Author Correction: The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Trevor P. Fidler, Chenyi Xue, Mustafa Yalcinkaya, Brian Hardaway, Sandra Abramowicz, Tong Xiao, Wenli Liu, David G. Thomas, Mohammad Ali Hajebrahimi, Joachim Pircher, Carlos Silvestre-Roig, Andriana G. Kotini, Larry L. Luchsinger, Ying Wei, Marit Westerterp, Hans-Willem Snoeck, Eirini P. Papapetrou, Christian Schulz, Steffen Massberg, Oliver Soehnlein, Benjamin Ebert, Ross L. Levine, Muredach P. Reilly, Peter Libby, Nan Wang, Alan R. Tall
Author Correction: Postprandial lipid metabolism durably enhances T cell immunity
Alok Kumar, Dayana B. Rivadeneira, Isha Mehta, Bingxian Xie, Rachel Cumberland, Supriya K. Joshi, Jitendra S. Kanshana, William G. Gunn, Victoria Dean, Angelina Parise, Kristin Morder, Erica S. Myers, Steven J. Mullett, Richard T. Cattley, Stacy L. Gelhaus, Abigail E. Overacre-Delgoffe, Jishnu Das, William F. Hawse, Alison B. Kohan, Greg M. Delgoffe
Sleep chart of biological ageing clocks in middle and late life
, Cliodhna Kate OâToole, Zhiyuan Song, Filippos Anagnostakis, Zhijian Yang, Ye Ella Tian, Michael R. Duggan, Chunrui Zou, Yue Leng, Yi Cai, Wenjia Bai, Cynthia H. Y. Fu, Michael S. Rafii, Paul Aisen, Gao Wang, Philip L. De Jager, Jian Zeng, Hamilton Se-Hwee Oh, Xia Zhou, Keenan A. Walker, Daniel W. Belsky, Andrew Zalesky, Eleanor M. Simonsick, Susan M. Resnick, Luigi Ferrucci, Christos Davatzikos, Junhao Wen
Long-term editing of brain circuits using an engineered electrical synapse
Elizabeth Ransey, Gwenaëlle E. Thomas, Elias M. Wisdom, Agustin Almoril-Porras, Ryan Bowman, Elise Adamson, Kathryn K. Walder-Christensen, Jesse A. White, Dalton N. Hughes, Hannah Schwennesen, Caly Ferguson, Kay M. Tye, Stephen D. Mague, Longgang Niu, Zhao-Wen Wang, Daniel Colón-Ramos, Rainbo Hultman, Nenad Bursac, Kafui Dzirasa
Eosinophils drive intestinal remodelling and innate defence in reproduction
Chenyan Huang, Amanda Sun, Jojo Reyes, Jessica Ribeiro de Souza, Thomas R. Cafiero, Krist H. Antunes Fernandes, Fabricio Marcus Silva Oliveira, Yujie Qiao, Pedro Gazzinelli-Guimaraes, Yuri Pritykin, Ai Ing Lim
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Antoine Fages, Maëva Luxey, Fabrizia Ronco, Charlotte E. T. Huyghe, Sabrina Fischer, Gudrun Viktorin, P. Navaneeth Krishna Menon, Adrian Indermaur, Walter Salzburger, Patrick Tschopp
White matter micro- and macrostructure brain charts for the human lifespan
Michael E. Kim, Chenyu Gao, Karthik Ramadass, Nancy R. Newlin, Praitayini Kanakaraj, Sam Bogdanov, Gaurav Rudravaram, Derek Archer, Timothy J. Hohman, Angela L. Jefferson, Victoria L. Morgan, Alexandra Roche, Dario J. Englot, Susan M. Resnick, Lori L. Beason-Held, Laurie E. Cutting, Laura A. Barquero, Micah A. Dâarchangel, Tin Q. Nguyen, Kathryn L. Humphreys, Yanbin Niu, Sophia Vinci-Booher, Carissa J. Cascio, , Sid OâBryant, , Arthur Toga, , Marilyn Albert, L. Taylor Davis, Zhiyuan Li, Simon N. Vandekar, Panpan Zhang, John C. Gore, Bennett A. Landman, Kurt G. Schilling
Julian Klein, Kevin M. Roccapriore, Mads Weile, Sergii Grytsiuk, Andrew R. Lupini, Zdenek Sofer, Dimitar Pashov, Mark van Schilfgaarde, Swagata Acharya, Malte Rösner, Frances M. Ross
Efficient robot navigation inspired by honeybee learning flights
Dequan Ou, Jesse J. Hagenaars, Maciej R. Jankowski, Michiel V. M. Firlefyn, Christophe De Wagter, Florian T. Muijres, Jacqueline Degen, Guido C. H. E. de Croon
Maciej Gluc, Higor Rosa, Maria Bozko, Lesley A. Turner, Cassidy R. Prince, Yelena Peskova, Heather A. Feaga, Kathleen L. Gould, Simone Mattei, Ahmad Jomaa
Large-scale discovery, analysis and design of protein energy landscapes
Ăllan J. R. Ferrari, Sugyan M. Dixit, Jane Thibeault, Mario Garcia, Scott Houliston, Robert W. Ludwig, Pascal Notin, Claire M. Phoumyvong, Cydney M. Martell, Michelle D. Jung, Kotaro Tsuboyama, Lauren Carter, Cheryl H. Arrowsmith, Miklos Guttman, Gabriel J. Rocklin
An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism
Clarrisa A. Bradley, Sangyoon Y. Ko, Meng Tian, Liam T. Ralph, Lia DâAbate, Jinyeol Lee, Tianyi Liu, Junhui Wang, Patrick Tidball, Marla Mendes, Xiaolian Fan, Jennifer L. Howe, Roumiana Alexandrova, Giovanna Pellecchia, Guillermo Casallo, Tara Paton, Leanne E. Wybenga-Groot, Worrawat Engchuan, Bhooma Thiruvahindrapuram, Brett Trost, Jill de Rijke, Ashish Kadia, Fuzi Jin, Nelson Bautista Salazar, J. Javier Diaz-Mejia, Jeffrey R. MacDonald, Eric Deneault, P. Joel Ross, James Ellis, Carole Shum, John Georgiou, Olivia Rennie, Miriam S. Reuter, Ny Hoang, Ege Sarikaya, Thanuja Selvanayagam, Aeen Ebrahim Amini, Annabel Rutherford, Natalia Rivera-Alfaro, Christian R. Marshall, Marcello Scala, Cassandra K. Runke, Hutton M. Kearney, John Christodoulou, David I. Francis, Brian H. Y. Chung, Jill Pluciniczak, Alana Iaboni, Kristen M. Wigby, Christine W. Nordahl, David G. Amaral, Melissa L. Hudson, Calvin P. Sjaarda, Andrea Guerin, Mayada Elsabbagh, Rebecca Landa, Seema Mital, Robert Lesurf, Anjali Jain, Michael D. Wilson, Jacob Ellegood, Jason P. Lerch, Leo J. Lee, Brendan J. Frey, Michael W. Salter, Jacob A. S. Vorstman, Evdokia Anagnostou, Paul W. Frankland, Graham L. Collingridge, Stephen W. Scherer
Lineage and organ signals sequentially build organ intrinsic nervous systems
I-Uen Yvonne Hsu, Jia Zhao, Yingxin Lin, Yunshan Guo, Qian J. Xu, Yuancheng Shao, Ruiqi L. Wang, Dominic Yin, Kakali Ghoshal, Rida Mourad, Ambra Pozzi, Carmen M. Halabi, Lawrence H. Young, Hongyu Zhao, Le Zhang, Rui B. Chang
Author Correction: Predictive coding of reward in the hippocampus
Mohammad Yaghoubi, M. Ganesh Kumar, Andres Nieto-Posadas, Coralie-Anne Mosser, Thomas Gisiger, Ămmanuel Wilson, Cengiz Pehlevan, Sylvain Williams, Mark P. Brandon
Predictable seismic cycles result from structural rupture barriers on oceanic transform faults
Jianhua Gong, Wenyuan Fan, Jeffrey J. McGuire, Mark D. Behn, Jessica M. Warren, Emily Roland, Margaret S. Boettcher, John A. Collins, Yajing Liu, Christopher R. German
Accelerated Himalayan river meandering and dynamics due to climate change
Zhipeng Lin, Zhongpeng Han, David R. Montgomery, Waqas Ul Hussan, Lars LĂžnsmann Iversen, Mette Bendixen, Xu Xu, Ling Yao, Yalige Bai, Xinhang Wang, Er Huang, Xingnian Liu, Chengshan Wang
Protist-dominated hard substrate faunas thrive at the deepest ocean depths
Xikun Song, Andrew J. Gooday, Dennis P. Gordon, Daniel Leduc, Yike Sun, Zizhu Wang, Qian He, Zhaoming Gao, Bernhard Ruthensteiner, Andrea Waeschenbach, Thomas Schwaha, Xiaolan Lin, Hanyu Zhang, Ashley Rowden, Hengchao Xu, Shuangquan Liu, Shun Chen, Liang Meng, Dee Li, Yustian Rovi Alfiansah, Huijie Guo, Mengran Du, Xiaotong Peng
Implantable living materials autonomously deliver therapeutics using contained engineered bacteria
Tetsuhiro Harimoto, Fernando Herrero Quevedo, Janis Zillig, Sanjay Schreiber, Yi Wu, Christine Heera Ahn, Tania To, Rohan Thakur, Alexander M. Tatara, Shawn Kang, Zheqi Chen, Nuria Lafuente-GĂłmez, Blake Hanan, Alexander Pauer, Shanda Lightbown, David A. Weitz, David J. Mooney
Genetic variability of SARS-CoV-2 in wastewater and associations with community transmission
Dustin T. Hill, Rafael Schulman, Ian Vasconcellos Caldas, Christopher Dunham, Yifan Zhu, Daryl Lamson, Lindsey Rickerman, Kirsten St. George, Yasir Ahmed-Braimah, Hyatt Green, Brittany L. Kmush, Frank Middleton, David A. Larsen
Decoding collective dynamics and complexity in nanoparticle assemblies using graph theory
Jonas Hallstrom, Puquan Pan, Jayson Sia, Sangwok Bae, Dingwen Qian, Chang Qian, Sindy Liu, Lehan Yao, Thomas M. Truskett, Delia J. Milliron, Qian Chen, Xiaoming Mao, Paul Bogdan, Nicholas A. Kotov
Science abstract < 200 char.: Not a research
article
In Science Journals
Sacha Vignieri, Angela Hessler, Phil Szuromi, Madeleine Seale, Marc S. Lavine, Yury Suleymanov, Christiana N. Fogg, Leslie Ferrarelli, Bianca Lopez, Michael A. Funk, Jack Huang, Priscilla N. Kelly, Stella M. Hurtley, Ekeoma Uzogara, Yevgeniya Nusinovich, Jelena Stajic, Melissa L. Norton
Science abstract < 200 char.: Not a research
article
Improve genetic quality control to increase rigor and reproducibility of mouse research
Fernando Pardo-Manuel de Villena, James M. Amos-Landgraf, Timothy A. Bell, Matthew W. Blanchard, Jennifer Brennan, Charisse Carlson, Dominic J. Ciavatta, Paul A. Cotney, Martin T. Ferris, Pablo Hock, Ian Korf, K. C. Kent Lloyd, Cathleen Lutz, Rachel M. Lynch, Terry Magnuson, Stephen A. Murray, Samit Patel, Laura G. Reinholdt, John Sebastian Sigmon, Brandon Willis, James G. Xenakis
Less than a week after its inauguration, the second Trump administration issued a blanket stop-work order for the United States Agency for International Development (USAID), the largest national humanitarian donor. The social and political effects of abrupt aid withdrawal are poorly understood, especially in fragile states where relief is a key safety net. We provide quasi-experimental evidence on the shutdownâs impact on subnational conflict across Africa. Leveraging historical exposure to USAID programs, we show that conflict increased sharply after the shutdown in areas that previously received the most support. The increase spanned incidence and severity, including armed clashes, protests, and riots. The effects appeared immediately and persisted for months. Inclusive local institutions substantially mitigated these harms, underscoring vulnerability under weak governance and the capacity of institutions to buffer humanitarian and economic shocks.
Last monthâs parliamentary elections ended Prime Minister Viktor OrbĂĄnâs 16-year rule, giving Hungary something more consequential than a change of government: a chance to show the world how to rebuild science after political control. With a two-thirds parliamentary majority, the new leadership has the mandate and the constitutional power to rebuild Hungaryâs scientific enterprise around merit, and resistance against future interference. If Hungary gets this right, it will offer a model that matters far beyond its borders.
Nature Human Behaviour
Generic title: Not a research article
Children reach consensus using flexible imitation and emergent roles in networks
Early-career-researcher-led best practices for social science and behavioural genetics
Vincent J. Straub, Nadia V. Harerimana, Lyydia I. A. AlajÀÀskö, Sergio Ordonez Beltran, Asya BĂŒlbĂŒl, Tomeu LĂłpez-Nieto Veitch, Qiyuan Peng, Rossella De Sabbata, Mar Talens
Public health disparities provide an important lens for understanding social and political change in the USA. Using individual-level medical data and death records, this study shows that conservative Americans experienced worsening health and higher mortality than liberals during the 2010s. Here we find evidence consistent with two potential mechanisms. First, demographic realignment within political coalitions brought less healthy individuals into the conservative camp. Yet by the 2020s, demographic change, public policy and COVID-19 do not fully account for the widening gap in mortality rates. Public opinion data are consistent with a second mechanism: declining trust in medical professionals among right-leaning individuals, including lower willingness to seek care, follow clinical advice or believe in medication effectiveness, even for issues unrelated to COVID-19. These patterns suggest that growing ideological divides in health behaviours are leaving conservative Americans increasingly vulnerable to preventable health risks.
Remote delivery of STEM and entrepreneurship role models at scale changes college major choice in Ecuador
SIRT6 overexpression counteracts chromatin aging in the male murine liver
Ron Nagar, Zacharia Schwartz, Almog Katz, Noga Touitou, Efrat Sharon, Kobi Tzdaka, Odeya Waner, Noam Shalev, Rotem Clo, Leah Weiss, Benjamin Epstein, Michel Bernier, Roni B. Shtark, Nirad Banskota, Kwan-Wood G. Lam, Supriyo De, Nathan L. Price, Batia Lerrer, Daniel Z. Bar, Rafael de Cabo, Haim Y. Cohen
Platinum oxide formation under oxygen evolution reaction conditions
Leon Jacobse, Ralf Schuster, Mona Kohantorabi, Daniel Silvan Dolling, Johannes Pfrommer, Xin Deng, Tim Weber, Olof Gutowski, Ann-Christin Dippel, Olaf Brummel, Yaroslava Lykhach, Heshmat Noei, Herbert Over, Jörg Libuda, Vedran Vonk, Andreas Stierle
Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Xia Han, Gregory M. Rosenberg, Vivianne M. Kisling, Tao Zhang, Chia-Yi Lee, Ashvin Ravi, Mikhail Melnik, Tina Bilousova, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Karen H. Gylys, Laura M. Huckins, Towfique Raj, Kristen J. Brennand, Jessica E. Rexach
m6A modification suppresses innate anti-tumour immunity in colorectal cancer by limiting alu-derived dsRNA accumulation
Yucheng Wang, Alice A. Daddi, Amir Hosseini, Kazuki Kato, Ehsan Khalili, HĂ„vard T. Lindholm, Mengjie Li, Yadong Wang, David C. Michael, Catherine A. OâBrien, Daniel D. De Carvalho, Jan Rehwinkel, Parinaz Mehdipour
Using rotational integration of oblique interferometric scattering to track axial spatiotemporal responses of tubular membrane protrusions
Junyu Liu, Yean Jin Lim, David Herrmann, Paul Timpson, Tri Giang Phan, Viviane Delghingaro-Augusto, Christopher Richard Parish, Huafeng Liu, Min Guo, Woei Ming Lee
Cuffless hemodynamic monitoring with physics-informed machine learning models
Henry Crandall, Tyler Schuessler, Filip BÄlĂk, Albert Fabregas, Barry M. Stults, Alexandra Boyadzhiev, Huanan Zhang, Jim S. Wu, Aylin R. Rodan, Stephen P. Juraschek, Ramakrishna Mukkamala, Alfred K. Cheung, Stavros G. Drakos, Christel Hohenegger, Braxton Osting, Benjamin Sanchez
Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid
Heterogeneous photocatalyst enables large-scale broadband light-driven atom transfer radical polymerization with high oxygen and inhibitor tolerance
Wei-Wei Fang, Zi-Hui Fan, Bin Xia, Yi-Xing Liu, Fan Zhang, Ning Chen, Tian-Ci Sun, Xun-Liang Hu, Hui Gao, Bing Hu, Xiao-Guo Zhou, Bi-En Tan, Lei Xia, Tao He
Dopant-controlled oxygen vacancy dynamics define CO2-to-methanol catalysis on In2O3
Matthias Becker, Margareth S. Baidun, Annelies Landuyt, Agnieszka Kierzkowska, Felix Donat, Alexander A. Kolganov, Evgeny A. Pidko, Paula M. Abdala, Alexey Fedorov, Christoph R. MĂŒller
Efficacy and durability of immediate versus delayed single-dose HPV vaccination for persistent infection among young women in Kenya: a randomized, blinded, cross-over clinical trial
Ruanne V. Barnabas, Elizabeth R. Brown, Elizabeth A. Bukusi, Betty Njoroge, Rachel L. Winer, Denise A. Galloway, Imeldah N. Wakhungu, Charlene Biwott, Syovata Kimanthi, Kate B. Heller, Meighan Krows, Susan Morrison, Elena A. Rechkina, Stephen L. Cherne, R. Scott McClelland, Nelly R. Mugo, Maricianah A. Onono
Maveropepimut-S, pembrolizumab and low dose cyclophosphamide in metastatic ovarian cancer: phase 1/2 PESCO trial
Ana C. Veneziani, Stephanie Lheureux, Douglas G. Millar, Neesha Dhani, Ilaria Colombo, Ainhoa Madariaga, Pamela Soberanis Pina, Swati Atale, Yin-Ling Chan, Joshua Lee, Janelle Ramsahai, Judy Quintos, Lisa Wang, Xuan Li, Valerie Bowering, Pam Ohashi, Ben Wang, Amit M. Oza
Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history
Jordan T. Ort, Ashley Sobel Leonard, Shuk Hang Li, Reilly K. Atkinson, Lydia M. Mendoza, Marcos Costa Vieira, Sydney Gang, Sarah Cobey, Scott E. Hensley
Endothelial-erythrocyte glycocalyx exchange enables liquid biopsies of endothelial function
Matthew J. Butler, Raina R. Ramnath, Michael Crompton, Jasmine Aldam, Monica Gamez, Colin Down, Charley Heffer, Chris Neal, Jialu Li, Yan Qiu, Laura Carey, Laura Skinner, Stephen Cross, Yamaguchi Yu, Judit Sutak, Victoria Bills, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Publisher Correction: Strong nickel enrichment co-located with redox-organic interactions in Neretva Vallis, Mars
H. T. Manelski, R. C. Wiens, A. Broz, J. A. Hurowitz, M. Tice, S. Clegg, E. Dehouck, N. Randazzo, S. A. Connell, O. Forni, S. J. VanBommel, S. Schröder, L. Mandon, T. S. J. Gabriel, C. C. Bedford, R. K. Martinez, E. A. Cloutis, A. Cousin, M. L. Cable
Biochemical and brain heterogeneity characterizes psychiatric and non-psychiatric illness
Maria A. Di Biase, William R. Reay, Hadis Jameei, Yuanzhe Liu, Ye E. Tian, Elysha Ringin, Susan Rossell, James A. Karantonis, Tamsyn E. Van Rheenen, Junhao Wen, Christos Pantelis, Andrew Zalesky
Author Correction: Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids
Ohman Kwon, Hana Lee, Jaeeun Jung, Ye Seul Son, Sojeong Jeon, Won Dong Yu, Naeun Son, Kwang Bo Jung, Eunho Choi, In-Chul Lee, Hyung-Jun Kwon, Chuna Kim, Mi-Ok Lee, Hyun-Soo Cho, Dae Soo Kim, Mi-Young Son
Developmental origins of exceptional health and survival: a four-generation family cohort study
Matthew Thomas Keys, SĂžren Netra, Dorthe Almind Pedersen, Pernille Stemann Larsen, Alexander Kulminski, Mary F. Feitosa, Mary Wojczynski, Michael Province, Kaare Christensen
Speckle-based measurement of the fractional azimuthal index of orbital angular momentum beams for refractive index sensing
Christopher Perrella, Aman Anil Punse, Anastasiia Zalogina, Crispin Szydzik, Megan Lim, Andreas Boes, Arnan Mitchell, Kylie R. Dunning, Kishan Dholakia
Tailoring light emission in colloidal nanocrystals through lattice distortion engineering
Jeong Woo Park, Sejong Min, Jong Ah Chae, Jonathan C. Lemus, Dongju Jung, Jin Su Park, Seongbin Im, Lucas B. Melo, Diego Scolfaro, Luigi Pieri, Leonardo W. T. Barros, Euyheon Hwang, Young-Shin Park, Diogo B. Almeida, Ji-Sang Park, Victor I. Klimov, Lazaro A. Padilha, Wan Ki Bae
Citywide indoor air sampling mirrors wastewater and clinical case surveillance of respiratory viruses
Hannah J. Barbian, Erin P. Newcomer, Sofiya Bobrovska, Rachel S. Poretsky, Stephanie Greenwald, Sarah M. Owens, Anuj Tiwari, Rachel J. Berkowitz, Samantha Smith, Dorothy Wright, Stefan J. Green, Dolores Sanchez Gonzalez, Chi-Yu Lin, Adam Horton, Modou Lamin Jarju, Rosemarie Wilton, Mary K. Hayden, Stephanie R. Black, V. Eloesa McSorley, Alyse Kittner
An end-to-end hybrid deep-learning approach for single-shot wavefront sensing and correction
Sina Moayed Baharlou, Muhammad Waleed Khalid, Guli Gulinihali, Jeongho Ha, Liyi Hsu, Samantha C. Lewis, Lei Tian, Yeshaiahu Fainman, Alexander V. Sergienko, Abdoulaye Ndao
Hierarchical small molecule inhibition of MYST acetyltransferases
Xuemin Chen, Alexandra Castroverde, Minervo Perez, Ronald Holewinski, Kiall F. Suazo, Rashmi Karki, Thorkell Andresson, Benjamin A. Garcia, Jordan L. Meier
Intrinsically stretchable large-area pixelated electrochromic displays via direct photopatterning
Kang Sik Kim, Soo Yeon Eom, Seong Hwan Yang, Jeong-Wan Jo, Fayong Sun, Roun Lee, Beomjin Jeong, Myoung-Jae Lee, Jong-Woong Kim, Yong-Hoon Kim, Jong S. Park, Sung Kyu Park
Social implications of the 30Ă30 global conservation target
Javier Fajardo, Heather C. Bingham, Dan Brockington, Rebecca Chaplin-Kramer, James A. Fitzsimons, Forrest Fleischman, Alain Frechette, Rachael D. Garrett, Carolina Hazin, Tobias Kuemmerle, Janeth Lessmann, Milagre O. F. Nuvunga, Brian OâDonnell, Fred Onyai, Ruth Pinto, Marion Pfeifer, Rose Pritchard, Casey M. Ryan, Priya Shyamsundar, Josefa Cariño Tauli, David Mwesigye Tumusiime, Jasmin Upton, Gary R. Watmough, Julie G. Zaehringer, Chris Sandbrook
A metasurface-enabled green-smart window for intelligent wireless communications with high visible transparency and low infrared emissivity
Rui Zhe Jiang, Chuan Kui Shen, Hui Dong Li, Qun Yan Zhou, Zhi Hui Fu, Zheng Xing Wang, Terry Tao Ye, Jun Yan Dai, Lie Kun Yang, Jitong Ma, Qiang Cheng, Tie Jun Cui
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling
YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L. Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, Eric M. Morrow
Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi
Mireia Larrosa-Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake T. Creasey, Jack M. Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice Adedeji, Estela Gonzalez, Joshua X. D. Ang, Michelle A. E. Anderson, Luke Alphey
Personalized machine learning-guided radiation dose escalation in newly diagnosed glioblastoma: prospective pilot study
Hamed Akbari, Suyash Mohan, Fang Liu, Cecilia Jiang, Anahita Fathi Kazerooni, Melanie Berger, Saima Rathore, Michel Bilello, Chiharu Sako, Jose Garcia, Steven Brem, Spyridon Bakas, Elizabeth Mamourian, Abigail Pepin, Paul James, Jay Dorsey, Ashish Singh, Drew Parker, Ragini Verma, Quy Cao, Stephen J. Bagley, Arati Desai, Donald M. OâRourke, Russell T. Shinohara, MacLean P. Nasrallah, Boon-Keng Kevin Teo, Goldie Kurtz, Gaurav Shukla, Michelle Alonso-Basanta, Robert A. Lustig, Christos Davatzikos
Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution
Mahsa Zabihi, Ali Khadim, Arun Lingampally, Ana Ivonne Vazquez-Armendariz, Stefan Hadzic, Georgios-Dimitrios Panagiotidis, Daniel Kalina, Jan Halweg, Tara Procida-Kowalski, Marek Bartkuhn, Xuran Chu, Janine Koepke, Christos Samakovlis, Mario Boehm, Norbert Weissmann, Andreas GĂŒnther, Werner Seeger, Peter Braubach, Susanne Herold, Malgorzata Wygrecka, Saverio Bellusci, Elie El Agha
Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, Ueon Sang Shin, Sak Lee, Buuvee Bayarkhangai, Rajendra K. Singh, Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim
Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavior
Aikaterina Manoli, Neville Magielse, Felix Hoffstaedter, Nilsu SaÄlam, Thanos Tsigaras, Augustijn A. A. de Boer, Lorenz Ahle, Ceyda Yalçin, Milin Kim, Torgeir Moberget, Thomas Wolfers, Casey Paquola, Charlotte Grosse Wiesmann, Andre F. Marquand, Jorn Diedrichsen, Sofie L. Valk
Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer
Yasaman Setayeshpour, Ssu-Yu Chen, Divya L. Dayanidhi, Yunji Lee, Shao-Chin Wu, Juan J. Aristizabal-Henao, Jianli Wu, Chao-Chieh Lin, Nazanin Setayeshpour, Chiara Federico, Alexander A. Mestre, Michael A. Kiebish, Andrew Berchuck, David S. Hsu, Zhiqing Huang, Susan K. Murphy, Jen-Tsan Chi
Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses
Xue-Bing Ni, Yong-Tao Ye, Gong-Pei Wang, Ye-Xiao Cheng, Yu-Qian Wu, Yi Song, Jin-Jin Zhang, Ning-Qi Zhao, Xin Li, Dong-Sheng Chen, Tao Xiong, Tian-Feng An, Zi-Yun Chen, Zhong-Ze Fang, Edward C. Holmes, Wu-Chun Cao, Na Jia, Tommy Tsan-Yuk Lam
Integrated catalystâtransport nickel-iron porous electrode for anion exchange membrane water electrolysis
Hye Ri Kim, Sang-Hun Shin, Gahyeon Lee, Keun-Hwan Oh, Soomin Choi, Kangmin Seo, Jihyun Ra, Hyunseob Lim, Tae-Ho Kim, Sungjun Kim, Jang Yong Lee, Jong Hoon Joo
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
Nikolas Klink, Sebastian Urban, Johanna A. Seier, Bikash Adhikari, Martin P. Schwalm, Juliane MĂŒller, Madeleine Dorsch, Philine Steinbach, Jennifer Jung, Markus Vogt, Farnusch Kaschani, Johannes Koch, Siska FĂŒhrer, Markus Kaiser, Nina Schulze, Stefan Knapp, Elmar Wolf, Annette Paschen, Barbara M. GrĂŒner, Malte Gersch
Astroglial disinhibition of cortical circuits disrupts cognition via kynurenic acid in mice
Viktor Beilmann, Johanna Furrer, Sina M. Schalbetter, Ron Schaer, Edoardo Tiziani, Kim D. Ferrari, Felisa Herrero, Celine Heeb, Alexandra von Faber-Castell, Jacqueline Condrau, Ulrike Weber-Stadlbauer, Matthias T. Wyss, Aiman S. Saab, Sarah Beggiato, Urs Meyer, Bruno Weber, Tina Notter
CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Wallace Bourgeois, Hannah E. Rice, Daniela V. Wenge, Florian Perner, Hong Yue, Brandon D. Regalado, George Wan, Jan C. Schroeder, Alba Sommerschield, Charlie Hatton, Shivendra Singh, Sweta Singh, Shipra Bijpuria, Brian M. McKeever, William H. Miller, Jordan F. Safer, Sumaiya Iqbal, Jennifer A. Perry, Eric S. Fischer, John G. Doench, Gerard M. McGeehan, Jevon A. Cutler, Scott A. Armstrong
Reprogramming gut microenvironment for the treatment of acute severe ulcerative colitis via a synergistic therapy of necroptosis blockade and organoid transplantation
Heterogeneous endocrine cell composition defines human islet functional phenotypes
Carmella Evans-Molina, Yasminye D. Pettway, Diane C. Saunders, Seth A. Sharp, Thomas SR. Bate, Han Sun, Heather Durai, Shaojun Mei, Anastasia Coldren, Corey Davis, Conrad V. Reihsmann, Alexander L. Hopkirk, Jay Taylor, Amber Bradley, Radhika Aramandla, Greg Poffenberger, Adel Eskaros, Regina Jenkins, Danni Shi, Ke Xu, Hakmook Kang, Varsha Rajesh, Swaraj Thaman, Fan Feng, Jean-Philippe Cartailler, Alvin C. Powers, Kristin Abraham, , Anna L. Gloyn, Joyce C. Niland, Marcela Brissova
Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model
Davide Caredio, Giovanni Mariutti, Lisa Polzer, Beatrice Gatta, Martina Cerisoli, Yasmine Laimeche, Giulia Miracca, Jeanne Droux, Mohamad El Amki, Marc Emmenegger, Marian Hruska-Plochan, Susanne Wegener, Magdalini Polymenidou, Matthias Schmitz, Inga Zerr, Elena De Cecco, Adriano Aguzzi
Artificial intelligence for predicting hospital admissions from the emergency department: a prospective, quasi-experimental study
Alexander J. Ryu, Shant Ayanian, Ray Qian, Riddhi S. Parikh, Sagar B. Dugani, Karen M. Fischer, Heather A. Heaton, Jens P. Boyum, Benjamin J. Hinton, Donna K. Lawson, M. Caroline Burton
Long Ren, Arianna Esposito-Verza, Raphael Gasper, Marion E. Pesenti, Petra Janning, Franziska MĂŒller, Carolin Koerner, Petra Geue, Sabine Wohlgemuth, Ingrid R. Vetter, Andrea Musacchio
Engineering B cells to express fully customizable antibodies with enhanced Fc functions
Chun Huang, Atishay Mathur, Chan-Hua Chang, Xiaoli Huang, Hsu-Yu Chen, Zachary B. Davis, Karla OâDell, Elizabeth A. Shuman, Raymond W. Kung, Geoffrey L. Rogers, Paula M. Cannon
Asymmetric two-photon response of an incoherently driven quantum emitter
Lennart Jehle, Lena M. Hansen, Patrik I. Sund, Thomas W. SandĂž, Raphael Joos, Michael Jetter, Simone L. Portalupi, Mathieu Bozzio, Peter Michler, Philip Walther
Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury
Lynn Farner, Paulina S. Scheuren, Kiomars Sharifi, Tim M. Emmenegger, Maryam Seif, MichĂšle Hubli, Martin Schubert, Marc Bolliger, RĂŒdiger Rupp, Norbert Weidner, Rainer Abel, Doris Maier, Klaus Röhl, Michael Baumberger, Margret Hund-Georgiadis, Marion Saur, JesĂșs Benito, Kerstin Rehahn, Mirko Aach, Andreas Badke, Jiri Kriz, Tim Killeen, Alan J. Thompson, Nikolaus Weiskopf, Martin E. Schwab, Armin Curt, Patrick Freund,
Global-scale population genetic analysis of Plasmodium falciparum identifies region-specific patterns of malaria parasite adaptation
Nina Billows, Jamille G. Dombrowski, Joseph Thorpe, Leen Vanheer, Sophie Moss, Jesse Gitaka, Colin J. Sutherland, Claudio R. F. Marinho, Nguyen Thi Hong Ngoc, Nguyen Thi Huong Binh, Nguyen Quang Thieu, Susana Campino, Taane G. Clark
A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis
Ryuji Yanase, Molly Hair, Mohammad Zeeshan, David J. P. Ferguson, Declan Brady, Carla Pasquarello, Andrew Bottrill, Suhani Bhanvadia, Armund Neal, Eelco C. Tromer, Karine G. Le Roch, Alexandre Hainard, Anthony A. Holder, Sue Vaughan, David S. Guttery, Rita Tewari
Non-equilibrium reducing flame aerosol process to create supported high-entropy alloy nanoparticles
Shuo Liu, Jiashun Liang, Jonas L. Kaufman, Qike Jiang, Dominik Wierzbicki, Kang-Lan Tung, Kaiwen Chen, Haolan Sun, Zhengxi Xuan, Mohd Ashhar Khan, Chengyu Song, Shinyoung Kang, Wei Chen, Gang Wu, Jeffrey J. Urban, Mark T. Swihart, Chaochao Dun
BromoCatch: a self-labelling tag platform for protein modification and live cell imaging
Maria Rodriguez-Rios, Conner Craigon, Mark A. Nakasone, Gajanan Sathe, Adam G. Bond, Mark Dorward, Anthony K. Edmonds, Mark C. Norley, Robert E. Arnold, Paul M. Wood, Stephen J. Reynolds, Joel O. Cresser-Brown, Graham P. Marsh, Hannah J. Maple, Alessio Ciulli
CD38âș endothelial remodeling marks spatially patterned vasculopathy in rapidly advancing periodontitis and peri-implantitis
Quinn T. Easter, Khoa L. A. Huynh, Camila Schmidt Stolf, Jialiu Xie, Bruno F. Matuck, Akira Hasuike, Zabdiel Alvarado-Martinez, William S. Kim, Zhaoxu Chen, Apoena Aguiar Ribeiro, Nivedita Pareek, Andrea M. Azcarate-Peril, Di Wu, Renato Casarin, Kang I. Ko, Jinze Liu, Kevin M. Byrd
The honey bee triad: a comprehensive catalogue of phages in the Apis mellifera gut microbiome
Nikolas Basler, Lina De Smet, George Bouras, Jill Swinnen, Katarzyna Pranga, Corina P. D. Brussaard, Peter Vandamme, Dirk C. de Graaf, Jelle Matthijnssens
Nivolumab plus ipilimumab for chemotherapy-refractory metastatic castration-resistant prostate cancer: results from the randomized portion of the phase 2 CheckMate 650 trial
Resolving liquid-to-glass transitions of water under soft nanoconfinement
Patrick ZĂŒblin, Eva Zunzunegui-Bru, Livia Salvati Manni, Alice Klapproth, Richard Mole, Nageshwar Rao Yepuri, Syrine Khaled, Guillaume Pierre Laurent, Thierry AzaĂŻs, Serena Rosa Alfarano, Jean-Blaise Brubach, Salvatore Assenza, Francesco Sciortino, Raffaele Mezzenga
Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress
Saber H. Saber, Nyakuoy Yak, Konstantin Dolski, Sanna MĂ€ki, Lev Levanov, Levina A. Willenbrink, Julian D. J. Sng, Mohammed R. Shaker, Sean D. Morrison, Huiwen Zheng, Selin Pars, Giovanni Pietrogrande, Yih Tyng Bong, Tania Vane-Tempest, Teemu Smura, Tomas Strandin, Ravi Ojha, Ravi Kant, Janika Ruuska, Francesco Topi, Diana Vaskiv, Lauri Kareinen, Tobias Binder, Siyuan Lu, Matthias Floetenmeyer, Bahaa Al-mhanawi, Yanshan Zhu, Tarja Sironen, Gert Hoy Talbo, Kirsty R. Short, Wouter W. Kallemeijn, Roberto Solari, Jessica Mar, Edward W. Tate, Ashley J. van Waardenberg, Olli Vapalahti, Ernst Wolvetang, Giuseppe Balistreri, Merja Joensuu
A tunable CTD grammar governs the spatial programming of the transcription cycle
Qian Zhang, Haley A. Hardtke, Yuanmin Zheng, Haopeng Yang, Alan Gerber, Mukesh Kumar Venkat Ramani, Edwin E. Escobar, Jennifer S. Brodbelt, Ruobo Zhou, Y. Jessie Zhang
CD84 is a specific target for acute myeloid leukemia CAR-T cell therapy
Martina Pigazzi, Silvia Merlini, Ambra Da Ros, Olivia Marini, Giovanni Faggin, NicolĂČ Fortuna, Raffaele Mattera, Barbara Buldini, Paolo Rizzardi, Soheil Meshinchi, Giuseppe Basso, Franco Locatelli, Alessandra Biffi
Extensive cryptic circulation sustains mpox among men who have sex with men
Joseph A. Lewnard, Miguel I. Paredes, Matan Yechezkel, Gregg S. Davis, Vennis Hong, Jessica Skela, Utsav Pandey, Noah T. Parker, Lauren C. Granskog, Magdalena E. Pomichowski, Iris Anne C. Reyes, Isabel Rodriguez-Barraquer, Nicola F. MĂŒller, Sara Y. Tartof
Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection
Anna Maria Pfefferkorn, Lorenz Jahn, Patrick T. Gauthier, Vera Anna Kulow, Johannes Roeles, Niklas MĂŒller-Bötticher, Louisa M. S. Gerhardt, Janna Leiz, Sadia Sarfraz, Izabela Plumbom, Robert Greite, Svjetlana Lovric, Jaba Gamrekelashvili, Florian Limbourg, Jessica Schmitz, Jan Hinrich BrĂ€sen, Irina Scheffner, Igor M. Sauer, Felix Aigner, Janine AltmĂŒller, Thomas Conrad, Wilfried Gwinner, Naveed Ishaque, Michael FĂ€hling, Kai M. Schmidt-Ott, Philip F. Halloran, Muhammad Imtiaz Ashraf, Christian Hinze
A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses
Samy Sid Ahmed, Liv Zimmermann, Andrea Imle, Katrin Wuebben, Nadine Tibroni, Lena Rauch-Wirth, Jan MĂŒnch, Petr Chlanda, Frederik Graw, Oliver T. Fackler
Distribution of microbial carrageenan foraging pathways reveals a widespread latent trait within the ruminant intestinal microbiome
Jeffrey P. Tingley, Thea O. Andersen, Liam G. Mihalynuk, Xiaohui Xing, Kristin E. Low, Douglas P. Whiteside, Ianina Altshuler, Nic Jujihara, Anna Y. Shearer, Leeann Klassen, Spencer Serin, Edgar Smith, Greta Reintjes, Trushar R. Patel, Alisdair B. Boraston, Live H. Hagen, Phillip B. Pope, D. Wade Abbott
Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model
Krista B. Gunter, James M. Bowen, Andrew T. Clarke, Melanie McFarlane, Dorcus C. A. Omoga, Stephanie Pozuelos, Henry Giesel, Curtis Witt, Lisa M. Rogers, David M. Aronoff, Andrew M. Lunel, Jay Vornhagen, Benjamin Brennan, Natasha L. Tilston
Cetacean evolution through the lens of ecospace modeling and disparity analyse
MĂłnica R. Buono, Florencia Paolucci, Lisandro Campos, Mariana Viglino, C. Maximiliano GaetĂĄn, Viviana N. Milano, NicolĂĄs D. Farroni, Marta S. FernĂĄndez
Condensin I but not Condensin II is crucial for mitotic chromosome mechanics
Christian F. Nielsen, Hannes Witt, Andrea Ridolfi, Bas Kempers, Emma M. J. Chameau, Stijn van der Smagt, Justine Sitz, Marin Barisic, Erwin J. G. Peterman, Gijs J. L. Wuite, Ian D. Hickson
Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling
Kristine J. Fernandez, Ghazal Sultani, Max Nobis, Brian Gloss, Leila Eshraghi, Amy E. McCart Reed, Sarah Alexandrou, Christine Lee, Daniel L. Roden, Emily I. Jones, Maryam Hasha Simad, Ewan K. A. Millar, Nenad Bartonicek, Samantha R. Oakes, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Ellie T. Y. Mok, Hannah L. Williams, Jamie R. Kutasovic, Margaret C. Cummings, Janett Stoehr, Victoria Lee, Kate Harvey, Sunny Wu, Sunil R. Lakhani, Peter T. Simpson, Thomas R. Cox, Lisa M. Ooms, Christina A. Mitchell, Rob Salomon, Alexander Swarbrick, David Gallego-Ortega, Elgene Lim, Paul Timpson, C. Elizabeth Caldon
Systematic multi-omic deconvolution of the clinical heterogeneity of Down syndrome
Micah G. Donovan, Srija Chillamcherla, Belinda A. Enriquez Estrada, Kayleigh R. Worek, Zenitha Sundararajan, Kyle W. Barstch, Kelly D. Sullivan, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa
Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution
Rongyu Zhang, Jingqi Qi, Michaela McKasson, Jongchan Choi, Vanessa Gutierrez, Conor Brennan, Sunga Hong, William Chour, Rachel H. Ng, Jingyi Xie, Dan Yuan, Andrew Webster, Simranjeet K. Sidhu, Abby Anderson, Daniel Chen, Rick Edmark, Kim M. Murray, Sarah Li, Connor McDonald, Lee Rowen, Shuo Wang, Yusuf Rasheed, Yapeng Su, Jamie R. Wagner, Jia Ming Chen, Karla Nawaly, Jie Fu, Alexandria Duven, Stephen J. Forman, Mihae Song, Saul J. Priceman, Christine E. Brown, Antoni Ribas, Deborah J. Wong, Kelly G. Paulson, Charles W. Drescher, Cristina Puig-Saus, Jason D. Goldman, Cornelia L. Trimble, James R. Heath
Ultrafast charge-generation dynamics through interfacial energetic modulation for high-performance single-component organic photovoltaics with 14.8% efficiency
Yao Li, Yongmin Luo, Yulong Hai, Xinkang Wang, Lunbi Wu, Ruijie Ma, Kezhou Fan, Top Archie Dela Peña, Sha Liu, He Yan, Kam Sing Wong, Gang Li, Tao Jia, Junwu Chen, Jiaying Wu
The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes
Karsten Krey, Jennifer Risso-Ballester, Sabri Hamad, Susanne Maidl, Sara Bilekova, Quirin Emslander, Melissa Verin, Sarah Mundigl, Alexandrina Cernat, Antonio Piras, Valter Bergant, Vincent Grass, Andreas Pichlmair
Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders
Tingting Cui, Ye Gong, Zhen Wang, Pei Li, Luhang Dai, Jia Chen, Zhe Feng, Xueli Liu, Shaogang Li, Huanyi Liu, Ke Li, Xiaoli Ding, Xiaochang Xue, Luting Yang, Lei Zhang, Rui Li, Ying Fu, Yaling Zhang, Yaping Yan
The role of environmental, developmental, and psychological processes in translating genetic dispositions into observed academic achievement remains under-investigated. Here, we examine whether non-cognitive skillsâincluding motivation, attitudes, and emotional and behavioural functioningâmediate the genetic prediction of academic achievement across development. We analyse data from 5,016 children enrolled in the Twins Early Development Study at ages 7, 9, 12, and 16, as well as their parents and teachers. We find that non-cognitive skills mediate between less than 5 and up to 64% of the genetic prediction of academic achievement. Mediation effects are larger and more robust for motivation and attitudes (ÎČ â 0.13) than for emotional and behavioural functioning (ÎČ â 0.01â0.03). This pattern holds longitudinally and is replicated in within-family analyses, where non-cognitive skills account for up to 83% of the total mediation effects. These findings highlight the contribution of non-cognitive skills beyond shared familial factors, likely reflecting how children evoke and select experiences that align with their genetic propensity and lead to differences in academic development.
Temporality modulates the effect of network heterogeneity on cooperation fixation
Aming Li, Yao Meng, Lei Zhou, Naoki Masuda, Long Wang
Understanding the evolution of cooperation in structured populations remains a central challenge in multidisciplinary areas. Although previous findings suggest that structural heterogeneity in static networks hinders cooperation, real-world interactions in most natural and social systems are dynamic and best represented as temporal networks. Here, we challenge this conventional wisdom and, by developing a systematic mathematical framework, we report that structural heterogeneity in temporal networks can instead promote collective cooperation. Importantly, we reveal that such advantages depend on an often-overlooked metricâfixation timeâquantifying the time required for a single cooperator to drive the entire population to cooperation. Highly heterogeneous networks accelerate this process within each subnetwork, resulting in a quantitative enhancement of cooperation in temporal networks compared to their homogeneous counterparts. By validating our results on empirical datasets through theoretical analyses and simulations, we provide a consistent framework for analysing cooperative dynamics across static and temporal networked systems.
Science Advances
Generic title: Not a research article
Erratum for the Research Article âA splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccineâ by Y. Zhai et al .
Polyketide synthaseâlike functionality acquired by plant fatty acid elongase
Hyojin Kim, Kiyoul Park, Hao Jia, Fan Huang, Xinyu Tang, Ting Zhong, Wenlin Yu, Jean-Jack M. Riethoven, Rebecca E. Cahoon, Chunyu Zhang, Edgar B. Cahoon
High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transferâweighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness
Behnaz Ghaemi, Hernando Lopez-Bertoni, Shreyas Kuddannaya, Sophie Sall, John Laterra, Guanshu Liu, Jeff W. M. Bulte
Preemptive cardioprotection with a small molecule in rodents that suppresses genes predictive of heart failure
Yue Li, Matthew V. Andrews, David T. Humphreys, Eric Lam, Christopher J. OâKeeffe, Michaella N. Albao, Zuhayr Jafri, Mark J. Raftery, Ling Zhong, Connor H. OâMeara, Iveta Slapetova, Maria Kasherman, Vaibhao Janbandhu, Ravinay Bhindi, Peter Libby, Levon M. Khachigian
Pulsed volcanic sulfur emissions linked to the end-Triassic terrestrial crisis
Linhao Fang, Robert J. Newton, Xiaoyu Zhang, Hongjia Li, Guangli Wang, Shenghui Deng, Paul B. Wignall, Yuanzheng Lu, Chaokun Zhang, Meijun Li, Huaichun Wu, Tianchen He, Benzhong Xian, Shengbao Shi, Lei Zhu, Simon H. Bottrell, Stephen P. Hesselbo
Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs
Tamiru N. Alkie, Carissa Embury-Hyatt, Anthony V. Signore, Estella Moffat, Darwin Ramos, Sugandha Raj, Tamiko Hisanaga, Ifeoluwa Ayilara, Daniel S. Sullivan, Patrick Lloyd, Lemarie Pama, Cassidy N. G. Erdelyan, Andrew S. Lang, Darwyn Kobasa, Davor Ojkic, Loren Matheson, Oliver Lung, Zvonimir Poljak, Yohannes Berhane
Biogenesis and downstream effects of 3âČ,5âČ and 2âČ,3âČ cAMP isomers in plants
Mingyue Li, Monika Chodasiewicz, Malavika Muraleedharan, Israel M. Lopez, Michal Gorka, Olga Kerber, Saqer S. Alotaibi, Andrew D.L. Nelson, Rene Lenobel, Jaroslava FriedeckĂĄ, Aleksandra Skirycz, JiĆĂ Friml
Three cryo-EM structures of complement C3d-bound α M ÎČ 2 reveal an unexpected layer of dynamics for αI-containing integrin receptors
Josefine Lorentzen, Marlene Uglebjerg Fruergaard, Szilvia LukĂĄcsi, Martin HĂžgholm JĂžrgensen, Timo Lambertus Gerardus van Veghel, Rasmus Kjeldsen Jensen, Krzysztof Jakub Pietrzak-Lichwa, Zsuzsa Bajtay, VĂĄclav HoĆejĆĄĂ, Rasmus Kock Flygaard, Daan Vorselen, Simon Arnold Mortensen, Gregers Rom Andersen
Beyond formic acid: Peptides in carpenter ant venoms aid in disease protection
Lukas Koch, Sandro Andreotti, Mario Schubert, Elisa Liebhart, Anton M. ZĂŒrbig, Julian Gatzki, Benjamin-Florian Hempel, Lydia Kollhoff, Barbara Feldmeyer, Martin Herzberg, Valerie I. C. Rebhahn, Nwet Nwet Win, Adria C. LeBoeuf, Marat Meleshin, Fabian Herrmann, Christian Schwieger, Heike Brötz-Oesterhelt, Andrea Sinz, Mike Schutkowski, Timo H. J. Niedermeyer, Simon Tragust
Wireless, skin-interfaced multimodal sensing system for continuous psychophysiological monitoringâA wearable polygraph device
Sun Hong Kim, Tae Wan Park, Seunghee Cho, Tianyu Yang, Seonggwang Yoo, Khaytin Ilya, Jacie R. McHaney, Jana Jaffe, Anisha Kshetrapal, Yue Wang, Yunyun Wu, Jan-Kai Chang, Jihun Park, Hak-Young Ahn, Min-Seung Jo, Jacob Trueb, Yei Hwan Jung, Seyong Oh, Sang Min Won, Debra E. Weese-Mayer, Jae-Young Yoo, John A. Rogers
Symmetric instability drives exchange between surface and bottom waters in a coastal front
Mareike Körner, Jesse M. Cusack, Jonathan Nash, R. Kipp Shearman, Leif N. Thomas, Jennifer MacKinnon, Fucent Hsuan Wei Hsu, John Taylor, Jinliang Liu, James P. Hilditch
Fate of isoprene peroxy radical constrains the urban photochemical regime
Michael A. Robinson, Matthew M. Coggon, Kelvin H. Bates, Jeff Peischl, Christopher M. Jernigan, Gordon Novak, Subi Thakali, James M. Roberts, J. Andrew Neuman, Patrick R. Veres, Kristen Zuraski, Eleanor M. Waxman, Wyndom S. Chace, Andrew W. Rollins, Victoria Treadaway, Morgan Selby, Colby Francoeur, Jessica B. Gilman, Shang Liu, Erin R. Delaria, Abby E. Sebol, Nidhi S. Desai, Jennifer Kaiser, Kathryn E. Kautzman, Jason M. St. Clair, Glenn M. Wolfe, Lu Xu, Chelsea E. Stockwell, Carsten Warneke, Han N. Huynh, Ming Lyu, Adam Ahern, Charles A. Brock, Alison Piasecki, Sarah Albertin, Ann M. Middlebrook, Amy P. Sullivan, Magesh Kumaran Mohan, Rodney Weber, Emily Lill, Ilana Pollack, Katherine Ball, John D. Crounse, Paul O. Wennberg, Anna Novelli, Aaron Stainsby, Hendrik Fuchs, Birger Bohn, Georgios I. Gkatzelis, Joshua P. DiGangi, Glenn S. Diskin, J. Jerrold M. Acdan, R. Bradley Pierce, Chia-Hua Hsu, Siyuan Wang, Rebecca Schwantes, Gonzalo GonzĂĄlez Abad, Caroline R. Nowlan, Xiong Liu, Nathan Howard, Steven S. Brown
From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles
Haoming Bao, Emily Xi Tan, Jie Zhou, Xiang Zhao, Sheng Yuan Leong, Chang Hoong Chek, Guo Kang Leon, Jaslyn Ru Ting Chen, Lam Bang Thanh Nguyen, Ling Li, Han Wei Hou, Hongwen Zhang, In Yee Phang, Xing Yi Ling
A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/ÎČ-catenin signaling
Miroslav Micka, Jitender Kumar, Petra PaclĂkovĂĄ, Zuzana Hayek, KateĆina HanĂĄkovĂĄ, Cherine Bechara, Hana PleĆĄingerovĂĄ, Ondrej Ć edo, Sara Bologna, Elise Del Nero, KristĂna GömöryovĂĄ, VojtÄch BystrĂœ, TomĂĄĆĄ GybeÄŸ, Tereza ÄĂhalovĂĄ, Marek Kravec, David PotÄĆĄil, ZbynÄk ZdrĂĄhal, Konstantinos Tripsianes, VĂtÄzslav Bryja
Compound drivers of Antarctic sea ice loss and Southern Ocean destratification
Aditya Narayanan, Holly Ayres, Matthew H. England, F. Alexander Haumann, Matthew R. Mazloff, Alessandro Silvano, Theo Spira, Shenjie Zhou, Alberto C. Naveira Garabato
Light-switchable swarming of biohybrid microrobots
VĂctor de la AsunciĂłn-Nadal, Casper Nisula, Carmen CuntĂn-Abal, Robert Kobrin, Gloria Mendis, Jack Latella, Chuanrui Chen, Beatriz Jurado-SĂĄnchez, Liangfang Zhang, Alberto Escarpa, Anja Boisen, Joseph Wang
Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway
Alice M. Ma, Peter H. Tran, Nicole L. Yang, Jennifer Ngo, Hirotaka Iwasaki, Wenjuan Ren, Simone Livit, Linsey Stiles, Sarah Wang, Trinity Ho, Emma Y. Yim, Noelle Morrow, Morgan M. Johnson, Caroline Cleary, Kai Zou, Rachelle H. Crosbie, Yuwei Jiang, Orian S. Shirihai, Jonathan Wanagat, Sushil Mahata, James A. Wohlschlegel, Andrea L. Hevener, Zhenqi Zhou
Swartkrans Paranthropus and Sterkfontein Australopithecus from southern Africa had different locomotor repertoires
Marine Cazenave, Annalisa Pietrobelli, Andrea LukovĂĄ, Sebastian Bachmann, Matthew V. Caruana, Ronald J. Clarke, Christopher J. Dunmore, Ashley S. Hammond, Jason L. Heaton, A. J. Heile, Jakobus Hoffman, Kathleen Kuman, Dieter H. Pahr, Christopher M. Smith, Dominic Stratford, Alexander Synek, Zewdi J. Tsegai, Tracy L. Kivell, Travis Rayne Pickering, Matthew M. Skinner
A broad-spectrum inhibitor of copper-exporting P 1B -type ATPases
Vinit C. Shanbhag, Samuel Anakpeba-Dinguyella, Nikita Gudekar, Kristyn Conrad, Chiemerie Azubuogu, Corinna Probst, Martina Ralle, MarĂa G. Mediavilla, Julia A. Cricco, Natalie M. Garza, Vishal M. Gohil, Scott Peck, Siddhartha Kumar, Amarnath Natarajan, Madujika A. Horadigala-Gamage, Gabriele Meloni, Kamal Singh, Michael J. Petris
A brain circuit of bidirectional modulation of social and nonsocial cognition by androgens and estrogens in male mice
Dario Aspesi, Anjana Varatharajah, Lucia Cioffi, Silvia Diviccaro, Donatella Caruso, Natalina Becke, Jasmin Lalonde, Melissa L. Perreault, Roberto C. Melcangi, Neil J. MacLusky, Elena Choleris
Measurement of atomic scattering factors by cryoelectron microscopy
Alexander Shtyrov, Hugh Wilson, Daria Slowik, Keitaro Yamashita, Jade Li, Marcin Wojdyr, Shaoxia Chen, Greg McMullan, Jude M. Short, Christopher J. Russo, Richard Henderson, Garib N. Murshudov
Sterol divergence across eukaryotic kingdoms determines membrane susceptibility to saponins, a class of plant defense compounds
Malbor Dervishi, Jan GĂŒnther, Jinhui Li, Huriye Deniz Uzun, Hans Christian Bruun Hansen, Thomas GĂŒnther Pomorski, Anja Thoe Fuglsang, Viviana Monje, SĂžren Bak
Nestor Kippes, Meric C. Lieberman, Darrin Culp, Isabelle J. DeMarco, Helen T. Tsai, Kanae Masuda, NiccolĂČ Terzaroli, Jordan Lopez, Robert G. Wilson, Luca Comai, Isabelle M. Henry
Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes
Agnieszka Kalinowski, Claudia Macaubas, Hanmin Guo, Lauren A. Anker, Diane E. Wakeham, Marcus Ho, Reenal Pattni, Batuhan Bayram, Surbhi Sharma, Joanna Liliental, Jong H. Yoon, Elizabeth D. Mellins, Lawrence Steinman, Alexander E. Urban
Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks
Huayu Hou, Jimin Wu, Jinyun Liu, Vivek Boominathan, Argaja Shende, Karthik Goli, Jennifer Carns, Richard A. Schwarz, Ann M. Gillenwater, Preetha Ramalingam, Mila P. Salcedo, Kathleen M. Schmeler, Tomasz S. Tkaczyk, Jacob T. Robinson, Ashok Veeraraghavan, Rebecca R. Richards-Kortum
Human pannexin mutations and their implications in erosive osteoarthritis
Justin Tang, Jason Lu, Danielle Johnston, Kazuyuki Hoshijima, Brent Wakefield, Donglin Bai, Peter B. Stathopulos, Roger J. Thompson, Alexander W. Lohman, Michael J. Jurynec, Frank Beier, Silvia Penuela
Binocular vision emerges from the coordinated development of orbit convergence, eye orientation, and high-acuity retinal specializations
Alfonso Deichler, Macarena Ruiz-Flores, Natalia I. MĂĄrquez, Cristian Morales, Luciana LĂłpez-Jury, Tomas Vega-Zuniga, Jorge Mpodozis, Macarena Faunes, Gonzalo J. MarĂn
Field data challenge predictions of universal crop pest proliferation under warming
Mia K. Lippey, Jay A. Rosenheim, Daniel Paredes, Richard Sharp, Daniel S. Karp, Rebecca Chaplin Kramer, Sara E. Emery, Colleen R. Miller, Emily K. Meineke
Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes
Raquel GĂłmez-Sintes, Inmaculada Tasset, Ignacio RamĂrez-Pardo, AdriĂĄn MartĂn-Segura, Sandra Alonso-Gil, Antonio DĂaz, Kristen Lindenau, ConcepciĂłn Lillo, Pedro de la Villa, Simone Sidoli, Evripidis Gavathiotis, Ana MarĂa Cuervo, Patricia Boya
Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations
Ruiyang Ge, Yuetong Yu, Faye New, Shalaila S. Haas, Nicole Sanford, Kevin Yu, Paul Allen, Seda Arslan, Mihai Avram, Stefan Borgwardt, Nicolas A. Crossley, Camilo de la Fuente-Sandoval, Masaki Fukunaga, Jia-Hong Gao, Alfonso Gonzalez-Valderrama, Ryota Hashimoto, Felice Iasevoli, Daniel Keeser, Kader Kubat, Veena Kumari, Junya Matsumoto, Urvakhsh M. Mehta, Kiyotaka Nemoto, Giuseppe Pontillo, Florian J. Raabe, Francisco Reyes-Madrigal, Neelabja Roy, Didenur Ćahin-Ăevik, Tuba Sahin-Ilikoglu, Timothea Toulopoulou, Elias Wagner, Guoyuan Yang, Mariana Zurita, Paul M. Thompson, Sophia Frangou
Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation
Sungmo Park, Bozhi Wu, Sofiya Zbaranska, Joseph Lee, Alexander D. Jacob, Annelies Hoorn, Andrew Mocle, Alessandro Luchetti, Mahe Chen, Jung Hoon Jung, Paul W. Frankland, Sheena A. Josselyn
Modular genetic architecture underlies human hand and foot evolution
Alexander S. Okamoto, Gayani Senevirathne, Pushpanathan Muthuirulan, Campbell Rolian, Ian A. Glass, , Terence D. Capellini, Ian A. Glass, Kimberly A. Aldinger, Dan Doherty, Ian G. Phelps, Jennifer C. Dempsey, Mei Deng, Eric Y. So, Yasmeen Otaibi, Iris M. Rappin Benge
Anoxic photo-oxidation of Mn(II)-bearing carbonates on Mars and early Earth
Jiye Guo, Yuke Zhu, Nicholas J. Tosca, Lu Pan, David C. Catling, Yi Liu, Wenhua Zhang, Amrit S. Chaddha, Pengcheng Ju, Jie Li, Zongbin Zhang, Anya Huo, Yunguo Li, Fang Huang, Paul G. Falkowski, Jihua Hao
Synovial fibroblasts modulate endothelial activation in an acute injury-on-a-chip model
Hannah M. Zlotnick, Declan N. Goddard, Christopher J. Calo, Abhishek P. Dhand, Matthew D. Davidson, Aina Solsona-Pujol, Jonathan T. Makhoul, Hannah K. Weppner, Melissa Wong, Carla R. Scanzello, Laurel E. Hind, Jason A. Burdick
MHC-I diversity enables rapid adaptation during a viral pandemic in wild rabbit populations
Yexin Zhang, Jonathan P. Day, Marina Lirintzi, Jiayi Ji, Clive A. Tregaskes, Miguel Carneiro, Joel M. Alves, Tanja Strive, Jim Kaufman, Francis M. Jiggins
Spectral mapping reveals a resemblance of the anesthetic brain state to both sleep and coma
Janna D. Helfrich, Jerzy Szaflarski, Marianne C. J. NĂŠvra, Luis Romunstad, Matthew P. Walker, Bryce A. Mander, Robert T. Knight, PĂ„l G. Larsson, Randolph F. Helfrich
Emergent anisotropic three-phase order in critically doped superconducting diamond films
Jyotirmay Dwivedi, Saurav Islam, Jake Morris, Kalana D. Halanayake, Gabriel A. VĂĄzquez-Lizardi, David Snyder, Anthony Richardella, Luke Lyle, Danielle Reifsnyder Hickey, Nazar Delegan, F. Joseph Heremans, David D. Awschalom, Nitin Samarth
D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes
Fiona L. Kearns, Anthony T. Bogetti, Carla CalvĂł-Tusell, Mac Kevin E. Braza, Lorenzo Casalino, Amanda J. Gramm, Sean Braet, Mia A. Rosenfeld, Harinda Rajapaksha, Bryan Barker, Ganesh Anand, Lillian T. Chong, Surl-Hee Ahn, Rommie E. Amaro
PAM1 regulates meiosis by coupling RNA processing to the chromosome axis
Qian Du, Minghui Wang, Choon-Lin Tiang, Moira J. Sheehan, Paul Altendorf, Ju-Kyung Yu, Otto Hudecz, Elisabeth Roitinger, Chung-Ju Rachel Wang, Robert Bukowski, Robert B. Meeley, Clint Ko, Inna N. Golubovskaya, Wojciech P. Pawlowski
Sperm, egg, and embryo proteins critical for genetic adaptation of herring to low salinity in the Baltic Sea
Cheng Ma, Fahime Mohamadnejad Sangdehi, Mari Kawaguchi, Kaori Sano, Svenja V. Dannenberg, Mats E. Pettersson, Andreas Wallberg, Joshua L. Wort, Yumeng Yan, Sergei Moshkovskii, Florian Berg, Arild Folkvord, Christof Lenz, Henning Urlaub, U. Benjamin Kaupp, Shigeki Yasumasu, Leif Andersson
Identification of immunostimulatory antigens in Group A Streptococcus âderived vesicles
Meztlli O. GaytĂĄn, Rebecca S. Dookie, Sayoni Chakraborty, Anandi Narayana Moorthy, Stefan Kreida, Anna Norrby-Teglund, John Boss, Max Heurgren, Staffan Normark, Birgitta Henriques-Normark
Chengxi Zhong, Vincent Winderoll, Khemraj Gautam Kshetri, Cornel Dillinger, Tommaso Bianchi, Zhan Shi, Justus Schnermann, Marco Amabili, Song Liu, Raphael Wittkowski, Nitesh Nama, Daniel Ahmed
People make strategic decisions many times a dayâduring negotiations, when coordinating actions with others, or when choosing partners for cooperation. The resulting dynamics can be studied with learning theory and evolutionary game theory. These frameworks explore how people adapt their decisions over time, in light of how effective their strategies have been. The outcomes of such learning processes depend on how sensitive individuals are to the performance of their strategies. When they are more sensitive, they systematically favor strategies they deem more successful. When they are less sensitive, their learning process is noisier and more erratic. Traditionally, most models treat this sensitivity as a fixed parameterâlike the âselection strengthâ parameter in evolutionary models. Instead, we study how strategies and sensitivities coevolve. We find that the coevolutionary endpoints depend on both the type of strategic interaction and the learning rule employed. In prisonerâs dilemmas, we often observe sensitivities to increase indefinitely. But in snowdrift and stag-hunt games, sensitivities often converge to a finite value, or we observe evolutionary branching altogether. These results shed light on how evolution might shape learning mechanisms for social behavior. They suggest that noisy learning does not need to be a by-product of cognitive constraints. Instead, it can serve as a means to gain strategic advantages.
Politics embodied: How politics shapes and is shaped by the bodily experience of emotions
Andrea Vik, Alejandro Galvez-Pol, Sohee Park, Manos Tsakiris
Political emotions are widely acknowledged as key drivers of political participation and polarization. Yet while it is well established that political emotions matter, far less is known about how they are felt and represented in the body. Across a preregistered, nationally representative study ( N = 992), we introduce an embodied approach to political emotion using the validated emBODY-tool, which allows participants to map where in the body they experience sensations when feeling canonical emotions (e.g., anger) and their political counterparts (e.g., âpolitical angerâ). Specifically, we address three questions: 1) how political emotions are embodied and differ from their nonpolitical counterparts, 2) whether political dispositions influence how these political emotions are embodied, and 3) how their embodied experience interacts with political dispositions in explaining political attitudes and behavior. Pixelwise bodily sensation maps and aggregated âembodied impactâ metrics show that political anger, anxiety, depression, disgust, and hope do not merely mirror their canonical forms, but take on distinct bodily patterns. Political ideology, but not political sophistication, modulates these bodily experiences, with Democrat-leaning participants reporting more intense sensations for negative political emotions, suggesting the presence of âideological bodies.â Crucially, political participation is not explained by how intensely people report feeling emotions, but is instead closely linked to how strongly these emotions are embodied in the body. Together, our findings underscore the bodyâs central role in democratic engagement by showing how political contexts shape embodied emotional experience and how these embodied experiences shape politics and democracy.
Educational policies can strengthen climate coalitions
Max Bradley, Rens Chazottes, Susanna Garside, Nina Lopez-Uroz
Building public support for ambitious climate policies is a central challenge for governments seeking to decarbonize their economies. Many climate change mitigation policies impose visible material costs on citizens, and governments have limited fiscal capacity to deploy compensatory measures. Education is often used as a tool to build public awareness about climate change, but its effect on support for climate policies is not well understood. We evaluate the effects of a climate education policy through the study of a real-world large-scale educational intervention: a 3-h interactive workshop which has so far been implemented in over 500 French universities. We employed a randomized control trial reaching 1,845 students across 167 workshops. Students who took the workshop expressed 7 percentage points higher support for costly climate policies, including a beef tax, short-haul flight ban, and meat-free university canteen, compared with the control group. The workshop increased beliefs in the effectiveness of these policies and elicited more positive emotions about climate action. Evidence from a subsample of follow-up survey respondents suggests these effects may persist for at least 6 wk. We find no evidence that the workshop increases willingness to donate to a climate NGO. Overall, the results suggest that well-designed climate education can play a role in broadening public coalitions for ambitious climate policies by strengthening perceived policy effectiveness and support for costly policies.
Global and regional climate modes modulate armed conflict risk
Tyler E. Bagwell, Sylvia G. Dee, Xinyue Luo, Anna Stravato, Divya Saikumar, Frederi Viens, Bomi K. Lee, Diana Z. OâBrien, Justin S. Mankin
Because of their impacts on droughts, famines, and floods, modes of climate variability can shape patterns of social instability. Yet the mechanisms linking climate variability to armed conflict remain contested, especially relative to the myriad sociopolitical and economic determinants of conflict. A key challenge is that most studies rely on coarse, state-level data and treat climatic teleconnections as invariant. As such, it is unknown whether there are distinct climate hazards that select for conflict risk; whether conflict scales with climate hazard exposure; and whether such associations exist for more regional forms of climate variability. Here we leverage empirical modeling using a high-resolution gridded dataset of armed conflicts and the natural experiment afforded by two major climate modesâthe El NiñoâSouthern Oscillation (ENSO) and the Indian Ocean Dipole (IOD)âto clarify how systematic hydroclimatic anomalies influence conflict emergence. Our results reveal the following: First, conflict risk heightens during El Niño, but ENSO-associated risk does not scale linearly with teleconnection strength; and, evidence for threshold behavior varies with spatial aggregation. Second, El Niño-related increases in conflict risk arise through its dry teleconnections, with limited evidence for wet teleconnections. Finally, the more regionally confined IOD also influences conflict, with both positive and negative phases elevating risk in strongly teleconnected regions, namely the Horn of Africa and Southeast Asia. These results reveal that modes of climate variability can differentially shape conflict risk, offering insight into societiesâ vulnerabilities to natural climate fluctuations and, by extension, anthropogenic climate change.
A multinational megastudy of the effects of gratitude practices on subjective well-being
Nicholas A. Coles, Annabel V. Dang, Shigehiro Oishi, Abigail Adade, Aderonke A. Akintola, Beatriz B. de Souza, Biljana Gjoneska, Christine R. Harris, Dev Kesarwani, Dinara Pisareva, Eugene Y. J. Tee, Goo Lyann, Gul Gunaydin, Gyuri Lee, Hongbo Yu, Hyewon Choi, JohnBosco Chika Chukwuorji, Karoline Klitgaard, Maciej Behnke, Magnus Bergquist, Marit Gunda Gundersen Engeset, Nattasuda Taephant, Nikita Durnev, Ognen Spasovski, Paulo Sergio Boggio, Ram Manohar Singh, Robin Irmel, Sergio Barbosa, Shangcheng Zhao, Sinem Acar-Burkay, Stefan Pfattheicher, Tatsunori Ishii, Victor Goh Weng Yew, Vivian Dzokoto, Zeynep Soyalan, Michael E. McCullough
Scholars have observed people from a variety of cultures using a variety of gratitude-related practices to change their emotions, outlooks, and social relationships. Across 34 countries purposively sampled to cover a broad set of cross-cultural differences (total N = 10,696), we experimentally tested the effects of 6 brief gratitude interventions on subjective moods, life outlooks, and social evaluations. Compared to 3 control tasks, gratitude practices immediately produced theorized improvements in positive affect ( d = 0.37), negative affect ( d = â0.22), optimism ( d = 0.24), life satisfaction ( d = 0.12), indebtedness ( d = 0.15), and envy ( d = â0.16). Notably, these effects varied across different gratitude practices (0.00 < Ï practice < 0.08) and countries (0.10 < Ï country < 0.19). For instance, based on existing evidence, stakeholders can expect gratitude interventions deployed in a randomly selected country to improve positive affectâbut not our other measured outcomes. To guide future inquiry into why this might be the case, we provide exploratory Bayesian estimates of the importance of 12 cross-cultural differences.
Evaluating the statistical realism of LLM-generated social science data
Large language models (LLMs) hold great promise for generating social science data, potentially expanding the methodological toolkit of quantitative social research. Prior studies have primarily focused on individual-level predictability or behavioral plausibility of LLM-generated data. We propose a framework for assessing the validity of LLM-generated data by returning to the foundational principles of survey research in the social sciences. Just as surveys based on representative samples yield statistics that approximate the corresponding statistical moments of the target population, assessment should center on the ability of LLM-generated data to reproduce real-world, population-level statistical patterns. We introduce SSDataBench, a systematic benchmark designed to evaluate population-level statistical realism in LLM-generated social science data. The benchmark assesses five types of statistical patterns central to social research: univariate distributions, bivariate associations, multivariate outcome predictions, life event sequence distributions, and associations between life event sequences and covariates. We illustrate SSDataBench using four longitudinal datasets and three cross-sectional datasets spanning six major social domains: demographics, socioeconomic status, marriage, health, abilities, and attitudes. Our study reveals representational limitations in current LLMs under sparse conditioning settings, manifested in a pronounced tendency to compress real-world heterogeneity into simplified typological structures. Finally, we outline a roadmap toward improved statistical realism and report preliminary results indicating that domain-specific training can enhance population-level realism.
Discovering regularity and mechanisms of word sense acquisition in childhood
How does language use inform the emergence of word meanings in early life? Prior work in developmental psychology and the cognitive sciences typically focuses on studying word acquisition in children without specifying how different senses within a word emerge through time. To shed light on word sense acquisition, we propose a framework grounded in state-of-the-art computational methodologies of contextual word embedding to characterize how different senses of a word unfold as children acquire their lexicon. Our framework identifies word senses automatically by forming semantic clusters through natural language use, and analyzes 1,270 words from approximately 4 million utterances produced by children (19 to 144 mo) and their caretakers. The psychological validity of these senses was assessed based on a combination of dictionaries, human judgment of semantic similarity, and evaluation from a large language model. We then tested three hypotheses motivated by existing work on word sense emergence in language evolution. First, concrete senses of a word tend to emerge earlier than more abstract senses in child language. Second, word senses grow incrementally in semantic space across development. Third, algorithms of semantic chainingâhow words spawn new senses by extending from existing sensesârecapitulate the order of word senses in development. We find support for all three hypotheses. Our work suggests that the development of word meaning in language acquisition resembles that in language evolution and offers a converging view on the cognitive principles and mechanisms across timescales in the ontogeny and phylogeny of word sense emergence.
Alleviating administrative burdens in rental assistance promotes access and program efficiency
Applicants to government programs often face âadministrative burdensâ that can prevent people from accessing benefits for which they are qualified. However, it is difficult to evaluate the causal impact of relieving administrative burdens, as program requirements are rarely changed in ways that are amenable to quantitative causal inference methods. We evaluate the causal effect of reducing administrative burdens for applicants to emergency rental assistance (ERA), a program intended to support housing stability during the COVID-19 pandemic that distributed more than $46 billion to eligible renters. We analyze application data from two state housing authorities that quasi-randomly changed documentation requirements for applicants, in line with guidance provided by the U.S. Department of the Treasury. Using quasi-experimental methods that leverage strict eligibility cutoffs, we find that replacing the requirement to upload separate income verification documents with an automated eligibility check increased the probability that a rental assistance application was approved by approximately 15 percentage points. Further, and in line with staff reports that the program change streamlined time-consuming document review procedures, we show that eligible applications were processed nearly two weeks faster, a critical improvement for renters facing rental debts and eviction. Finally, we use data on ERA audits to show that increases in application approval and efficiency were met with no corresponding detectable increase in instances of suspected fraud.
Do negative social ties accelerate aging in adults, or does aging erode social ties?
Many strategic decisions involve both substantial complexity and time pressure, but the association between decision speed and decision quality of cognitively demanding strategic decisions is not well understood. This paper presents evidence on this question using a setting with exceptionally detailed and precise information about decision times and decision qualityâit analyses move-by-move data from in-person professional chess tournaments. Decision quality is measured by comparing actual moves to a computational benchmark of best moves constructed using the artificial intelligence of a chess engine. The results show that faster decisions are associated with higher decision quality, even after accounting for computational complexity, distinctiveness between alternatives, and time pressure. Greater computational complexity and lower distinctiveness between move alternatives are associated with longer decision times, whereas greater time pressure is associated with shorter decision times. All three factors are associated with lower decision quality. We discuss the findings against the predictions of different decision models in which individuals sequentially acquire information about alternatives with uncertain valuations, extending theories originally developed in the context of nonstrategic decisions to a strategic environment.
Scientific Data
GPT-4o mini: Non-social science research article
A national-scale database of groundwater level data for Switzerland
Raoul A. Collenteur, Joaquin Jimenez-Martinez, Mario Schirmer, Christian Moeck
Digitization of Historical Data from Somaliaâs Last Smallpox Outbreaks 1976-1977
Rabia Khan, Hannah Williams, Galena Kuyumdzhieva, Christopher Carroll, Katherine Griffiths, Leonardo Gada, Brodie Walker, Joseph Shingleton, Joe Flannagan, Rosamund Lewis, Thomas Finnie, Ian Hall, Emma Bennett
Chromosome-level assembly of the Critically Endangered school shark, Galeorhinus galeus (Linnaeus, 1758)
Emma de Jong, Floriaan Devloo-Delva, Liam Anstiss, Bruce Deagle, Adrianne Doran, Pierre Feutry, Lauren Huet, Katherine Ollerhead, Lara Parata, Jayson Semmens, Shannon Corrigan
Full-range (VNIRâSWIRâMWIRâLWIR) mineral and VNIR water spectra with co-located geochemistry from an acid mine drainage (AMD) site (Kirki, NE Greece)
The GEOS/ECCO C1440-LLC2160 Coupled Atmosphere-Ocean Simulation Dataset
Dimitris Menemenlis, Andrea Molod, Christopher N. Hill, Atanas Trayanov, Ehud Strobach, Jean-Michel Campin, Abdullah A. Fahad, Patrick Heimbach, Hong Zhang, Young-Kwon Lim, Sina Khani, Christopher E. Henze, David A. Ellsworth, Nina McCurdy
This data paper presents a dataset, of 12,361 observations compiled from the Happiness Meanders project, which explores cultural variations in individual and family well-being, ideal and actual happiness, emotional experiences and expressions, and cultural models of selfhood across 48 countries. Participants were recruited through academic networks. Data were collected using standardised scales, including the Satisfaction with Life Scale, the Interdependent Happiness Scale, the Cultural Models of Selfhood Scale, and the Emotional Experience and Expression inspired by Affect Valuation Index. The dataset underwent thorough technical validation, including checks for variable consistency, handling missing data, and identifying potential response biases. A filter for data quality was applied, with potentially unreliable data flagged for exclusion. This dataset offers a valuable resource for examining cultural influences on emotional dynamics (frequence of experience and expression), individual and family oriented evaluations of happiness, ideal and actual evaluation of happiness, cultural models of selfhood, and can support further research in cross-cultural psychology and related social sciences.
A dataset on the experimental study of online and offline communication with digital and biomarkers
Elina Tsigeman, Larisa Mararitsa, Olga Lopatina, Ailar Avliyakulyeva, Ekaterina Kindyakova, Olessia Koltsova
The rise of videoconferencing (VC) technologies has transformed how individuals collaborate and interact across professional and personal contexts. However, empirical studies comparing VC and face-to-face (FtF) interactions remain fragmented, partly due to a lack of open, multimodal datasets capturing both modalities with rich behavioural, physiological, and self-report measures. To address this gap, we introduce the dataset, comprising approximately 180 hours of audio-visual recordings of unacquainted dyads engaging in structured and creative collaborative tasks under controlled laboratory conditions. Participants were randomly assigned to VC or FtF interaction. The dataset includes six salivary oxytocin measurements, self-reports on affect, personality traits, relevant attitudes, communication outcomes, and a repeated sustained attention task. Behavioural recordings from frontal and side camera views are available for most dyads, with individual-level data for 127â131 participants. The dataset enables research into social bonding, cooperation, behavioural and physiological synchrony, and broader communication dynamics, filling a critical gap in resources for comparative communication studies.
Socio-Economic Review
Unemployment, inactivity, and hiring chances: A systematic review and meta-analysis
Policymakersâ push for higher employment rates has renewed attention to the labour market position of long-term unemployed jobseekers and inactive persons. However, stigma related to unemployment or inactivity can hinder their hiring chances when applying for a job. This systematic literature review investigates whether, when, and why periods of not working are penalized in hiring. Our review confirms employers treat the unemployed and inactive less favourably than their employed counterparts. A meta-regression analysis of multi-country experimental data points to heterogeneity by the duration of being out of work: short-term unemployment of up to six months positively affects hiring prospects, while the adverse effects of unemployment scarring become noticeable after about twelve months. These patterns align with signalling mechanisms: immediate availability may offset negative signals in short spells, whereas expectations about reduced productivity plausibly drive negative effects of longer spells. The latter signal seems more pronounced when unemployment rates are low.