Ute Koeber, Mantas Matjusaitis, Neza Alfazema, Katharine Furlong, Zeyu Wang, Rachel White, Alhafidz Hamdan, Pooran Dewari, Gregoire Morisse, Mariela Navarette, Rosie Willis, Jin Wang, Michelle P. Clark, Carla Jacinto de Sousa, Hei Ip Hong, Shahida Sheraz, Ben Southgate, Justyna Cholewa-Waclaw, Sabine Gogolok, Gillian M. Morrison, Felipe Galvez Cancino, Faye Robertson, Anna Williams, Susan J. Rosser, Paul M. Brennan, Dirk Sieger, Abdenour Soufi, Sergio A. Quezada, Steven M. Pollard
Single-cell spatiotemporal dissection of the human maternalâfetal interface
Cheng Wang, Yan Zhou, Yuejun Wang, Tuhin Kumar Guha, Zhida Luo, Anxhela Mustafaraj, Tara I. McIntyre, Marisa E. Schwab, Brittany R. Davidson, Gabriella C. Reeder, Ronald J. Wong, Sarah K. England, Juan M. Gonzalez, Robert Blelloch, Alexis J. Combes, Linda C. Giudice, Adrian Erlebacher, Tippi C. MacKenzie, David K. Stevenson, Gary M. Shaw, Michael P. Snyder, Xiaofei Sun, Virginia D. Winn, Susan J. Fisher, Jingjing Li
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale, Piergiorgio Pettazzoni, Costas A. Lyssiotis, Haoqiang Ying, Nora SĂĄnchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Maria Kost-Alimova, Florian Muller, Simona Colla, Luigi Nezi, Giannicola Genovese, Angela K. Deem, Avnish Kapoor, Wantong Yao, Emanuela Brunetto, Yaâan Kang, Min Yuan, John M. Asara, Y. Alan Wang, Timothy P. Heffernan, Alec C. Kimmelman, Huamin Wang, Jason B. Fleming, Lewis C. Cantley, Ronald A. DePinho, Giulio F. Draetta
Genetic predictors of GLP1 receptor agonist weight loss and side effects
Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu, Vinh Tran, R. Ryanne Wu, Catherine H. Weldon, Jingchunzi Shi, Barry Hicks, , Robert K. Bell, Katelyn Kukar Bond, Zayn Cochinwala, Sayantan Das, Kahsaia de Brito, Devika Dhamija, Payambr Dibaeinia, Emily DelloRusso, Chris Eijsbouts, Sarah L. Elson, Shirin Fuller, Chris German, Julie M. Granka, Larry Hengl, David A. Hinds, Reza Jabal, Aly Khan, Matthew J. Kmiecik, Alan Kwong, Yanyu Liang, Keng-Han Lin, Matthew H. McIntyre, Alex Moran, Carrie Northover, Shubham Saini, Anjali J. Shastri, Suyash Shringarpure, Teague Sterling, Joyce Y. Tung, Noura S. Abul-Husn, Stella Aslibekyan, Michael V. Holmes, Bertram L. Koelsch, Adam Auton
Author Correction: Foundation model of neural activity predicts response to new stimulus types
Eric Y. Wang, Paul G. Fahey, Zhuokun Ding, Stelios Papadopoulos, Kayla Ponder, Marissa A. Weis, Andersen Chang, Taliah Muhammad, Saumil Patel, Zhiwei Ding, Dat Tran, Jiakun Fu, Casey M. Schneider-Mizell, , Nuno Maçarico da Costa, R. Clay Reid, Forrest Collman, Nuno Maçarico da Costa, Katrin Franke, Alexander S. Ecker, Jacob Reimer, Xaq Pitkow, Fabian H. Sinz, Andreas S. Tolias
Multiomics and deep learning dissect regulatory syntax in human development
Betty B. Liu, Selin Jessa, Samuel H. Kim, Yan Ting Ng, Soon Il Higashino, Georgi K. Marinov, Derek C. Chen, Benjamin E. Parks, Li Li, Tri C. Nguyen, Austin T. Wang, Sean K. Wang, Meng How Tan, Serena Y. Tan, Michael Kosicki, Len A. Pennacchio, Eyal Ben-David, Anca M. Pasca, Anshul Kundaje, Kyle K. H. Farh, William J. Greenleaf
Satellite imagery reveals increasing volatility in human night-time activity
Tian Li, Zhuosen Wang, Christopher C. M. Kyba, Miguel O. RomĂĄn, Karen C. Seto, Yun Yang, Shi Qiu, Theres Kuester, Michail Fragkias, Xiang Chen, Thomas H. Meyer, Chadwick D. Rittenhouse, Xiaonan Tai, Mari Cullerton, Falu Hong, Ashley Grinstead, Kexin Song, Ji Won Suh, Xiucheng Yang, Virginia L. Kalb, Chengbin Deng, Zhe Zhu
Population-scale repeat expansions elucidate disease risk and brain atrophy
Vijay Kumar Pounraja, Jae Hoon Sul, Joseph Herman, Sean OâKeeffe, Veera Rajagopal, Xiaodong Bai, Michael D. Kessler, Neelroop Parikshak, Karl Landheer, Xingmin Zhang, Sean Yu, Lance Zhang, Michelle G. LeBlanc, Jennifer Rico-Varela, Frederic Grau, Sarah Wolf, Sriramkumar Sundaramoorthy, Farshid Sepehrband, Eli A. Stahl, Yuda Huo, Mohsin Ahmed, Susan Croll, , Adam Buchanan, David J. Carey, Christa L. Martin, Michelle Meyer, Kyle Retterer, David Rolston, , , James R. Cerhan, Fergus J. Couch, Janet E. Olson, , Nicholas B. Larson, Zachary S. Fredericksen, , Mine Cicek, , Joanna M. Biernacka, Victor M. Karpyak, Prashanthi Vemuri, Vijay K. Ramanan, Owen A. Ross, Mark A. Frye, Jeanette E. Eckel Passow, Robert R. Jenkins, Daniel H. Lachance, Kristen L. Drucker, Paul A. Decker, Matthew L. Kosel, Sarah A. McLaughlin, Kathryn J. Ruddy, Nicholas J. Boddicker, Wenan Chen, Suzette J. Bielinski, John C. Lieske, W. Michael Hooten, Lisa A. Boardman, Richard B. Kennedy, Andrew D. Badley, Sean C. Dowdy, Shariska Harrington, Gretchen E. Glaser, Ping Yang, Celine M. Vachon, Stacey Winham, Angela Dispenzieri, Samuel O. Antwi, Ann L. Oberg, Kari G. Rabe, Scott H. Kaufmann, Ellen L. Goode, William A. Cliby, Jamie Bakkum-Gamez, Sun-Hee Lee, J. Eric Ahlskog, James H. Bower, Peter C. Harris, Naveen L. Pereira, Nadia N. Laack, Daniel J. Ma, Robert W. Mutter, , Jonathan J. Harrington, , Jason Torres, Jonathan R. Emberson, Rory Collins, Jaime Berumen, JesĂșs Alegre-DĂaz, Roberto Tapia-Conyer, Pablo Kuri-Morales, , , Daniel J. Rader, Marylyn D. Ritchie, , JoEllen Weaver, Nawar Naseer, Giorgio Sirugo, Afiya Poindexter, Yi-An Ko, Kyle P. Nerz, Jenna Dever, Aidan Harvey, Sydney Linn, , Meghan Livingstone, Fred Vadivieso, Stephanie DerOhannessian, Teo Tran, Julia Stephanowski, Salma Santos, Ned Haubein, Joseph Dunn, , Anurag Verma, Colleen Morse Kripke, Marjorie Risman, Renae Judy, Colin Wollack, , Shefali S. Verma, Scott Damrauer, Yuki Bradford, Scott Dudek, Theodore Drivas, William Salerno, John D. Overton, Jonathan Marchini, Jeffrey Reid, Luca A. Lotta, Aris Baras, , , Gonçalo Abecasis, Adolfo Ferrando, Andrew Deubler, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Katherine Siminovitch, Jason Portnoy, Marcus B. Jones, Lyndon Mitnaul, Alison Fenney, Manuel Allen Revez Ferreira, Maya Ghoussaini, Mona Nafde, Cristen Willer, Lourdes Crane, Niek Verweij, Eric Jorgenson, Joseph Pickrell, , Christina Beechert, Erin Fuller, Laura M. Cremona, Eugene Kalyuskin, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Prathyusha Challa, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria Sotiropoulos Padilla, Chenggu Wang, Sarah E. Wolf, , Manan Goyal, George Mitra, Rouel Lanche, Vrushali Mahajan, Sai Lakshmi Vasireddy, Gisu Eom, Krishna Pawan Punuru, Sujit Gokhale, Shehroze Aamer, Pooja Mule, Mudasar Sarwar, Muhammad Aqeel, Razvan Panea, Evan Edelstein, Devika Torvi, Ayesha Rasool, Evan K. Maxwell, Boris Boutkov, Alexander Gorovits, Ju Guan, Alicia Hawes, Olga Krasheninina, Samantha Zarate, Adam J. Mansfield, Lukas Habegger, Stephen Tahan, Naveen Karumuri, , Joshua Backman, Kathryn Burch, Adrian Campos, Liron Ganel, Sheila Gaynor, Benjamin Geraghty, Arkopravo Ghosh, Christopher Gillies, Lauren Gurski, Tyler Joseph, Michael Kessler, Jack Kosmicki, Adam Locke, Priyanka Nakka, Olivier Delaneau, Anthony Marcketta, Joelle Mbatchou, Jonathan Ross, Carlo Sidore, Eli Stahl, Timothy Thornton, Rujin Wang, Kuan-Han Wu, Bin Ye, Blair Zhang, Andrey Ziyatdinov, Yuxin Zou, Jingning Zhang, Kyoko Watanabe, Mira Tang, Frank Wendt, Suganthi Balasubramanian, Suying Bao, Kathie Sun, Chuanyi Zhang, Aaron Zhang, David Corrigan, Dhruv Shidhaye, Chen Wang, Keyrun Adhikari, Alexander Lachmann, Anna Alkelai, Mark Weiner, Julian Stamp, , Brian Hobbs, Jon Silver, William Palmer, Rita Guerreiro, Amit Joshi, Antoine Baldassari, Sarah Graham, Ernst Mayerhofer, Erola Pairo Castineira, Mary Haas, George Hindy, Jonas Bovijn, Tanima De, Luanluan Sun, Olukayode Sosina, Arthur Gilly, Peter Dornbos, Moeen Riaz, Manav Kapoor, Gannie Tzoneva, Vijay Kumar, Jacqueline Otto, Jose Bras, Silvia Alvarez, Jessie Brown, Hossein Khiabanian, Joana Revez, Kimberly Skead, Jae Soon Sul, Lei Chen, Sam Choi, Amy Damask, Nan Lin, Charles Paulding, Sameer Malhotra, Jacob McPadden, David Blair, Joshua Motelow, Julie Horowitz, , Michelle G. LeBlanc, Nadia Rana, Jennifer Rico Varela, Jaimee Hernandez, Larizbeth Romero, Ashley Paynter, , Randi Schwartz, Jody Hankins, Anna Han, Samuel Hart, Ryan Smith, Sarah Murphy, , Ann Perez-Beals, Gina Solari, Johannie Rivera-Picart, Michelle Pagan, Sunilbe Siceron, Goncalo R. Abecasis, Giovanni Coppola, Sahar Gelfman
High-fidelity collisional quantum gates with fermionic atoms
Petar BojoviÄ, Timon Hilker, Si Wang, Johannes Obermeyer, Marnix Barendregt, Dorothee Tell, Thomas Chalopin, Philipp M. Preiss, Immanuel Bloch, Titus Franz
DNA damage drives antigen diversification in Trypanosoma brucei
Jaclyn E. Smith, Kevin J. Wang, Erin M. Kennedy, Jane C. Munday, Lulu Singer, Jill M. C. Hakim, Jaime So, Alexander K. Beaver, Aishwarya Magesh, Shane D. Gilligan-Steinberg, Jessica Zheng, Bailin Zhang, Dharani Narayan Moorthy, Zachary E. Brown, Elgin Henry Akin, Lusajo Mwakibete, Richard McCulloch, Monica R. Mugnier
Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity
Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, Sofia Mrowka, Ilario Scapozza, Zelalem Demere, Sachin V. Kammula, Margaret Hu, Sarah Y. Kim, YuhJong Liu, Celeste Nobrega, Jonathan J. Perera, Ewa Wrona, Collins K. Cheruiyot, Yunkang Lin, David W. Wu, Maria Saberi, Aidan Cruickshank, Elliot C. Woods, Cun Lan Chuong, Filippo Birocchi, Ashwin V. Kammula, Omar I. Avila, Nelson Knudsen, Mustafa Kocak, John G. Doench, Dean Procter, Lindsey Thornton, Andrew M. Brunner, Eric Winer, Daniel J. DeAngelo, Jacqueline S. Garcia, Richard M. Stone, Russell W. Jenkins, Marcela V. Maus, Timothy A. Graubert, Kathleen B. Yates, Todd R. Golub, Robert T. Manguso
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration
Byron W. H. Mui, Joseph J. Y. Wong, Camille E. Dumas, Jia Hua Wang, Toni Bray, Kentaro Hirose, Lauren Connolly, Alexander Winkel, Sebastian Timmler, Nicholas A. Bright, Evelina Sliauteryte, Ragnhildur ThĂłra KĂĄradĂłttir, Pamela G. Robey, Kristian Franze, Kevin J. Chalut, Mekayla A. Storer
D. Jirovec, S. Reale, P. Cova Fariña, C. Ventura-Meinersen, M. P. Nguyen, X. Zhang, S. D. Oosterhout, G. Scapucci, M. Veldhorst, M. Rimbach-Russ, S. Bosco, L. M. K. Vandersypen
Lethal conflict after group fission in wild chimpanzees
Aaron A. Sandel, Yixuan He, Junpeng Ren, Yik Lun Kei, Kevin C. Lee, Isabelle R. Clark, Rachna B. Reddy, Jacob D. Negrey, Charles Birungi, Blessing A. Apamaku, Diana Kanweri, Davis Kalunga, Christopher Aliganyira, SebastiĂĄn RamĂrez-Amaya, Phionah Nakayima, Raymond Katumba, Brian Kamugyisha, Daniela Acosta-Florez, Bas van Boekholt, Godfrey Mbabazi, Erone Akamumpa, Sharifah Namaganda, Alfred Tumusiime, Samuel Angedakin, Gesine Reinert, Oscar Madrid-Padilla, Mihai Cucuringu, David Wipf, Kevin E. Langergraber, David P. Watts, John C. Mitani
Observation of Kardar-Parisi-Zhang universal scaling in two dimensions
Simon Widmann, Siddhartha Dam, Johannes DĂŒreth, Christian G. Mayer, Romain Daviet, Carl Philipp Zelle, David Laibacher, Monika Emmerling, Martin Kamp, Sebastian Diehl, Simon Betzold, Sebastian Klembt, Sven Höfling
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Georgios Tsissios, Marion Leleu, Kelly Hu, Alp Eren Demirtas, Hanrong Hu, Sabrina Vinzens, Toru Kawanishi, Evangelia Skoufa, Atharva Valanju, Alessandro Valente, Lorenzo Noseda, Haruki Ochi, Antonio Herrera, Selman Sakar, Mikiko Tanaka, Sara A. Wickström, Fides Zenk, Can Aztekin
Science abstract < 200 char.: Not a research
article
In Science Journals
Caroline Ash, Ian S. Osborne, Jake S. Yeston, Stella M. Hurtley, Marc S. Lavine, Mattia Maroso, Courtney Malo, Michael A. Funk, Ekeoma Uzogara, Corinne Simonti, Priscilla N. Kelly, Angela Hessler, Sacha Vignieri, Annalisa VanHook, Claire Olingy
Despite decades of research, the conditions under which punishment promotes cooperation remain unclear. Through an integrative experiment varying 14 design parameters of public goods games across 360 experimental conditions (147,618 decisions from 7100 participants), we reveal substantial heterogeneity in punishment effectiveness: Its impact on welfare ranges from 43% improvement to 44% reduction depending on the game parameters. To characterize these patterns, we developed models that outperformed human forecasters in predicting punishment effectiveness in new experiments. Communication emerges as the most important factor, followed by contribution framing (opt out versus opt in), contribution type (variable versus all-or-nothing), game length, and outcome visibility, though these factors often interact. The results reframe the debate from whether punishment works to when it does, demonstrating how integrative experiments enable discovery of generalizable patterns in social phenomena.
There is widespread concern about the hostility of political discussions on social media, but there is no consensus about the underlying dynamics. In particular, the relationship between online hostility and the broader sociopolitical context has received less attention, in part because of limited research outside Western countries. Here we report results from observational data collected through quota-sampled online surveys in 30 countries across six continents ( N = 15,202) about experiences of online hostility. Our findings show that people in less democratic and less economically equal countries experience more hostility online. We also found that, in every country, respondents who are hostile online are also hostile offline and that these people score higher in status-seeking motivations. Exploratory analyses suggest that less democratic societies include more status-motivated individuals and young menâgroups showing higher hostility on average. Overall, these findings highlight how online political hostility is intertwined with wider societal tensions.
How deceptive online networks reached millions in the US 2020 elections
Ruth E. Appel, Young Mie Kim, Jennifer Pan, Yiqing Xu, Ben Nimmo, Daniel Robert Thomas, Hunt Allcott, Pablo BarberĂĄ, Taylor Brown, Adriana Crespo-Tenorio, Drew Dimmery, Deen Freelon, Matthew Gentzkow, Sandra GonzĂĄlez-BailĂłn, Andrew M. Guess, Shanto Iyengar, David Lazer, Neil Malhotra, Devra Moehler, Brendan Nyhan, Jaime Settle, Emily Thorson, Rebekah Tromble, Carlos Velasco Rivera, Arjun Wilkins, Magdalena Wojcieszak, Beixian Xiong, Chad Kiewiet de Jonge, Annie Franco, Winter Mason, Natalie Jomini Stroud, Joshua A. Tucker
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants
Vinay Shukla, Sergio Iacopino, Laura Dalle Carbonare, Alessia Del Chiaro, Yuming He, Mauricio NicolĂ s Tronca, Thomas P. Keeley, Antonis Papachristodoulou, Beatrice Giuntoli, Francesco Licausi
Oxide interface-based polymorphic electronic devices for neuromorphic computing
Soumen Pradhan, Kirill Miller, Fabian Hartmann, Merit Spring, Judith Gabel, Berengar Leikert, Silke Kuhn, Martin Kamp, Victor Lopez-Richard, Michael Sing, Ralph Claessen, Sven Höfling
Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex
Joana Sa de Almeida, Andrew Boehringer, Serafeim Loukas, Elda Fischi-Gomez, Annemijn Van Der Veek, Lara Lordier, Sebastien Courvoisier, François Lazeyras, Dimitri Van De Ville, Gareth Ball, Petra S. HĂŒppi
Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor
Marcus Renner, MaĆgorzata OleĆ, Nagarajan Paramasivam, Christoph E. Heilig, Annika Schneider, Caroline Modugno, Catherine Herremans, Jennifer HĂŒllein, Barbara Hutter, Cihan Erkut, Andreas Mock, Eva Krieghoff-Henning, Cecilia B. Jensen, Amirhossein Sakhteman, Matthew The, Tony Prinz, Panna Lajer, Annika Baude-MĂŒller, Katja Beck, Bettina Beuthien-Baumann, Leonidas Apostolidis, Sebastian Bauer, Melanie Boerries, Christian H. Brandts, Damian T. Rieke, Thomas Kindler, Frederick Klauschen, Klaus Schulze-Osthoff, Richard F. Schlenk, Guy Berchem, Michael AllgĂ€uer, Gunhild Mechtersheimer, Albrecht Stenzinger, Daniel B. Lipka, Matthias Schlesner, Bernhard Kuster, Arne Jahn, Evelin Schröck, Christoph Heining, Maria-Veronica Teleanu, Peter Horak, Simon Kreutzfeldt, Daniel HĂŒbschmann, Wolfgang Hartmann, Hanno Glimm, Stefan Fröhling
Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification
Chunling Hu, Sounak Sahu, Wenan Chen, Melissa Galloux, Marcy E. Richardson, Megan F. Bishop, Rachid Karam, Tina Pesaran, Jie Na, Huaizhi Huang, Jeffrey N. Weitzel, Katherine N. Nathanson, Siddhartha Yadav, Nicholas J. Boddicker, Susan M. Domchek, Alvaro N. Monteiro, Edwin S. Iversen, Shyam K. Sharan, Fergus J. Couch
HIV-1 uncoating location dictates sites of integration
Ryan C. Burdick, Sean C. Patro, Ellie Bare, Rokeya Siddiqui, Krista A. Delviks-Frankenberry, Olga A. Nikolaitchik, Stephen H. Hughes, Xiaolin Wu, Wei-Shau Hu, Vinay K. Pathak
Specialised and persistent raw material procurement by humans in the Middle Pleistocene
Manuel Will, Christian Sommer, Gunther H. D. Möller, Greg A. Botha, Matthias A. Blessing, Lawrence Msimanga, Aron Mazel, Aurore Val, Flavia Venditti, Svenja Riedesel
Deep neural network inference on an integrated, reconfigurable photonic tensor processor
Lennart Meyer, Jelle Dijkstra, Simon Tebeck, Liam McRae, Niklas Bahr, Daniel Steinmeyer, Sergey Koptyaev, Johana Bernasconi, Nikolay G. Pavlov, Maxim Karpov, John D. Jost, Wolfram Pernice, Frank BrĂŒckerhoff-PlĂŒckelmann
Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif
Jingbo Kan, Kaylyn Spotton, Adrian Morales-Amador, Yozen Hernandez, JĂĄn Burian, Cecilia Panfil, Melinda A. Ternei, Robert E. Boer, Abir Bhattacharjee, Sean F. Brady
Genetic genealogy of the Piast dynasty and related European royal families
Michal Zenczak, Luiza Handschuh, Malgorzata Marcinkowska-Swojak, Ireneusz Stolarek, MichaĆ GolubiĆski, Anna Juras, Dawid TrzciĆski, Maciej ChyleĆski, Artur DÄbski, Aleksandra Losik, Tomasz JasiĆski, Anna WrzesiĆska, Marzena Matla, Hanna KĂłÄka-Krenz, Andrzej B. Legocki, JĂłzef Dobosz, Marek Figlerowicz
Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids
Constanza Espada, Kai Ye, Yingyi Long, Kritika Pasai, Thomas J. DeLiberto, Jonathon Heale, Riley Wiese, Qiongying Yang, Mingyi Zhou, Sean Streich, Yizhi Jane Tao, Jeffrey C. Chandler, Xiu-Feng Wan
Author Correction: A porous tellurium interlayer for high-power and long-cycling garnet-based quasi-solid-state lithium-metal batteries
Ju-Sik Kim, Gabin Yoon, Yong Su Kim, Tae-Hee Kim, Sewon Kim, Jirae Kim, Junhyeong Lee, Ryounghee Kim, Myung-Jin Lee, Nobuyoshi Yashiro, Shinya Suzuki, Tetsuya Asano, Michael Badding, Zhen Song, Sung Heo
Permafrost landsystems define regional variability in climate change effects on northern environments
Steven V. Kokelj, Stephen A. Wolfe, Niels Weiss, Duane Froese, Jennifer L. Baltzer, Trevor C. Lantz, H. Brendan OâNeill, Peter D. Morse, Anastasia Sniderhan, Niek J. Speetjens, Jurjen Van der Sluijs, Alejandro Alvarez, Suzanne E. Tank, Stephan Gruber
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes
Chungsoo Kim, Fan Bu, Clair Blacketer, Anna Ostropolets, Talita Duarte-Salles, Benjamin Viernes, Thomas Falconer, Andrea Pistillo, Jing Li, Can Yin, Mui Van Zandt, Paul Nagy, Akihiko Nishimura, Evan Minty, Seng Chan You, Mitsuaki Sawano, Shoko Sawano, Ja Young Jeon, Arya Aminorroaya, Lovedeep S. Dhingra, Aline F. Pedroso, Phyllis Thangaraj, David A. Dorr, Nicole Pratt, Kenneth K. C. Man, Wallis C. Y. Lau, Daniel R. Morales, Rohan Khera, Martijn J. Schuemie, Patrick B. Ryan, George Hripcsak, Harlan M. Krumholz, Marc A. Suchard, Yuan Lu
Occlusion-activated autonomous piezoelectric implants for adaptive prevention of peri-implantitis
Annan Chen, Ke Li, Yinjin Li, Che Fan, Zhiyao Zhang, Yuanchao Liu, Jin Su, Yunsong Shi, Huachen Cui, Kai Liu, Yusheng Shi, Zhen Zhang, Chunze Yan, Jian Lu
Proviral NUP153 binding to viral proteins and RNA regulates structuralânonstructural protein ratios in orthoflavivirus infection
Marie B. A. Peters, Richard Lindqvist, Eszter Kassa, Wai-Lok Yau, Pallabi Sengupta, Isabell Niedermoser, Gisa Gerold, Nasim Sabouri, Ylva Ivarsson, Richard Lundmark, Anna K. Ăverby
Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal
Anna Oravetzova, Marketa Dvorakova, Anca-Irina Mihai, Martin Andrs, Margarita Sobol, Anton Zuev, Kaustubh Shukla, Barbora Boleslavska, Vinicio Rosano, Christiane König, Jiri Prokes, Hana Hanzlikova, Libor Macurek, Jana Dobrovolna, Pavel Janscak
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity
Garrett W. Cooper, Benjamin P. Lee, Won Jun Kim, Yongdong Su, Victor Z. Chen, Eliseo Salas, Xiaoping Yang, Robert E. Lintner, Federica Piccioni, Andrew O. Giacomelli, Thomas P. Howard, Pritha Bagchi, Karen N. Conneely, David E. Root, Bo Liang, James C. Gumbart, William C. Hahn, David U. Gorkin, Jaclyn A. Biegel, Susan N. Chi, Andrew L. Hong
A single viral enzyme drives tRNA-dependent hypermodification of DNA at adenine
Rebekah M. B. Silva, Anton Slyvka, Yan-Jiun Lee, Chudi Guan, Sean R. Lund, Elisabeth A. Raleigh, Krzysztof Skowronek, Michael S. Kuska, Matthias Bochtler, Peter R. Weigele
High-performance caffeic acid-based superhydrophilic membranes for efficient removal of microplastics-oil co-contaminants
Qin Chen, Riri Liu, Wenyi Zhang, Jiale Du, Zijian Yu, Jinhan Chen, Quan Chen, Mengni Ge, Yue Wang, Dong Han Seo, Ming Xie, Raf Dewil, Wenyuan Ye, Jiuyang Lin, Bart Van der Bruggen
In vivo CAR T cell generation using retargeted and functionalized lentiviral vectors with reduced immunogenicity
Kyrellos E. Ibrahim, Kepler S. Mears, Peter M. Allen, Jordan M. Chinai, Omar I. Avila, Audrey J. Muscato, Sarah K. Lane-Reticker, Alexander Rojas, Nelson H. Knudsen, Chun-Cheih Chao, Kathleen B. Yates, Robert T. Manguso
Retinocortical in-sensor neuromorphic vision platform for NIR-augmented artificial vision
Jong Bin An, Kyungtae Park, I. Sak Lee, Shilin Lu, Hong Gyu Park, Nam Su Heo, Yong Seon Hwang, Kyungmoon Kwak, Kyungho Park, Si Hyun Park, Jong Min Lee, Jinkee Hong, Sung Kyu Park, Hyun Jae Kim
Experimental and modeling demonstration of stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles
Layer-selective hydrogenation and proton transport in twisted bilayer graphene
J. Tong, G. Chen, H. Li, E. Hoenig, M. Alhashmi, X. Zhang, D. Bahamon, G. R. Tainton, S. Sullivan-Allsop, Y. Mayamei, D. R. da Costa, L. F. Vega, S. J. Haigh, D. Domaretskiy, F. M. Peeters, M. Lozada-Hidalgo
Structural and mechanistic basis for antibody neutralization of the measles fusion protein
Dawid S. Zyla, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer, Gillian Zipursky, Laura Di Clemente, Mare H. L. Verbruggen, Laura L. A. van Dijk, Oscar Martinez Ceh, Gabriella Jonathan-Trakht, Gavreel Kalantarov, Marissa Acciani, Giulia Laterza, Dariia Vyshenska, Cameron Leedale, Emily Pawlack, Kathryn M. Hastie, Branka Horvat, Rik L. de Swart, Rory D. de Vries, Alexander L. Greninger, Stefan Niewiesk, Erica Ollmann Saphire, Matteo Porotto
Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice
Ken Matoba, Eisuke Dohi, Phoebe A. Garcia, Jose Francis-Oliveira, Mirmohammadali Mirramezanializamini, Inssaf Berkiks, Frida Anguiano, Jana H. Badrani, Oluwaseun Fatoba, Eric Y. Choi, Julia See, Md. Sorwer Alam Parvez, Takahiro Kochi, Norimichi Ito, Rei Mitani, Indigo V. L. Rose, Takashi Imai, David K. Crossman, Mikhail V. Pletnikov, Kenneth W. Witwer, Minae Niwa, Shin-ichi Kano
Targeting IP6 signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance
Seon-gyeong Lee, Yuri Seo, Seula Jeong, Yuheon Chung, Sukyeong Kong, Minyoung Kim, Joon Ho Rhlee, Sihyeon Um, Bijoy P. Mathew, Saikat Maiti, Malleswara Rao Kuram, Mohamed Ahmed Abozeid, Areum Park, Ji-Na Yoo, Keon Woo Khim, Kyuwon Son, Enkhzul Amarsanaa, Kyunghan Kim, Sehoon Hong, Jiyeon Choi, In Bae Park, Eun A. Lee, Ji Hwan Jeon, Jun Hong Park, Joo Seok Han, Chan Young Park, Seyun Kim, Jang Hyun Choi, Sung You Hong, Min-Duk Seo, Hyuk Lee, Joo-Yong Lee, Kyungjae Myung
Probing ultrafast heating and ionization dynamics in solid density plasmas with time-resolved resonant X-ray absorption and emission
Lingen Huang, Mikhail Mishchenko, Michal Ć mĂd, Oliver S. Humphries, Thomas R. Preston, Xiayun Pan, Long Yang, Johannes Hagemann, Thea Engler, Yangzhe Cui, Thomas Kluge, Carsten Baehtz, Erik Brambrink, Alejandro Laso Garcia, Sebastian Göde, Christian Gutt, Mohamed Hassan, Hauke Höppner, Michaela Kozlova, Josefine Metzkes-Ng, Masruri Masruri, Motoaki Nakatsutsumi, Masato Ota, ĂzgĂŒl ĂztĂŒrk, Alexander Pelka, Irene Prencipe, Lisa Randolph, Martin Rehwald, Hans-Peter Schlenvoigt, Ulrich Schramm, Jan-Patrick Schwinkendorf, Monika Toncian, Toma Toncian, Jan Vorberger, Karl Zeil, Ulf Zastrau, Thomas E. Cowan
A hypothalamic circuit for circadian regulation of corticosterone secretion
Oscar D. Ramirez-Plascencia, Roberto De Luca, Natalia L. S. Machado, Dominique Eghlidi, Mudasir A. Khanday, Sathyajit S. Bandaru, Francesca Raffin, Nina Vujovic, Elda Arrigoni, Clifford B. Saper
Föhn-induced melting over Larsen C modulated by atmospheric river shape, direction and landfall location
Xun Zou, Penny M. Rowe, Irina V. Gorodetskaya, Andrew Orr, David H. Bromwich, Dan Lubin, Matthew A. Lazzara, Zhenhai Zhang, Kawzenuk Brian, Jonathan D. Wille, Jason M. Cordeira, Nicolaj Hansen, Jinxi Li, Pu Gan, F. Martin Ralph
Bacterial extracellular vesicles as recyclable nutrient reservoirs
Astrid Laimer-Digruber, Tanja V. Edelbacher, Masoumeh Alinaghi, Mia S. C. Yu, Dapi Menglin Chiang, Benedikt Kirchner, Susanne I. Wudy, Waltraud Tschulenk, Ingrid Walter, Stefan Kummer, Christina Ludwig, Jan PĆibyl, Michael W. Pfaffl, Monika Ehling-Schulz
Distinct modes of dopamine modulation on striatopallidal synaptic transmission
Youngeun Lina Lee, Maria Reva, Ki Jung Kim, Hyun-Jin Kim, Yemin Kim, Eunjeong Cho, Minseok Jeong, Youngjong Kwak, Kyungjae Myung, Yulong Li, Seung Eun Lee, Dong Pyo Jang, C. Justin Lee, Christian LĂŒscher, Jae-Ick Kim
A deep representation learning model to predict response to vagus nerve stimulation
Hrishikesh Suresh, Karim Mithani, Vicki Li, Timur H. Latypov, Nebras M. Warsi, Simeon M. Wong, Lauren Erdman, Jaeyoung Kang, Jurgen Germann, Flavia Venetucci Gouveia, Sebastian C. Coleman, Alexandre Berger, Vann Chau, Shelly Weiss, Carolina Gorodetsky, Elizabeth Donner, Alexander G. Weil, Jignesh Tailor, Taylor J. Abel, Madison Remick, Emefa Akwayena, Dewi Schrader, Robert J. Bollo, Matthew D. Smyth, Diana Aum, Sean M. Lew, Shelly Wang, Toba N. Niazi, Aria Fallah, Jeffrey S. Raskin, Howard L. Weiner, Nisha Gadgil, Gregory W. Albert, Aristides Hadjinicolaou, Philippe Major, Farbod Niazi, Guillaume Theaud, Sami Obaid, Elysa Widjaja, Birgit Ertl-Wagner, Logi Vidarsson, Margot J. Taylor, Alexandre Boutet, James T. Rutka, Melissa A. LoPresti, Puneet Jain, George M. Ibrahim
Mechanofusion-derived cathode composite microstructures with scalable mixed conducting matrix coatings for solid state batteries
Maximilian Kissel, Finn Frankenberg, Thomas Demuth, Anton Lai, Niklas Laser, Daniel Wagner, Ahmed Eisa, Peter Michalowski, Kerstin Volz, Arno Kwade, JĂŒrgen Janek
Bed nucleus of the stria terminalis connectivity during food cue and taste processing under stress
Eva Guerrero-Hreins, Matthew D. Greaves, Po-Han Kung, Bradford A. Moffat, Rebecca K. Glarin, Stuart B. Murray, Ben J. Harrison, Priya Sumithran, Robyn M. Brown, Trevor Steward
Intraocular pressure induced blood retinal barrier compromise in mouse models and human glaucoma
Chi Zhang, Haeyn Lim, Jennifer D. Ballheim, Marina SimĂłn, Rui Fu, Nicholas G. Tolman, Logan J. Horbal, Felicia A. Juarez, Qing Wang, Aakriti Bhandari, Christa Montgomery, Ling Zhu, Jonathan G. Crowston, Nicolas Robine, Michael P. Fautsch, Michael H. Elliott, Simon W. M. John
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial
Frank A. Giordano, Julian P. Layer, Roberta Turiello, Lea L. Friker, Oriol Mirallas, Barbara E. F. Pregler, Anna-Laura Potthoff, Thomas Zeyen, Johannes Weller, Elena Sperk, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Niklas SchĂ€fer, Sebastian Kadzik, Mirjam Renovanz, Torsten Pietsch, Sotirios Bisdas, Juan Manuel SepĂșlveda-SĂĄnchez, Diego GĂłmez-Puerto, Maria Vieito, Michael Platten, Eleni Gkika, Oliver M. Grauer, Ghazaleh Tabatabai, Matthias Schneider, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Nanoscale photonic artificial neuron with biological signal processing
Joachim E. Sestoft, Thomas K. Jensen, Vidar Flodgren, Abhijit Das, Rasmus D. Schlosser, David Alcer, Mariia Lamers, Thomas Kanne, Magnus T. Borgström, Jesper NygÄrd, Anders Mikkelsen
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions
Hanjun Lee, Ioanna-Maria Gkotinakou, Connor G. McGrath, Badri Krishnan, Sambhavi Animesh, Isabella Salinas, Robert Morris, Moshe Sade-Feldman, Wilhelm Hass, Michael S. Lawrence, Ioannis Sanidas
B cell immunity to the Lassa virus glycoprotein is a correlate of vaccination-induced virus control in mice
Tiago Abreu-Mota, Anna-Friederike Marx, Dorothee Winterberg, Karen Tintignac, Jonas Fixemer, Florian Geier, Nicole Brodmann, Cemre Seven, Claudia Reichmuth, Anna Lena Kastner, Min Lu, Weldy V. Bonilla, Mirela Dimitrova, Mehmet Sahin, Gert Zimmer, Matthias Peipp, Daniel D. Pinschewer
Influence of B cell-lineage targeted CAR-T cell therapy on humoral immunity and vaccine-induced antibody response
Stosh Ozog, Elizabeth M. Krantz, Karyn Tindbaek, Julian Munoz, Winnie L. Liu, Clementine Chalal, Sara Pernikoff, Khaleel Yahya, Terry Stevens-Ayers, Sayan Dasgupta, Andrew J. Cowan, Damian J. Green, Jordan Gauthier, Brian G. Till, Rebecca A. Gardner, Mazyar Shadman, Marie Bleakley, Michael Boeckh, Jim Boonyaratanakornkit, Cameron J. Turtle, Joshua A. Hill
VPS26A retromer complex and SNX27 mediate stress-induced Golgi bypass of membrane proteins
Ye Jin Kim, Chaeyoung Lee, Soo Kyung Seo, Jae Won Roh, Hye Ryung Lee, Su Jin Hwang, Nienping Chang, Hee Seong Choi, Dong Hoon Shin, Hui Kwon Kim, Han Sang Kim, Hyun-Soo Cho, Jae Myun Lee, Heon Yung Gee, Min Goo Lee, Shin Hye Noh
Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
Teodora Piskova, Aleksandra N. Kozyrina, GiedrÄ AstrauskaitÄ, Mohamed Elsafi Mabrouk, Sebastian Schepl, Stacy Lok Sze Yam, Ragul Ravithas, Wolfgang Wagner, Massimo Vassalli, Jacopo Di Russo
Non-canonical ILâ22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance
Nicolas Millet, Jinendiran Sekar, Norma V. Solis, Jian Miao, Antoine Millet, Felix E. Y. Aggor, Asia Wildeman, Melissa E. Cook, Amirhossein Davari, Brian M. Peters, Michail S. Lionakis, Sarah L. Gaffen, Nicholas Jendzjowsky, Scott G. Filler, Marc Swidergall
Next-generation inhibitors of SARS-CoV-2 Mpro overcome the deficiencies of Paxlovid
Gan Luo, Gang Wang, Chongbing Liao, Baisen Zhong, Lianfeng Fan, Jue Zhang, Jie Rao, Junjie Zhang, Ziqiao Wang, Man Luo, Yan Yan, Lu Lu, Wei Xu, Fan Wu, Xihui Gao, Wuyuan Lu
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers
Hayden A. Malone, Jacquelyn A. Myers, Emma G. Gruss, Marc A. Morgan, Jake D. Friske, Tabitha C. McCarty, John J. Navarro, Sarah Robinson, Rebecca L. Halliburton, Sandra J. Kietlinska, Francisca N. De Luna Vitorino, Baranda S. Hansen, Shondra M. Pruett-Miller, Benjamin A. Garcia, Martine F. Roussel, Janet F. Partridge, Charles W. M. Roberts
Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials
Carolyn Williamson, Chivonne Moodley, Craig A. Magaret, Elena E. Giorgi, Morgane Rolland, Dylan H. Westfall, Anna Yssel, Wenjie Deng, Raabya Rossenkhan, Nonhlanhla N. Mkhize, Lennie Chen, Hong Zhao, Tanmoy Bhattacharya, Alec Pankow, Ben Murrell, Talita York, Asanda Gwashu-Nyangiwe, Nonkululeko Ndabambi, Ruwayhida Thebus, Paula Cohen, Bronwen Lambson, Haajira Kaldine, Sinethemba Bhebhe, Michal Juraska, Hongjun Bai, Allan C. deCamp, Maurine D. Miner, James Ludwig, Cindy Molitor, Nicolas Beaume, David Matten, Yunda Huang, Lily Zhang, Daniel B. Reeves, Bryan Mayer, Shelly T. Karuna, John A. Hural, Lynn Morris, David Montefiori, Roger E. Bumgarner, Penny L. Moore, Paul T. Edlefsen, Srilatha Edupuganti, Nyaradzo Mgodi, M. Juliana McElrath, Myron S. Cohen, Lawrence Corey, Peter B. Gilbert, James I. Mullins
Multiplexed back focal plane imaging with on-chip integrated microlens array
Magdalena Furman, Marcin MuszyĆski, PrzemysĆaw Oliwa, Ćukasz Zinkiewicz, Aleksander Bogucki, Jacek Szczytko, Piotr Wasylczyk, Wojciech Pacuski, Mateusz KrĂłl, Barbara PiÄtka
Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial
Li-Chuan Zheng, Kelvin K. W. Wong, Stephen S. Y. Lam, Garret M. K. Leung, Chenqinyao Li, Kwui-Wa Tong, Wing Lam, Xiao-yuan Zeng, Koon-Chuen Chan, Natalie Nok-Man Chan, Ka-Lam Ng, Chee-Chean Dang, Tsz-Ho Kwok, Sze-Pui Tsui, Rakesh Sharma, Jason W. H. Wong, Suet-Yi Leung, Anskar Y. H. Leung, Cheuk-Him Man
A conversational multi-agent AI system for automated plant phenotyping
Feng Chen, Ilias Stogiannidis, Andrew Wood, Danilo Bueno, Dominic Williams, Fraser Macfarlane, Bruce D. Grieve, Darren Wells, Jonathan A. Atkinson, Malcolm J. Hawkesford, Stephen A. Rolfe, Tracy Lawson, Tony Pridmore, Sotirios A. Tsaftaris, Mario Valerio Giuffrida
Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks
Paris Mazzachi, Ella McDonald, Zarina Greenberg, Alejandra Noreña Puerta, Jenne Tran, Manam Inushi De Silva, Cade Christensen, Robert Adams, Sebastian Loskarn, Helen Beard, Michael Zabolocki, Meera Elmasri, Megan Maack, Kristina L. Elvidge, Mark R. Hutchinson, Cara OâNeill, Kim M. Hemsley, Lisa Melton, Nicholas Smith, Cedric Bardy
Subglacial water flow and ice dynamics during glacial lake outburst floods observed from space
EyjĂłlfur MagnĂșsson, Vincent Drouin, Finnur PĂĄlsson, TĂłmas JĂłhannesson, JoaquĂn M. C. Belart, Jan Wuite, Valentyn Tolpekin, Krista HannesdĂłttir, Etienne Berthier, Gunnar Sigurðsson, Bergur Einarsson, Benedikt G. Ăfeigsson, Thomas Nagler, MagnĂșs T. Gudmundsson, ThĂłrdĂs HögnadĂłttir
Genomic analysis of T Cell receptors reveals lynch syndrome specific immune signatures
Nan Deng, Fahriye Duzagac, Ana M. Bolivar, Laura Reyes-Uribe, Melissa W. Taggart, Selvi Thirumurthi, Luigi Ricciardiello, Patrick M. Lynch, Y. Nancy You, Scott Kopetz, Paul Scheet, Gregory A. Lizee, Alexandre Reuben, Fatima Marin, Marta Pineda, Krishna M. Sinha, Ajay Bansal, Gabriel Capella, Eduardo Vilar
Daratumumab in high-risk MGUS and low-risk smoldering myeloma: results of the Phase II D-PRISM study
Omar Nadeem, Michelle P. Aranha, Robert A. Redd, Michael Koontz, Jeffrey V. Matous, Andrew J. Yee, Jeffrey A. Zonder, Andrew Kin, Sophie Magidson, Elizabeth D. Lightbody, Ting Wu, Floris Chabrun, Jean-Baptiste Alberge, Ankit K. Dutta, Jacqueline Perry, Ashlee Sturtevant, Mahshid Rahmat, Junko Tsuji, Christine Davie, Caroline Ricciardi, Frances Arters, Marjorie Marto, Amy Bergeron, Jacalyn Rosenblatt, Elizabeth K. OâDonnell, Tarek H. Mouhieddine, Lorena Pantano, Jacob P. Laubach, Paul G. Richardson, Gad Getz, Lorenzo Trippa, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial
Hemostatic Tough Adhesives seal tissue and control hemorrhage
Daniel O. Kent, Phoebe S. Kwon, Kyle C. Wu, Matthew Torre, Hamza Ijaz, Favour Omafuvwe Obuseh, Brittany Pattison, Arthur Nedder, Francis McGovern, Jeremy Cannon, David J. Mooney, Benjamin R. Freedman
African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children
John Muthii Muriuki, Alexander J. Mentzer, Gavin Band, Amanda Y. Chong, Alex W. Macharia, Reagan M. Mogire, Kelvin Mokaya Abuga, Ruth Mitchell, James J. Gilchrist, Emily L. Webb, Francis M. Ndungu, Laura M. Raffield, Lynette Ekunwe, Amy R. Bentley, Sodiomon B. Sirima, Shabir A. Madhi, Adrian V. S. Hill, Andrew M. Prentice, Philip Bejon, Gibran Hemani, George Davey Smith, Manjinder S. Sandhu, Alison M. Elliott, Thomas N. Williams, Adebowale Adeyemo, Sarah H. Atkinson
Social interaction processing and theory of mind (ToM) frequently co-occur, but their commonalities and distinctions at behavioral and neural levels remain unclear. Participants ( N = 231) provided moment-by-moment ratings of four text and four audio narratives on social interactions and ToM engagement, which were reliable (split-half r = 0.98 and 0.92, respectively) but only modestly correlated ( r = 0.32). In a second sample ( N = 90), we analyzed the co-variation between social interaction and ToM ratings and fMRI activity during text and audio narratives. Activity maps associated with social interaction processing and ToM generalized across text and audio (spatial r = 0.60 and 0.58, respectively) and overlapped in canonical ToM regions (FDR q < 0.01). ToM uniquely engaged the anterior intraparietal sulcus, right lateral occipitotemporal cortex, and right supplementary motor area. These results suggest that observing social interactions automatically engages canonical ToM regions, even without explicit mentalizing, and ToM additionally engages brain regions related to action understanding.
Assessing European cities with the 3-30-300 rule underscores the need for enhanced urban greening efforts
L. E. Bertassello, M. van der Velde, J. Maes, S. Liu, M. Brandt, L. Feyen
Urban green spaces are fundamental to sustainable city living, providing essential temperature regulation and social well-being. However, rapid urbanization often threatens these areas, exacerbating socio-economic disparities in access. This study evaluates adherence to the 3-30-300 rule - a guideline advocating for three trees visible from every home, 30% neighborhood canopy cover, and a park within 300 meters - across 862 European cities. Here we show that less than 15% of the studied population lives in full accordance with these criteria, while 21% reside in areas that do not meet any of the three benchmarks. Our analysis reveals strong vegetation inequalities, where higher levels of urban greenness are consistently associated with wealthier settlements. These findings indicate that most European cities currently fall short of providing equitable access to nature, underscoring an urgent need for a paradigm shift in urban planning to sustainably and equitably address the demands of growing populations.
Horticultural intensification and plant-based diets of 18th century CE Waikato MÄori in Aotearoa New Zealand
Rebecca L. Kinaston, Sian Keith, Beatrice Hudson, Jonny Geber, Torsten Kleffmann, Claudine Stirling, Malcolm Reid, David Barr, Robyn Kramer, Emma Sudron, , Marina Hape, Piripi Matika, Harry Wilson, Simon Anderson, Sonny Karena, Rongopai Heta, Moko Tauariki, Ikimoke Tamaki-Takarei
Erratum for the Research Article âEnhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemiasâ by Y. Nishida et al .
Erratum for the Research Article âTracking bioturbation through time: The evolution of the marine sedimentary mixed and transition layersâ by L. Tarhan et al .
Erratum for the Research Article âTIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1â by M. Hossain et al .
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
Masa A. Shimazoe, Jan Huertas, Charles Phillips, Satoru Ide, Sachiko Tamura, Stephen Farr, S. S. Ashwin, Masaki Sasai, Rosana Collepardo-Guevara, Kazuhiro Maeshima
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Sarah J. Shemtov, Eric McGann, Lucy Carrillo, Sangmin Lee, Herbert Anson, Eric Hwang, Claire S. Chung, Jaye L. Weinert, Maria-Eleni Anagnostou, Guan-Ju D. Lai, Bert M. Verheijen, Junxiang Wan, Ivetta Vorobyova, Monica Sanchez-Contreras, Cheryl A. Conover, Max A. Thorwald, Pinchas Cohen, Scott R. Kennedy, Jean-François Gout, Suraiya Haroon, Marc Vermulst
Regulation of mitochondrial ROS by C15ORF48 in a basal cell subpopulation contributes to chemotherapy resistance in TNBC
Yan Jiang, Noor M. Abdulkareem, Amanda L. Rinkenbaugh, Yuan Qi, Steven W. Wall, Xiaomei Zhang, Jiansu Shao, Sabrina Jeter-Jones, Shirong Cai, Faiza Baameur Hancock, Gloria V. Echeverria, Jeffrey T. Chang, Helen Piwnica-Worms
Tunable high-efficiency microwave photon detector based on a double quantum dot coupled to a superconducting high-impedance cavity
Fabian Oppliger, Wonjin Jang, Aldo Tarascio, Franco De Palma, Christian Reichl, Werner Wegscheider, Ville F. Maisi, Dominik ZumbĂŒhl, Pasquale Scarlino
A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer
Tenzin Ngodup, Brynn Elson, Ashley M. Mello, Sean Hannifin, Miranda Liu, Yaqing Zhang, Jiaqi Shi, Yatrik M. Shah, Daniel A. Lawrence, Marina Pasca di Magliano, Kyoung Eun Lee
Inertial sensing of water content in tumor spheroids
Georgios Katsikis, Jennifer C. Yoon, Thomas R. Usherwood, Seth Malinowski, Jiaquan Yu, Chuyi Chen, Sukbom Son, Julie L. Sutton, Keith L. Ligon, Jungchul Lee, Teemu P. Miettinen, Scott R. Manalis
As above, not so below: Ion fractionation in planetary analog ices
Jacob J. Buffo, Mark G. Fox-Powell, Andrii Murdza, Tara C. Tomlinson, Alexa Schultz, Timothy Barton, Caroline Gurd, Angus McEwen, Natalie S. Wolfenbarger, Chase J. Chivers, Britney E. Schmidt, Colin R. Meyer
Vasculogenic tissue nanotransfection accelerates functional recovery after peripheral nerve injury
Ana I. Salazar-Puerta, Sara Kheirkhah, Jonathan P. Stranan, Hallie Harris, Nada Khattab, Megumi Fukuda, Grant Barringer, Carlos A. Vasquez-Martinez, Samuel Cortes, Neil Ott, William R. Lawrence, Devleena Das, Jordan T. Moore, Tiam M. Saffari, Juan D. Salazar-Gil, Diego Alzate-Correa, Junyan Yu, Kavya Dathathreya, Natalia Higuita-Castro, Tatiana Z. Cuellar-Gaviria, W. David Arnold, Amy M. Moore, Daniel Gallego Perez
The optical nose: Monolayer sensitization of Au surfaces for plasmonic gas sensing
Elle W. Wyatt, Sarah May Sibug-Torres, Marika Niihori, James W. Beattie, Tabitha Jones, Nicolas Spiesshofer, Jana Hofmann, Bart de Nijs, Jeremy J. Baumberg
From vibrations to function: Spectroscopic detection and quantification of Ï-Ï stacking in drug-responsive protein complexes
Narangerel Altangerel, Esther J. Ocola, Benjamin W. Neuman, Vladislav V. Yakovlev, Syuan-Ting Kuo, Veerabhadra Reddy Vulupala, Kaustav Khatua, Hanyuan Zhang, Xin Yan, David H. Russell, Shiqing Xu, Carol A. Fierke, Wenshe Ray Liu, Alexei V. Sokolov, Philip R. Hemmer, Marlan O. Scully
Ancient genomes reveal an extensive kinship network and endogamy in a Three-Kingdoms period society in Korea
Hyoungmin Moon, Daewook Kim, Alina N. Hiss, Don-Nyeong Lee, Juhyeon Lee, Eirini Skourtanioti, Guido Alberto Gnecchi-Ruscone, Johannes Krause, Eun Jin Woo, Choongwon Jeong
Land subsidence on Java Island and its contributions to relative sea level change
Leonard O. Ohenhen, Manoochehr Shirzaei, Praveen Kumar, Arif Aditiya, Ashutosh Tiwari, James L. Davis, Folarin Kolawole, Estelle Chaussard, Nitheshnirmal Sadhasivam, Oluwaseyi Dasho, Wen Zhong, Roselyn H. James, Samuel Daramola, Robert J. Nicholls, Philip S.J. Minderhoud
B cells enable autoreactive T cells to avoid suppression
Matthew Funsten, Renee de Pooter, Vineeth Varanasi, Michael Burrows, Katharine Block, Andrey Kuznetsov, David Serreze, Haochu Huang, Alexander Chervonsky
Probing rock rupture with naturally occurring nuclide signals
Jia-Qing Zhou, Rong Mao, Xin Luo, M. Bayani Cardenas, Yi-Feng Chen, Fu-Shuo Gan, Chuang-Bing Zhou, Changdong Li, Huiming Tang, Ran Hu, Zhibing Yang, Michael Manga
MDFIC2 is a sensory neuronâspecific PIEZO channel auxiliary subunit
Zijing Zhou, Fei Dai, Delfine Cheng, Xiaonuo Ma, Seyedeh Farzaneh Omidkhoda, Jack Clarke, Huijing Zhang, Michael Laden, Yang Guo, Jinyuan Vero Li, Renjing Liu, Emily S. Wong, Yixiao Zhang, Charles D. Cox
Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa
Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim, Rachel H. Cohen, Brittany D. Gomez, Rebecca L. Roer, Faiz Minhajuddin, Kiranmayee Yenugudhati Vijaya Sai, Liheng Zhou, Julia L. M. Dunn, Caleb Chandler, Philip Reigan, Ian M. Cartwright, Caroline H. T. Hall, Geetha Bhagavatula, Joseph C. Onyiah, Alexander S. Dowdell, Sean P. Colgan
Jiyeon Ha, Parul Sharma, Sammi Ta, Senko Tsukuda, James M. Harris, Rebekah Penrice-Randal, Eleanor Bentley, Adam Kirby, Daniele F. Mega, David A. Matthews, Peter Balfe, Jan Rehwinkel, Anja Kipar, James P. Stewart, Jane A. McKeating, Peter A. C. Wing
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis
Lucien P. Garo, Kevin Brueck, Sarah Walachowski, Archana Jayaraman, Marcel Strueve, Shuang Xu, Hulbert Yang, Matthew Helmkamp, Seung Hoan Choi, Christoph Reinhardt, Markus Bosmann
Cosmic rayâdriven electron-induced reaction theory does not quantify spatiotemporal variations in lower-stratospheric ozone and temperature
Sophie Godin-Beekmann, Martyn P. Chipperfield, Rolf MĂŒller, Jessica L. Neu, Paul A. Newman, Michelle L. Santee, Susan Solomon, David Tarasick, Anne M. Thompson, Zihao Wang
The influence of electrical charge on plasmodesma conductivity
Alexander H. Howell, Vincent James, Anneline H. Christensen, Viktoriya V. Vasina, Kaare H. Jensen, James Foley, James E. Evans, Howard A. Stone, Winfried S. Peters, Michael Knoblauch
SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response
Nicholas A. Parenti, Renee Cusic, David M. Renner, Nathaniel Jackson, Chengjin Ye, Li Hui Tan, Jessica J. Pfannenstiel, Anthony R. Fehr, Noam A. Cohen, Luis Martinez-Sobrido, James M. Burke, Susan R. Weiss
Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability
Sergio LĂłpez, Roberto Elizondo-Vega, Vinka AzĂłcar, Vania SepĂșlveda, Valentina Opazo-Mellado, Walter VĂĄsquez, Juan C. SĂĄez, Ricardo C. Araneda, MarĂa de los Ăngeles GarcĂa-Robles
AI-derived therapeutic development of a serotonin receptorâtargeting drug for the treatment of opioid use disorder
Valeria Lallai, Samuel Kho, A. C. Martin, James P. Fowler, Madison L. Roach, Kevin Wang, Kendyl N. Laumann, Tyler G. Morrison, Mina Palaniappan, Malia Bautista, Allison S. Mogul, Jinjutha E. Cheepluesak, Bijay Shrestha, Dhanaji M. Lade, Julia E. Lagomarsino, Vaishnavi Narayan, Jayson Uffens, Waldemar Lernhardt, Saman Mirzaei, Ian Jenkins, Arturo R. Zavala, Jonathan R. T. Lakey, Robert Tinder, Christie D. Fowler
Reconstruction of human metabolic models with large language models
Jiahao Luo, Hao Wang, Devlin Moyer, Zhetao Guo, Jonathan L. Robinson, Johan Gustafsson, Mihail Anton, Yu Chen, Eduard J. Kerkhoven, Jens Nielsen, Feiran Li
A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen
Alexander J. McClelland, Bin Hu, Yuantao Xu, Xiaodong Fang, Chunxia Wang, Benjamin L. Koch, Amelia H. Lovelace, Eva Hawara, Yuanchun Wang, Zhiqian Pang, Agustina De Francesco, Suzanne P. van Wier, Andrew M. Beekman, Amit Levy, Nian Wang, Renier A. L. van der Hoorn, Qiang Xu, Wenbo Ma
Senderâreceiver subdivisions of the default mode network in perceptual and memory-guided cognition
Meichao Zhang, Casey Paquola, Katya Krieger-Redwood, Brontë Mckeown, Charlotte Murphy, Chang Liu, Daniel S. Margulies, Robert Leech, Jonathan Smallwood, Elizabeth Jefferies
Deep learningâenabled scaffolding of spatial arrays of PfCSP epitopes
Nelson R. Wu, Karla M. Castro, Nathan Beutler, Wen-Hsin Lee, Sai S. R. Raghavan, Gregory M. Martin, Monika Jain, Sashank Agrawal, Alessia Liguori, Oleksandr Kalyuzhniy, Patrick D. Skog, Sierra Terada, Yen-Chung Lai, Justin Ndihokubwayo, Danny Lu, Saman Eskandarzadeh, Nushin Alavi, Nicole Phelps, Ryan Tingle, John E. Youhanna, Sonya Amirzehni, Thomas F. Rogers, Dennis R. Burton, Ian A. Wilson, Andrew B. Ward, Bruno E. Correia, William R. Schief
BpFLC coordinates seasonal and age-related flowering in Betula platyphylla through environmental cues and epigenetic regulation
Yi Liu, Sui Wang, Tangchun Zheng, Huiying Suo, Di Xiao, Dong Zeng, Xiangling You, Heike W. Sederoff, Vincent L. Chiang, Xiyang Zhao, Ronald R. Sederoff, Guanzheng Qu
Sanjana Eyunni, Shih-Chun Chu, Mary L. Guan, Michaela Louw, Eleanor Young, Sandra E. Carson, Jianhui Gong, Marcin Cieslik, Arul M. Chinnaiyan, Abhijit Parolia
Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1
Stephanie Tanis, Leah E. Simon, Adriana K. Alexander, Tegan S. Horan, Maria de las Mercedes Carro, Samantha Jane Bonnett, Audrey Xie, Roni Ben-Shlomo, Connor E. Owens, Charles G. Danko, Jelena Lujic, Paula E. Cohen
Hydraulic stress limits thermal acclimation in trees under chronic drought
Alyssa T. Kullberg, Arianna Milano, Alvaro Poretti, Yike Ma, Patrick Favre, Kate M. Johnson, Giovanni Bortolami, Maxwell Bergström, Thibaut Juillard, Jin Wu, Zhengfei Guo, Jonas Gisler, Marcus Schaub, Charlotte Grossiord
Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test
Weihua Zeng, Chun-Chi Liu, Shuo Li, Yonggang Zhou, Mary L. Stackpole, Ying Xiao, Ran Hu, Caitlin Tang, Qiao Liu, Wanwen Zeng, Angela Yeh, Andrew Melehy, Benjamin Tran, Zorawar Noor, Megumi Yokomizo, Dominic Amara, Shreya Gumate, Preeti Ahuja, David Yuanze Li, Junting Zhao, Inga Rose, Cattlena Walker, Sadaf Malik, Yazhen Zhu, Hsian-Rong Tseng, Edward B. Garon, Samuel W. French, Clara E. Magyar, Sarah M. Dry, Clara M. Lajonchere, Daniel Geschwind, Gina Choi, Sammy Saab, Akshay Shetty, Carrie R. Wong, Kevin G. King, David S. Lu, Steven S. Raman, Xiyan Xiang, Kirti Shetty, Lopa Mishra, Sanaz Memarzadeh, Yan Liu, Frank Albe, William Hsu, Kostyantyn Krysan, Steven M. Dubinett, Denise R. Aberle, Vatche Agopian, Steven-Huy B. Han, Wing Hung Wong, Xiaohui Ni, Wenyuan Li, Xianghong Jasmine Zhou
Reefense: Living shoreline mosaics can achieve ecological and engineering outcomes with interdisciplinary design
Rebecca L. Morris, Jaden E. Akers, Sandra Casas, Justin Geldard, Alex Goad, Marco Ghisalberti, Ximing Guo, Reid Holland, Hongyue Jin, Kelly M. Kibler, Danielle Kreeger, Brendan S. Lanham, Jerome F. La Peyre, Ryan J. Lowe, Cynthia E. M. Lupton, Hani Nassif, William Mather, Andrew W. M. Pomeroy, Ella Rothermel, Michael Ruszala, Madhuwanthi Rupasinghe, F. Scott Rikard, Richard E. Riman, Rackel San Nicolas, Jenny P. Shinn, Prashansa Shrestha, Eric L. Sparks, Stephen E. Swearer, Jyotismita Taye, Nigel A. Temple, Manisha N. Thenuwara, Peter B. Vien, Zhenwei Wang, Mason L. Williams, David Bushek
Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection
Masao Hashimoto, Tahseen H. Nasti, Hyun-Tak Jin, Melissa Bu, Koichi Araki, Junghwa Lee, Rajesh M. Valanparambil, Akil Akhtar, Mohammad Affan Khan, Zhipeng Peng, Yinghong Hu, Daniel T. McManus, Ilham Bahhar, Andreas Wieland, Carl W. Davis, Suresh S. Ramalingam, Arlene H. Sharpe, Jeffrey V. Ravetch, Gordon J. Freeman, Rafi Ahmed
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases
Yuhua Tian, Soohyeon Bae, Xuesong Wu, Kyle C. Rouen, Adriana HernĂĄndez-Gonzalez, Yanxiao Han, Abdullah Al Tekreeti, Simon Vu, Irene Chen, Ellen Li, Igor Vorobyov, Vladimir Yarov-Yarovoy, Byung-Chang Suh, Samuel T. Hwang, Jie Zheng
The global decline in satisfaction with democracy, as measured in surveys, is sometimes used as evidence of democracyâs precarious health. However, existing evidence on the link between democratic attitudes and behaviors is mostly based on self-reported behaviors or country-level comparisons. We study the link between satisfaction with democracy and democratic behaviors at the individual level with original data consisting of 50,000+ surveys of Mexican citizens matched with individual-level administrative information about three democratic behaviors: attendance to poll worker training, staffing a polling station on Election Day, and turning out to vote a year later. We find that survey-measured dissatisfaction with democracy predicts lower democratic engagement on all three behaviors. Our findings suggest that the global decline in survey-measured satisfaction with democracy is indeed cause for concern.
The rhythm of aging: Stability and drift in the individual rate of senescence
Human aging is marked by a steady rise in the risk of dying with ageâa process demographers call senescence. Over the past century, life expectancy has risen dramatically, but is this because we are aging slower, or simply starting it later? Vaupel hypothesizes that the pace at which individuals age may be constant, with gains in longevity coming from the delayed onset of senescence rather than its slowing down. We test this idea using a framework that decomposes the pace of senescence into three components: a biological baseline, a long-term trend, and the cumulative impact of period shocks. Applying this to cohort mortality data above age 80 from 12 countries, we find that once period shocks are accounted for, there is no statistical evidence of a long-term trend, consistent with Vaupelâs hypothesis. Analyses using lower starting ages yield the same qualitative conclusion. Rather than indicating a change in the process that drives senescence, these variations are consistent with echoes of shared historical events. These results suggest that while longevity has shifted, the rhythm of human aging may be conserved.
Reconsideration of Secure Communities rollout reveals preemptive local-federal cooperation in immigration enforcement
Cesar D. Vargas Nunez, Sakshina Bhatt, Basil F. Seif, Fernando S. Mendoza, David D. Laitin, Asad L. Asad
Qualitative studies on local police collaborations with federal immigration enforcement authorities reveal risks to the well-being of noncitizens, particularly the undocumented, and their families and communities. Yet statistical evidence of these policiesâ effects is mixed. We propose that quantitative studies may misidentify the timing of when these policies begin disrupting immigrant communities by relying on a policyâs formal enactment date to indicate its activation. We test this proposal in the context of Secure Communities, a federal program with a staggered rollout that asked local police to detain noncitizens they arrested for possible transfer into Immigration and Customs Enforcement (ICE) custody and deportation. Individual states signed a Memorandum of Agreement (MOA) with the federal government as a framework for their county-by-county activation of Secure Communities. Counties were not required to activate immediately; their formal enactment frequently occurred later when prompted by ICE. We find that the date when a state signed an MOA consistently predicts a countyâs increased probability of receiving ICE requests to hold noncitizens in detention, transferring detained noncitizens into ICE custody, and removing noncitizens from the country. This relationship operates most strongly in counties with preexisting enforcement infrastructure between local police and federal immigration authorities. By contrast, while we find that enactment dates are associated with increases in each outcome, pretreatment trends render these relationships statistically indeterminate. Our results highlight how multilayered relationships between local and federal authorities allow for policing to be used as a tool for facilitating the preemptive implementation of immigration enforcement across the country at the expense of noncitizens and their families and communities.
From female to female: Communication via chemosignals
Susanne Nehls, Elena Losse, Issa Salloum Sleibi, Maya Armin, Ute Habel, Natalia Chechko
In many species, chemosensory cues convey important information about reproductive status, but their role in shaping social interactions among women is less understood. Here, we combined functional neuroimaging with behavioral measures to test how chemosignals from women at different reproductive stages [menstruation, ovulation (OV), and early pregnancy (PRG)] affect social perception in female recipients across their own menstrual cycle. Chemosignal donors were screened and tracked for cycle phase (n = 59) and pregnancy status (n = 36). Female functional MRI participants (n = 33) completed a single-blind within-subject crossover design with two sessions, one during menstruation and one during ovulation. The participants rated attractiveness, desired proximity, and pregnancy status of standardized female faces while being unknowingly exposed to the axillary chemosignals. Neuroimaging analyses showed OV chemosignals to elicit greater activation across frontal, parietal, temporal, and subcortical regions, including the temporoparietal junction, insula, hippocampus, hypothalamus, and basal ganglia. PRG chemosignals were associated with more circumscribed responses, particularly in the prefrontal and cingulate areas. These effects were modulated by the recipientâs own cycle phase, with broader networks being engaged during ovulation than menstruation. Behaviorally, the participants maintained a greater distance from faces paired with PRG but approached them more closely during their own ovulation. Attractiveness ratings and pregnancy categorizations were unaffected by chemosensory condition or cycle phase. Together, these findings demonstrate that subtle chemosensory signals shape female social cognition in a cycle-dependent manner, highlighting an adaptive mechanism by which chemosensory cues guide competition, vigilance, and affiliation without necessarily altering explicit judgments.
Refugee labor market integration at scale: Evidence from Germanyâs fast-track employment program
Jens Hainmueller, Moritz Marbach, Dominik Hangartner, Niklas Harder, Ehsan Vallizadeh
Governments face persistent challenges in integrating refugees into the local labor market, and many past interventions have shown limited impact. This study examines the Job-Turbo program, a large-scale initiative launched by the German government in 2023 to accelerate employment among refugeesâprimarily individuals from Ukraine and eight other major countries of origin. Using monthly administrative panel data from Germanyâs network of public employment service offices and a difference-in-differences design, we find that the program significantly increased both caseworkerârefugee contact and job placements over a 23-mo follow-up period. Among Ukrainian refugees, the exit-to-job rate nearly doubled. Effects were broad-basedâspanning demographic subgroups, unemployment durations, skill levels, regions, and local labor-market conditionsâand were concentrated in regular, unsubsidized employment. The program also raised both the rate and share of placements followed by sustained employment, consistent with improved placement quality. Other refugee groups saw meaningful gains as well, but increases in job placements were concentrated among males and in low-skilled jobs, with only limited effects for females. We detect no negative spillovers on contact rates or exit-to-job rates for unemployed German or other immigrant job seekers, finding no evidence of resource reallocation or displacement. The results offer insights for governments responding to displacement crises. They indicate that intensified job-search assistanceâembedded within the early stage of integration and implemented at scale through public employment infrastructureâcan meaningfully improve refugeesâ labor-market outcomes, even amid significant arrivals.
Estimating returns to education using the genetic lottery
Tarjei Widding-Havneraas, Perline A. Demange, Henrik Daae Zachrisson, Nicolai Borgen, Eivind Ystrom, Felix Elwert
Does more schooling cause higher lifetime earnings? Social scientists have long sought to determine the economic returns to schooling given its importance to individual life chances and public policy. Prior estimates are limited by unobserved confounding in observational studies and the focus of popular quasi-experimental studies on increases in schooling at only one particular age. Genotyped data offer an opportunity to address unobserved confounding and to estimate the returns to an additional year of schooling at any age by using quasi-randomly assigned genetic variants related to education as instrumental variables [Mendelian randomization (MR)]. We analyze comprehensive Norwegian population registries with career-long earnings data and genotyped data from the Norwegian Mother, Father and Child Cohort Study (MoBa). We employ three identification strategies for triangulation: ordinary least squares (OLS) with covariate-adjustment, sibling and twin fixed-effects models, and MR. Estimated returns to schooling are 8.0% in MR (N = 109,800) and 6.3% in sibling-MR (N = 18,666). Extensive sensitivity analyses suggest that MR results are robust even to large potential violations of MR assumptions, including pleiotropy. MR estimates somewhat higher returns than OLS for the full population (5.9%, N = 1,255,604) and fixed-effects models for siblings (5.3%, N = 966,976) or monozygotic twins (3.2%, N = 2,630). The estimated internal rate of return to schooling exceeds opportunity costs of education as proxied by the market interest rate. The lifetime returns to schooling are positive and substantial across all models.
Chinaâs demographic dividend has moved from age-based labor supply to skill-based productivity
Hengyu Gu, Yingju Wu, Guillaume Marois, Wolfgang Lutz, Tianlong Niu
Accelerated global population aging challenges conventional economic growth paths. Yet, the mechanisms underlying the transition from the age-based demographic dividend, derived from a favorable age support ratio (ASR), to a skill-based dividend, driven by human capital accumulation, remain insufficiently understood. Using population census data for 336 Chinese cities from 2000 to 2020, we develop a task-based skill ratio (TSR) index to quantify the skill composition of local labor markets, capturing the relative intensity of high- and low-skill tasks within city-level employment structures. We identify a divergence trend where the ASR peaked around 2010 and has since declined, while the TSR has continued to rise and diffuse geographically. We further examine a synergistic effect between ASR and TSR on economic growth and project the compensatory TSR required under alternative demographic scenarios to 2100. It shows that both ASR and TSR positively affect the per capita GDP of a city, but the latter plays a dominant role. A higher ASR amplifies the economic returns to TSR, with the old-age support ratio (OSR) as the binding constraint. Projections indicate that delayed retirement can partly alleviate the effects of the ASR decline, but cannot reverse the long-term trend. Continued improvement in the TSR is therefore necessary to offset this structural demographic shift. Economic growth relies less on favorable age structures and increasingly depends on the skill composition of the workforce, making skill upgrading central to sustained prosperity.
Building courage, strength, and knowledge: Mindfulness training reduces psychological threat and increases engagement in college physics
Tessa M. Benson-Greenwald, Avital Pelakh, Michael J. Tumminia, Sara Jahanian, Michael S. Diamond, Eric Kuo, Melanie Good, Timothy J. Nokes-Malach, Brian M. Galla
Many college students experience introductory physics as psychologically threatening. In a preregistered RCT, we applied the biopsychosocial model of challenge-threat to describe patterns of threat in introductory physics and test whether a 5-d mindfulness training could reduce threat and increase engagement among undergraduates. Course-wide surveys (N = 954) screened students for the RCT and revealed roughly half of students experience psychological threat. Students identified with systemically excluded groups were more likely to experience psychological threat while systemically advantaged students were more likely to experience psychological challenge in their introductory physics course. In the RCT (N = 149), mindfulness training reduced psychological threat and fostered greater engagement in introductory physics, and, consistent with our theory of change, mindfulness training was associated with greater physics engagement through reductions in threat. The results demonstrate that mindfulness can help students manage stress more effectively by reducing psychological threat and fostering engagement in contexts like introductory physics.
Standard EF tasks can still have predictive validity within diverse cultural contexts
SoFAIR Dataset - A multidisciplinary dataset of research papers annotated with software mentions
Cezary RosiĆski, Ewa Rudnicka, David Pride, Alain Monteil, Marcin Oleksy, Luca Foppiano, Martin DoÄekal, Matteo Cancellieri, Samuel Scalbert, Laurent Romary, Tomasz Umerle, Petr Knoth
A distribution-wide dataset of Atlantic walrus terrestrial haul-out sites
Hannah C. Cubaynes, Cory J. D. Matthews, Eva Garde, Maria Gavrillo, Mads Peter Heide-JĂžrgensen, Jeff W. Higdon, Kit M. Kovacs, Margarita Leskova, Christian Lydersen, Boris Solovyev, Alejandra Vergara-Pena, Peter T. Fretwell
This study gathered evidence on the state of primary schools in Sokoto State, Nigeria, in 2018 and 2019. The datasets contain two survey waves of a sample of 128 primary schools. Data was collected during unannounced visits to each school using several survey tools, including an observational survey of the school, interviews with the headmaster, teachers, and school-based management committee members. Topics covered in the interviews include school characteristics, the financial situation of the school, cooperation between stakeholders, the role of the school-based management committee, teaching methods, and absenteeism. While the data was primarily collected for the purpose of the evaluation of a school development programme, it can also be used to understand the state of primary schools in Sokoto, Nigeria.
REST, Exploring Sleep Patterns and Influencing Factors in Elite Female Football Athletes
Matthias Boeker, Andreas Alexandersen, Vajira Thambawita, Cise Midoglu, Dag Johansen, Michael A. Riegler, PÄl Halvorsen
This paper presents a novel dataset of 21 elite female football athletes comprising 17 days of actigraphy, well-being, caffeine consumption, screen time, and a daily hand strength test. This dataset aims to provide a comprehensive understanding of the interplay between lifestyle factors, sleep, and athletic performance. Sleep is a crucial process for physical and mental recovery, memory retention, and brain development. The quality of athletesâ sleep is significantly impacted by factors such as rigorous training schedules, stress, light exposure, and caffeine consumption. By examining these factors in detail, this dataset can aid in the development of personalised training models that take into account each athleteâs individual sleep patterns and recovery phases. Such an approach aims to optimise training and recovery strategies to improve athletesâ overall performance and well-being.
Bridging the Gap in Chinese Legal Conflict Review: A Dataset, Benchmark Tasks, and Framework
Siwen Zhao, Yunnuo Xu, Zhe Chen, Feng Qiao, Hailong Chen, XiaoRui Li, Sen Lin, Zhonghang Ji, Yujun Li, Wei Wang