Author Correction: Physiology and immunology of a pig-to-human decedent kidney xenotransplant
Robert A. Montgomery, Jeffrey M. Stern, Farshid Fathi, Nathan Suek, Jacqueline I. Kim, Karen Khalil, Benjamin Vermette, Vasishta S. Tatapudi, Aprajita Mattoo, Edward Y. Skolnik, Ian S. Jaffe, Imad Aljabban, Tal Eitan, Shivani Bisen, Elaina P. Weldon, Valentin Goutaudier, Erwan Morgand, Fariza Mezine, Alessia Giarraputo, Idris Boudhabhay, Patrick Bruneval, Aurelie Sannier, Kevin Breen, Yasmeen S. Saad, Constanza Bay Muntnich, Simon H. Williams, Weimin Zhang, Larisa Kagermazova, Eloi Schmauch, Chandra Goparaju, Rebecca Dieter, Nikki Lawson, Amy Dandro, Ana Laura Fazio-Kroll, Lars Burdorf, David Ayares, Marc Lorber, Dorry Segev, Nicole Ali, David S. Goldfarb, Victoria Costa, Timothy Hilbert, Sapna A. Mehta, Ramin S. Herati, Harvey I. Pass, Ming Wu, Jef D. Boeke, Brendan Keating, Massimo Mangiola, Philip M. Sommer, Alexandre Loupy, Adam Griesemer, Megan Sykes
Deguang Song, Brianna Duncan-Lowey, Varnica Khetrapal, Randy Hamchand, Tong Deng, Hailey Brown, Anchi Wu, Anjelica L. Martin, Kaylyn M. Bauer, Yanyu Zhao, Mytien T. Nguyen, Nicole D. Sonnert, Shana R. Leopold, Qihao Wu, Jason M. Crawford, Noah W. Palm
Mechanophore cross-linking enhances ballistic energy dissipation of polymers
Zhen Sang, Suong T. Nguyen, Kwangwook Ko, Senpeng Lin, Heecheol Jang, Simon Gonzalez-Zapata, Sullivan Fitz, Yun Kai, Steven Kooi, Chuting Deng, Monica Olvera de la Cruz, Marisol Koslowski, Heather J. Kulik, Stephen L. Craig, Keith A. Nelson, Jeremiah A. Johnson
Centromeric footprints preserve telomere integrity in ALT cancers
Ragini Bhargava, Megan A. Mahlke, Tobias T. Schmidt, Christoph Bartenhagen, Baylee A. Smith, Katherine L. Ramsey, Takoda T. Zuehlke, Ray W. Bowman, Michelle L. Lynskey, Anne R. Wondisford, Jean-Baptiste Ouriou, Sandra Schamus-Hayes, Michael J. Calderon, Simon C. Watkins, April E. Williams-Wehner, Jennifer M. Bone, Alok V. Joglekar, Matthias Fischer, Jan Karlseder, Yael Nechemia-Arbely, Roderick J. OâSullivan
D. Nguyen, C. Yero, H. Szumila-Vance, F. Hauenstein, N. Swan, L. B. Weinstein, J. Kahlbow, G. A. Miller, A. Schmidt, E. Piasetzky, O. Hen, C. Ayerbe Gayoso, E. Cohen, P. Datta, A. Denniston, B. R. Devkota, M. Diefenthaler, C. Fogler, B. R. Gamage, D. Higinbotham, I. Korover, C. Morean, M. Nycz, M. Satnik, S. Seeds, P. Sharp, M. Suresh, A. S. Tadepalli, R. Wagner, E. W. Wertz
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Manpreet Kaur, Dmitrii Y. Travin, Max J. Berger, Manoj Jangra, Martino Morici, Haaris A. Safdari, Dorota Klepacki, Wenliang Wang, Michael Cook, Sommer Chou, Allison K. Guitor, Kalinka Koteva, Min Xu, Linda Ejim, Aline Fiebig, Yeganeh Yousefi, Brian K. Coombes, Lesley Macneil, Nora VĂĄzquez-Laslop, Alexander S. Mankin, Daniel N. Wilson, Gerard D. Wright
High-fidelity modular skeletons authenticate a Cambrian origin for Bryozoa
Baopeng Song, Zhifei Zhang, Luke C. Strotz, Timothy P. Topper, Andrej Ernst, Junye Ma, Zhiliang Zhang, Mei Luo, Lars E. Holmer, Yue Liang, Yazhou Hu, Caibin Zhang, Yanlong Chen, Glenn A. Brock
Enamel nanocrystal misorientation increased with meat-eating and agriculture
Pupa U. P. A. Gilbert, Daniel R. Green, Patrick Mahoney, Debbie Guatelli-Steinberg, W. Scott McGraw, Emma Lagan, Fredrick Kyalo Manthi, Samuel Muteti, Emmanuel Ndiema, Fernando Ramirez Rozzi, Cayla A. Stifler, Connor A. Schmidt, Barat Q. Achinuq, Andreas Scholl, Benjamin Gilbert, Mackie C. OâHara
Author Correction: US oil and gas system emissions from nearly one million aerial site measurements
Evan D. Sherwin, Jeffrey S. Rutherford, Zhan Zhang, Yuanlei Chen, Erin B. Wetherley, Petr V. Yakovlev, Elena S. F. Berman, Brian B. Jones, Daniel H. Cusworth, Andrew K. Thorpe, Alana K. Ayasse, Riley M. Duren, Adam R. Brandt
Publisher Correction: White matter micro- and macrostructure brain charts for the human lifespan
Michael E. Kim, Chenyu Gao, Karthik Ramadass, Nancy R. Newlin, Praitayini Kanakaraj, Sam Bogdanov, Gaurav Rudravaram, Derek Archer, Timothy J. Hohman, Angela L. Jefferson, Victoria L. Morgan, Alexandra Roche, Dario J. Englot, Susan M. Resnick, Lori L. Beason-Held, Laurie E. Cutting, Laura A. Barquero, Micah A. Dâarchangel, Tin Q. Nguyen, Kathryn L. Humphreys, Yanbin Niu, Sophia Vinci-Booher, Carissa J. Cascio, , Sid OâBryant, , Arthur Toga, , Marilyn Albert, L. Taylor Davis, Zhiyuan Li, Simon N. Vandekar, Panpan Zhang, John C. Gore, Bennett A. Landman, Kurt G. Schilling
Acquired genetic and cell-state changes in IDH-mutant glioma progression
Kevin C. Johnson, Avishay Spitzer, Frederick S. Varn, Masashi Nomura, Luciano Garofano, Tamrin Chowdhury, Anuja Lipsa, Linbin Zhang, Ester Calvo FernĂĄndez, Tanyeri Barak, A. Gulhan Ercan-Sencicek, Ayse Buket Peksen, Kevin J. Anderson, C. Mircea S. Tesileanu, Samirkumar B. Amin, Emre Kocakavuk, Dacheng Zhao, Fulvio DâAngelo, Simona Migliozzi, Lillian Bussema, Simon Gritsch, Hyo-Eun Moon, Sun Ha Paek, Franck Bielle, Alice Laurenge, Anna Luisa Di Stefano, Bertrand Mathon, Alberto Picca, Marc Sanson, Ann-Christin Hau, Frank Hertel, Kamil Grzyb, Zheng Zhao, Qianghu Wang, Tao Jiang, Julie J. Miller, Hiroaki Wakimoto, Daniel P. Cahill, Jennifer Moliterno, Murat GĂŒnel, Beth Hermes, Nader Sanai, Anna Golebiewska, Simone P. Niclou, Jason Huse, W. K. Alfred Yung, Anna Lasorella, Mario L. SuvĂ , Antonio Iavarone, Itay Tirosh, Roel G. W. Verhaak
Passive heart-rate monitoring during smartphone use in everyday life
Shun Liao, Paolo Di Achille, Jiang Wu, Silviu Borac, Jonathan Wang, Xin Liu, Eric S. Teasley, Lawrence Cai, Yuzhe Yang, Yun Liu, Daniel McDuff, Hao-Wei Su, Brent Winslow, Anupam Pathak, Mark Malhotra, Shwetak Patel, James A. Taylor, Jameson K. Rogers, Ming-Zher Poh
Tobi Alegbe, Bradley T. Harris, Laura Fachal, Lucia Ramirez-Navarro, Marcus Tutert, Monika Krzak, Mennatallah Ghouraba, Michelle Strickland, Matiss Ozols, Celeste E. Cohen, Saniya Khullar, Eleonora Khabirova, Nikolaos I. Panousis, David Ochoa, Noor Wana, May Xueqi Hu, Jason Skelton, Jasmin Ostermayer, Kimberly Ai Xian Cheam, D. Leland Taylor, Yong Gu, Claire Dawson, Tina Thompson, Kenneth Arestang, Nilanga Nishad, Biljana Brezina, Charry Queen Caballes, Wendy Garri, Steven Leonard, Vivek Iyer, Miles Parkes, Chris Wallace, Rebecca E. McIntyre, Cristina Cotobal Martin, Gareth-Rhys Jones, Tim Raine, Carl A. Anderson
Global extent and drivers of tree cover loss quantified with high-resolution satellite data
Alexandra Tyukavina, Andrew J. Poulson, Jeffrey Pickering, Bernard Adusei, Matthew C. Hansen, Peter Potapov, Antoine Baggett, Carolina Ortiz Dominguez, Aleksandra Mikus, Andre Oktaviandra, Svetlana Turubanova, Anna Komarova, Diana Parker, Amy H. Pickens, Viviana Zalles, Will Byrne, Steven Painter, Lauren Thomas, Arden Ireland, Yuhao He, Nancy Harris, Xiao-Peng Song
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Diana GĂłmez De La Cruz, Thomas Ingram, RafaĆ ZdrzaĆek, Jodie Taylor, Aleksandra Wawryk-Khamdavong, Kinga Bachowska, Mark J. Banfield, Nicholas J. Talbot, Matthew J. Moscou
Landscape efficiency frontiers for biodiversity, climate mitigation, and net economic value
Stephen Polasky, Peter L. Hawthorne, Rebecca Chaplin-Kramer, Jeffrey Smith, James S. Gerber, Saleh Mamun, Mary Ruckelshaus, Jason Russ, Rafael Schmitt, Adrian L. Vogl, Adam C. Castonguay, James Douglass, Virginia Kowal, Ian Madden, Richard Sharp, Brent Sohngen, Jinfeng Chang, Gretchen Daily, Martin Philipp Heger, Matthew Holden, Justin Johnson, Lisa Mandle, Eve McDonald-Madden, Urvashi Narain, Deepak Ray, Giovanni Ruta, Paul C. West, Stacie Wolny, Esha Zaveri, Richard Damania
Fires reverse progress toward ozone air quality standards in the United States
Weizhi Deng, Jun Wang, Meng Zhou, Xi Chen, Xiaodong Wu, Huanxin Zhang, Jason B. Cohen, Jing Wei, Arlindo da Silva, Guy P. Brasseur, Claire Granier, Laurence Rouil
A stellar dynamical mass measurement of an inactive black hole at redshift 2
Andrew B. Newman, Meng Gu, Sirio Belli, Richard S. Ellis, Sai Gangula, Jenny E. Greene, Jonelle L. Walsh, Sherry H. Suyu, Sebastian Ertl, Gabriel Caminha, Giovanni Granata, Claudio Grillo, Stefan Schuldt, Tania M. Barone, Simeon Bird, Karl Glazebrook, Marziye Jafariyazani, Mariska Kriek, Allison Matthews, Takahiro Morishita, Themiya Nanayakkara, Justin D. R. Pierel, Ana AcebrĂłn, Pietro Bergamini, Sangjun Cha, Jose M. Diego, Nicholas Foo, Brenda Frye, Yoshinobu Fudamoto, M. James Jee, Patrick S. Kamieneski, Anton M. Koekemoer, Asish K. Meena, Shun Nishida, Masamune Oguri, Piero Rosati, Adi Zitrin
Unexpected expansion and regrowth in Earthâs mangrove forests over the past four decades
Zhen Zhang, Nicholas J. Murray, Xiao-Peng Song, Pete Bunting, Thomas A. Worthington, Lola Fatoyinbo, Dehua Mao, Mingming Jia, Virni Budi Arifanti, Toh Aung, San San Htay, Daniel A. Friess
Yu Wang, Jiawei Sun, Yin Li, David A. Cagan, Oliver T. Ring, Xin Zeng, Jet Tsien, Luca Massaro, Jillian E. Smith, Brandon J. Orzolek, Michael R. Collins, Yu Kawamata, Phil S. Baran
Long-range extended chains arising from polymerization-driven spontaneous assembly
Min Chen, Dongyang Wang, Ye Zou, Changsheng Chen, Xixian Yang, Lixin Niu, Guan Sheng, Jin Wang, Lucas Q. Flagg, Lee J. Richter, Bethany A. Phillips, Bufan Xiao, Guangchao Liu, Liyan You, Julia Laskin, Dean M. DeLongchamp, Kejie Zhao, Ye Zhu, Chong-an Di, Jianguo Mei
Science abstract < 200 char.: Not a research
article
In Science Journals
Sacha Vignieri, Unnati Sonawala, Madeleine Seale, Jack Huang, Keith T. Smith, Bianca Lopez, Jake S. Yeston, Annalisa M. VanHook, Karin Leder, Ekeoma Uzogara, Yevgeniya Nusinovich, Mattia Maroso, Jesse Smith, Phil Szuromi, Dorothy Hallberg
How does remote work affect isolation and mental health? We drew on five nationally representative surveys of American workers ( N = 588,322) conducted from 2011 to 2024, omitting the peak pandemic years of 2020â2021. Our difference-in-differences approach compared changes in mental health among people in remotable jobsâwho experienced a large and persistent rise in remote work since COVID-19âto people in nonremotable jobs, where remote work increased far less. We found that remote work increases time spent alone, worsens mental well-being across multiple measures, and increases the use of mental health services and prescriptions. These effects were concentrated among individuals living alone. We estimate that the rise of remote work explains about a third of the increase in isolation and mental distress between 2011â2019 and 2022â2024.
Homo cooperans : Understanding the nature of human cooperation
Peter Andre, Teodora Boneva, Felix Chopra, Armin Falk
Human cooperation is fundamental to solving collective challenges, yet its individual drivers remain insufficiently understood. Using globally representative data from an incentivized two-player cooperation experiment conducted in 125 countries ( N = 101,123 individuals), we assess the extent of human cooperation and study its individual determinants. Across the globe, about two-thirds of people choose to cooperate. The decision to cooperate is significantly shaped by cooperation beliefs, injunctive norms, and preferences. Effect sizes of these determinants vary across countries, a variation that is systematically associated with historical and cultural markers. Globally, people underestimate othersâ willingness to cooperateâhumans are more cooperative than they believe. A simple information treatment reduces misperceptions and causally increases cooperation.
Nature Communications
GPT-4o mini: Non-social science research article
AI-Assisted segmentation and volumetric reconstruction of radiographs through multi-angular scintillation imaging
Seokho Kim, Byungjoon Bae, Do Wan Kim, Yoo Jin Lee, Siyeon Kim, Sungwoo Kim, Jawoon Kim, Cheong Beom Lee, Yongmin Baek, Sree Sourav Das, Jiyoung Boo, Jinho Choi, Mona Zebarjadi, Kyeounghak Kim, Sangeun Cho, Dong Hyuk Park, Kyusang Lee
Wearable, broadband auscultation patch with cantilever pressure transducer for remote healthcare monitoring
Tran Bach Dang, Chi Cong Nguyen, Seung Yun Heo, Thanh Vinh Nguyen, Nicholas Tong, Michael G. Ruppert, Thanh An Truong, Michael Listyawan, James Davies, Sinuo Zhao, Quang Anh Nguyen, Nhat Minh Doan, Anthony Sunjaya, Tracie Barber, Nigel H. Lovell, Thanh Nho Do, Hoang-Phuong Phan
Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement
Kai Wing Kevin Tang, Benjamin Baird, William D. Moscoso-Barrera, Mengxia Yu, Mengmeng Yao, Jinmo Jeong, Ilya Pyatnitskiy, Anakaren Romero Lozano, Jiachen Wang, Ju-Chun Hsieh, Tony Sungjin Chae, Daniel Song, Julieta Garcia, Rithvik Mittapalli, Adam Bush, Wynn Legon, Vincent Mysliwiec, Gregory A. Fonzo, Huiliang Wang
Structural dynamics of kappa opioid receptor interactions with ÎČ-arrestin 1
Jianming Han, Eve J. Fine, Qianru Jiang, Yuxuan Zhuang, Carl-Mikael Suomivuori, Zi-Wei Chen, Elizabeth Denn, Kyle Whiddon, Kunpeng Li, Alex S. Evers, James Fuller, Joshua Carter, Jonathan F. Fay, Muyuan Chen, Ron O. Dror, Tao Che
A synaptic mechanism for encoding the learned value of action-derived safety
Emma E. Macdonald, Jun Ma, Di Liu, Kai Yu, Rachel A. Walker, Michael E. Authement, Yan Leng, Hannah C. Goldbach, Guochuan Li, Yulong Li, Veronica A. Alvarez, Bruno B. Averbeck, Mario A. Penzo
ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity
Richard R. Spinks, Aleksa Lakic, Celine Kelso, Slobodan Jergic, Olga Yurieva, Zhi-Qiang Xu, Michael E. OâDonnell, Nicholas E. Dixon, Antoine M. van Oijen, Jacob S. Lewis, Lisanne M. Spenkelink
Tayo E. Adekeye, Troy E. Hupper, Teresa E. Easterbrooks, Emily M. Teets, Emily A. Tomak, Sadie L. Waterman, Kailee A. Sprague, Angelina White, Maddison L. Coffin, Daniel K. Tanaka, Sabrina M. Varga, Mason T. Soares, Sarah J. Shepherd, Jared D. Austin, Dmitrii Krivorotko, Emma S. Perry, Sharon L. Amacher, Joshua B. Kelley, Jared C. Talbot
Co-enrichment of proteins in extracellular vesicles
Molly L. Shen, Andreas Wallucks, Rosalie Martel, Zijie Jin, Lucile Alexandre, Philippe DeCorwin-Martin, Lorenna Oliveira Fernandes de Araujo, Andy Ng, Peter M. Siegel, David Juncker
Methylation-based ctDNA monitoring in metastatic breast cancer during CDK4/6 inhibitor therapy
Mitchell J. Elliott, JesuÌs Fuentes-AntraÌs, Sasha C. Main, Aaron Dou, Elizabeth Shah, Caroline Weipert, Geethika Yalamanchili, Taylor Bird, June Roh, Celeste Yu, Michelle B. Nadler, Eitan Amir, Hal K. Berman, Lillian L. Siu, Philippe L. Bedard, David W. Cescon
Multimodal deep-learning optimization of chiroptical properties in all-inorganic perovskite-coated TiO2 nanohelices and inverse-design transfer to organic chiral luminophores
GWAS on short tandem repeats identifies genetic mechanisms in Alzheimerâs disease
David Gmelin, Olena Ohlei, M. Muaaz Aslam, Marit P. Junge, Laura Parkkinen, Kristina Mullin, Dmitry Prokopenko, Christina M. Lill, Rudolph E. Tanzi, Valerija Dobricic, Lars Bertram
Turbulence drives seabed modification by offshore windfarms
Christopher A. Unsworth, Connor J. McCarron, Richard J. S. Whitehouse, Thomas D. G. Benson, Ignacio Barranco, Michael A. Clare, James J. Waggitt, Lisa Skein, Veerle A. I. Huvenne, Martin J. Austin, Katrien J. J. Van Landeghem
Therapeutic effect of T-cell engager in two patients with autoimmune neuropathy
Jonathan Wickel, Mihai Ceanga, Benjamin Vlad, Nikolai von Stackelberg, Nounagnon Romaric Tochoedo, Danilo Schulz, Olaposi Yomade, Diana Dudziak, Christian Geis
MYOD1 mutation drives cancer stem cell pathways and therapy-resistance in spindle cell/sclerosing rhabdomyosarcoma
Yun Wei, Luis Antonio Corchete SĂĄnchez, Sabateeshan Mathavarajah, Diego Antelo, Shuze Wang, Jihee Lee, Alexander Daiki Weissman, Devika D. Kannambadi, Qian Qin, Sara G. Danielli, Elisa J. Quantin, Tiffany C. Eng, Alexandra Veloso, Yueyang Wang, Gunnlaugur P. Neilsen, Chuan Yan, Valerie Shiwen Yang, Anand G. Patel, Selene C. Koo, Patience Odeniyide, Christine A. Pratilas, Miguel N. Rivera, Esther Rheinbay, David M. Langenau
Flipping antimicrobial peptides in the exit tunnel of the bacterial ribosome
Weiping Huang, Max J. Berger, Haaris A. Safdari, Dorota Klepacki, Helge Paternoga, Chetana Baliga, Daniel N. Wilson, Nora VĂĄzquez-Laslop, Alexander S. Mankin
Large-scale analysis of temporal gene expression variation in peripheral blood
Neha Mishra, Franziska Kimmig, Doris Vandeputte, Valentina Talevi, Lindsey De Commer, Chloe Verspecht, Arnau Vich Vila, Julia S. El-Sayed Moustafa, Lukasz Kreft, Alexander Botzki, Youssef El Darzi, Sebastian Proost, Lindsay Devolder, Dongmeng Wang, Joana P. Bernardes, N. Ahmad Aziz, , Konrad Aden, Vibeke Andersen, Aggelos Banos, George Bertsias, Marc Beyer, Johanna I. Blase, Dimitrios Boumpas, Paraskevi Christofidou, Axel Finckh, Gilles Gasparoni, Michel Georges, Wei Gu, Robert HÀsler, Stephan Huthmacher, Mohamad Jawhara, Amy Kenyon, Christina Kratsch, Roland Krause, Gordan Lauc, Paul A. Lyons, Massimo Mangino, Eoin F. McKinney, Gioacchino Natoli, Karl Nordström, Marek Ostaszewski, Silja H. Overgaard, Marija Pezer, Souad Rahmouni, Benedikt Reiz, Elisa Rosati, Despina Sanoudou, Venkata Satagopam, Reinhard Schneider, Jonas Schulte-Schrepping, Prodromos Sidiropoulos, Kenneth G. C. Smith, Signe B. SÞrensen, Timothy Spector, Aleksandar Vojta, Jörn Walter, Stefanie Warnat-Herresthal, Vlatka Zoldoƥ, Andre Franke, Stefan Schreiber, Emmanouil T. Dermitzakis, Sara Vieira-Silva, Gwen Falony, Kerrin S. Small, Monique M. B. Breteler, Joachim L. Schultze, Jeroen Raes, Philip Rosenstiel
Tectonic and climatic implications of the Aleutian Arc initiation â„56 million years ago
K. Hoernle, B. Jicha, M. Portnyagin, S. Zahirovic, D. MĂŒller, F. Hauff, C. Timm, T. W. Höfig, G. Yogodzinski, M. Guillong, C. Berndt, D. Savelyev, R. Bezard, B. Baranov
Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation
MarĂa Mateo-TĂłrtola, Inga V. Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, AndrĂĄs Szolek, Jelena Grga, Francesca Bork, Jana S. MĂŒller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N. R. Weber, Ana Tapia-AbellĂĄn
Functional implications of the conformational landscape of a multidrug transporter revealed by Zebrafish Abcb4 structures
Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser, Zabrina C. Lang, Abraham J. Morton, Robert Robey, Fei Zhou, Suresh V. Ambudkar, Rick K. Huang, Michael M. Gottesman, Di Xia
Brieflow: an integrated computational pipeline for high-throughput analysis of optical pooled screening data
Matteo Di Bernardo, Roshan S. Kern, Ana Karla Cepeda Diaz, Alexa Mallar, Samuel J. Choi, Andrew Nutter-Upham, Sebastian Lourido, Paul C. Blainey, Iain Cheeseman
Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics
Aaron Wacholder, Eric W. Deutsch, Leron W. Kok, Jip T. van Dinter, Jiwon Lee, James C. Wright, Sebastien Leblanc, Ayodya H. Jayatissa, Kevin Jiang, Ihor Arefiev, Kevin Cao, Francis Bourassa, Felix-Antoine Trifiro, Michal Bassani-Sternberg, Pavel V. Baranov, Annelies Bogaert, Sonia Chothani, Ivo Fierro-Monti, Daria Fijalkowska, Kris Gevaert, Norbert Hubner, Jonathan M. Mudge, Jorge Ruiz-Orera, Jana Schulz, Juan Antonio VizcaĂno, John R. Prensner, Marie A. Brunet, Thomas F. Martinez, Sarah A. Slavoff, Xavier Roucou, Jyoti S. Choudhary, Sebastiaan van Heesch, Robert L. Moritz, Anne-Ruxandra Carvunis
Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity
Jillian L. Seiler, Anna C. Impastato, Emma Xiaoyu Zhang, Kade J. Kelley, Thomas L. Bennett, Bradley Studnitzer, Claudia R. Prindle, Benjamin H. Rajewski, Barry A. Badeau, Xinjian Jiang, Russell Potterfield, Jordan Y. Delev, Daniel L. Marks
Soft mode origin of charge ordering in superconducting kagome CsV3Sb5
Philippa Helen McGuinness, Fabian Henssler, Manex Alkorta, Mark Joachim Graf von Westarp, Artem Korshunov, Alexei Bosak, Daisuke Ishikawa, Alfred Q. R. Baron, Michael Merz, Amir-Abbas Haghighirad, Maia G. Vergniory, Sofia-Michaela Souliou, Rolf Heid, Ion Errea, Matthieu Le Tacon
Tonotopic specialization of MYO7A isoforms in auditory hair cells
Sihan Li, Jinho Park, Tobey M. Phan, Giusy A. Caprara, Natchanon Sittipongpittaya, Gloria M. Sheynkman, Anthony W. Peng, Edward H. Egelman, Jonathan E. Bird, Jung-Bum Shin
Mitochondrial RNA degradation regulates differentiation, stemness, and immune sensitivity in acute myeloid leukemia
Geethu Emily Thomas, Veronique Voisin, Kazem Nouri, Rose Hurren, Karen Kai-Lin Fang, Ali Chegini, Marcela Gronda, Yongran Yan, Neil MacLean, Yulia Jitkova, Dakai Ling, Mary Ma, Xiao Ming Wang, Andrea Arruda, Vito Spadavecchio, Mark D. Minden, Li Zhang, Jong Bok Lee, Aaron D. Schimmer
The benchmarking and application of tag-degraders in vivo to validate therapeutic targets
Charlene M. Magtoto, Stephen Mieruszynski, Hao Dong, Ashley P. Ng, Ladina Di Rago, Andrew J. Kueh, Martin Brzozowski, Christoph Grohmann, Joel R. Walker, Ngee Kiat Chua, Laura F. Dagley, Alessio Ciulli, Guillaume Lessene, Marco J. Herold, Joan K. Heath, John Silke, Rebecca Feltham
Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody
Kumar Sachin Singh, Suman Bharti, Bruce A. Rosa, Mahdiyeh Bigham, Samuel C. Uzoechi, Young-Jun Choi, John C. Martin, Danielle Kemper, Slavica Pavlovic Djuranovic, Darren A. Pickering, Rachael Ryan, Bethany K. Bracken, Maria Elena Bottazzi, Eric C. Carnes, Wannaporn Ittiprasert, Matthew Moyle, Paul J. Brindley, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva
Multifactorial sheltering in peristromal niches shapes in vivo responses of lung cancers to targeted therapies
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, Daria Miroshnychenko, Pragya Kumar, Menkara Henry, Viktoriya Marusyk, Natalia Souza Nunes Siqueira, Chandler Gatenbee, Hilal Ozakinci, Marilyn Bui, Theresa A. Boyle, Jacob Scott, Philipp M. Altrock, Bruna Pellini, Eric Haura, Alexander R. A. Anderson, David Basanta, Andriy Marusyk
Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice
Danise Ann Onda, Chieh-Hsin Yang, Callen Goldsmith, Cait A. Beddows, Rui Qi Teo, Lei Zhang, XiaoZhuo Yuan, Yifei Zhu, Man KS Lee, Ashley J. Ovens, Dingyi Yu, Kei Sakamoto, John W. Scott, Andrew J. Murphy, Noriyuki Tsumaki, Herbert Herzog, Garron T. Dodd, Kim Loh
Two Plasmodium vivax hypnozoite-expressed RNA-binding proteins inhibit liver stage replication
Kim Chi Vo, Riëtte van Biljon, Gigliola Zanghi, Bryan Zavala, William Betz, Charlie Jennison, Ashley M. Vaughan, Heather J. Painter, Stefan H. I. Kappe
Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids
Junyeop Daniel Roh, Mihyun Bae, Yusang Oh, Yeji Yang, Suho Lee, Woo-Chang Hwang, Esther Yang, Hyeonji Kim, Hyunjee Jang, Hyung-Wook Choi, Hyun Kim, Jin Young Kim, Eunjoon Kim
An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan
Eitan Moses, Marva Bergman, Tehila Atlan, Elizabeth M. L. Duxbury, Roman FranÄk, Omer Ben Dor, Henrik von Chrzanowski, Enas R. Abu-Zhayia, Nabieh Ayoub, Shay Kinreich, Ido Ben-Ami, Alexei A. Maklakov, Itamar Harel
Diversity-driven biochemical survey reveals widespread dimerization throughout the rubisco superfamily
Alexander J. Kehl, Leah Taylor-Kearney, Alexander L. Jaffe, Jose Henrique Pereira, Jennifer Lee, Michal Hammel, Lucas M. Waldburger, Caroline Yeow, Luis Valentin-Alvarado, Paul D. Adams, Jillian F. Banfield, Justin B. Siegel, Noam Prywes, Patrick M. Shih
In situ ptychographic x-ray nanotomography of temperature-controlled crystallization processes
Zhao Jiang, Zirui Gao, Christian Appel, Maxime Durelle, Thomas Turner, Andreas Menzel, Alexander N. Kulak, Yi-Yeoun Kim, Manuel Guizar-Sicairos, Mirko Holler, Fiona C. Meldrum, Johannes Ihli
Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells
Aarushi A. Caro, Daliya Kancheva, Eva Hadadi, Bram Boeckx, Clint De Nolf, Pauline M. R. Bardet, Kevin Verstaen, Luqing Li, Lobna Oueslati, Nil Figueras-Duch, Yvon Elkrim, Niels Vandamme, Sofie Deschoemaeker, Arnaud Blomme, Pierre Close, Sophie Janssens, Michele De Palma, Diether Lambrechts, An Coosemans, Damya Laoui
Large stocks of permafrost soil organic carbon and nitrogen in Arctic river deltas
Matthias Fuchs, Torsten Sachs, Loeka L. Jongejans, Jens Strauss, Gustaf Hugelius, Gerald V. Frost, Benjamin M. Jones, Steven V. Kokelj, Lars Kutzbach, Ingmar Nitze, Pier Paul Overduin, Juri Palmtag, Chien-Lu Ping, Oleg S. Pokrovsky, Elizaveta Rivkina, Alexandra Runge, Lutz Schirrmeister, Georg Schwamborn, Matthias B. Siewert, Claire Treat, Alexandra Veremeeva, Sebastian Zubrzycki, Guido Grosse
Metabolic feedbacks drive population dynamics and can lead to oscillations among leaf bacteria
Alan R. Pacheco, Giovanni Stefano Ugolini, Simon H. RĂŒdisser, Andrea Zamuner, Miriam Bortfeld-Miller, Patrick Kiefer, Franziska Oschmann, Samuel G. V. Charlton, Michael Berger, Tommaso Redaelli, Miguel Ăngel Salazar, Ilija Dukovski, Jan Roelof van der Meer, Olga T. Schubert, Martin Ackermann, Roman Stocker, Julia A. Vorholt
COXFA4L2 upregulation preserves residual cytochrome c oxidase activity in COXFA4-related Leigh-like encephalopathy
Micol Falabella, Sandra Lopez Calcerrada, Jana Aref, Jiaze Gao, William L. Macken, Chiara Pizzamiglio, Renata Kabiljo, Anna Lucia Francavilla, Pauline Gaignard, Antoine Pouzet, Jonathan Levy, Giulia Barcia, Jamie K. Leighton, Efstathia Chronopoulou, Germaine Pierre, Riza Köksal ĂzgĂŒl, Ali Dursun, Rebecca Halligan, Helen Mundy, Javeria Raza Alvi, Tipu Sultan, William James Craigen, Lisa Emrick, Jill A. Rosenfeld, Gehad Elmakkawy, JiHye Kim, Joseph J. Gleeson, Aboulfazl Rad, Gabriela Oprea, Maqbool Hussain, Khalil Ur Rehman, Sadia Riaz, Robert W. Taylor, Vincent Procaccio, Maha S. Zaki, Erika Fernandez-Vizarra, Ciro Leonardo Pierri, Michael G. Hanna, Henry Houlden, Reza Maroofian, Cristina Ugalde, Jan-Willem Taanman, Robert D. S. Pitceathly
Epiblast lumenogenesis is not a mammalian-specific trait
Antonia Weberling, Natalia A. Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A. Williams, Florian Hollfelder, Paul A. Trainor
The need for sustaining mpox vaccination in Africa
Yap Boum, Reena H. Doshi, Charles U. Ibeneme, Sheillah Nsasiirwe, Nebiyu Dereje, Hilary Njenge, Alba Vilajeliu, Thierno Balde, Ngashi Ngongo, Jean Kaseya, Rosamund F. Lewis
ToxiTaRGET: a multi-omics database for toxicant-responsive molecular targets
Ravindra Kumar, Tianyi Fu, Prashant Kumar Kuntala, Benpeng Miao, Shuhua Fu, Daofeng Li, , Frederick L. Tyson, Marisa S. Bartolomei, Cheryl L. Walker, Ting Wang, Bo A. Zhang
Trivalent ions kinetic-gating for producing high-concentration and shelf-stable plasmid DNA/PEI particles
Jinghan Lin, Yizong Hu, Turash H. Pial, Kailei D. Goodier, Di Yu, Paetra Brailsford, Maria Choi-Ali, Jonathan T. Feng, Sixuan Li, Yining Zhu, Jingyao Ma, Leonardo Cheng, Xiaoya Lu, Nicole Korinetz, Marine Guise, Tza-Huei Jeff Wang, Tine Curk, Hai-Quan Mao
Histamine shapes the neurocomputational dynamics of human learning
Michael J. Colwell, Fin J. E. van Uum, Philip J. Cowen, Marieke A. G. Martens, Michael Browning, Helen C. Barron, Catherine J. Harmer, Susannah E. Murphy
Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology
Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Jifeng Wang, Ran Tao, Bingshan Li, Joshua A. Bauer, Yuhan Xie, Stefan Ambs, Mollie E. Barnard, Yu Chen, Ji-Yeob Choi, Yu-Tang Gao, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Motoki Iwasaki, Esther M. John, Sun-Seog Kweon, Christopher I. Li, Koichi Matsuda, Keitaro Matsuo, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Sue K. Park, Boyoung Park, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Song Yao, Ying Zheng, Thomas Ahearn, Abenaa M. Brewster, Adeyinka Falusi, Anselm J. M. Hennis, Hidemi Ito, Michiaki Kubo, Eun-Sook Lee, Timothy Makumbi, Berthe S. E. Mapoko, Dong-Young Noh, Katie M. OâBrien, Oladosu Ojengbede, Andrew F. Olshan, Min-Ho Park, Sonya Reid, Taiki Yamaji, Gary Zirpoli, Ebonee N. Butler, Maosheng Huang, Siew-Kee Low, John Obafunwa, Clarice R. Weinberg, Haoyu Zhang, Hongyu Zhao, Christine B. Ambrosone, Michelle L. Cote, Dezheng Huo, Christopher A. Haiman, Daehee Kang, Julie R. Palmer, Melissa A. Troester, Xiao-Ou Shu, Jirong Long, Wei Zheng
Multimodal control of Cas13d activity through domain insertion at an allosteric hotspot
Liyuan Zhu, Long T. Nguyen, Alexandra G. Bell, Tom Krebel, Kara M. Gillmann, Qinhao Cao, Harrison Oatman, Jack Hariri, Andreas Möglich, Cameron Myhrvold, Jared E. Toettcher
The stage-wise macromolecular assembly and structure evolution of silk along the silk gland
Ori Brookstein, Eyal Shimoni, Dror Eliaz, Nili Dezorella, Ehud Sivan, Idan Biran, Israel Greenfeld, Katya Rechav, Anna Kozell, H. Daniel Wagner, Ulyana Shimanovich
Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline
William S. Stuart, Michail N. Isupov, Mathew McLaren, Christopher H. Jenkins, Adam Monier, Bertram Daum, Isobel H. Norville, Vicki A. M. Gold, Nicholas J. Harmer
Potential for risk reduction of chronic health conditions through lifestyle in childhood cancer survivors
Aron Onerup, Qi Liu, Shizue Izumi, Stephanie B. Dixon, Rebecca M. Howell, Matthew J. Ehrhardt, Lenat Joffe, Lucie M. Turcotte, Deo Kumar Srivastava, Tara M. Brinkman, Kevin C. Oeffinger, Claire Snyder, Paul C. Nathan, Yutaka Yasui, Gregory T. Armstrong, Kirsten K. Ness
Genome-wide modelling of plant transcription factor binding captures regulatory variants associated with phenotypic traits
Fritz Forbang Peleke, Simon Maria Zumkeller, Dominic Schirmer, Gernot Schmitz, Thomas Hartwig, Julia Engelhorn, Sergius Weizel, Armin Otto Schmitt, Tobias Jores, JÄdrzej SzymaĆski
Structural basis for uracil removal from DNA by human SMUG1
Julian M. LudÀscher, Emma Scaletti Hutchinson, Guillem Vila-Julià , Ann-Sofie Jemth, Saher Shahid, Elisee Wiita, Israel Cabeza de Vaca, Szymon Pach, Lukas Gajdos, Swati Aggarwal, Ellen Walse, Oliver Mortusewicz, Thomas Helleday, Jens Carlsson, PÄl Stenmark
Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety
Sarah J. Ingram, Srimann Ramachandruni, Natalia Carreras-Gallo, Varun B. Dwaraka, Ryan Smith, John M. Hettema, Edwin J.C.G van den Oord, Shaunna L. Clark
Berry pseudorotation enabled photodissociation of Fe(CO)5 observed by ultrafast electron diffraction
Haoran Ma, J. Pedro F. Nunes, Ambar Banerjee, Martin Centurion, Kareem Hegazy, Renkai Li, Yusong Liu, Xiaozhe Shen, Xijie Wang, Stephen Weathersby, Philippe Wernet, Thomas J. A. Wolf, Michael Odelius, Jie Yang
HPV16 genetic variation provides evidence of positive natural selection driven by HLA class I
Chase W. Nelson, Sambit K. Mishra, Michael Dean, Colm Ohuigin, Robert D. Burk, Bin Zhu, Difei Wang, Laurie Burdett, Mathias Viard, Hyo Jung Lee, Aimee J. Koestler, Apurva Narechania, Zigui Chen, Nicolas Wentzensen, Mark Schiffman, Gary M. Clifford, Elizabeth Suh-Burgmann, Thomas Lorey, Mary Carrington, Meredith Yeager, Lisa Mirabello
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
Meihan Liu, Edmund R. R. Moody, Farrah Blades, Caroline Puente-Lelievre, Kai-En Chen, Ella J. Stephens, Katharine A. Michie, Rosemary J. Cater, Tom A. Williams, Brett M. Collins, Michael D. Healy
The spatial proteome of the Plasmodium falciparum schizont illuminates the composition and evolutionary trajectories of its organelles
Scott A. Chisholm, Victor Flores, Alison Kemp, Lisa M. Breckels, Ludek Koreny, Nicolas Dos Santos Pacheco, Konstantin Barylyuk, Anna Kuroshchenkova, Kathryn S. Lilley, Julian C. Rayner, Ross F. Waller
Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock
Christopher Litwin, Qing Zhang, Ioannis Tsialtas, Zhihong Li, Sophia Hernandez, Steffi Prem, Kristi Dietert, Mallory Keating, Tomoki Sato, Jiyoon Ryu, Lily Q. Dong, Kevin F. Bieniek, Kevin B. Koronowski
Stress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex
FabiĂĄn A. Cornejo, Kristina Driller, Rina Ahmed-Begrich, Katja Schmidt, Michael Jahn, Vivekanandan Shanmuganathan, Karin Hahnke, Florian Kondrot, Thomas F. Wulff, Sebastian RĂ€misch, Kathirvel Alagesan, Emmanuelle Charpentier, KĂŒrĆad Turgay
Compliance modulation of a soft robotic atrioventricular model of heart failure with preserved ejection fraction
James Davies, Bibhu Sharma, Adrienne Ji, Gabriel Matus Vasquez, Chi Cong Nguyen, Emanuele Nicotra, Kefan Zhu, Phuoc Thien Phan, Jingjing Wan, Jelena Rnjak-Kovacina, Michael Stevens, Hoang-Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do
A ferroelectric-ionic-trapping transistor for low power and secure neuromorphic computing
Changhyeon Han, Youngchan Cho, Dongbin Kim, Se-Hyun Hwang, Minsuk Song, Been Kwak, David Radermacher, Min Wook Kang, Sangwan Kim, Jangsaeng Kim, Wonjun Shin, Daewoong Kwon
Peng Wang, Rana Saha, Holger L. Meyerheim, Ke Gu, Hakan Deniz, David Eilmsteiner, Andrea Migliorini, Banabir Pal, Juan Rubio Zuazo, Eugenia Sebastiani-Tofano, Ilya Kostanovski, Abhay Kant Srivastava, Arthur Ernst, Stuart S. P. Parkin
Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects
Sang-Woo Kim, Nag-Young Kim, Anseong Park, Jinho Ha, Cheol Bak, Yoojin Kim, Seong-Seok Chae, Jung-Hui Kim, Sang-Cheol Nam, Chaoji Chen, Yong Min Lee, Jung-Il Choi, Won Bo Lee, Sang-Young Lee
Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease
Kyla Z. Gelev, Seung Hyuk T. Lee, Marcus Alvarez, Rosellina M. Mancina, Federica Tavaglione, Oveis Jamialahmadi, Umberto Vespasiani-Gentilucci, Asha Kar, Zitian Wang, Dorota Kaminska, Minna U. Kaikkonen, Ville MÀnnistö, Sini Heinonen, Tuure Saarinen, Anne Juuti, Kirsi H. PietilÀinen, Jussi PihlajamÀki, Stefano Romeo, PÀivi Pajukanta
O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses
Hannah H. Kim, Ellen Y. Zhang, Flavio R. Palma, Aayush Kant, Jose Angel Martinez-Sarmiento, Zixian Guo, Robert L. Mauck, Vivek Shenoy, Marcelo G. Bonini, Su Chin Heo, Melike Lakadamyali
Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis
Paramita Chakraborty, Shilpak Chatterjee, Mohamed Faisal Kassir, Wyatt Wofford, Seungho Choi, Natalia Oleinik, Ozge Saatci, Odai Darawshi, Satyajit Das, Nathaniel Oberhoeltzer, Anupam Gautam, Stephanie Mills, Reid DeMass, Zacharia Hedley, Yueying Liu, Rasesh Y. Parikh, Sandip Paul, Souvik Seal, Charles D. Smith, Michael B. Lilly, Vamsi K. Gangaraju, Yuri Peterson, Meenal Mehrotra, Elizabeth Hill, Ozgur Sahin, Norbert Leitinger, Paulo C. Rodriguez, Besim Ogretmen, Shikhar Mehrotra
Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life
Bhavjinder K. Dhillon, Travis M. Blimkie, Olubukola T. Idoko, Rebecca Ford, Asimenia Angelidou, Rym Ben-Othman, Sebastiano Montante, Nelly Amenyogbe, Tida Dibassey, Joann Diray-Arce, Reza Falsafi, Abdulazeez Imam, Kerry McEnaney, Oludare A. Odumade, Al Ozonoff, William S. Pomat, Peter C. Richmond, Kinga K. Smolen, Oghenebrume Wariri, Ofer Levy, Anita H. J. van den Biggelaar, Beate Kampmann, Tobias R. Kollmann, Amy H. Y. Lee, Robert E. W. Hancock
Native long-read RNA sequencing of human monocytes reveals activation-induced alternative splicing toward functional isoforms
Alejandra BodelĂłn, Maurice J. H. van Haaren, Paula Sobrevals Alcaraz, Lyanne J. P. M. Sijbers, Rianne C. Scholman, Lucas W. Picavet, Aafke de Ligt, Daphne van Ginneken, Remco G. A. Erkens, Harmjan R. Vos, Jorg J. A. Calis, Sebastiaan J. Vastert, Jorg van Loosdregt
Humans are unique in our ability to acquire diverse skills and inhabit myriad environments, but the cognitive mechanisms underlying such fast, flexible learning remain unresolved. Inspired by theories of artificial intelligence, here we show evidence for one such learning mechanism - program induction - in US American and indigenous Tsimaneâ children in the Bolivian Amazon. Participants viewed novel patterns and were asked to generalize them to new stimuli, alphabets, and lengths, without feedback. Given very limited data, participants across ages, cultures, and conditions constructed response patterns that shared abstract structure with the sample patterns. Computational modeling shows that responses likely reflect discovery of latent rules, rather than simple heuristics or associations, even among children without formal schooling. The results suggest program induction serves as a domain-general learning mechanism from early in life, allowing children across cultures to rapidly infer the algorithmic structure of their natural and cultural environment, whatever it might be.
A computational model of reward learning and habits on social media
Georgia Turner, Lukas J. Gunschera, Shashanka Subrahmanya, Aadesh Salecha, Johannes C. Eichstaedt, Stefano Palminteri, Amy Orben
Social media have fundamentally transformed how we live and communicate. However, the methods to study how our cognitive systems interact with technology platforms are very limited. Computational modelling represents a new avenue to uncover the finegrained cognitive processes driving social media behaviour. Here, we develop a computational model of real-world social media posting data, adapted from the animal reward learning literature. Using a Twitter (currently X) dataset ( n = 2696 users), including a preregistered replication, we show that a hybrid reinforcement learning and habitual cognitive process underlies social media posting behaviour. More frequent posters show more signs of habitual behaviour. Further, younger people and women are more driven by reinforcement learning â updating their strategy more adaptively to maximise social media rewards â while older users and men are more habitual.
Implications of regional variations in climate change vulnerability and mitigation behaviour for social-climate dynamics
Amrita Punnavajhala, Timothy M. Lenton, Chris T. Bauch, Madhur Anand
Erratum for the Research Article âMembrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spreadâ by S. Dagar et al .
CCDC32 collaborates with the membrane to assemble the AP-2 clathrin adaptor complex
Dillon E. Sloan, Ariel E. Matthews, Haruaki Yanagisawa, Tanita Tedamrongwanish, Kevin Cannon, Jake Simmons, Garrett Chappell, Nathan I. Nicely, Rebecca Berlow, Masahide Kikkawa, Richard W. Baker
In situ proteomics unveils specialized domains for extrasynaptic signaling on neuronal cilia
Chia-Hsiang Chang, Van Ngu Trinh, Sammy Weiser Novak, Nidhi Rani Lokesh, Catalina Kretschmar Montecinos, Daniela Boassa, Mark E. Pownall, Marian Kalocsay, Maxence V. Nachury
Water doping sodium battery electrolyte controls nanostructure, interactions, and electrochemical properties
Xuhui Zhang, Qianlu Zheng, Hua Li, Zachary A. H. Goodwin, Alexis G. Hoane, Alexander Deptula, Owen M. Johnson, Juhyun Song, Daniel M. Markiewitz, Martin Z. Bazant, Cecilia Leal, Filippo Mangolini, Andrew A. Gewirth, Rob Atkin, Mark W. Rutland, Rosa M. Espinosa-Marzal
Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine
Behnaz Eshaghi, Erika Yan Wang, Sevinj Mursalova, Timothy A. Forster, Ninaad Lasrado, Jinbi Tian, Dorin Artzi, Stacey Qiaohui Lin, Zongting Wu, Xin Yang, Wontaek Chung, Ilin Sadeghi, Johnny Garcia, Ziqi Chen, Olivia Sheridan, Rishi Das, Alicia Lau, Aki Gurram, Bernardo A. Mainou, Kathryn A. V. Jones, Yi Liu, Dan H. Barouch, Ulrich von Andrian, Robert Langer, Ana Jaklenec
Silicon carbonate, Si[CO 3 ] 2 , is a potential carbon host in the deep Earth
Dominik Spahr, Lkhamsuren Bayarjargal, Valentin Kovalev, Ninel Sharapova, Lukas BrĂŒning, Pascal L. Jurzick, Sean S. Sebastian, Maxim Bykov, Victor Milman, Konstantin Glazyrin, Elena Bykova, Björn Winkler
EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach
Misbah Aziz, Karly C. Sourris, Jairo A. Pinzon-Cortes, Tomasz J. Block, Aozhi Dai, Scott Maxwell, Jun Okabe, Anna C. Calkin, Mark E. Cooper, Karin A. M. Jandeleit-Dahm, Abdul Waheed Khan
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticleâmediated infection in humanized liver chimeric mouse models
Seung Bum Park, Jaime SĂĄnchez-Meza, Regina Umarova, Justin Shields, Laura Collignon, Xhuliana Sula, Kenn Holmbeck, Ji Hoon Oh, Patrizia Farci, D. Lorne Tyrrell, Jordan J. Feld, Jens Bukh, Charles M. Rice, T. Jake Liang
Yentli E. Soto Albrecht, Ryan M. Morrow, Devin Kenney, Arnold Z. Olali, Alan Wacquiez, Nader Chehadeh, Zimu Cen, Jeffrey A. Haltom, Ian Chen, Sujata S. Ranshing, Gabrielle A. Widjaja, Alessia Angelin, Jesus A. Tintos-Hernandez, Wanqing Xie, Prasanth Potluri, Marie T. Lott, Shiping Zhang, Mohsan Saeed, Deborah G. Murdock, Susan R. Weiss, Florian Douam, Douglas C. Wallace
Charting the human-specific properties of gene expression networks in the infant prefrontal cortex
Jonathan Klavert, Djawad Radjabzadeh, Erlantz Gonzalez Sanchez, Bas Castelijns, Ilia S. Timpanaro, Joachim Boers, Federica Fabro, Gerjanne Vroeg in de wei, Eric Bindels, Ivanela Kondova, Joost Gribnau, Menno P. Creyghton
Redirection and reshaping of intense extreme-ultraviolet radiation
Yu He, Alexander Magunia, Harijyoti Mandal, Muwaffaq Ali Mourtada, Carlo Kleine, Arikta Saha, Marc Rebholz, Gergana D. Borisova, Lina Hedewig, Hannes Lindenblatt, Florian Trost, Ulrike FrĂŒhling, Christina C. Papadopoulou, Elisa Appi, Stefan DĂŒsterer, Tino Lang, Skirmantas Alisauskas, Christoph M. Heyl, Steffen Palutke, Markus Braune, Christina Bömer, Dietrich Krebs, Doriana Vinci, Philip Mosel, Peer Biesterfeld, Ingmar Hartl, Robert Moshammer, Milutin Kovacev, Kiyoshi Ueda, Mette B. Gaarde, Christian Ott, Thomas Pfeifer
Rise of modern marine fishes captured in an early Paleocene LagerstÀtte
Sanaa El-Sayed, Matt Friedman, Belal S. Salem, Abdullah S. Gohar, Shorouq F. Al-Ashqar, Mohamed Amin, Hossam El-Saka, Hadeel Saad, Robert P. Speijer, Hesham M. Sallam
Lymph nodeâtargeted DNA engages TBK1/IFN-Iâdriven innate immunity to induce potent T cell responses and durable memory in mice and NHPs
Martin P. Steinbuck, Lochana M. Seenappa, Wei Zhan, Erica Palmer, Mimi M. Jung, Aniela Jakubowski, Xavier Cabana-Puig, Lisa K. McNeil, Christopher M. Haqq, Katherine A. Fitzgerald, Peter C. DeMuth
Drawing on evolutionary game theory, we present a stylized model of gun acquisition for individuals in a society where all have the right to bear arms. In our dynamic model, pairwise confrontations with attendant payoffs take place between individuals who are either armed or unarmed. Individual payoffs depend on the probability of confrontation, the choice to arm, and othersâ choices. We show that the likelihood of confrontation affects the optimal societal arming rate and the arming rate that occurs in equilibrium. The latter rate quickly surpasses the former one as the probability of confrontation increases, a phenomenon we call âoverarming.â This reflects a misalignment of individual and societal interests. We further show that spatial structures can exacerbate overarming, especially when individuals perceive a deteriorating social environment. Results from our base model and its extensions highlight the importance of understanding how fundamental behavioral dynamics and network heterogeneity influence individual decisions to acquire firearms, informing empirical research for mitigating overarming.
PNAS
Generic title: Not a research article
Correction for Craig et al., Lipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture
Virus-induced transgene- and tissue culture-free heritable genome editing in tomato
Ye Liu, Trevor Weiss, Jinhee Lee, Jessica Powell, Shi Ying Charlize Choo, Elnaz Roshannai, Maris Kamalu, Jasmine Amerasekera, Suhua Feng, Steven E. Jacobsen
Direct evidence and quantification of homologous recognition between DNA duplexes
Andrew Stannard, Ehud Haimov, Jonathan G. Hedley, Yaxuan Xiao, Marco Di Antonio, Gleb Oshanin, Claudia Danilowicz, Mara Prentiss, Lorenzo Di Michele, Alexei A. Kornyshev
Impacts of future sea level change on Greenland from community knowledge, coastal mapping, and glacial isostatic adjustment models
Kirsty J. Tinto, Jacqueline Austermann, Robin E. Bell, David Blockley, Casey E. Brayton, Diana Krawczyk, Lauren Lewright, Andrew J. Lloyd, Frank O. Nitsche, Guy J. G. Paxman, David F. Porter, Aqqaluk SĂžrensen, Margie Turrin, Karl Zinglersen
HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity
Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Bassant Eldaly, W. W. J. Gihan Perera, James A. Lazar, Evgenii L. Kovrigin, Smita S. Chandran, Christopher A. Klebanoff, Brian M. Baker
Synthetic pectinâcellulose nanofiber capsule recapitulates the mechanical properties of a regenerating plant cell wall
Cyril Grandjean, Ravi Shanker, Sarah A. Pfaff, Anran Mao, Jordi Chan, Sophie Asnacios, Atef Asnacios, Sulin Zhang, Daniel J. Cosgrove, Enrico Coen, Anna J. Svagan, Pauline Durand-Smet
Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage
David L. Gillett, Thilini Koralegedara, Tess F. Hutchinson, Thanh Nguyen-Dinh, Thomas D. Watts, Jessica Solari, Manasi Mudaliyar, William J. Jowsey, Nadeesha Athukorala, Wei Wen Wong, Jake U. S. Locop, Ning Hall, Luis Jimenez, Iresha Hanchapola, Han-Chung Lee, Erwin Tanuwidjaya, Joel R. Steele, Ralf B. Schittenhelm, Christopher K. Barlow, Rhys Grinter, Gregory M. Cook, Matthew B. McNeil, Debnath Ghosal, Pok Man Leung, Perran L. M. Cook, Chris Greening
Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes
Euan Millar, Eline Huethorst, Vytautas Zickus, GiedrÄ AstrauskaitÄ, Jiuxuan Zhao, Gregor G. Taylor, Claudio Bruschini, Edoardo Charbon, Godfrey L. Smith, Caroline MĂŒllenbroich, Daniele Faccio
Mechanistic links between coexistence, productivity, and stability in experimental grasslands
Pubin Hong, Bernhard Schmid, Dylan Craven, Maowei Liang, Mingyu Luo, Zeyu Wang, Chen Yang, Libin Zhou, Eric Allan, Jane A. Catford, Nico Eisenhauer, Yanhao Feng, Yann Hautier, Mengjiao Huang, Yuanyuan Huang, Forest Isbell, Lin Jiang, Michel Loreau, Peter B. Reich, Christiane Roscher, Jasper van Ruijven, David Tilman, Alexandra Weigelt, Shaopeng Wang
A 3âUTR-derived small RNA modulates the life cycle of the cholera toxinâencoding filamentous phage, CTXÏ
Anne Lippegaus, James R.J. Haycocks, Eoghan OâDriscoll, Marcel Sprenger, Kerstin Thriene, Elke-Martina Jung, Malte Siemers, Sebastian Krautwurst, David C. Grainger, Kai Papenfort
Mating-dependent lifespan cost of sterol depletion in male Drosophila melanogaster
Andrew W. McCracken, Nicola White, Jola Tanianis-Hughes, Elena Rosca, Thomas Gill, Libby McKinney, Stephen J. Simpson, Klaus Reinhardt, Marko Brankatschk, Matthew D. W. Piper, Juliano Morimoto, Stuart Wigby
Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor
Richard G. Webster, Setareh Alabaf, Anna Li, Rene Beerli, Sandra Siehler, Pierre-Eloi Imbert, Leonard Lee, Judith Cossins, Magdalena Koziczak-Holbro, Ludivine Flotte, Laurent Gaudet, Nicole Gerwin, David Beeson, Yin Y. Dong
Ancient oaks reveal rewilding of Mediterranean forests after the Black Death
Gianluca Piovesan, Michele Baliva, Franco Biondi, Jordan Palli, Lucio Calcagnile, Alessandro Chiarucci, Raffaele Manicone, Gianluca Quarta, Giovanni Quilghini, Antonino Siclari, Charles H. Cannon
15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonistâinduced weight loss
Minas Nalbandian, Jameel Lone, Emmeran Le Moal, Ireh Kim, Kaitlin Jeuris, Yutong Kelly Li, Peggy Kraft, Meng Zhao, Kassie Koleckar, Zeyuan Zhang, Katrin J. Svensson, Helen M. Blau
Damselflies overcome color saturation barriers of photonic glasses via pigment loading and refractive index modulation
Tali Lemcoff, Lotem Alus, Albert Batushansky, Yahel Fishman, Nila Theodor, Keshet Shavit, Lahav Hyitner, Almut Kelber, Johannes S. Haataja, Dan Oron, Benjamin A. Palmer
A centrinâSfi1 myoneme fishnet powers ultrafast calcium-triggered contraction in the giant ciliate Spirostomum ambiguum
Joseph Lannan, Carlos Floyd, L. X. Xu, Peter M. Thompson, Connie Yan, Wallace F. Marshall, Suriyanarayanan Vaikuntanathan, Aaron R. Dinner, Jerry E. Honts, Saad Bhamla, Mary Williard Elting
Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform
NicolĂĄs M. Morato, Yunfei Feng, Kitmin Chen, Kai-Hung Huang, Alexis Owen, Joseph V. Caruso, Beinan Yang, Samadhi C. Kulathunga, Andrew D. Mesecar, Carleen Klumpp-Thomas, Aco Radujevic, Alexander G. Godfrey, Sean Gardner, Dobrila D. Rudnicki, Matt Galbraith, Adam Gloeckner, Csaba Hajdu, Steven D. Pringle, Michael Morris, Julia Balog, R. Graham Cooks
Persistent trade-offs balance competition and colonization across centuries
Talia Backman, Jiajun Cui, Emma Caullireau, Ella Bleak, Ilja Bezrukov, Patricia Girardi, Aubrey Hawks, Jesse R. Lasky, Sergio M. Latorre, Joel M. Erberich, Lua Lopez, Manuela Neumann, Allison M. Perkins, Efthymia Symeonidi, Parastoo Azadi, Martin P. Horvath, Artur MuszyĆski, Patricia L. M. Lang, Talia L. Karasov, HernĂĄn A. Burbano
GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain
Minjun Liu, Madison Hung, Ellen Kozlov, Megan Hung, Mariana Colaço-Gaspar, Shristi Roy, Yiping Tu, Shino D. Magaki, Christopher K. Williams, Maarja Andaloussi MÀe, Erik C. B. Johnson, Robert W. Siegel, Robert J. Konrad, Michael Ploug, Christer Betsholtz, Anne P. Beigneux, Liqun He, Loren G. Fong, Stephen G. Young
The functioning of complex systems depends on the coordination of diverse components, often supported by regulatory structures that incur costs. In human organizations, such costs manifest as administrative burden, which has been rising despite often reducing efficiency. Classic explanations point to bureaucrat self-interest or regulation, yet they do not explain variation across organizations or clarify how this burden can be reduced. Here, we develop a dynamical model of administrative growth that integrates known behavioral mechanisms of process creation, obsolescence, and removal. The model conceptualizes processes as developed for problem solving, but becoming obsolete as conditions change, while continuing to consume resources until actively pruned. This interplay generates two long-term outcomes: stable equilibrium or run-away growth. The threshold separating these outcomes is shaped by organizationsâ propensity to create new processes when faced with problems, and their propensity to prune obsolete ones in response to administrative burden. Importantly, their effects are asymmetric: Sufficiently high creation propensity leads to bloat regardless of pruning propensity. Faster environmental change shifts this threshold, making bloat more likely. Simulations of interventions show that lasting reductions in administrative costs and waste require permanent shifts in priorities and investments in distinguishing obsolete from useful processes. Temporary efforts or indiscriminate cuts provide only short-lived relief, and counterintuitively, prioritizing direct production can increase waste. Our work highlights a general mechanism by which well-intentioned problem-solving can create self-reinforcing inefficiencies in complex systems, offering insights possibly generalizable to broader applications, such as legal, policy, and software systems where obsolete elements accumulate.
Nondisclosure agreements and externalities from silence
How do contractual restrictions on worker voice affect information flows about employers? We develop a framework in which the legal risk from violating a nondisclosure agreement (NDA) reduces the willingness of workers to share negative information, making it more difficult for high-road employers to differentiate themselves to workers. Empirical support for these ideas comes from studying the relationship between NDA use and the content of Glassdoor reviews after three states prohibited employers from using NDAs to conceal unlawful conduct. By curtailing the flow of negative information, NDAs impose negative externalities on workers who value such information and on competing employers who are less able to stand out.
Resolving Feynmanâs restaurant problem reveals optimal solutions and human strategies
Brian Christian, Evan M. Russek, Thomas L. Griffiths
In the 1970s, physicist Richard Feynman turned lunch with a friend into a math problemâhow to optimize dish selection over multiple mealsâbut his handwritten notes remained a mystery for decades. Here we present the fully deciphered problem and solution, prove its optimality, generalize it to related problems, and compare the results to human behavior. The optimal policy specifies decreasing thresholds for switching from exploring new dishes to exploiting the best, with thresholds varying based on the distribution of the quality of dishes. We connect these results to the existing psychological literature on optimal stopping problems, which has explored close variants on Feynmanâs problem, and use our generalization of the solution to explore how the underlying distribution of the quality of the options influences peopleâs choices. A preregistered experiment with 2,520 participants shows that people adopt thresholds that decrease linearly with the proportion of trials remaining, consistent with the observation of linear thresholds in other optimal stopping problems. However, we show that people tend to explore more than predicted by linear thresholds, and that different distributions of quality result in thresholds with the same slope but different intercepts. These results indicate that people adapt linear thresholds used in optimal stopping tasks in a way that is sensitive to the underlying distributionâa simple strategy that we show is nearly as effective as Feynmanâs solution.
Mean field game model of the impact of reductions in support on faculty research activity
Every research university has a distribution of faculty research activity that is fueled by the external support from government, industry, and philanthropy. The large decreases in federal support proposed in 2025 by the Administration would dramatically alter the distribution of faculty research activity. Mean field game (MFG) theory is used to model federal support of faculty research assuming that each researcher seeks to maximize their funding according to a specified utility function. Modeling the collection of researchers as a continuum with individual researchers only influenced by the distribution of othersâreferred to as the mean fieldâpredicts ergodic distributions that represent a Nash equilibrium. Results representing the funding for faculty in colleges of engineering demonstrate that a decrease in overall federal support of the magnitude proposed by the Administration could lead to over half the faculty inadequately funded to support research. The results have important implications to the university research environment and to their strategies for maintaining the vibrancy of their programs.
The diffusion of large language models in published academic articles
Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. This article analyzes full texts of 7.3 million journal articles published from 2020â2025 by four major publishers (Elsevier, Frontiers, MDPI, and PLoS) to track the prevalence of LLM-associated language and identify social and institutional correlates of adoption. A corpus of 228 focal words exhibiting sharp post-2022 frequency increases consistent with LLM output was developed; articles were scored on their rate of focal word usage. By 2025, an estimated 57% of published articles exhibited evidence of LLM influence, up from 12% in 2023. Among articles exhibiting LLM-influenced text, there is substantial heterogeneity, ranging from subtle linguistic influence to articles mostly or entirely LLM-generated. Difference-in-differences models reveal that LLM-associated language varies markedly across regions, institutional ranks, publishers, disciplines, and journal tiers. Economic development and proximity to English as a primary language are key predictors of regional variation. Lower-ranked institutions exhibit higher rates than elite universities, young for-profit publishers show elevated rates vis-Ă -vis competitors, and academic fields differ widely in adoption. LLM adoption in academic writing is pervasive but socially stratified. As models grow more powerful and their use becomes further entrenched in academic research, understanding social dynamics of adoption will be essential for governing the evolving relationship between AI and academic knowledge production.
The cost of caring: Gendered health and labor market effects of grandparenthood
Maria Lyster Andersen, Rannveig Kaldager Hart, Hans Fredrik Sunde, Neil Martin Davies, Fartein Ask Torvik
While the effects of the transition to parenthood are well researched, less is known about how the transition to grandparenthood affects health and labor market outcomes. Using comprehensive Norwegian register data covering the entire population born between 1950 and 1960, we examine the effects of first-born grandchildren born during 2007â2018. Employing event-study models with person-year records, we compare grandparents to not-yet grandparents. Our findings reveal a sharp increase in the likelihood of respiratory infections during the first two years of grandparenthood, with infections increasing by 56% for women and 31% for men. Additionally, grandparenthood modestly reduces the likelihood of doctorâs visits related to mental disorders (4.5%) and cardiovascular health (3.3%). Grandmothers also see a decline in musculoskeletal-related visits (3.8%). These health-related changes coincide with notable gendered effects on labor market participation. Ten years after the birth of their first grandchild, employed women are 12% less likely to hold full-time positions compared to a 2% reduction for men. Overall, our findings demonstrate that the transition to grandparenthood significantly reshapes health and economic outcomes for both women and men. The larger effects observed for women likely reflect their greater involvement in informal childcare provision. Our results underscore the intersection of health, family dynamics, and gendered labor market behaviors in late adulthood.
Scientific Data
GPT-4o mini: Non-social science research article
A dataset from ten disasters for studying location descriptions and training AI models
Quantitative transcriptome and proteome maps of classical nonclinical species
Elias Oziolor, Liang Xue, Dennis Pelletier, Darien Capunitan, Emi Kimoto, Joel D. Federspiel, Mark Sheehan, Seda Arat, Leah Newman, Gahyun Lee, Jessie Qian, Steven Kumpf, Thomas A. Lanz, Matthew Martin, Nagappan Mathialagan
Chromosome-level genomes of scleractinian corals: gene prediction and functional annotation
Sebastian Metz, Michael Paulini, Kara Rising, Kate M. Quigley, Christian R Voolstra, David J. Combosch, Maren Ziegler, John E. Parkinson, Victoria McKenna, Rebecca OâBrien, Haoyu Niu, Alice Linsdell, Eerik Aunin, Noah Gettle, Graeme Oatley, Radka Platte, Jonathan Wood, Shane McCarthy, Nancy Holroyd, Caroline Howard, Jim Downie, Camilla A. Santos, Wiesia Johnson, Elizabeth Sinclair, Joanna Collins, Sarah Pelan, Danil Zilov, Karen Brooks, Karen van Niekerk, Dominic E. Absolon, Thomas C. Mathers, Benjamin Jackson, Kerstin Howe, Mark Blaxter, Michael Sweet
Chromosome-level de novo assembly of the nuclear and mitochondrial genomes of Arcopilus aureus, a filamentous fungus with multifaceted ecological and economic roles
The problem of climate change further confounds the already complex relationship between states and markets in modern capitalism. In this state of the art article, we argue that current political economy scholarship is making sense of this occasion by incorporating decarbonization into the âreturn of the stateâ and âfinancializationâ literatures and thus creating a âstatesâmarketsâdecarbonization nexus.â We categorize this nexus into three core topic areas: international financial subordination, industrial policy, and comparative capitalisms. In each, we review key insights and provide an overview of the main scholarly contributions on how states and markets intersect with decarbonization. From there, we discuss how current scholarship can be more policy relevant, appreciate the coming realities of climate adaptation, and benefit from integrating the three core topics to capture a rapidly evolving global order.