortality, narrowing sex differences in mortality, and sex-selective abortions in some countries. Population structures are important determinants of marriage markets and childbearing. In this study, we estimate the past, current, and future difference between the male and the female total fertility rates around the world using an established indirect demographic approach drawing on data from the UN World Population Prospects. Our results indicate a crossover from historically higher male fertility to increasingly higher female fertility, which occurs globally in 2024. This shift is not toward parity, but rather reflects a growing disparity driven by the increasing male surplus at reproductive ages, which exerts downward pressure on male fertility rates relative to those of women. The difference is expected to grow to up to 20% in countries like China and India, where sex-selective abortion has reinforced sex imbalances in population structures. Overall, we highlight the growing sex inequalities in reproduction and call for more research on sex differences in fertility.
Institutional dynamics produce resource curse traps
Communities reliant on extractive industries face a paradox: Despite the promise of economic growth from lucrative, well-paying industries, they often experience poor socioeconomic outcomes. While the so-called âresource curseâ has been debated and studied extensively in a variety of disciplines, understanding when and why the resource curse occurs, and whether it is possible to escape it, remains a challenge. This study examines these questions through a dynamical systems model that incorporates theories from the literature about how extractive industries interact with institutions and the communities in which they are based. The model reveals that both the resource curse and a more diversified economy are possible, depending on the initial level of human and social capital. It also reveals how various factors, such as declining commodity prices, can trigger an abrupt and irreversible transition from the diversified equilibrium to the resource curse. A generalized version of the model further reveals that the feedback between extractive industries and institutional strength are critical in determining the occurrence of this type of transition. The results illustrate the difficulty of escaping the resource curse, identify potential leverage points or change, and highlight the critical role of institutional dynamics in producing and perpetuating extractive dynamics in these regions.
How parenthood affects the economic consequences of separation for women in same-sex and different-sex couples
Women in different-sex couples experience larger economic losses after separation than men, largely due to unequal divisions of paid and unpaid work. Women in female same-sex couples divide paid and unpaid work more equally, offering a unique opportunity to examine how partner sex, parenthood, and giving birth shape womenâs economic outcomes after separation. Using Finnish population register data (2002â2020), we analyze 1,157 women in same-sex couples and 67,384 women in different-sex couples experiencing their first separation. Women in same-sex couples experience smaller reductions in equivalized household income than women in different-sex couples. Among childless women, those in same-sex couples lose substantially less income, consistent with their more equal division of labor. Among parents, women in same-sex couples also lose less than women in different-sex couples, but this difference is explained by birth motherhood. In both couple types, birth mothers lose far more income than nonbirth mothers, reflecting the concentration of caregiving and childrenâs residence in the birth motherâs household. Women in same-sex couples have the unique possibility to both give birth, and when they do, they experience smaller income declines after separation, indicating that more equally shared caregiving attenuates economic losses. Overall, women in same-sex couples show that more equal divisions of labor can lessen womenâs losses after separation, but this advantage is overridden when caregiving and childrenâs residence concentrate in one household. These findings highlight the need for policies that support more equal workâcare arrangements and reduce the financial costs tied to concentrated caregiving and birth motherhood.
The institutional dynamics of inequality for women inventors who break with conventional thinking
Though women comprise a growing share of the scientific workforce, the gender innovation gap in patenting between men and women inventors persists, potentially limiting innovation output and equity. We study millions of scientific and technological innovations and find that the innovation gap faced by women is not universal. No gap exists for highly conventional innovations, which combine ideas in familiar ways. Rather, it exists when women inventors attempt to patent unconventional inventions, which combine ideas in surprising ways and drive scientific advancements. Our data suggest that rather than deliberate bias, a confluence of institutional practices lower women inventorâs chances of patenting unconventional innovations. We find that women examiners relative to men have less of the on-the-job experience needed to appraise unconventional innovations. Additionally, women examiners are overassigned to women applicants, reducing their odds of successfully patenting unconventional inventions. Lastly, traditional explanations weakly account for this innovation gap because men examiners grant comparably more unconventional innovations to women inventors than do women examiners. These institutional barriers reveal new factors that slow innovation, but at the same time can be more directly addressed than deeply rooted gender norms.
Scientific Data
GPT-4o mini: Non-social science research article
A global chronologically standardised database of high-resolution proxy sea-level reconstructions since 1800 CE
S. L. Williams, L. P. Jackson, E. Garrett, F. D. Hibbert, W. R. Gehrels
Synthetic dataset of pore scale multiphase flow from direct numerical simulations
Unais Ashraf, Saideep Pavuluri, Mohammed Ishaq, Mohammed Yaqoob, Thomas Daniel Seers, Chaudhry Ali Usman, Rizwan Muneer, Jamal Hannun, Riyadh l. Al-Raoush, Harris Sajjad Rabbani
De novo assembly at Chromosomal level of the Indigenous Venda chicken
A. H. Molotsi, V. Ramothibedi, S. Mdyogolo, L. T. Nesengani, T. S. Tshilate, T. M. Masebe, N. L Hlongwane, R. M. Smith, C. A. Gill, A. Djikeng, N. O. Mapholi
A multi-modal dataset for insect biodiversity with imagery and DNA at the trap and individual level
Johanna Orsholm, John Quinto, Hannu Autto, Gaia Banelyte, Nicolas Chazot, Jeremy deWaard, Stephanie deWaard, Arielle Farrell, Brendan Furneaux, Bess Hardwick, Nao Ito, Amlan Kar, Oula KalttopÀÀ, Deirdre Kerdraon, Erik Kristensen, Jaclyn McKeown, Tommi Mononen, Ellen Nein, Hanna Rogers, Tomas Roslin, Paula Schmitz, Jayme Sones, Maija Sujala, Amy Thompson, Evgeny V. Zakharov, Iuliia Zarubiieva, Akshita Gupta, Scott C. Lowe, Graham W. Taylor
2,366 new mitochondrial genomes with preliminary identification and phylogeny of >5,500 putative species of beetles
Thomas J. Creedy, Seunghyun Lee, Darren Yeo, Huaxi Liu, Sarawut Ounjai, Fiona L. Carpenter, Zichen Zhou, Yilei Wu, Maria Pestana Correia, Eric E. Flores, Michal Motyka, Beulah H. Garner, Ladislav Bocak, Alfried P. Vogler
A Virtual Reality Dataset to Support Hand Action Observation in Rehabilitation and Motor Learning Studies
A. Ciraolo, E. Scalona, A. Zilli, A. Nuara, G. Rizzolatti, D. De Marco, P. Adamo, R. Gatti, P. Rossi, S. Banfi, M. A. Rocca, M. Filippi, P. Avanzini, M. Fabbri-Destro
The University of Texas Southwestern Glioma Dataset - MRI, Molecular Markers and Segmentations
Divya D. Reddy, Niloufar Saadat, James M. Holcomb, Benjamin C. Wagner, Nghi C. Truong, Jason Bowerman, Kimmo J. Hatanpaa, Toral R. Patel, Marco C. Pinho, Fang Yu, Kuan Zhang, Sadeem Lodhi, Ananth J. Madhuranthakam, Chandan Ganesh Bangalore Yogananda, Joseph A. Maldjian
Chromosome-level genome assembly of the sponge Halisarca dujardinii
Vasiliy Zubarev, Alexander Cherkasov, Leonid Sidorov, Kim I. Adameyko, Alexander D. Finoshin, Alina Ryabova, Anastasiia Kashtanova, Guzel Gazizova, Natalia Gogoleva, Anton V. Burakov, Olga Kozlova, Elena Shagimardanova, Oleg Gusev, Kirill Mikhailov, Oksana Kravchuk, Yulia Lyupina, Ekaterina Khrameeva
A comprehensive bedside chest radiography dataset with structured, itemized and graded radiologic reports
Daniel Truhn, Daniel Geiger, Robert Siepmann, Marc Sebastian von der StĂŒck, Keno Kyrill Bressem, Jakob Nikolas Kather, Christiane Kuhl, Gustav MĂŒller-Franzes, Sven Nebelung
High-Density EEG and Multi-Muscle EMG Dataset during Object Prehension with a sensorized Grasping Box in Humans
G. Lomele, T. Lencioni, S. DâAmbrosio, A. Comanducci, F. Lucchetti, A. Marzegan, C. Derchi, S. Garzonio, T. Atzori, M. Rabuffetti, P. Castiglioni, M. Ferrarin, L. Fornia
Hiring Discrimination in the Organisational Context: A Harmonized Factorial Survey Dataset from Four European Countries (Germany, Norway, Poland, Romania)
Dominik Buttler, Christian Imdorf, Vegar BjĂžrnshagen, Anatolie Cosciug, Katarzyna Lipowska, Iga Magda, Marta PalczyĆska, Mateusz Smoter, Sara AyllĂłn, Justyna Bell, Mateusz KrzÄ kaĆa, Iuliana Precupetu, Rosa Maria Radogna, Jon Rogstad, Robin Samuel, Laura Tufa, Ona Valls, Nick Wessel
Hiring discrimination has been extensively documented in numerous studies. It is not driven solely by individual actions but is context-dependent, shaped â among other factors â by organisational features that enable or constrain discriminatory behaviour. However, little is known about why some organisations, such as companies or public agencies, discriminate more than others. This data descriptor presents the dataset from a harmonised factorial survey experiment (FSE) on hiring discrimination, which enabled detailed analyses of discriminatory behaviour and the organisational contexts that shape it. The FSE measured discrimination based on nationality, gender and care obligations and was conducted between 2024 and 2025 in four European countriesâGermany, Norway, Poland and Romaniaâamong 2,506 recruiters. The dataset includes 15,036 evaluations of hypothetical job candidates for medium-skilled positions, complemented by extensive information on recruiters and the organisations they represent.
Socio-Economic Review
Beyond the breadline: a relational and comparative framework for studying charitable food provision in high-income countries
Charitable food provision (CFP) has become a central response to poverty in high-income countries. Despite growing scholarly attention, there is a notable lack of conceptual tools for the systematic comparison of CFP across different contexts. To address this gap, this article proposes a relational research framework grounded in field theory. It situates CFP at the intersection of three institutional domains: welfare systems, civil society, and the agri-food system. It then introduces three dimensions for comparative study: the diachronic (field emergence and consolidation), the synchronic (field structure, boundaries, and coordination), and the everyday life (recipientsâ navigation of the CFP field). The framework offers a complementary perspective to existing studies by emphasizing institutional embeddedness, meso-level interactions, and survival strategies, while enabling systematic yet context-sensitive comparison. This article thus lays a foundation for future comparative research and invites further theoretical development that would advance understanding of CFPâs role in contemporary poverty governance.