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Science abstract < 200 char.: Not a research
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Paige D. Diamond, Paul V. Sauer, Mikael Holm, Canessa J. Swanson-Swett, Lucas Ferguson, Natalie M. Bratset, Grant W. Wienker, Justin Seiwert Sim, Hailey K. Adams, Lillian Kenner, Margot Meyers, David Gygi, Zef A. Könst, Sogole Sami Bahmanyar, Lawrence G. Hamann, Anthony P. Schuller
Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data
Helaina E. Huneault, Pradeep Tiwari, Zachery R. Jarrell, Matthew Ryan Smith, Chih-Yu Chen, Ana Ramirez Tovar, Cristian Sanchez-Torres, Scott Gillespie, Shasha Bai, Rodrigo M. Carrillo-Larco, Ajay K. Jain, Katherine P. Yates, Brent A. Neuschwander-Tetri, Jeffrey B. Schwimmer, Stavra A. Xanthakos, Jean P. Molleston, Cynthia A. Behling, Mark H. Fishbein, Terryl J. Hartman, Francisco J. Pasquel, Rishikesan Kamaleswaran, Dean P. Jones, Jean A. Welsh, Miriam B. Vos
Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer
Meng Liu, Maria O. Hernandez, Darko Castven, Hsin-Pei Lee, Wenqi Wu, Limin Wang, Marshonna Forgues, Jonathan M. Hernandez, Jens U. Marquardt, Lichun Ma
Localized quasiparticles in a fluxonium with quasi-two-dimensional amorphous kinetic inductors
Trevyn F. Q. Larson, Sarah Garcia Jones, TamĂĄs KalmĂĄr, Pablo Aramburu Sanchez, Sai Pavan Chitta, Varun Verma, Kristen L. Genter, Stephen T. Gill, Katarina Cicak, Sae Woo Nam, Gergö FĂŒlöp, Jens Koch, Raymond W. Simmonds, AndrĂĄs Gyenis
A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments
Devon J. Griggs, Noah Stanis, Julien Bloch, Jasmine Zhou, Karam Khateeb, Shawn Fisher, Larry Shupe, Felix Schwock, Eberhard E. Fetz, Hesamoddin Jahanian, Azadeh Yazdan-Shahmorad
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling
Rachel Scheck, Mark Melzer, Gregory Gladkov, Louise Leyre, Adam R. Ward, Daniel B. Reeves, Naomi Perkins, T. Thinh Huynh, Deborah K. McMahon, Ronald J. Bosch, Bernard J. Macatangay, Joshua C. Cyktor, Joseph J. Eron, John W. Mellors, Rajesh T. Gandhi, Lisa Buchauer, R. Brad Jones, Christian Gaebler
Mengxin Lin, Zihan Li, Alexander Kotz, Hugo Larocque, Nikolai Kuznetsov, Jiale Sun, Yichi Zhang, Shuhang Zheng, Johann Riemensberger, Christian Koos, Tobias J. Kippenberg
Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Annu Nagar, Ryuji Yanase, Mohammad Zeeshan, David J. P. Ferguson, Steven Abel, Sarah L. Pashley, Akancha Mishra, Anthonius Eze, Edward Rea, Declan Brady, Andrew R. Bottrill, Sue Vaughan, Karine G. Le Roch, David S. Guttery, Anthony A. Holder, Eelco C. Tromer, Pushkar Sharma, Rita Tewari
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis
Evgenij Fiskin, Gökcen Eraslan, Maria B. Alora-Palli, Tanvi Jain, Juan Manuel Leyva-Castillo, Sean Kim, Heather Choe, Caleb A. Lareau, Helena Lau, Emily P. Finan, Isabella Teixeira-Soldano, Brenna LaBere, Anne Chu, Brian Woods, Janet Chou, Michal Slyper, Julia Waldman, Sabina Islam, Lynda Schneider, Wanda Phipatanakul, Craig Platt, Orit Rozenblatt-Rosen, Toni M. Delorey, Orr Ashenberg, Jacques Deguine, Gideon P. Smith, Raif S. Geha, Aviv Regev, Ramnik J. Xavier
The genetic landscape of human functional brain connectivity
Bernardo de APC Maciel, Marijn Schipper, Cato Romero, Christiaan de Leeuw, Koen Helwegen, Danielle Posthuma, Jeanne E. Savage, Martijn P. van den Heuvel
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-ÎČ-hydroxylase
Mariska de Munnik, Amelia Brasnett, Tiankun Zhou, William Myers, Yicheng Wang, Kuntal Chatterjee, Anthony Tumber, Stephen A. Marshall, Philipp S. Simon, Pierre Aller, Anastasiia Shilova, Danny Axford, Hiroki Makita, Daniel W. Paley, Vandana Tiwari, Alexander T. Stead, Sebastian Dehe, Humberto Sanchez, Daniel J. Rosenberg, Roberto Alonso-Mori, Asmit Bhowmick, Junko Yano, Vittal K. Yachandra, Jaehyun Park, Sehan Park, Allen M. Orville, Lennart Brewitz, Jan F. Kern, Christopher J. Schofield, Patrick Rabe
Pattern-enhanced Resonant Soft X-ray Scattering for Operando monitoring of electrochemical solid-liquid interfaces
Haoyi Li, Kas Andrle, Qi Zhang, Isvar A. Cordova, Yao Yang, Zhengxing Peng, Feipeng Yang, Guillaume Freychet, Scott Dhuey, Alexander Hexemer, Brett A. Helms, Weilun Chao, Bruno La Fontaine, Ricardo Ruiz, Jinghua Guo, Wanli Yang, Junko Yano, Cheng Wang
In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism
Andrei Fokine, Jingen Zhu, Thomas Klose, Frank Vago, Charles-Adrien Arnaud, Zhiqing Wang, Baldeep Khare, Michael G. Rossmann, Zhenguo Chen, Lei Sun, Qianglin Fang, Richard J. Kuhn, Venigalla B. Rao
A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice
Pattarawan Pattamaprapanont, Roberto C. Nava, Rea Grover, Mia Formato, Eileen M. Cooney, Ana Paula Pinto, Ana B. Alves-Wagner, Anamica Das, Yuntian Guan, Meghana Annambhotla, Saanvi Acharya, Donato A. Rivas, Sarah J. Lessard
Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool
Eleanor Meader, Morgan T. Walcheck, Mindy R. Leder, Patrice Delaney, Marcelo Falchetti, Ran Jing, Christopher Li, Netra K. Kambli, Paul J. Wrighton, Wade W. Sugden, Mohamad A. Najia, Isaac M. Oderberg, Vivian M. Taylor, Zachary C. LeBlanc, Eleanor D. Quenzer, Sung-Eun Lim, Thorsten Schlaeger, George Q. Daley, Wolfram Goessling, Trista E. North
Genetic modifiers of APOE-Δ4-associated cognitive decline
Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Michelle Clifton, Subhabrata Mukherjee, Michael L. Lee, Seo-Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Carlos Cruchaga, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda B. Kuzma, , Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Norbert Schuff, Charles DeCarli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Lisa Taylor Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven Potkin, Li Shen, Faber Kelley, Sungeun Kim, Kwangsik Nho, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Susan Molchan, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, John C. Morris, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla deToledo-Morrell, Raj C. Shah, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Chiadi Onyike, Daniel DâAgostino, Stephanie Kielb, James E. Galvin, Dana M. Pogorelec, Brittany Cerbone, Christina A. Michel, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Terence Z. Wong, Steven E. Arnold, Jason H. Karlawish, David Wolk, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. Lopez, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc Adams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Michael DeVous, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Heather S. Anderson, Russell H. Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H. S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Benita Mudge, Michele Assaly, Andrew Kertesz, John Rogers, Charles Bernick, Diana Kerwin, Marek Marsel Mesulam, Kristine Lipowski, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Keith A. Johnson, Gad Marshall, Meghan Frey, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Rob Bartha, Sanjay Asthana, Cynthia M. Carlsson, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Robert B. Santulli, Tamar J. Kitzmiller, Eben S. Schwartz, Kaycee M. Sink, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabether Finger, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Laura L. Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, , Eveleen Darby, Paul Massman, Valory Pavlik, Monica Rodriguear, Matthew P. Frosch, Hakon Hakonarson, Thomas Wisniewski, John M. Olichney, Marcia Ory, Alan Stevens, Thomas G. Beach, Jagan Pillai, James B. Leverenz, Tamar Gefen, Robert Vassar, John S. K. Kauwe, Gyungah Jun, Kathryn L. Lunetta, Katrina Bazemore, Taha Iqbal, Jin Sha, Barbara Davis, Linda Hynan, Bruce Jones, Joan S. Reisch, Jackie Bartlett, Penelope Benchek, Alan J. Lerner, Yeunjoo Song, Nick Wheeler, Victor Henderson, Deborah Blacker, Sarah A. Biber, Kwun C. Chan, Yen-Chi Chen, Jessica Culhane, Nic Dobbins, Kathryn M. Gauthreaux, Benjamin Keller, Melissa Lerch, Charles Mock, Sean D. Mooney, Kyle Ormsby, Raymond Palmer, Marsha Polk, Jeffrey Tilson, Kirk C. Wilhelmsen, Gail P. Jarvik, Ellen Wijsman, Douglas Mains, M. Ilyas Kamboh, Joseph E. Parisi, Kelley M. Faber, Tatiana M. Foroud, Kathleen Hall, Donghe Li, Xiaoling Zhang, John Farrell, Xudong Han, Moon Il Kang, Logue Mark, Richard M. Sherva, Congcong Zhu, James R. Burke, Kathleen A. Welsh-Bohmer, Eric B. Larson, Wayne C. McCormick, Craig S. Atwood, Mark A. Sager, Frank M. LaFerla, David Marquez, Lei Yu, Mindy J. Katz, Richard B. Lipton, Ann C. McKee, Robert A. Stern, James J. Lah, Allan I. Levey, Thomas S. Wingo, Martin R. Farlow, Steven E. Arnold, Bradley T. Hyman, John H. Growdon, Bradley F. Boeve, Ronald C. Petersen, Vijay Ramanan, Deborah C. Mash, Oscar Harari, Jeffrey A. Kaye, Joseph F. Quinn, Daniel C. Marson, Erik D. Roberson, Charles DeCarli, Harry V. Vinters, Adam Boxer, Bruce L. Miller, Howard J. Rosen, William W. Seeley, Roger L. Albin, Helena C. Chui, John M. Ringman, Lon S. Schneider, Alyssa Aguirre, David Paydarfar, Roger N. Rosenberg, Thomas D. Bird, Thomas Grabowski, Suman Jayadev, John C. Morris, Joel H. Kramer, Mariet Allen, Minerva M. Carrasquillo, Dennis W. Dickson, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Steven G. Younkin, Joseph D. Buxbaum, Alison M. Goate, Brian Fulton-Howard, James B. Brewer, Douglas R. Galasko, Ronald L. Hamilton, Bernardino Ghetti, Lee-Way Jin, Elizabeth Head, Ronald Kim, Edwin Monuki, Vivianna M. Van Deerlin, Xiongwei Zhu, Juan C. Troncoso, Marsel Mesulam, Sandra Weintraub, Randall L. Woltjer, Thomas J. Montine, Kenneth B. Fallon, Andrew P. Lieberman, Robert C. Barber, James R. Hall, Leigh Johnson, Michelle A. Grunin, Ellen L. Palmer, David Sultzer, Amanda J. Myers, Elizabeth A. Crocco, Laura Ibanez, Constantine G. Lyketsos, Abhay Moghekar, Mary Sano, Arjun V. Masurkar, John Bertelson, Munro C. Cullum, Daniele Fallin, Liana G. Apostolova, Kelley Nudelman, Ryan M. Huebinger, John C. DeToledo, Michelle Hernandez, Kimberly Johnson, Victoria Perez, Henrick Wilms, Donald R. Royall, James T. Becker, Clinton B. Wright, Sanjay Asthana, Cynthia M. Carlsson, Nathaniel A. Chin, Suzanne Craft, Howard Andrews, John Hardy, Janice Knebl, Sid E. OâBryant, Regina M. Carney, Henry L. Paulson, Duane Beekly, Marie-Francoise Chesselet, Daniel H. Geschwind, Matthew J. Huentelman, Eric M. Reiman, Beth A. Dombroski, Pavel P. Kuksa, Wan-Ping Lee, Laura B. Cantwell, Marissa Cranney, Yuk Yee Leung, Liming Qu, Otto Valladares, Yi Zhao, Stephen Strittmatter, Christopher Van Dyck, Philip L. De Jager, Jeffrey L. Tilson, Denis A. Evans, Erin Abner, Linda J. Van Eldik, David W. Fardo, Susan M. McCurry, Goldie Byrd, Ekaterina Rogaeva, Peter St George-Hyslop, Jean-Paul Vonsattel, Sandra Barral, Lawrence S. Honig, Jennifer Manly, James Noble, Christiane Reitz, Andrew Teich, Giuseppe Tosto, Badri N. Vardarajan, Jennifer Williamson, Gary W. Beecham, John R. Gilbert, Anthony R. Griswold, Farid Rajabli, Jeffery M. Vance, Susan H. Slifer, Patrice L. Whitehead, Jeffrey M. Burns, Russell H. Swerdlow, Oscar L. Lopez, Chuanhai Cao, Debby W. Tsuang, , Eric Boerwinkle, Richard Gibbs, Kim Worley, Nancy Heard-Costa, Moon-Il Kang, Zainab Kurshid, Donghe Li, Tong Tong, Benjamin Wolozin, Congcong Zhu, Richard Sherva, Marlene Tejeda, Xinyu Sun, Logue Mark, Xudong Han, Jaeyoon Chung, John Farrell, Gyungah Jun, Kathy Lunetta, Xiaoling Zhang, Anita DeStefano, Gina Peloso, Achilleas Pitsillides, Keoni Kauwe, Audrey Lynn, Scott Williams, Nicolas Wheeler, Alan J. Lerner, Jackie Bartlett, Penelope Benchek, Yeunjoo Song, Jungsoo Gim, Sandra Barral Rodriguez, Phil De Jager, Suzanne Leal, Yiyi Ma, Richard Mayeux, Christiane Reitz, Dolly Reyes-Dumeyer, Badri Vardarajan, Shahzhad Ahmad, Hata Comic, Hannah Craft, Taeho Jo, Shannon Risacher, Min Soo Byun, Dong Young Lee, Dahyun Yi, John McNeil, Shea Andrews, Brian Fulton-Howard, Alison Goate, Jack Humphrey, Dado Marcora, Tulsi Patel, Towfique Raj, Alan Renton, Andrew Sharp, Ricardo Vialle, Kelley Faber, Tatiana Foroud, Kelly Nudelman, Kaci Lacy, David Knowles, Chirag Lakhani, Anjali Das, Teresa Lin, Yun Freudenberg-Hua, Sungho Wang, Michael Greicius, Anshul Kundaje, Stephen Montgomery, Tom Montine, Ryan Corces, Vilmundur Guðnason, Kara Hamilton-Nelson, Nicholas Kushch, Pedro Mena, Farid Rajabli, Mike Schmidt, Karen Nuytemans, Patrice Whitehead, Larry D. Adams, John R. Gilbert, Sharon Kardia, Jennifer Smith, Wei Zhao, Najaf Amin, Cornelia van Duijn, Laura Cantwell, Yi-Fan Chou, Christos Davatzikos, Heather Nicaretta, Wan-Ping Lee, Fanny Leung, John Malamon, Li Shen, Otto Valladares, Alexis Lerro Rose, Andy Wilk, Beth Dombrosk, Emily Greenfest-Allen, Flawless Robbins, Heather White, Jacob Haut, Jascha Brettschneider, Jeffrey Cifello, Jin Sha, Joseph Manuel, Lauren Bass, Liming Qu, Luke Carter, Maureen Kirsch, Michelle K. Moon, Naveensri Saravanan, Pavel Kuksa, Pei-Chuan Ho, Peter Keskinen, Prabhakaran Gangadharan, Sam Tate, Taha Iqbal, Wei-Hsuan Chuang, Wenhwai Horng, Yi Zhao, Youli Ren, Yumi Jin, Zivadin Katanic, Robert Babak Frayabi, Mingyao Li, Marissa Cranney, Kamnaa Arya, Heng Huang, Sophia Thomopolous, Myriam Fornage, Chloe Sarnowski, Peter St. George-Hyslop, Josh Bis, Liz Blue, Andrea Horimoto, Rafael Nafikov, Tim Thornton, Ellen Wijsman, Seth Temple, Tyler Day, Eugine Lin, Bruce Psaty, Dagmar Bacikova, Clifton Dalgard, Bernard Fongang, Xueqiu Jian, Muralidharan Sargurupremraj, Claudia Satizabal, Sudha Seshadri, Habil Zare, Jose Bras, Rita Guerreiro, Piper Below, Susan Dutcher, Victoria Fernandez, Achal Neupane, Jung-Ying Tzeng, Shin-Yi Chou, Alessandra F. A. Chesi, Struan F. A. Grant, Michael L. Cuccaro, Margaret A. Pericak-Vance, Lindsay A. Farrer, Li-San Wang, Gerard D. Schellenberg, Jonathan L. Haines, Angela L. Jefferson, Walter A. Kukull, C. Dirk Keene, Andrew J. Saykin, Paul M. Thompson, Eden R. Martin, Marilyn S. Albert, Sterling C. Johnson, Corinne D. Engelman, Luigi Ferrucci, David A. Bennett, Lisa L. Barnes, Julie A. Schneider, Reisa A. Sperling, Susan M. Resnick, Paul K. Crane, Logan Dumitrescu, Timothy J. Hohman
Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress
Milan JirkĆŻ, William Parker, OldĆiĆĄka KadlecovĂĄ, Martin Moos, Monika M. WiĆniewska, Roman Kuchta, Petra TlĂĄskalovĂĄ, Vladislav IlĂk, AleĆĄ TomÄala, Zuzana PavlĂÄkovĂĄ, KristĂœna BroĆŸovĂĄ, Julius LukeĆĄ, Miroslav ObornĂk, Martin KolĂsko, Barbora PafÄo, KateĆina JirkĆŻ
Blunt-force assembly of programmable DNA architectures using ÏâÏ stacking
Karol Woloszyn, Andrew Horvath, Mara Jaffe, Lara Perren, Joe Rueb, Samyra Mahiba, NataĆĄa Jonoska, Yoel P. Ohayon, James W. Canary, Simon Vecchioni, Ruojie Sha
An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing
Jonathan M. Craig, Andrew H. Laszlo, Henry Brinkerhoff, Christopher A. Thomas, Sinduja K. Marx, Eric F. Lebo, Sarah J. Abell, Michaela C. Franzi, Jesse R. Huang, Hwanhee C. Kim, Jessica D. Carrasco, Jens H. Gundlach
BRAHMA represses STOP1-NRT1.1 module to control plant rhizosphere alkalization and acid stress adaptation
Jia Yuan Ye, Wen Hao Tian, De Rui Zhang, Qian Yi Yu, Ji Ming Xu, Wo Na Ding, Gui Xin Li, Jing Ying Yan, Chong Wei Jin, Moussa Benhamed, Shao Jian Zheng, Zhong Jie Ding
Identification and engineering of highly functional potyviral proteases in cells using co-evolutionary models
Medel B. Lim Suan, Cheyenne Ziegler, Zain Syed, Arjun Sai Yedavalli, Jaimahesh Nagineni, Rodrigo Raposo, Ajay Tunikipati, Jaideep Kaur, Faruck Morcos, P. C. Dave P. Dingal
Structural and functional implications of phase separation of membrane protein LacY in Escherichia coli
Dmitrii Linnik, Sumayra Sultanji, Jan A. Stevens, Gea K. Schuurman-Wolters, Rinse de Boer, Christiaan M. Punter, Siewert J. Marrink, Ivan Maslov, Bert Poolman
Single-photon advantage in quantum cryptography beyond QKD
Daniel A. Vajner, Koray Kaymazlar, Fenja Drauschke, Lucas Rickert, Martin von Helversen, Hanqing Liu, Shulun Li, Haiqiao Ni, Zhichuan Niu, Anna Pappa, Tobias Heindel
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries
Veera M. Rajagopal, Andrey Ziyatdinov, Tyler Joseph, Ariane Ayer, Mohsin Ahmed, Joelle Mbatchou, Yuxin Zou, Amelia J. Averitt, Nilanjana Banerjee, Michael Cantor, Jason M. Torres, Esteban Chen, Jennifer Rico Varela, , Gonçalo Abecasis, Adolfo Ferrando, Andrew Deubler, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Katherine Siminovitch, Jason Portnoy, Marcus B. Jones, Lyndon Mitnaul, Alison Fenney, Manuel Allen Revez Ferreira, Maya Ghoussaini, Mona Nafde, William Salerno, Cristen J. Willer, Lourdes Crane, Christina Beechert, Erin Fuller, Laura M. Cremona, Eugene Kalyuskin, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Prathyusha Challa, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria Sotiropoulos Padilla, Chenggu Wang, Sarah E. Wolf, Manan Goyal, George Mitra, Sanjay Sreeram, Rouel Lanche, Vrushali Mahajan, Sai Lakshmi Vasireddy, Gisu Eom, Krishna Pawan Punuru, Sujit Gokhale, Benjamin Sultan, Pooja Mule, Mudasar Sarwar, Muhammad Aqeel, Xiaodong Bai, Lance Zhang, Sean OâKeeffe, Razvan Panea, Evan Edelstein, Ayesha Rasool, Evan K. Maxwell, Boris Boutkov, Alexander Gorovits, Ju Guan, Lukas Habegger, Alicia Hawes, Olga Krasheninina, Samantha Zarate, Adam J. Mansfield, Joshua Backman, Kathy Burch, Adrian Campos, Liron Ganel, Sheila Gaynor, Benjamin Geraghty, Arkopravo Ghosh, Salvador Romero Martinez, Christopher Gillies, Lauren Gurski, Eric Jorgenson, Michael Kessler, Jack Kosmicki, Adam Locke, Priyanka Nakka, Karl Landheer, Olivier Delaneau, Anthony Marcketta, Arden Moscati, Anita Pandit, Jonathan Ross, Carlo Sidore, Eli Stahl, Timothy Thornton, Sailaja Vedantam, Rujin Wang, Kuan-Han Wu, Bin Ye, Blair Zhang, Jingning Zhang, Kyoko Watanabe, Mira Tang, Frank Wendt, Suganthi Balasubramanian, Suying Bao, Kathie Sun, Chuanyi Zhang, Sean Yu, Aaron Zhang, David Corrigan, Dhruv Shidhaye, Chen Wang, Keyrun Adhikari, Alexander Lachmann, Brian Hobbs, Jon Silver, William Palmer, Rita Guerreiro, Amit Joshi, Antoine Baldassari, Sarah Graham, Ernst Mayerhofer, Erola Pairo Castineira, Mary Haas, Niek Verweij, George Hindy, Jonas Bovijn, Tanima De, Luanluan Sun, Olukayode Sosina, Arthur Gilly, Peter Dornbos, Juan Rodriguez-Flores, Moeen Riaz, Manav Kapoor, Gannie Tzoneva, Momodou W. Jallow, Anna Alkelai, Veera Rajagopal, Sahar Gelfman, Vijay Kumar, Jacqueline Otto, Jose Bras, Silvia Alvarez, Jessie Brown, Hossein Khiabanian, Joana Revez, Kimberly Skead, Valentina Zavala, Jae Soon Sul, Lei Chen, Sam Choi, Amy Damask, Nan Lin, Charles Paulding, Sameer Malhotra, Joseph Herman, Michelle G. LeBlanc, Nadia Rana, Jennifer Rico-Varela, Jaimee Hernandez, Larizbeth Romero, Ashley Paynter, Randi Schwartz, Jody Hankins, Anna Han, Samuel Hart, Ryan Smith, Ann Perez-Beals, Gina Solari, Johannie Rivera-Picart, Michelle Pagan, Sunilbe Siceron, Marcus Jones, John Overton, Olivier Harari, Luca Lotta, Gonçalo Abecasis, Aris Baras, Jaime Berumen, Pablo Kuri-Morales, JesĂșs Alegre-DĂaz, Roberto Tapia-Conyer, Rory Collins, Jonathan R. Emberson, Jonathan Marchini, Giovanni Coppola
Well-being is linked to income. However, lower well-being among lower-income individuals may reflect either economic relative deprivation or the lower social status associated with a lower income rank. Here, using Gallup World Poll data from 109 countries and over 90,000 individuals, we test a general model that includes both relative income deprivation and income rank as special cases. In 80% of countries, subjective well-being is more strongly associated with within-nation rank of income than with absolute income or relative income deprivation. Income rank coefficients are over three times larger in the most materialistic countries, but smaller in countries with higher social capital: In countries with the highest civic engagement, the association between income rank and well-being is about 80% smaller. Results replicated in multiple survey years and are consistent with a link between income-related social status and subjective well-being that is stronger when social capital is low.
National analysis of cancer mortality and proximity to nuclear power plants in the United States
Yazan Alwadi, Barrak Alahmad, Carolina L. Zilli Vieira, Philip J. Landrigan, David C. Christiani, Eric Garshick, Marco Kaltofen, Brent Coull, Joel Schwartz, John S. Evans, Petros Koutrakis
Understanding the potential health implications of living near nuclear power plants is important given the renewed interest in nuclear energy as a low-carbon power source. Here we show that U.S. counties located closer to operational nuclear power plants have higher cancer mortality rates than those farther away. Using nationwide mortality data from 2000-2018, we assess long-term spatial patterns of cancer mortality in relation to proximity to nuclear facilities while accounting for socioeconomic, demographic, behavioral, environmental, and healthcare factors. Cancer mortality is higher across multiple age groups in both males and females, with the strongest associations among older adults, males aged 65â74 and females aged 55â64. While our findings cannot establish causality, they highlight the need for further research into potential exposure pathways, latency effects, and cancer-specific risks, emphasizing the importance of addressing these potentially substantial but overlooked risks to public health.
Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families
Wenqi Lu, Oscar W. H. Wong, Jie Zhu, Sizhe Chen, Hein M. Tun, Yating Wan, Zhilu Xu, Chun Pan Cheung, Jessica Y. L. Ching, Pui Kuan Cheong, Sandra Chan, Samuel Wong, Dorothy Chan, Francis Ka Leung Chan, Qi Su, Siew Chien Ng
Autism spectrum disorder (ASD) is associated with alteration of gut microbiome, but the influence of familial structure on it remains poorly understood. We investigate gut microbiota across 429 children from multiplex families with multiple affected children, simplex families with one affected child, and single-child ASD families, alongside typically developing controls. We found that children from multiplex families exhibit the most distinct microbiome compositions. Cohabiting siblings in ASD families display higher microbiome similarity than those in healthy families, with a clear gradient in strain-sharing rates that is highest in multiplex, intermediate in simplex, and lowest in healthy siblings. This increased sharing involves specific taxa with reported opportunistic pathogenic potential, such as Eubacterium rectale , alongside reduced sharing of the commensal bacterium Bacteroides xylanisolvens . This suggests that their gut microbiome configurations, which are potentially influenced by shared environmental and host factors, are associated with increased persistence or detectability of specific bacterial strains. Our results underscore the significant contribution of family type to microbial heterogeneity in ASD and provide a hypothesis-generating context for future studies to explore the role of the shared microbial environment in a familial context.
Global increases in built-up volume indicate more divergent and less dispersed urban expansion patterns
Yingcheng Li, Xiaohan Zhong, Ben Derudder, Mingxing Hu, Xingjian Liu
Black and Hispanic faculty â underrepresented minorities (URMs) within academia â face career barriers that come to a crux in promotion and tenure decisions. Leveraging a natural experiment in choice architecture within a dataset of 1804 promotion and tenure decisions across six universities, we find that joint (906 faculty) vs. separate (898 faculty) evaluation reduces racial disparities in faculty outcomes. Specifically, in joint evaluation, an analysis of the simple slopes finds that Black and Hispanic faculty receive, on average, 9% fewer negative votes at the department level than in separate evaluations when controlling for research productivity, school, gender, rank, discipline, department size, and grant acquisition. Using moderated mediation analyses, we calculate that this translates into a 16.2% increase in the likelihood of a Black/Hispanic faculty member receiving a promotion. In a survey of 289 professors who have served on promotion and tenure committees (i.e., the key P&T decision-makers), we find that only 17% of faculty expect joint evaluation to improve underrepresented minority faculty outcomes and, conversely, 43% expect separate evaluation to improve underrepresented minority faculty outcomes. This natural experiment suggests that altering evaluation mode or simulating joint evaluation mode could help address academiaâs underrepresentation problem, but not in the way decision-makers expect.
Evaluating spatially targeted HIV interventions and harm reduction services among people who inject drugs in a high-burden setting
Jasmine Wang, Steven J. Clipman, Shruti H. Mehta, Aylur K. Srikrishnan, Shobha Mohapatra, Muniratnam S. Kumar, Gregory M. Lucas, Carl A. Latkin, Sunil S. Solomon, Amy Wesolowski
Shared Genetic Liability across Systems of Psychiatric and Physical Illness
Jeremy M. Lawrence, Isabelle F. Foote, Sophie Breunig, Lukas S. Schaffer, Siraj Lyons, Sarah A. Abramowitz, Michael G. Levin, Scott M. Damrauer, , Travis T. Mallard, Andrew D. Grotzinger
Immunometabolic resistors of aging in long-lived golden spiny mice
Hee-Hoon Kim, Tali Sagiv-Zangi, Yun-Hee Youm, Hagar Vardi-Naim, Tamara Dlugos, Francesco Strino, Mila Kazavchinsky-Bar, Lian Egulsky, Monica Bodogai, Arya Biragyn, Yuval Kluger, Noga Kronfeld-Schor, Vishwa Deep Dixit
Coupled geomorphic and climate-driven biogeochemical processes regulate soil organic carbon stocks in agricultural terraces
Pengzhi Zhao, Daniel J. Fallu, Sebastian Doetterl, Sara Cucchiaro, Paolo Tarolli, Ben R. Pears, Andreas Lang, Moritz F. Mainka, Xiaojing Ou, Jeanette Whitaker, Zhengang Wang, Antony G. Brown, Johan Six, Kristof Van Oost
Engineering controlled-release steroid therapeutics: fabrication and molecular design of self-assembled microparticles
Oluwaseun D. Akanbi, Michael L. Felder, Daniel Kupor, Jiachen Feng, Luana JanaĂna de Campos, Lisa J. Bain, Crystal Sanchez, Hanieh Safari, Thi Vo, Martin Conda-Sheridan, Omolola Eniola-Adefeso
Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia
Christopher Douville, Jeeun Parksong, Marco Dal Molin, Sarah Graham, Patricia T. Greipp, Ryan Knudson, Samuel Curtis, Yuxuan Wang, Lisa Dobbyn, Maria Popoli, Janine Ptak, Natalie Silliman, Katharine Romans, Christine A. Iacobuzio-Donahue, Alvin P. Makoohon-Moore, Anne Marie Lennon, Michael Goggins, Ralph H. Hruban, Ashley Kiemen, Chetan Bettegowda, Kenneth W. Kinzler, Nickolas Papadopoulos, Laura D. Wood, Bert Vogelstein
Causal parametric language mapping with electrical stimulation during awake neurosurgery
J. Raouf Belkhir, Frank E. Garcea, Eduardo Navarrete, Benjamin L. Chernoff, Max H. Sims, Sam Haber, Arka N. Mallela, Matthew Pease, Susan O. Smith, Eric B. Hintz, Thandar Aung, Eliza M. Reedy, Kevin Walter, Tyler Schmidt, Jorge Gonzalez-Martinez, Nduka Amankulor, Webster H. Pilcher, Bradford Z. Mahon
Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle
Ryan N. Montalvo, Xiaolu Li, Gina M. Many, Tyler J. Sagendorf, Qing Yu, Wenqing Shen, Nishikant Wase, A. Robert Burgardt, Tong Zhang, Marina A. Gritsenko, Matthew J. Gaffrey, Hemangi Bhonsle, Yuntian Guan, Xuansong Mao, Mei Zhang, Wei-Jun Qian, Zhen Yan
Specific SLC25 carriers regulate mitochondrial protein synthesis
Danielle L. Rudler, Laetitia A. Hughes, Martin S. King, Jessica Baker, Richard G. Lee, Andrianto P. Gandadireja, Anisha Sunil, Samuel V. Fagan, Blake Payne, Nicola Gray, Tim McCubbin, Edmund R. S. Kunji, Oliver Rackham, Aleksandra Filipovska
People are often faced with choices whose outcomes will affect other individuals in addition to themselves. Being responsible for deciding on behalf of others alters choice behavior and increases delegation rates in decisions involving risk and ambiguity. However, it is unknown whether the influence of social responsibility on decision-making acts primarily or directly on risk, loss, and ambiguity attitudes versus more general aspects of cognition. We report a series of experiments on objective magnitude judgments that demonstrate that the influences of responsibility on cognition and behavior extend beyond risk or ambiguity and act at the metacognitive level. Specifically, responsibility for others changes metacognitive biases, leading to a decrease in decision confidence without affecting choice accuracy. Last, we propose and empirically test a normative computational framework based on decision confidence that can explain decisions to assume or delegate responsibility for others without needing to assume changes in risk preferences.
PNAS
GPT-4o mini: Non-social science research article
The Nemp1âNesprin complex mediates cellular responses to matrix mechanics
Abira Ganguly, Hannah Zmuda, Javier Abello, Danielle Illy, Christopher Walter, Yonit Tsatskis, Nattapon Thanintorn, Ying Zhang, Bilal Ahmad Hakim, Didier Hodzic, Amber N. Stratman, Andrea Jurisicova, Amit Pathak, Helen McNeill
Differential disease tolerance mediates sex-biased illness severity in sepsis
Breenna Dobson, Kathryn Strayer, Ayesha Wijesinghe, Jared Schlechte, Oscar Tejada, Alexandria Bartlett, Matthew Stephens, Diana Changirwa, Nicole A. Cho, Ian-ling Yu, Nargis Khan, Braedon McDonald
Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori
Leif Benner, Makenzie Richmond, Youbin Xiang, LingSze Lee, Clio B. Hockens, Tianwei Li, Zulin Yu, Dai Tsuchiya, Shengping Huang, Eelco C. Tromer, R. Scott Hawley, Leah F. Rosin
Correction for Nasca et al., Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity
Structural and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases
Rebecca L. Frkic, Alex Giang, Sacha B. Pulsford, Jian-Wei Liu, Mojtaba Esmaeily, Paul D. Carr, Nicholas J. Fraser, Davis Hopkins, John G. Oakeshott, Philip Batterham, Peter D. Mabbitt, Colin J. Jackson
Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function
Higor Sette Pereira, Jason Luddu, Govardhan Reddy Veerareddygari, Shridhar Kiran Sanghvi, Priyanshi B. Patel, Zachary E. Robinson, M. Quadir Siddiqui, Harpreet Singh, Trushar R. Patel
Lipoprotein diffusion in dense yolk plasma is governed by softness, hydrodynamics, and caging: Insights from MHz-XPCS
Nimmi Das Anthuparambil, Michelle Dargasz, Sonja Timmermann, Anita Girelli, Sebastian Retzbach, Johannes Möller, Wonhyuk Jo, Agha Mohammad Raza, Aliaksandr Leonau, James Wrigley, Frederik Unger, Maddalena Bin, Prince Prabhu Rajaiah, Iason Andronis, William ChĂšvremont, Jörg Hallmann, Angel Rodriguez-Fernandez, Jan-Etienne Pudell, Felix Brausse, Ulrike Boesenberg, Mohamed Youssef, Roman Shayduk, Rustam Rysov, Anders Madsen, Felix LehmkĂŒhler, Michael Paulus, Fajun Zhang, Fivos Perakis, Frank Schreiber, Christian Gutt
Accelerated northâeast shift of the global green wave trajectory
Miguel D. Mahecha, Guido Kraemer, Martin Reinhardt, David Montero, Fabian Gans, Ana Bastos, Hannes Feilhauer, Ida Flik, Chaonan Ji, Teja Kattenborn, Mirco Migliavacca, Milena Mönks, Johannes Quaas, Sebastian Sippel, Sophia Walther, Sebastian Wieneke, Christian Wirth, Gustau Camps-Valls
The rapid integration of generative AI into academic writing has prompted widespread policy responses from journals and publishers. However, the effectiveness of these policies remains unclear. Here, we analyze 5,114 journals and over 5.2 million papers to evaluate the real-world impact of AI usage guidelines. We show that despite 70% of journals adopting AI policies (primarily requiring disclosure), researchersâ use of AI writing tools has increased dramatically across disciplines, with no significant difference between journals with or without policies. Non-English-speaking countries, physical sciences, and high-OA journals exhibit the highest growth rates. Crucially, full-text analysis on 164 k scientific publications reveals a striking transparency gap: Of the 75 k papers published since 2023, only 76 (~0.1%) explicitly disclosed AI use. Our findings suggest that current policies have largely failed to promote transparency or restrain AI adoption. We urge a reevaluation of ethical frameworks to foster responsible AI integration in science.
Why Biden-era clean energy investment policies had limited political returns
Alexander F. Gazmararian, Nathan M. Jensen, Dustin Tingley
The Biden Administration enacted the largest federal policy framework to incentivize clean energy and decarbonization in U.S. history. We examine whether Biden-era green investments produced political returns by affecting public opinion. Using geolocated survey data linked to investment records and a database of company and politician statements, we assess project visibility and credit attribution. People closer to new renewable energy and green manufacturing facilities are more likely to notice these investments but are not more likely to credit the Biden Administration. Instead, the public sees governors as most responsible. This credit allocation pattern aligns with the political message environment: Governors more frequently claim credit than the White House and companies spread recognition broadly across political actors. This fragmented information environment illustrates the limits of using less traceable forms of green spending to generate electoral gains and public support for climate policy.
Humans 40,000 y ago developed a system of conventional signs
As humans, we store and share information. This allows us to distribute knowledge necessary for survival and to coordinate large groups. Our hominin ancestors harnessed the surfaces of mobile artifacts and cave walls as information carriers since the Paleolithic time period. Theories abound as to the meaning and function of these Paleolithic signs. However, very little is known about their basic, measurable properties. We here analyze a corpus of more than 200 mobile objects of a 43,000 to 34,000 y old Aurignacian cultureâassociated with the first modern humans to settle in Central Europe. These objects are adorned with several thousand geometric signs. We apply classification algorithms and statistical models to capture their quantitative properties. First, our analyses illustrate that these sign sequences are clearly distinguishable from modern day writing. Second, however, their statistical properties are comparable to sign sequences on the earliest protocuneiform tablets. Third, Paleolithic signs were systematically applied to yield higher information density on certain types of objects, e.g. ivory figurines compared to tools. These results cannot be taken to strictly prove that Aurignacian sign sequences encoded numero-ideographic information as in the case of protocuneiform. However, they prove that the first hunter-gatherers arriving in Europe already applied sign sequences of comparable complexity in a deliberate, systematic, and conventional mannerâseveral ten thousand years before the advent of genuine writing.
Overlooked and overexploited: Extensive conversion of grasslands and wetlands driven by global food, feed, and bioenergy demand
Siyi Kan, Samuel A. Levy, Elise Mazur, Leah Samberg, U. Martin Persson, Lindsey Sloat, Ana L. Reboredo Segovia, Leandro Parente, Thomas Kastner
Natural ecosystems are increasingly threatened by global agricultural supply chains, and a narrow policy focus on forests has fueled agricultural expansion into ecologically significant but severely overlooked non-forest ecosystems, including grasslands and open wetlands. While a few emerging policies attempt to protect non-forest ecosystems, a globally consistent assessment of their conversion extent and drivers, especially related to livestock production and commodity-specific supply chain demand, remains lacking. Here, we conducted a spatially explicit analysis to identify pasture and cropland expansion into non-forest ecosystems between 2005 and 2020, as well as conversion-linked primary agricultural commodities and their underlying demand drivers (end uses and final market destinations). We found that the conversion rate of natural non-forest ecosystems was nearly four times that of lands with tree cover exceeding 5 m (a common forest height threshold), with Brazil contributing 13% of the global total and Russia, India, China, and the United States each contributing about 6%. While drivers varied greatly across regions, globally 50% of the conversion was linked to pasture, and 27, 17, and 6% to cropland for food, feed, and other uses (mainly bioenergy), respectively. Among conversion-linked commodities, most livestock-associated products served domestic demand, while 32% of feed crops and 20% of all crops were exported, with export shares reaching 70 to 80% in Brazil and Argentina. These findings reveal important areas for non-forest ecosystem conservation and highlight the need for integrated policies to prevent leakage across different ecosystems and different sustainable development goals while also aligning local actions with global supply chain governance.
Social mobilizations for sustainability transformations
In the wake of USAID cuts, we can create a Demographic and Health Survey Program founded on more equitable data infrastructure and stronger research integrity
Jasmin Abdel Ghany, Aasli A. Nur, Kerry L. D. MacQuarrie, Joshua Wilde, Elizabeth A. Sully, Mahesh Karra, Ursula Gazeley, Ben M. John, Livia Montana
Humans have been using psychoactive substances for millennia, despite their potential negative health and social consequences. According to some scholars, our craving for mind-altering drugs is an evolutionary mistakeâa hijacking of our reward system. In contrast, the âdrunk hypothesisâ argues that intoxication has been adaptive and essential for the rise of large-scale societies because it promotes social bonding, increases cooperation, alleviates stress, and enhances human creativity. Here, we test this hypothesis using the example of kava, a traditional Pacific beverage with a range of psychoactive effects, made from the root of Piper methysticum . Our analysis of 83 Oceanic-speaking societies shows a positive relationship between traditional kava consumption and both political complexity and social stratification. However, the results are not robust to controls for nonindependence. Moreover, we found no evidence of coevolution between kava drinking and either of the two sociopolitical traits after controlling for spatial nonindependence. Despite the cultural significance of kava in many Pacific societies, our results suggest that its consumption was unlikely to have been a major driver of sociopolitical complexity, underscoring the importance of controlling for nonindependence in cross-cultural studies.
School shootings and the strategic contributions of gun policy PACs in US House elections
The American public consistently supports stricter gun laws. We show that the gun lobby is most concerned that this support will translate into federal legislative action when fatal school shootings occur. Leveraging a dataset of political action committee (PAC) contributions and school shootings, we implement a staggered difference-in-differences design to estimate the causal effect of fatal school shootings on contributions to House candidates. We find progun Political Action Committees increase contributions by 31% to candidates in districts with fatal school shootings, and 20% for gun safety PACs. Neither show any significant response to nonfatal school shootings or mass shootings. The temporal pattern also reveals strategic behavior: For both progun and gun safety PACs, contribution spikes emerge in the wake of fatal school shootings, with effects dramatically amplified as Election Day approaches; when a shooting occurs within two months of Election Day, contributions from progun PACs increase by 2,820% while gun safety PAC contributions increase by 917%. These effects are concentrated in competitive districts ( †5% margins) where the two-sided surge in contributions offsets any measurable electoral impact. These results provide robust evidence that PACs strategically deploy contributions after school shootings, with the magnitude and timing suggesting a deliberate mobilization to advance its agenda. Our findings underscore a gap in democratic accountability: While public opinion should drive policy change, campaign contributions are wielded to blunt electoral responsiveness, providing insight into the inability of Congress to adopt broadly supported gun safety measures.
Scientific Data
GPT-4o mini: Non-social science research article
Chromosome-level genome assembly of the alpine extremophyte Tibetan snow lotus, Saussurea hypsipeta Diels
Dataset for multi-perspective traffic video analysis
Ramon Sanchez-Iborra, Vasileios Kouvakis, Stylianos E. Trevlakis, Gonzalo Alarcon-Hellin, Theodoros Tsiftsis, Luis Bernal-Escobedo, Rodrigo Asensio-Garriga, Alexandros-Apostolos A. Boulogeorgos, Antonio Skarmeta
Tao Li, Lixing Wang, Zihan Qiu, Philippe Ciais, Steven J. Davis, Zhu Deng, Yufei Zhao, Glen P. Peters, Piyu Ke, Matthew W. Jones, Robbie M. Andrew, Ye Hao, Taochun Sun, Xiaoting Huang, Robert B. Jackson, Pierre Friedlingstein, Chenxi Lu, Duo Cui, Zhu Liu
A comprehensive UK crop yield dataset incorporating satellite, weather, and soil type information
Evangeline Corcoran, Daniel P. Bebber, Stelian Curceac, Natalia Efremova, Azam Lashkari, Andrew Mead, Richard J. Morris, Richard F. Pywell, John W. Redhead, Sebastian E. Ahnert
CzechLynx: A Dataset for Individual Identification and Pose Estimation of the Eurasian Lynx
Lukas Picek, Jakub Straka, Miroslav Jirik, Elisa Belotti, Martin DuÄŸa, Josefa KrausovĂĄ, Michal Bojda, Vojtech Cermak, LudÄk Bufka, Rostislav DvoĆĂĄk, Luboslav HrdĂœ, VĂĄclav Kocourek, JiĆĂ Labuda, LudÄk Toman, Vlado TrulĂk, Martin VĂĄĆa, Miroslav Kutal
Zuzana Koscova, Qiao Li, Chad Robichaux, Valdery Moura Junior, Manohar Ghanta, Aditya Gupta, Jonathan Rosand, Aaron D. Aguirre, Erik Reinertsen, Steven Song, Shenda Hong, David E. Albert, Joel Xue, Aarya Parekh, Reza Sameni, Matthew A. Reyna, M. Brandon Westover, Gari D. Clifford
The International Monetary Fund (IMF) promotes reforms emphasizing individual economic freedom and market competition. However, IMF loan conditions face criticism for potentially undermining democracy by encouraging policy shifts that may not reflect citizensâ preferences. We examine how IMF lending impacts economic congruenceâthe alignment between government policies and public preferences for economic freedom and market competition. Lack of congruence can weaken government legitimacy and hinder development. We find that participation in IMF programs is associated with more liberal economic policies across all countries: greater economic congruence in autocracies but reduced congruence in democracies. These findings help explain the unpopularity of IMF programs, especially in democracies.
Fix the money, fix the world: bitcoin as techno-libertarian religion
This article examines how bitcoin has acquired religious significance among many techno-libertarians, who hold it as a symbol promising deliverance from a fallen world. Drawing on both participant observation at bitcoin meetups and the 2023 Bitcoin Conference, as well as digital ethnography on X, the article presents a thick description of how bitcoiners construct specific beliefs about the world and their place in it, as well as ritual practices that vivify these beliefs and sanctify those who hold them. These beliefs and practices constitute bitcoin, in turn, as a distinct moral community in which bitcoin is symbolized as an instrument of salvation from a failing institutional order. This Durkheimian analysis contributes to understanding how money in modern society carries with it religious meanings about the world and human history. And it also contributes to an understanding of the specific ideological formation driving techno-libertarianism as an ascendant political interest today.
Gray zones of green finance: the Canada Infrastructure Bank and the limits of derisking decarbonization
State-led decarbonization efforts increasingly rely on a derisking approach, where public resources absorb investment risk and create âbankableâ green projects to mobilize private capital. Yet, growing research highlights significant challenges in putting derisking into practice. I examine the Canada Infrastructure Bank (CIB) to assess how derisking shapes low-carbon infrastructure development. Drawing on document analysis and a review of its partnersâ financial structures, I find that the CIB has struggled to mobilize investment at scale despite adopting a derisking strategy. Moreover, several of its partnerships involve firms connected to offshore tax havens, raising concerns about the redirection of public resources toward private gain. These dynamics call into questions the bankâs capacity to support Canadaâs decarbonization goals. More broadly, the study contributes to research on the structural limits of derisking by showing how reliance on green finance can undermine decarbonization efforts, reproduce global inequalities, and shift climate policy away from public accountability.