Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
Christopher B. Medina, Ewelina Sobierajska, Minghao Gong, Daniel T. McManus, Maheshwor Thapa, Judong Lee, Se Jin Im, Jason E. Toombs, Joshua M. Mitchell, Yating Wang, Jennifer W. Carlisle, Gordon J. Freeman, Viraj A. Master, Suresh S. Ramalingam, Haydn T. Kissick, Shuzhao Li, Rolf A. Brekken, Rafi Ahmed
Parasites trigger epithelial cell crosstalk to drive gutâbrain signalling
Kouki K. Touhara, Jinhao Xu, Joel Castro, Hong-Erh Liang, Guochuan Li, Mariana Brizuela, Andrea M. Harrington, Sonia Garcia-Caraballo, Tracey OâDonnell, Daniel Neumann, Nathan D. Rossen, Fei Deng, Gudrun Schober, Yulong Li, Richard M. Locksley, Stuart M. Brierley, David Julius
Dogs were widely distributed across western Eurasia during the Palaeolithic
William A. Marsh, Lachie Scarsbrook, Eren YĂŒncĂŒ, Lizzie Hodgson, Audrey T. Lin, Maria De Iorio, Olaf Thalmann, Mark G. Thomas, Mahaut Goor, Anders Bergström, Angela Noseda, Sarieh Amiri, Fereidoun Biglari, DuĆĄan BoriÄ, Katia Bougiouri, Alberto Carmagnini, Maddalena GiannĂŹ, Tom Higham, Ophelie Lebrasseur, Anna Linderholm, Marcello A. Mannino, Caroline Middleton, Gökhan MustafaoÄlu, Angela Perri, Joris Peters, Mike Richards, Ăzlem SarıtaĆ, Pontus Skoglund, Rhiannon E. Stevens, Chris Stringer, Kristina Tabbada, Helen M. Talbot, Laura G. Van der Sluis, Silvia M. Bello, Vesna Dimitrijevic, Louise Martin, Marjan Mashkour, Simon A. Parfitt, Sonja Vukovic, Selina Brace, Oliver E. Craig, Douglas Baird, Sophy Charlton, Greger Larson, Ian Barnes, Laurent A. F. Frantz
Structural basis of supercoiling-induced CRISPRâCas9 off-target activity
Quentin M. Smith, Sylvia Whittle, Ricardo J. Aramayo, Daniel E. Rollins, Adam S. B. Jalal, Deborah I. Egharevba, Kyle L. Morris, Alice L. B. Pyne, David S. Rueda
Superluminal correlations in ensembles of optical phase singularities
T. Bucher, A. Gorlach, A. Niedermayr, Q. Yan, H. Nahari, K. Wang, R. Ruimy, Y. Adiv, M. Yannai, T. L. Abudi, E. Janzen, C. Spaegele, C. Roques-Carmes, J. H. Edgar, F. H. L. Koppens, G. M. Vanacore, H. H. Sheinfux, S. Tsesses, I. Kaminer
Topological soliton frequency comb in nanophotonic lithium niobate
Nicolas Englebert, Robert M. Gray, Luis Ledezma, Ryoto Sekine, Thomas Zacharias, Rithvik Ramesh, Benjamin K. Gutierrez, Pedro Parra-Rivas, Alireza Marandi
Jiajia Su, Chiyuan Miao, Francis Zwiers, Hylke Beck, Phil Jones, Qiaohong Sun, Louise J. Slater, Wouter R. Berghuijs, Yoshihide Wada, Daniel Rosenfeld, Jiaojiao Gou, Yi Wu, Paolo Tarolli, Pasquale Borrelli, Panos Panagos, Lisa V. Alexander, Qi Zhang, Jinlong Hu, Seung-Ki Min, Luis Samaniego, Qingyun Duan, Georgia Destouni, Jose A. Marengo, Reza Modarres, Soroosh Sorooshian
Epigenetic memory of colitis promotes tumour growth
Surya Nagaraja, Lety Ojeda-Miron, Ruochi Zhang, Ena Oreskovic, Conrad Hock, Yan Hu, Daniel Zeve, Karina Sharma, Roni R. Hyman, Qiming Zhang, Andrew Castillo, David T. Breault, Ămer H. Yilmaz, Jason D. Buenrostro
Electrochemical corrosion accompanies dendrite growth in solid electrolytes
Cole D. Fincher, Colin Gilgenbach, Christian Roach, Rachel Osmundsen, Aubrey Penn, Michael D. Thouless, W. Craig Carter, Brian W. Sheldon, James M. LeBeau, Yet-Ming Chiang
Oxygen supply through the tracheolarâmuscle system does not constrain insect gigantism
Edward P. Snelling, Antonia V. Lensink, Susana Clusella-Trullas, Chris Weldon, Philipp Lehmann, John S. Terblanche, Nicholas L. Payne, Jon F. Harrison, Anthony J. R. Hickey, Ashleigh Donaldson, Christian M. Deschodt, Roger S. Seymour
Dominant clones leverage developmental epigenomic states to drive ependymoma
Alisha S. Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, Taylor Bugbee, Rakesh Pathak, Amanda Bland, Sanya Mehta, Sophie Cochiolo, Amir Arabzade, Blake Holcomb, Kaitlin M. Budd, Gabriele Kembuan, Tristen Wright, Emma Caesar, Maxwell Park, Amelia Hancock, David Gee, Joel Murdoch, Yi Xiao, Samuel K. McBrayer, Thomas E. Merchant, Jun Qi, Adam D. Durbin, Lindsay A. Schwarz, Li Wang, Andrew M. Donson, Nicholas K. Foreman, Sameer Agnihotri, Alfonso Lavado, Suzanne J. Baker, David W. Ellison, Hyun Kyoung Lee, Shondra M. Pruett-Miller, Kelsey C. Bertrand, Benjamin Deneen, Stephen C. Mack
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
Christopher J. Cowley, Sairaj M. Sajjath, Luis F. Soto-Ugaldi, Mara Steiger, Samantha B. Larsen, Thomas Carroll, Douglas Barrows, Alexandra Mattei, Kevin A. U. Gonzales, Wei Wang, Kevin Li, Alexander Meissner, Helene Kretzmer, Dana Peâer, Elaine Fuchs
Population genomics of Anopheles darlingi , the principal South American malaria vector mosquito
Jacob A. Tennessen, Raphael Brosula, Estelle Chabanol, Sara Bickersmith, Angela M. Early, Margaret Laws, Katrina A. Kelley, Maria Eugenia Grillet, Dionicia Gamboa, Eric R. Lucas, Jean-Bernard Duchemin, Martha L. Quiñones, Maria Anice Mureb Sallum, Eduardo S. Bergo, Jorge E. Moreno, Sanjay Nagi, Nicholas J. Arisco, Mohini Sooklall, Reza Niles-Robin, Marcia C. Castro, Horace Cox, Mathilde Gendrin, Jan E. Conn, Daniel E. Neafsey
Experimental evidence of a liquid-liquid critical point in supercooled water
Seonju You, Marjorie Ladd-Parada, Kyeongmin Nam, Aigerim Karina, Seoyoung Lee, Myeongsik Shin, Cheolhee Yang, Yeseul Han, Sangmin Jeong, Kichan Park, Kyeongwon Kim, Minjeong Ki, Robin Tyburski, Iason Andronis, Keely Ralf, Jae Hyuk Lee, Intae Eom, Minseok Kim, Rory Ma, Dogeun Jang, Fivos Perakis, Peter H. Poole, Katrin Amann-Winkel, Kyung Hwan Kim, Anders Nilsson
High-temperature memristors enabled by interfacial engineering
Jian Zhao, Cameron S. Jorgensen, Krishnamurthy Mahalingam, Cynthia Bowers, Wataru Sugimoto, Kai Ito, Seung Ju Kim, Ruoyu Zhao, Yichun Xu, Han-Ting Liao, Rajiv K. Kalia, Aiichiro Nakano, Kohei Shimamura, Fuyuki Shimojo, Priya Vashishta, Ajit K. Roy, Ning Ge, Miao Hu, R. Stanley Williams, Qiangfei Xia, Sabyasachi Ganguli, J. Joshua Yang
Science abstract < 200 char.: Not a research
article
A global methane observation system to track climate feedbacks for verifiable climate impact
Jennifer D. Watts, Elsa Ordway, Sparkle L. Malone, Qing Zhu, Paul I. Palmer, Dhruv Patel-Tupper, Philippe Ciais, Fa Li, Danielle R. Monteverde, Kyle A. Arndt, Lori Bruhwiler, Brian Buma, Hinsby Cadillo-Quiroz, Eugenie Euskirchen, Alison M. Hoyt, Meredith Holgerson, Gustaf Hugelius, Robert B. Jackson, Daniel Jacob, McKenzie Kuhn, Susan M. Natali, Shushi Peng, Clarice R. Perryman, Benjamin Poulter, Camilo Rey-SĂĄnchez, Le Bienfaiteur Sagang, Edward A. G. Schuur, Ruth K. Varner, Rodrigo Vargas
Science abstract < 200 char.: Not a research
article
In Science Journals
Di Jiang, Sacha Vignieri, Angela Hessler, Corinne Simonti, Claire Olingy, Allison Williams, Yevgeniya Nusinovich, Ian S. Osborne, Stella M. Hurtley, Mattia Maroso, Peter Stern, Sarah H. Ross, Ekeoma Uzogara, Yury Suleymanov, John Foley
Despite rising concerns about sycophancyâexcessive agreement or flattery from artificial intelligence (AI) systemsâlittle is known about its prevalence or consequences. We show that sycophancy is widespread and harmful. Across 11 state-of-the-art models, AI affirmed usersâ actions 49% more often than humans, even when queries involved deception, illegality, or other harms. In three preregistered experiments ( N = 2405), even a single interaction with sycophantic AI reduced participantsâ willingness to take responsibility and repair interpersonal conflicts, while increasing their conviction that they were right. Despite distorting judgment, sycophantic models were trusted and preferred. This creates perverse incentives for sycophancy to persist: The very feature that causes harm also drives engagement. Our findings underscore the need for design, evaluation, and accountability mechanisms to protect user well-being.
Nature Human Behaviour
OpenAlex: Domain is not Social
Sciences
Sustainable neuroscience through open science
Lara M. C. Puhlmann, Alina Koppold, Gordon B. Feld, Tina B. Lonsdorf, Kirsten Hilger, Susanne Vogel, ĂaÄatay GĂŒrsoy, Alexandros Kastrinogiannis, Louisa Kulke, Alexander Lischke, Anett MĂŒller-Alcazar, Julian Packheiser, Matthias F. J. Sperl, Yu-Fang Yang, Laura Bechtold, Sebastian Ocklenburg, Helena Hartmann
An integrated germline and somatic genomic model for coronary artery disease
Xiong Yang, Min Seo Kim, Xinyu Zhu, Md Mesbah Uddin, Tetsushi Nakao, So Mi Jemma Cho, Satoshi Koyama, Tingfeng Xu, Laurens F. Reeskamp, Rufan Zhang, Zhaoqi Liu, Yunga A, Paul S. de Vries, Ramachandran S. Vasan, Eric Boerwinkle, Alanna C. Morrison, Bruce M. Psaty, Russell P. Tracy, Susan R. Heckbert, Michael H. Cho, Jeong H. Yun, Nicholette D. Palmer, Donald W. Bowden, Joanne M. Murabito, Daniel Levy, Nancy L. Heard-Costa, George T. OâConnor, Lewis C. Becker, Brian G. Kral, Lisa R. Yanek, Laura M. Raffield, Bertha Hidalgo, Jerome I. Rotter, Stephen S. Rich, Kent D. Taylor, Wendy S. Post, Charles Kooperberg, Alexander P. Reiner, Braxton D. Mitchell, Sharon L. R. Kardia, Jennifer A. Smith, Patricia A. Peyser, Lawrence F. Bielak, Dong Keon Yon, Hong-Hee Won, Donna K. Arnett, Albert V. Smith, Stacey B. Gabriel, Patrick T. Ellinor, , Pradeep Natarajan, Minxian Wang, Akl C. Fahed
Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope
Florian Buchholz, Lina M. Upterworth, Leif Tueffers, Espen E. Groth, Kira Haas, Daniel SchĂŒtz, Abigail Savietto Scholz, Aditi Batra, Surajit Pal, Samarpita Banerjee, Badri N. Dubey, Sören Franzenburg, Barbara Kalsdorf, Klaus F. Rabe, Dennis Nurjadi, Jan Rupp, Dan I. Andersson, Holger Sondermann, Marc Bramkamp, Roderich Roemhild, Hinrich Schulenburg
Engineering high environmental robustness in solar evaporation to bridge the lab-to-field performance gap
Chang-ting Wang, Canjie Lin, Kai Xu, Yang Liu, Zhongtao Lao, Jianping Cao, Bei Liu, Amal Baqais, Khaled Bin Bandar, Saud Aldrees, Mohammed A. Alhussaini, Shao-Yuan Leu, Noreddine Ghaffour, Qiaoqiang Gan, Wenbin Wang, Peng Wang
Mirvetuximab soravtansine plus pembrolizumab in recurrent folate receptor alpha-positive uterine serous carcinoma: a phase II trial
Rebecca L. Porter, Yinglu Zhou, Nebiyat Eskndir, Martin Hayes, Madeline Polak, Elizabeth K. Lee, Carolyn Krasner, Susana Campos, Alexi A. Wright, Joyce F. Liu, Elizabeth H. Stover, Hannah Sawyer, Niya Xiong, Kathleen L. Pfaff, Scott J. Rodig, Nabihah Tayob, Susan Zweizig, Veena John, Jennifer Veneris, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos
Deformation- and damage-free transfer of soft electronics onto highly curved and fragile biological surfaces
Kyeong Min Song, Myung-Kun Chung, Jeehoon Jung, Jungjae Park, Min-Uk Kim, Jae-Young Yoo, Minsu Park, Geumbee Lee, Jeehyun Hong, Jun-Bo Yoon, Yeon Sik Jung
Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs
Yao Ke, Ben-Zheng Li, Fulun Li, Resmi Ravindran, Donna Wang, Suyan Wang, Samuel T. Hwang, Scott I. Simon, Sean R. Collins, Christian D. Young, Xiao-Jing Wang
Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife
Dafna Pachter, Hadar Klein, Omer Kamer, Dana Tamar Goldberg Toren, Liav Alufer, Noa Ebstein Karamani, Tomer Atlas, Amit Yaary, Idan Hagbi, Yoash Chassidim, Ilan Shelef, Moti Salti, Frauke Beyer, Veronica Witte, Assaf Rudich, Uri Yoel, Gal Ben-Arie, Anat Yaskolka Meir, Alon Kaplan, Gal Tsaban, Hila Zelicha, Carmi Bartal, Lu Qi, Matthias BlĂŒher, Michael Stumvoll, Uta Ceglarek, Berend Isermann, Dong D. Wang, Meir J. Stampfer, Frank B. Hu, Galia Avidan, Iris Shai
3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer
Beatrice Malacrida, Samar Elorbany, Florian LaforĂȘts, Faisal Karim, Rachel C. Bryan-Ravenscroft, Michail Sideris, Joash D. Joy, Panoraia Kotantaki, Sophie L. P. Skingsley, Owen M. Heath, Ranjit Manchanda, Eleni Maniati, Frances R. Balkwill
Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis
Debbie M. Hunt, JoĂŁo Pedro Pisco, Angela Rodgers, Cesira de Chiara, Anisha Zaveri, Kamila L. Pacholarz, Dimitrios Evangelopoulos, Acely Garza-Garcia, Sabine Ehrt, Dirk Schnappinger, Perdita E. Barran, Maximiliano G. Gutierrez, Luiz Pedro S. de Carvalho
Governing principles of hydration of mixed proton conducting Co-based double perovskites
Ragnar Strandbakke, Sebastian Lech Wachowski, Maria Balaguer, Lasse Vines, Thomas Neset Sky, Iga Szpunar, Patricia A. Carvalho, Aleksandra Mielewczyk-GryĆ, Magnus H. SĂžrby, Maria Gazda, Jose M. Serra, Truls Norby
Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration
Binbin Ma, Guanghui Yang, Jonathan Yao, Charles Wu, Jean Pinckney Vega, Gabriel Manske, Saher Sue Hammoud, Satrajit Sinha, Abhyudai Singh, Haiqing Zhao, Xin Chen
Tazemetostat, an EZH2 inhibitor, in solid tumors harboring SWI/SNF alterations: a phase II basket study
Mrinal Gounder, Patrick Schöffski, Robin L. Jones, Silvia Stacchiotti, George D. Demetri, Gregory M. Cote, Mark Agulnik, Rashmi Chugh, Thierry Jahan, Abha A. Gupta, Tom Wei-Wu Chen, Ravin Ratan, Palma Dileo, Alexander Drilon, Gabriel G. Malouf, Attila Szanto, Neal Gupta, Nizar M. Tannir
CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts
Socorro Miranda-Hernandez, Manoharan Kumar, Alec Henderson, Erin Graham, Xiao Tan, Jim Taylor, Michael T. Meehan, Zuriel Ceja, Lidia del Pozo-Ramos, Yi Pan, Ellen Tsui, Meg L. Donovan, Miguel E. RenterĂa, Mario Alberto Flores-Valdez, Antje Blumenthal, Quan Nguyen, Selvakumar Subbian, Matt A. Field, Andreas Kupz
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
Gregory R. Smith, Bingqing Zhao, Malene E. Lindholm, Archana Raja, Mark Viggars, Hanna Pincas, Nicole R. Gay, Yifei Sun, Sindhu Vangeti, Yongchao Ge, Venugopalan D. Nair, James A. Sanford, Mary Anne S. Amper, Mital Vasoya, Kevin S. Smith, Irene Ramos, Stephen B. Montgomery, Elena Zaslavsky, Sue C. Bodine, Karyn A. Esser, Martin J. Walsh, Michael P. Snyder, Stuart C. Sealfon, , Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter, Karen P. Dalton, Surendra Dasari, Courtney Dennis, Karyn Esser, Charles R. Evans, Roger Farrar, Facundo M. FernĂĄndez, Kishore Gadde, Nicole Gagne, David A. Gaul, Nicole R. Gay, Yongchao Ge, Robert E. Gerszten, Bret H. Goodpaster, Laurie J. Goodyear, Marina A. Gritsenko, Kristy Guevara, Fadia Haddad, Joshua R. Hansen, Melissa Harris, Trevor Hastie, Krista M. Hennig, Steven G. Hershman, Andrea Hevener, Michael F. Hirshman, Zhenxin Hou, Fang-Chi Hsu, Kim M. Huffman, Chia-Jui Hung, Chelsea Hutchinson-Bunch, Anna A. Ivanova, Bailey E. Jackson, Catherine M. Jankowski, David Jimenez-Morales, Christopher A. Jin, Neil M. Johannsen, Robert L. Newton, Maureen T. Kachman, Benjamin G. Ke, Hasmik Keshishian, Wendy M. Kohrt, Kyle S. Kramer, William E. Kraus, Ian Lanza, Christiaan Leeuwenburgh, Sarah J. Lessard, Bridget Lester, Jun Z. Li, Malene E. Lindholm, Ana K. Lira, Xueyun Liu, Ching-ju Lu, Nathan S. Makarewicz, Kristal M. Maner-Smith, D. R. Mani, Gina M. Many, Nada Marjanovic, Andrea Marshall, Shruti Marwaha, Sandy May, Edward L. Melanson, Michael E. Miller, Matthew E. Monroe, Stephen B. Montgomery, Samuel G. Moore, Ronald J. Moore, Kerrie L. Moreau, Charles C. Mundorff, Nicolas Musi, Daniel Nachun, Venugopalan D. Nair, K. Sreekumaran Nair, Michael D. Nestor, Barbara Nicklas, Pasquale Nigro, German Nudelman, Eric A. Ortlund, Marco Pahor, Cadence Pearce, Vladislav A. Petyuk, Paul D. Piehowski, Hanna Pincas, Scott Powers, David M. Presby, Wei-Jun Qian, Shlomit Radom-Aizik, Archana Natarajan Raja, Krithika Ramachandran, Megan E. Ramaker, Irene Ramos, Tuomo Rankinen, Alexander Sasha Raskind, Blake B. Rasmussen, Eric Ravussin, R. Scott Rector, W. Jack Rejeski, Collyn Z-T. Richards, Stas Rirak, Jeremy M. Robbins, Jessica L. Rooney, Aliza B. Rubenstein, Frederique Ruf-Zamojski, Scott Rushing, Tyler J. Sagendorf, Mihir Samdarshi, Evan M. Savage, Irene E. Schauer, Simon Schenk, Robert S. Schwartz, Stuart C. Sealfon, Nitish Seenarine, Kevin S. Smith, Michael P. Snyder, Tanu Soni, Luis Gustavo Oliveira De Sousa, Lauren M. Sparks, Alec Steep, Cynthia L. Stowe, Yifei Sun, Christopher Teng, Anna Thalacker-Mercer, John Thyfault, Rob Tibshirani, Russell Tracy, Scott Trappe, Todd A. Trappe, Karan Uppal, Sindhu Vangeti, Mital Vasoya, Nikolai G. Vetr, Elena Volpi, Alexandria Vornholt, Michael P. Walkup, Martin J. Walsh, Matthew T. Wheeler, John P. Williams, Si Wu, Ashley Xia, Zhen Yan, Xuechen Yu, Chongzhi Zang, Elena Zaslavsky, Navid Zebarjadi, Tiantian Zhang, Jimmy Zhen
Unconventional bipartite entanglement in the quantum dimer magnet Yb2Be2SiO7
A. Brassington, Q. Ma, G. Duan, S. Calder, A. I. Kolesnikov, K. M. Taddei, G. Sala, E. S. Choi, H. Wang, W. Xie, B. A. Frandsen, N. Li, X. F. Sun, C. Liu, R. Yu, H. D. Zhou, A. A. Aczel
Retraction Note: Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani
Antigen-specific immunotherapy with a CD4+ T cell neoepitope restrains CD8+ T cell differentiation in murine pancreatic islet grafts
James E. DiLisio, K. Scott Beard, Tobias Neef, Stephen D. Miller, Janet M. Wenzlau, Maki Nakayama, Marc A. DâAntonio, Braxton L. Jamison, Kelli S. Nicholson, Rocky L. Baker, Tonya M. Brunetti, Laurent Gapin, Kathryn Haskins
Zinc isotope evidence for extensive carbonate recycling in the Arctic asthenosphere
Wei-Qi Zhang, Wei-Wei Ding, Chuan-Zhou Liu, C. Johan Lissenberg, Ye-Jian Wang, Tao Zhang, Ping-Chuan Tan, Zong-Qi Zou, Yang Xu, Jiang-Gu Lu, Yin-Xia Fang, Jia-Biao Li
Retraction Note: Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer
Alok Kumar Singh, Monali Praharaj, Kara A. Lombardo, Takahiro Yoshida, Andres Matoso, Alex S. Baras, Liang Zhao, Geetha Srikrishna, Joy Huang, Pankaj Prasad, Jonathan D. Powell, Max Kates, David McConkey, Drew M. Pardoll, William R. Bishai, Trinity J. Bivalacqua
Cortex-wide characterization of decision-making neural dynamics during spatial navigation
Samuel P. Haley, Daniel A. Surinach, Angela K. Nietz, Laurentiu S. Popa, Russell E. Carter, Lucas S. Zecker, Madelyn M. Hjort, Alexis M. Theis, Julie A. Gonzales, Suhasa B. Kodandaramaiah, Timothy J. Ebner
Solubility based mechanistic profiling of combinatorial drug therapy
Elham Gholizadeh, Ehsan Zangene, Uladzislau Vadadokhau, Danilo Ritz, Juho J. Miettinen, Rabah Soliymani, Marc Baumann, Mathias Wilhelm, Esko Kankuri, Paul A. Haynes, Caroline A. Heckman, Amir A. Saei, Mohieddin Jafari
An epithelial morphogenetic program for maximal urine concentration
Jane N. Warshaw, Sunhee Oh, Christopher P. Chaney, Bryanna L. Felan, Jacqueline B. Pham, Chitkale Hiremath, Kenya Geshow, Hao Liu, Alejandra M. Rivera, Rain Wong, Song Zhang, Kevin M. Dean, Reto P. Fiolka, Michael T. Dellinger, Jonathan M. Whittamore, Thomas J. Carroll, Denise K. Marciano
GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis
Vincentius Jeremy Suhardi, Anastasia Oktarina, Yingzhen Niu, Andrew L. Thomson, JÏrgen Alphonsus, Nicolas Suhardi, Jason McCormick, Ugur Ayturk, Matthew B. Greenblatt, Lionel B. Ivashkiv, Mathias P. G. Bostrom, Xu Yang
An ultrafast plenoptic-camera system for high-resolution 3D particle tracking in unsegmented scintillators
Till Dieminger, SaĂșl Alonso-Monsalve, Christoph Alt, Claudio Bruschini, Noemi BĂŒhrer, Edoardo Charbon, Kodai Kaneyasu, Tim Weber, Matthew Franks, Davide Sgalaberna
RNA functional modulation by Mitoxantrone via RNA structural ensemble repartitioning
Chundan Zhang, Ivana BorovskĂĄ, Teona Iobashvili, Edoardo Morandi, Marta Lionnez, Oluwatosin S. Olayinka, Rinse de Boer, Massimiliano Clamer, Martin D. Witte, Klaus Pors, John S. Schneekloth, Danny Incarnato
Bispecific GLP-1/GLP-2 agonism in advanced type 2 diabetes: preclinical characterization and a randomized, double-blind, placebo-controlled phase I trial
Sang-In Yang, Sae Won Kim, Kyung-Hwa Son, Seung-Ah Lee, Jong-Gyun Kim, Jae-Il Roh, Young Chul Sung
Major human schistosome species express different glycans with immunological and diagnostic implications
Laudine M. C. Petralia, Angela van Diepen, Tao Zhang, Anna O. Kildemoes, Tom Veldhuizen, D. Linh Nguyen, Cornelis H. Smit, Peter G. Kremsner, Manfred Wuhrer, Jeremy M. Foster, Cornelis H. Hokke
Post-pandemic changes in population immunity have reduced the likelihood of emergence of zoonotic coronaviruses
Ryan M. Imrie, Laura A. Bissett, Savitha Raveendran, Maria Manali, Julien A. R. Amat, Laura Mojsiejczuk, Nicola Logan, Andrew Park, Marc Baguelin, Mafalda Viana, Brian J. Willett, Pablo R. Murcia
Ultrathin crown ether-based polyamide membrane for ion-ion separations
Luis Francisco Villalobos, Junwei Zhang, Junwoo Lee, Alex T. Hall, Ryan M. DuChanois, Camille Violet, John Cumings, Mingjiang Zhong, Menachem Elimelech
Dalpiciclib plus chidamide in HR + /HER2âadvanced breast cancer after CDK4/6 inhibitor failure: a phase Ib trial
Jinmei Zhou, Xuexue Wu, Yimeng Du, Jinyi Xiao, Xiaofeng Kang, Jiaxin Chen, Xiaobo Wang, Yanhong Tai, Li Bian, Shaohua Zhang, Zheng Pang, Yang Li, Zefei Jiang, Xiaojie Xu, Tao Wang
Smallest acyclic tricationic molecule containing a Bis(phosphine)-stabilized low-valent triantimony-based Unit
Nilanjana Mukherjee, Benjamin Peerless, Vincent L. Nadurata, Vikas Kumar, Mayur P. Sangole, Kirandeep Singh, Haakon T. A. Wiedemann, Christopher W. M. Kay, Robert Kruk, Florian Weigend, Stefanie Dehnen, Rajesh G. Gonnade, Cem B. Yildiz, Moumita Majumdar
AP-1 mediates cellular adaptation and memory formation
Jingxin Li, Pavithran T. Ravindran, Aoife OâFarrell, Gianna T. Busch, Ryan H. Boe, Zijian Niu, Sean Woo, Margaret C. Dunagin, Naveen Jain, Yogesh Goyal, Kavitha Sarma, Meenhard Herlyn, Arjun Raj
Intrinsically chiral exciton polaritons in an atomically-thin semiconductor
M. J. Wurdack, I. Iorsh, S. Vavreckova, T. Bucher, M. KrĂłl, Z. Fedorova, E. Estrecho, D. Ilin, S. Klimmer, L. P. L. Mawlong, H. Deng, Q. Song, T. van der Laan, G. Soavi, T. Pertsch, F. Eilenberger, I. Staude, Y. Kivshar, E. A. Ostrovskaya
SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue
Tamires Duarte Afonso Serdan, Heidi Cervantes, Benjamin Frank, Akhil Gargey Iragavarapu, Qiyu Tian, Daniel Hope, Chan Hee J. Choi, Anne Hoffmann, Adhideb Ghosh, Christian Wolfrum, Matthew B. Greenblatt, Paul Cohen, Matthias BlĂŒher, Halil Aydin, Gary J. Schwartz, Farnaz Shamsi
Steps to transform African opportunity crops into reality crops
Pieter Rutsaert, Enoch G. Achigan-Dako, Mathieu A. T. Ayenan, Jordan Chamberlin, Happy Daudi, Aristide Carlos Houdegbe, Stephen Kresovich, Agnes Mbugua Gitonga, Tamerlane Mark Nas, Chris O. Ojiewo, Julia Sibiya, Harish Gandhi, Vishnuvardhan Reddy Banda, Mareme Niang, Javier Betran, Barbra Chisikaurayi, Chiedozie Egesi, Prakash Gangashetty, Dorcas Ibitoye, Hapson Mushoriwa, Dean Muungani, Joseph Onyeka, Roland Schafleitner, Dennis E. Tippe, Esnart Nyirenda Yohane, Kevin V. Pixley
Gaps and ways forward in atmospheric blocking and extreme weather research
Lei Wang, Jian Lu, Melissa L. Breeden, Gang Chen, Stephanie A. Henderson, Veeshan Narinesingh, Isla R. Simpson, Tim Woollings, Yanjun Hu, Sandro W. Lubis
Suppression of pathological oscillations with transcranial focused ultrasound in Parkinsonâs disease
John Eraifej, Jake Toth, Jeremy Hanemaaijer, Shenghong He, Xinghao Cheng, Amir Puyan Divanbeighi Zand, Max E. Stewart, James J. FitzGerald, Christopher R. Butler, Timothy Denison, Alexander L. Green, Robin O. Cleveland
First-line Nivolumab plus FOLFOXIRI/Bevacizumab in advanced RAS/BRAF-mutated colorectal cancer: efficacy, safety and biomarker discovery from the phase II NIVACOR trial
Angela Damato, Riziero Esposito Abate, Simona Tessitore, Daniela Frezzetti, Monica Rosaria Maiello, Dario Righelli, Francesca Bergamo, Lorenzo Antonuzzo, Guglielmo Nasti, Filippo Pietrantonio, Giuseppe Tonini, Tiziana Latiano, Roberto Bordonaro, Gerardo Rosati, Elisa Giommoni, Francesco Iachetta, Mario Larocca, Evaristo Maiello, Sara Lonardi, Alessandra Romagnani, Giuseppe Maglietta, Antonella De Luca, Nicola Normanno, Carmine Pinto
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
Monica C. Rodrigo-Brenni, Jasper C. Komen, Ghaith M. Hamza, Natacha Bohin, Tomas Adomavicius, Angelo Andres, Stefan Blaho, Ulf Börjesson, Gavin W. Collie, Gian Marco De Donatis, Frederik Eisele, Ning Gao, Andrea Gohlke, Christoph Grebner, Frida Gustafsson, Andreas Hock, Cecilia Kankkonen, Praveen Kumar, Emilyanne Leonard, Xin Li, Ruth Macdonald, Katja Madeyski-Bengtson, Eric Miele, Philip Nevin, Jeroen Overman, Fiona Pachl, Claudio Pathe, Matthew W. D. Perry, Christopher Phillips, Andy Pike, Ian Purvis, Timothy Rasmusson, Sophie Regan, Linda Reilly, Jonathan Rose, R. Ian Storer, Jingwen Wang, Xiang Zhai, Iacovos N. Michaelides, Kevin Moreau
Structural basis for prostaglandin and drug transport via SLCO2A1
Chitra Joshi, Justin C. Deme, Yoshinobu Nakamura, Wei-Tse Hsu, Jonathan D. Goult, Takafumi Kato, Joanne L. Parker, Philip C. Biggin, Susan M. Lea, Takeo Nakanishi, Simon Newstead
Kian P. Lopez, Max Saffer-Meng, Mohammad Allouzi, Yukai Tomsovic, Joshua N. Sherrit, Sasha R. Neefe, Patrick O. Saboe, Mou Paul, Abhishek Roy, Anthony P. Straub
Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target
Tilman Werner, Johanna Thiery, Klara-Luisa Budau, Annika Topitsch, Miguel Cosenza-Contreras, Niko Pinter, Frank Hause, Julius RĂŒhlmann, Gaia Gentile, Jannis Heyer, Konrad Kurowski, Julia SchĂŒler, Philipp Anton Holzner, Martin Werner, Carlie Sigel, Laura H. Tang, Peter Bronsert, Oliver Schilling
A single cluster of RNA Polymerase II molecules is stably associated with active genes
Apratim Mukherjee, Manya Kapoor, Kareena Shankta, Samantha Fallacaro, Raymond D. Carter, Gabriela Hayward-Lara, Puttachai Ratchasanmuang, Yara I. Haloush, Mustafa Mir
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis
Amir Banaei-Esfahani, Sonia Borrell, Andrej Trauner, Sebastian M. Gygli, Tige R. Rustad, Julia Feldmann, Ludovic C. Gillet, Olga T. Schubert, Christian Beisel, David R. Sherman, Ruedi Aebersold, Sebastien Gagneux, Ben C. Collins
Modulation of quantum geometry and its coupling to pseudo-electric field by dynamic strain
Surat Layek, Mahesh A. Hingankar, Ayshi Mukherjee, Atasi Chakraborty, Digambar A. Jangade, Anil Kumar, L. D. Varma Sangani, Amit Basu, R. Bhuvaneswari, Kenji Watanabe, Takashi Taniguchi, Amit Agarwal, Umesh V. Waghmare, Mandar M. Deshmukh
Maturase K forms a plastidial splicing complex with a neofunctionalized branching enzyme
Yuanyuan Liang, Yang Gao, Andrea Fontana, Melanie Abt, Adam Gicgier, Muriel Gehring, Chun Liu, Mayank Sharma, Reimo Zoschke, Samuel C. Zeeman, Barbara Pfister
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Min Mao, Hang Ji, Wen-Qian Yu, Qu-Jing Gai, Qiang Sun, Qian Yan, Sen-Lin Xu, Meng-Li Zhu, Mei-Hua Qu, Han-Min Liu, Jean-Philipe Hugnot, Xi He, Xin Wang, Yan Wang
SNX-mediated biogenesis of a plant-unique vesicle derived from the multivesicular body
Yanbin Li, Ran Tao, Hai Zhang, Xiaokang Wen, Stephen King Pong Leung, Qing Qi, Xiaohui Zheng, Haoxuan Guo, Congxian Wu, Zhifei Fu, Xiaorong Huang, Wilson Chun Yu Lau, Liwen Jiang, Yong Cui
IgA autoantibodies promote inflammation, Th17 polarization and fibrotic responses in hidradenitis suppurativa
Carmelo Carmona-Rivera, Liam J. OâNeil, Eduardo Patino-Martinez, William G. Ambler, Teja Mallela, Norio Hanata, Arsema K. Zadu, Kan Jiang, Ginette A. Okoye, Angel S. Byrd, Christopher J. Sayed, Mariana J. Kaplan
Vascular invasion-associated gene expression is detectable in pre-surgical biopsies of stage I lung adenocarcinoma
Dylan Steiner, Lila Sultan, Travis Sullivan, Hanqiao Liu, Xiaohui Xiao, Ashley LeClerc, Savannah Melvin, Yuriy O. Alekseyev, Gang Liu, Sarah A. Mazzilli, Jiarui Zhang, Kei Suzuki, Kimberly Rieger-Christ, Eric J. Burks, Jennifer Beane, Marc E. Lenburg
Erratum for the Research Article, âCooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphomaâGATA3 molecular subgroupâ by W.G. Lone et al .
Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages
Seong-eun G. Kim, Rachael Ott, Alexis Bretin, Hirohito Abo, Yanling Wang, Yadong Wang, Shawn Winer, Daniel A. Winer, Lavanya Reddivari, Stacey L. Heaver, Ruth E. Ley, Michael Pellizzon, Vu L. Ngo, Andrew T. Gewirtz
Enhanced two-dimensional ferromagnetism in van der Waals ÎČ-UTe 3 monolayers
Sean M. Thomas, Andres E. Llacsahuanga Allcca, Wolfgang Simeth, Caitlin S. Kengle, Zachary W. Riedel, Fabio Orlandi, Dmitry Khalyavin, Pascal Manuel, Filip Ronning, Eric D. Bauer, Joe D. Thompson, Jian-Xin Zhu, Allen O. Scheie, Yong P. Chen, Priscila F. S. Rosa
A reconfigurable dielectric elastomer actuator via phase-transitional ferrofluid enables sustainable operation
Yun Hyeok Lee, Seung Won Moon, Min-Gyu Lee, Won Jun Song, Seong-Yu Choi, Gimin Sung, Yong Eun Cho, Junhyun Choi, Byung Ik Park, Younghoon Lee, Ho-Young Kim, Jeong-Yun Sun
Wensai Shang, Ji Liu, Zigong Xu, Chao Yue, Ruilong Guo, Chao Xiao, Quanqi Shi, Robert F. Wimmer-Schweingruber, Jingnan Guo, Alexander W. Degeling, Robert Rankin, Anmin Tian, Qiu-Gang Zong, Chenyao Han, Jong-Sun Park, Huizi Wang, Wenlong Liu, Suiyan Fu, L. M. Zhai, D. Chen, Sulan Ni, T. L. Chen
Mechanistic insights into the therapeutic properties of delta opioid receptor
Sarah M. Bernhard, Susovan Roy Chowdhury, Tsuyoshi Murata, Erin L. Reinl, Nokomis Ramos-Gonzalez, Elizabeth Denn, Kevin Appourchaux, Asuka Inoue, Sarah K. England, Jonathan F. Fay, Susruta Majumdar, Baron Chanda, Tao Che
Quantifying urban and landfill methane emissions in the United States using TROPOMI satellite data
Xiaolin Wang, Daniel J. Jacob, Hannah Nesser, Nicholas Balasus, Lucas A. Estrada, Melissa P. Sulprizio, Daniel H. Cusworth, Tia R. Scarpelli, Zichong Chen, James D. East, Daniel J. Varon
MUTE drives asymmetric divisions to form stomatal subsidiary cells in Crassulaceae succulents
Xin Cheng, Heike Lindner, Lidia Hoffmann, Antonio Aristides Pereira Gomes Filho, Paola Ruiz Duarte, Susanna F. Boxall, YiÄit Berkay GĂŒndoÄmuĆ, Jessica H. Pritchard, Sam Haldenby, Matthew Gemmell, Alistair Darby, Miro LĂ€derach, James Hartwell, Michael T. Raissig
Altered morphology and diffusivity of water confined in MXenes: Machine learningâaccelerated computations combined with experiments
Jiawei Tang, Weiwei Sun, Chaofan Chen, Lars Bannenberg, Xuehang Wang, Tingwei Zhu, Litao Sun, Jinlan Wang, Guobing Ying, Yu Xie, Naresh C. Osti, Alexander I. Kolesnikov, Eugene Mamontov, Madhusudan Tyagi, Jingsong Huang, Paul R. C. Kent
Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis
Wei Xie, Laura Wyckaert, Mike Vadi, Bruno Verstraeten, Tatyana Divert, Jef Haerinck, Riet De Rycke, Femke Baeke, Mohamed Lamkanfi, Geert Berx, Adam Wahida, Peter Vandenabeele
HfO 2 -based memristive synapses with asymmetrically extended p-n heterointerfaces for highly energy-efficient neuromorphic hardware
Babak Bakhit, Xiao Xie, Simon M. Fairclough, Atif Jan, Ingemar Persson, Giuliana Di Martino, Bonan Zhu, Caterina Ducati, Quanxi Jia, Bilge Yildiz, Andrew J. Flewitt, Judith L. MacManus-Driscoll
Ultrasensitive soft vibration sensors based on atomically thin metal dichalcogenide ribbon networks
Chengyi Xu, Xufan Li, Lukas Felix Michalek, Jaeho Park, Eunyoung Kim, Zhiyu Zhang, Raymond R. Unocic, Eric Tianjiao Zhao, Wei-Chun Hsu, Baiyu Shi, Shuang Wu, Yang Yang, Avetik R. Harutyunyan, Zhenan Bao
Regulation of sodium/calcium homeostasis by BacNa v gene therapy rescues cardiac dysfunction in chronic heart failure
Tianyu Wu, Yongwu Li, Robin M. Perelli, Yiu Yan Siu, Anna Tornatore, Josue Nataren, Xixian Jiang, Sophia DeLuca, Donald M. Bers, Craig Henriquez, Andrew P. Landstrom, Nenad Bursac
Functional and structural basis of a hypermorphic TRPC3 variant
Briar Bell, Angela M. Jaramillo-Granada, Luis O. Romero, Irene A. Gutierrez, Venkata K.P.S. Mallampalli, Guizhen Fan, Sameer Varma, Matthew L. Baker, Irina I. Serysheva, Valeria VĂĄsquez, Julio F. Cordero-Morales
Role of Atlantic multidecadal variability in modulating Arctic sea ice loss and wetting
Ziyi Cai, Qinglong You, James A. Screen, Hans W. Chen, Ruonan Zhang, Zhiyan Zuo, Deliang Chen, Judah Cohen, Shichang Kang, Weiming Ma, Sergey K. Gulev, G. W. K. Moore, Renhe Zhang
High-profile cases of police violence have given rise to contentious debates, yet scholars know little about why individuals interpret violent police encounters differently. We fielded a survey experiment in Germany designed to probe whether the victimâs identity matters to public opinion ( N = 15,941). Our design approximates the way news events unfold sequentially over time, allowing us to measure whether eventual discriminatory beliefs persist even in the face of mounting evidence. We show that respondents are less likely to consider the actions of the police to constitute misconduct when the victim has an immigrant name compared to a traditionally German name. Discriminatory beliefs remain even when respondents are informed about evidence confirming that misconduct occurred. Our analysis shows that these results are driven by right-wing respondents, with both moderates and extremists exhibiting discriminatory beliefs and a resistance to updating. These findings help illuminate why debates over policing are so intractable.
Correction for Goyette et al., Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V H 1-2-rearranging mouse models
Himanshu Batra, Sai Luo, Kevin O. Saunders, Jaclyn S. Higgins, Fanchong Jian, Jun Zhang, Md Golam Kibria, G. M. Jonaid, Qingchen J. Zhou, Amanda Eaton, Kenneth Cronin, Michael L. Mallory, Melissa Mattocks, Robert J. Edwards, Robert Parks, Esther M. Lee, Adam Yongxin Ye, Aimee Chapdelaine Williams, Geeyoun Jung, Katayoun Mansouri, S. Munir Alam, David C. Montefiori, Ming Tian, Ralph S. Baric, Yunlong Cao, Barton F. Haynes, Bing Chen, Frederick W. Alt
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress
Tomasz Slezak, Kelly M. OâLeary, Tanya Guevara Avella, Natalia Musial, Jinyang Li, Anna Andrzejczak, Elizabeth F. Scott, Duc Anh Le, Anthony A. Kossiakoff
Ultrasound-responsive liposomes: A mechanistic framework to decode the effects of acoustic parameters
Ignasi Simon, Rebecca F. A. van den Elshout, Gandhika K. Wardhana, Masoumeh Aqamolaei, Isabella S. T. de Jonge, Remco Hartkamp, Riccardo Alessandri, Tiago L. Costa, Alina Y. Rwei
KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3
Taylor A. DePauw, Kexin Gai, Jian Shen, Nicholas J. Maurice, Ka Hyun Rhee, William J. Valente, Christine H. OâConnor, Weiguo Cui, Changwei Peng, Stephen C. Jameson
Tau catalyzes amyloid-ÎČ aggregation and toxicity in a polymorph-dependent manner
Michele Mosconi, Chiara Leonardi, Zev Armour-Garb, Beatrice Rocutto, Marten Beeg, Georg Meisl, Lei Ortigosa-Pascual, Luca Broggini, Mario Salmona, Stefano Ricagno, Tuomas P. J. Knowles, Luisa Diomede
Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade
Evan R. Abt, Liang Wang, Grigor Varuzhanyan, Jack Freeland, Tian He, Guadalupe M. Peña-Garcia, Lauryn Ruegg, Jami McLaughlin, Donghui Cheng, Nikolas G. Balanis, Chia-Chun Chen, Yang Xu, Yi Xing, Sanaz Memarzadeh, Caius G. Radu, Thomas G. Graeber, Owen N. Witte
Small moleculeâconstrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins
Rameshwar U. Kadam, Jarek Juraszek, Boerries Brandenburg, Divita Garg, Xueyong Zhu, Mandy Jongeneelen, Chan Tang, Wim B. G. Schepens, Christophe Buyck, Bart Stoops, Jan Vermond, Ronald Vogels, Robert H. E. Friesen, Maria J. P. van Dongen, Ian A. Wilson
Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases
Liliana M. Sanmarco, Alex Pellerin, Tobias Green, Agustin Plasencia, Jordan M. Anderson, Nam Le, Andita Newton, Jiyun Chen, Maria Cecilia Ramello, Ryan Peckner, Julia Manasson, Yi Xing, Heather Vital, Nathan Higginson-Scott, John S. Sundy, Kevin L. Otipoby, Ivan D. Mascanfroni
A modular platform for Sterically Masked Activated Cytokines (SMACks)
Travis J. Morgenstern, Naruhisa Ota, Zhonghua Lin, Laura M. Lechermann, Herman Gill, Annie Ogasawara, Simon Williams, Kevin A. Marroquin, Alexis Scherl, Christopher W. Davies, James R. Byrnes, Dhaya Seshasayee, James T. Koerber
CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination
Ruhi Polara, Briony L. Gliddon, Raja Ganesan, Lorena T. Davies, John Toubia, Sakthi Lenin, Ghizal Siddiqui, Olivia Morris-Hanon, Melinda N. Tea, Paul A. B. Moretti, Dung A. Nguyen, Chung Hoow Kok, Chloe Shard, Alexander H. Staudacher, Michael P. Brown, Darren J. Creek, Guillermo A. Gomez, Daniel Thomas, Stuart M. Pitson, Nirmal Robinson
Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI
Mohamed I. Barmada, Erin N. McGinity, Suparno Nandi, Debayan Dey, Natalia Zelinskaya, George M. Harris, Lindsay R. Comstock, Christine M. Dunham, Graeme L. Conn
Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model
Satoru Fujii, Scott T. Espenschied, Vibha Anand, Joao Bettencourt-Silva, Yi Han, Go Ito, Akira Koseki, Akihiro Kosugi, James Kozloski, Ryoma Matsumoto, Shanshan Meng, Natasha Mulligan, Ryan J. Musich, Kevin P. Newhall, Eri Oshina, Shuhei Sekiguchi, Yi Wang, Jianying Hu, Matthew Ciorba, L. David Sibley, Ryuichi Okamoto, Thaddeus S. Stappenbeck
Depth of nutrient uptake by deep-rooted plants is regulated by water availability
Langlang Li, John N. Christensen, Markus Bill, Wenming Dong, Yuxin Wu, Curtis Beutler, Matthias Sprenger, Brian W. Gulick, Sharon E. Bone, Boris Faybishenko, John Sanders, Chunwei Chou, Amanda Henderson, Nicholas J. Bouskill, Kenneth H. Williams, Benjamin Gilbert
Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to have two options: contribute toward public solutions such as global warming mitigation or free ride. However, many collective action problems today involve a third option of investing in a âprivate solutionâ such as local adaptation. The availability of this third option can lead to a private solution trap whereby private solutions are adopted, collectively optimal public solutions are not provided, and existing inequalities are exacerbated. We investigated the private solution trap with a collective action game featuring private and public solutions, wealth inequality determined by luck or merit, and participants from 34 countries. We found that the joint existence of private solutions and wealth inequality had a consistent effect across countries: Participants given a higher endowment adopted private solutions almost twice as often as those given a lower endowment, regardless of whether it was determined by luck or merit, and contributed proportionally less toward public solutions. Wealth inequality increased in every country and those given lower endowments were often left unprotected as public solutions were not provided. Across countries, cultural values of hierarchy and harmony were associated with preferences for private and public solutions, respectively. We also identified two universal pathways toward public solution provision: early contributions and conditional cooperation. Our findings highlight the ubiquity of the private solution trap, its cultural underpinnings, and its potential consequences for global collective action problems.
Cross-cultural evidence that shame is a defense against reputational damage
Because shame leads to evasions, aggression, and other behaviors that victims and third parties find undesirable, a prominent theory regards this emotion as maladaptive. By contrast, an alternative, adaptationist theory asks whether shame might benefit the actor. Indications that an individual now offers fewer benefits or imposes greater costs on others, if they reach othersâ minds, lead the individual to be socially devalued: Others become less inclined to help and more inclined to harm her. Thus, an adaptationist theory views shame as a neurocognitive adaptation designed to minimize the leakage of reputation-damaging information and the cost of being devalued. Here, we report tests of two predictions derived from the adaptationist theory across six countriesâthe United States, the Netherlands, Portugal, Spain, Japan, and Chinaâand two cultural regions within the United StatesâSouthern states (honor) and Northern states (nonhonor). First, failures that indicate reductions in abilities more highly valued by others will elicit more intense shame. Second, failures will trigger greater shame when they occur in public rather than in private. The data supported both predictions in all six countries and in both US cultural regions. The improbable fit between the severity of the devaluative threat and the intensity of shame suggests that this emotion is an adaptation. Further, the replication of these findings across regions that vary widely along the individualismâcollectivism and honorânonhonor dimensions suggests that shame is part of human nature rather than a cultural construction.
The psychology of offensive and defensive intergroup violence: Preregistered insights from 58 countries
Evolutionary theory and historical evidence suggest humans possess distinct psychological tendencies for defensive and offensive violence, which have insufficiently been considered in research. In a large-scale preregistered study across 58 countries ( N = 18,128), we demonstrate that violent extremist intentions manifest along two distinct psychological phenomena: defensive extremism, motivated by protecting oneâs group from (perceived) threats, and offensive extremism, driven by establishing group dominance. We show that these dimensions a) can be reliably differentiated across diverse cultural contexts, b) are distinctively associated with psychological dispositions, and c) systematically differentiate countries varying in macrolevel sociopolitical functioning and violence. Across nations, a two-factorial structure was observed that was invariant at the scalar level. Defensive extremist intentions were consistently higher than offensive extremism in 56 out of 58 countries, suggesting greater moral acceptance of protective violence. While psychopathy was positively related to both types of violent extremist intentions, those high in Machiavellianism and narcissism demonstrated particularly higher levels of defensive extremist intentions. By contrast, those scoring high on religious fundamentalism and social dominance orientation demonstrated particularly higher levels of offensive extremist intentions. Unexpectedly, liberal political group identification was associated with higher offensive but lower defensive extremist intentions. Crucially, offensive (but not defensive) intentions were associated with macrolevel societal dysfunction, including political terror and internal conflict. These findings establish that defensive and offensive violent extremist intentions represent two conceptually different forms of extremism across a large and diverse range of countries, with consequences for research and practice.
Rethinking same-sex sexual behavior: From sensory error to social function
An unwritten expectation in our everyday social interactions is that intimate personal information about someoneââinsider knowledgeââis usually confined within close relationships. For example, it would be odd, or even unsettling, if a stranger knew about your favorite movie. Such expectations about who knows what about whom constitute a cornerstone of complex social behavior, but much remains unknown about their cognitive underpinnings and developmental origins. Drawing on parental report (Study 1) as well as a novel experimental approach using controlled but naturalistic videochat conversations (Study 2 & 3), we find that 4- to 5-y-old children have an abstract, theory-like understanding of how social connections give rise to interpersonal knowledge. Self-report, facial expressions, and memory errors provide converging evidence that children were surprised when someone possessed insider knowledge that is misaligned with their relationships, such as a stranger knowing their favorite food (Study 2a) or their own parent knowing a strangerâs favorite movie (Study 2b). Children also generated coherent ad-hoc explanations about how someone might have acquired that knowledge, appealing to either first-hand observations or second-hand sources (Study 3). These findings demonstrate an early-emerging understanding of how individual minds are shaped in the context of their social networks, supporting a precocious ability to detect and explain anomalies in what people know about each other in real-time conversations. The current work also opens possibilities for leveraging open-ended online interactions to study social cognition without compromising experimental control.
VIBES: A multiscale modeling approach integrating within-host and between-hosts dynamics in epidemics
Paulo Cesar Ventura, Yong Dam Jeong, Maria Litvinova, Allisandra G. Kummer, Shingo Iwami, Hongjie Yu, Stefano Merler, Alessandro Vespignani, Keisuke Ejima, Marco Ajelli
Infectious disease spread is a multiscale process composed of within-host (biological) and between-host (social) drivers and disentangling them from each other is a central challenge in epidemiology. Here, we introduce VIBES, a multiscale modeling framework that explicitly integrates viral dynamics based on patient-level data with population-level transmission on a data-driven network of social contacts. Using SARS-CoV-2 as a case study, we analyze three emergent epidemic properties, namely the generation time, serial interval, and presymptomatic transmission. First, we established a purely biological baseline, thus independent of the reproduction number ( R ), from the within-host model, estimating a generation time of 6.3 d for symptomatic individuals and 43.1% presymptomatic transmission. Then, using the full model incorporating social contacts, we found a shorter generation time (5.4 d at R = 3.0) and an increase in presymptomatic transmission (52.8% at R = 3.0), disentangling the impact of social drivers from a purely biological baseline. We further show that as pathogen transmissibility increases ( R from 1.3 to 6), competition among infectious individuals shortens the generation time and serial interval by up to 21% and 13%, respectively. Conversely, a social intervention, like isolation, increases the proportion of presymptomatic transmission by about 30%. Our framework also estimates metrics that are challenging to obtain empirically, such as the generation time for asymptomatic individuals (5.6 d; 95%CI: 5.1 to 6.0 at R = 1.3). Our findings establish multiscale modeling as a powerful tool for mechanistically quantifying how pathogen biology and human social behavior shape epidemic dynamics as well as for assessing public health interventions.
Multigenerational and gender-symmetric transmission of migration behaviors in historical Quebec
Migration decisions are embedded in social and family trajectories that escape traditional data sources, which tend to observe individuals in isolation. Genealogical microdata now make it possible to trace these dynamics over long time horizons. This paper documents how prior generationsâ migration histories shape future internal migration behavior, leveraging rich historical microdata spanning over two centuries and multiple generations at the scale of an entire population (Quebec, Canada; 1621â1861). As the cultural norm preserved womenâs maiden names throughout the life course, genealogies could be assembled as exhaustively for women as for men. Using residential trajectories reconstructed from these linked vital data, the study shows that the mobility of married couples depends on both spousesâ parentsâ and grandparentsâ migration histories. Descendants of migratory people are substantially more likely than their peers from sedentary families to migrate themselves, the effect of the grandparental generation being about half that of the parental generation. These effects compound such that couples with multiple migratory ascendants are even more likely to migrate. Moreover, husbandsâ and wivesâ migration backgrounds are equally predictive of their joint mobility decisions, suggesting a substantial role of women in shaping couplesâ mobility and challenging the conventional assumption that migration decisions were historically made by men. These results reveal deep family history as an underexplored axis of migrant selection. The long-lasting influence of family should be integrated in migration theories.
Gender gaps in reading increase during unplanned and planned school closures
Emil Smith, Ea H. BlaabĂŠk, David Reimer, Mads M. JĂŠger
Why do girls outperform boys in education? One contributing factor might be that girls read more than boys, which fosters competencies relevant in education. Moreover, boys might rely more heavily on schools to support and encourage reading, meaning that unplanned and planned school closures disproportionally affect boys. We map the gender gap in reading in the period 2020 to 2022 using two large-scale datasets from Denmark, one measuring studentsâ weekly reading in school via a popular reading app and the other measuring studentsâ borrowing of library books. Our data document a clear gender gap in reading that increased during unplanned school closures due to the COVID-19 pandemic and planned closures due to vacations. Our findings underscore the role of schools in mitigating gender differences in reading.
The power of leadership in changing social norms in heterogeneous societies
Fabio Galeotti, Jona Krutaj, Marie Claire Villeval
Abandoning detrimental social norms is complex due to the strong pressure to conform. We examine how leaders can guide norm change in heterogeneous societies where individual preferences evolve at different rates. Inspired by the model and experimental design of [J. Andreoni, N. Nikiforakis, and S. Siegenthaler, Proc. Natl. Acad. Sci. U.S.A. 118 , e2014893118 (2021)], we conduct a large-scale laboratory experiment in which we manipulate the speed at which preferences change within a society and introduce leaders with different, evolving preferences. Without leaders, a minority of citizens with rapidly changing preferences cannot overturn an existing norm in a society where most individuals have slow-changing preferences. When fast-changing citizens form the majority, norm change occurs in most groups, but at high welfare costs. In contrast, exogenously selected leaders are highly effective at coordinating expectations and shifting heterogeneous societies toward a more efficient normâat lower welfare costs and regardless of the underlying distribution of preference evolution across individuals. However, the timing of norm change depends on whether leaders prioritize their preferences (autocratic leadership) or those of the majority (democratic leadership). A follow-up experiment shows that peer-to-peer communication encourages leaders to adopt a more democratic leadership style. These results highlight the pivotal role of leadership in driving norm change and the importance of public voice in shaping leadersâ behavior.
Scientific Data
GPT-4o mini: Non-social science research article
FePTP: A text-mined dataset of transformation pathways among iron-containing phases
Le Lin, Changhai Ren, Yang Xiao, Jingyu Nie, Chongchong Qi, Xiaoqin Li, Han Wang, Zhang Lin
Tidal Wetland Soil Carbon Accumulation Rates for Coastal California
James R. Holmquist, Lauren N. Brown, Elizabeth Fard, Richard F. Ambrose, Kathryn E. Hargan, Douglas E. Hammond, Nathaniel J. Kemnitz, John P. Smol, Karen Thorne, Glen M. MacDonald
Dataset of solubility values for organic compounds in binary mixtures of solvents at various temperatures
Dmitry Malikov, Lev Krasnov, Marina Kiseleva, Elizaveta Meshcheriakova, Fedor Kuznetsov, Vladimir Elistratov, Matvei Vasiyarov, Sergei Tatarin, Stanislav Bezzubov
âDense Amygdalaâ: Extensive Complex-valued Functional MRI of the Ventral and Medial Temporal Lobe during Passive Movie Watching in Three Individuals
J. Michael Tyszka, Zachary Diamandis, Umit Keles, Yue Xu, Na Yeon Kim, Wenying Zhu, Qianying Wu, David A. Kahn, Ralph Adolphs
An aerial color image anomaly dataset for search missions in complex forested terrain
Rakesh John Amala Arokia Nathan, Matthias Gessner, Nurullah Ăzkan, Marius Bock, Mohamed Youssef, Maximilian Mews, Björn Piltz, Ralf Berger, Oliver Bimber
COVID Diaries, State Response to COVID Vaccination Program, December 2020 to September 2021
Avalon S. Moore, Bridget Vitu, Felicia Fraizer-Bisner, Peter J. Williams, Lucy van der Merwe, Abdelrhman Gouda, Dessislava Kirilova, Christopher Pittenger, Helen Pushkarskaya
National COVID-19 response plans in the United States recognized that the primary responsibility for addressing domestic health emergencies lay with states and localities, though each stateâs pandemic response authority varied. States utilized a range of tools to manage infectious-disease outbreaks, including vaccination rules, incentives, and communication strategies. This database includes online publications from state governors and departments of health across all 50 U.S. states and the District of Columbia. It spans from December 2020, when Phase 1a of the COVID-19 vaccination allocation began, to September 2021, when vaccines were widely available and often mandated. In total, 5,223 unique publications were collected, each classified by type: Flyer, Milestone, Info, and Policy. We also address key considerations for analyzing this data and suggest potential research questions that can be explored with it.
A Dataset of University Students' Stress and Anxiety Levels based on Questionnaires and Wearable Sensors
Enrique Garcia-Ceja, Joanna Alvarado-Uribe, Ponciano Jorge Escamilla-Ambrosio, Adriana Lara, Alma Mena-Martinez, Gina Gallegos-Garcia, Miguel Gonzalez-Mendoza, Raul Monroy, Gilberto Martinez Luna, Juan Manuel FernĂĄndez-CĂĄrdenas
A prevailing perspective in economic sociology suggests that economic forecasts do not need to be accurate to hold political value; instead, what matters is the credibility of the accompanying narrative. However, drawing on the case of the 2012 Kansas tax cuts, I argue that the accuracy of forecasts can significantly influence forecast credibility and the associated politics of expectations. I show how initial supply-side expectations for the policy were embedded in official revenue forecasts, raising the political consequences of their eventual failure. As repeated forecast errors mounted, typical narrative strategies used to defend forecasting errors lost plausibility, making the tax cuts politically untenable and eventually contributing to their repeal. This study highlights that the relationship between forecast accuracy and political credibility is crucial for shaping public perception and policy outcomes.
Where ideology matters: evidence from a global analysis of market intervention policies
While many studies argue that the ideology of governments affects their policies, most research has focused on OECD countries. This narrow scope is because of a lack of data and common assumptions that political institutions in non-OECD countries extinguish the impact of government ideology. This article challenges these assumptions by analyzing a new dataset on the ideological orientation of governments in 182 countries since 1945. Focusing on market intervention policies, fixed-effects estimates show that government ideology influences certain market intervention tools worldwide, including in non-OECD countries. The analysis further suggests that ideology matters more in countries with fewer constraints on the executive. But counter to common expectations, ideology does not seem to matter more in countries with strong states, democratic institutions, and little clientelism. The findings have important implications for the study of partisan politics, political institutions, and politics in young and non-democracies.
What goes up, must come down: speculation-encouraging institutions and house price cycles across countries
Since the Global Financial Crisis, there is a growing literature on the Comparative Political Economy (CPE) of housing, but it has not systematically incorporated boom-bust cycles in house prices. This matters as cycles in house prices are large relative to their trend and the intensity of house price cycles differs across countries. Bringing Minskyan and behavioural theories of endogenous financial cycles to CPE, this article argues that the intensity of house price booms and busts is shaped by institutions that encourage speculative behaviour. In an empirical analysis for 23 OECD countries, the article explores the role of speculation-encouraging institutions, credit permissiveness, welfare state regimes and macroeconomic policy as potential factors. We find that low capital gains taxes and strong landlord-protection policies that may push households onto the property ladder are linked to more intense house price booms and busts.